KEGG   ORTHOLOGY: K06279
Entry
K06279                      KO                                     

Name
SHC1
Definition
SHC-transforming protein 1
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04013  MAPK signaling pathway - fly
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05100  Bacterial invasion of epithelial cells
map05206  MicroRNAs in cancer
map05214  Glioma
map05220  Chronic myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K06279  SHC1; SHC-transforming protein 1
   04012 ErbB signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04014 Ras signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04072 Phospholipase D signaling pathway
    K06279  SHC1; SHC-transforming protein 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06279  SHC1; SHC-transforming protein 1
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K06279  SHC1; SHC-transforming protein 1
   04062 Chemokine signaling pathway
    K06279  SHC1; SHC-transforming protein 1
  09152 Endocrine system
   04910 Insulin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04915 Estrogen signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04917 Prolactin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04926 Relaxin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
   04935 Growth hormone synthesis, secretion and action
    K06279  SHC1; SHC-transforming protein 1
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K06279  SHC1; SHC-transforming protein 1
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K06279  SHC1; SHC-transforming protein 1
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K06279  SHC1; SHC-transforming protein 1
   05226 Gastric cancer
    K06279  SHC1; SHC-transforming protein 1
   05214 Glioma
    K06279  SHC1; SHC-transforming protein 1
   05220 Chronic myeloid leukemia
    K06279  SHC1; SHC-transforming protein 1
   05224 Breast cancer
    K06279  SHC1; SHC-transforming protein 1
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K06279  SHC1; SHC-transforming protein 1
  09165 Substance dependence
   05034 Alcoholism
    K06279  SHC1; SHC-transforming protein 1
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K06279  SHC1; SHC-transforming protein 1
   01522 Endocrine resistance
    K06279  SHC1; SHC-transforming protein 1
Genes
HSA: 6464(SHC1)
PTR: 457351(SHC1)
PPS: 100993361(SHC1)
GGO: 101136424(SHC1)
PON: 100173225(SHC1)
NLE: 100606068(SHC1)
MCC: 718982(SHC1)
MCF: 102142777(SHC1)
CSAB: 103223899(SHC1)
CATY: 105585292 105585293 105593504(SHC1)
PANU: 101001939(SHC1)
RRO: 104663483(SHC1)
RBB: 108526812(SHC1)
TFN: 117075160(SHC1)
PTEH: 111543732(SHC1)
CJC: 100390337(SHC1)
SBQ: 101038895(SHC1) 101047748
MMUR: 105873192(SHC1)
MMU: 20416(Shc1)
MCAL: 110290710(Shc1)
MPAH: 110320247(Shc1)
RNO: 85385(Shc1)
MCOC: 116093178(Shc1)
MUN: 110551574(Shc1)
CGE: 100758936(Shc1)
PLEU: 114707889(Shc1)
NGI: 103751254(Shc1)
HGL: 101717434(Shc1)
CCAN: 109688030(Shc1)
OCU: 100342812(SHC1)
TUP: 102481002(SHC1)
CFA: 490439(SHC1)
VVP: 112918897(SHC1)
VLG: 121485053(SHC1)
AML: 100480856(SHC1)
UMR: 103668383(SHC1)
UAH: 113245295(SHC1)
ORO: 101373821(SHC1)
ELK: 111138866
MPUF: 101680880(SHC1)
EJU: 114198628(SHC1)
MLX: 118013864(SHC1)
FCA: 101092911(SHC1)
PTG: 102949026(SHC1)
PPAD: 109256269(SHC1)
AJU: 106988382(SHC1)
HHV: 120244661(SHC1)
BTA: 507196(SHC1)
BOM: 102265814(SHC1)
BIU: 109553931(SHC1)
BBUB: 102409515(SHC1)
CHX: 102170926(SHC1)
OAS: 101113548(SHC1)
ODA: 120855734(SHC1)
SSC: 100156321(SHC1)
CFR: 102524489(SHC1)
CDK: 105089005(SHC1)
BACU: 103015382(SHC1)
LVE: 103074885(SHC1)
OOR: 101276908(SHC1)
DLE: 111167062(SHC1)
PCAD: 102991486(SHC1)
ECB: 100063053(SHC1)
EPZ: 103552865(SHC1)
EAI: 106828516(SHC1)
MYB: 102245916(SHC1)
MYD: 102755241(SHC1)
MMYO: 118669819 118672782(SHC1)
MNA: 107543890(SHC1)
HAI: 109393422(SHC1)
DRO: 112316734(SHC1)
SHON: 118990179(SHC1)
AJM: 119061761(SHC1)
MMF: 118637475(SHC1)
PALE: 102894443(SHC1)
RAY: 107505474(SHC1) 107512423
MJV: 108407280(SHC1)
TOD: 119235491(SHC1)
LAV: 100653766(SHC1)
TMU: 101358105
MDO: 100016090(SHC1)
SHR: 100926921(SHC1)
PCW: 110198538 110211965(SHC1)
OAA: 114808180(SHC1)
GGA: 395934(SHC1)
PCOC: 116237337(SHC1)
MGP: 100540048(SHC1)
CJO: 107324486(SHC1)
NMEL: 110391258(SHC1)
APLA: 101791792(SHC1)
ACYG: 106048510
TGU: 100229782(SHC1)
LSR: 110471528(SHC1)
SCAN: 103823958(SHC1)
PMOA: 120498883(SHC1)
GFR: 102039503(SHC1)
FAB: 101807411(SHC1)
PHI: 102106714(SHC1)
PMAJ: 107214540(SHC1)
CCAE: 111939466(SHC1)
ETL: 114068431(SHC1)
FPG: 101919976(SHC1)
FCH: 102048929(SHC1)
CLV: 102093713(SHC1)
EGZ: 104127244(SHC1)
NNI: 104012052(SHC1)
ACUN: 113488759(SHC1)
PADL: 103922288(SHC1)
AAM: 106483710
ASN: 102376721(SHC1)
AMJ: 106737253(SHC1)
CPOO: 109324765(SHC1)
GGN: 109303877(SHC1)
PSS: 102457971(SHC1)
CMY: 102941809(SHC1)
CPIC: 101952789(SHC1)
TST: 117888534(SHC1)
CABI: 116830123(SHC1)
ACS: 100566335(shc1)
PVT: 110081020(SHC1)
PBI: 103049298(SHC1)
PMUR: 107296691(SHC1)
TSR: 106537474(SHC1)
PGUT: 117658844(SHC1)
PMUA: 114586090(SHC1)
ZVI: 118075732(SHC1)
GJA: 107117081(SHC1)
XLA: 108700442(shc1.S) 399198(shc1.L)
XTR: 116406911(shc1)
NPR: 108795195(SHC1)
DRE: 323818(shc1)
SANH: 107673667(shc1) 107677023
SGH: 107582132 107594952(shc1)
CCAR: 109108120
IPU: 108265869(shc1)
PHYP: 113542402(shc1)
AMEX: 103030808(shc1)
EEE: 113590613(shc1)
TRU: 101071954(shc1) 105417270(shc4)
LCO: 104918187(shc1)
NCC: 104962177(shc1)
ELY: 117265729(shc1)
PLEP: 121945480(shc1)
SLUC: 116049544(shc1)
ECRA: 117946714(shc1)
PFLV: 114556600(shc1)
GAT: 120810662(shc1)
MSAM: 119897594(shc1)
CUD: 121513974(shc1)
MZE: 101480827(shc1)
ONL: 100704980(shc1)
OAU: 116315698(shc1)
OLA: 101154895(shc1)
OML: 112143897(shc1)
XMA: 102228847(shc1)
XCO: 114140972(shc1)
XHE: 116716789(shc1)
PRET: 103478162(shc1)
CVG: 107088415(shc1)
CTUL: 119786725(shc1)
NFU: 107379732(shc1)
KMR: 108241071(shc1)
ALIM: 106529899(shc1)
AOCE: 111566077(shc1)
CSEM: 103388227(shc1)
POV: 109633454(shc1)
LCF: 108885949(shc1)
SDU: 111230117(shc1)
SLAL: 111656972(shc1)
XGL: 120783842(shc1)
HCQ: 109521038(shc1)
BPEC: 110162980(shc1) 110173049(shc4)
MALB: 109964107(shc1)
OTW: 112222667
SALP: 111959065(shc1)
ELS: 105024470(shc1)
SFM: 108925486(shc1)
PKI: 111848307(shc1)
LOC: 102684095(shc1)
PSPA: 121307017(shc1)
ARUT: 117395410(shc1)
LCM: 102356771(SHC1)
CIN: 100181792
SCLV: 120342172
APLC: 110990360
SKO: 102802005
DME: Dmel_CG3715(Shc)
DER: 6545643
DSE: 6605028
DSI: Dsimw501_GD14181(Dsim_GD14181)
DAN: 6507278
DSR: 110190630
DPE: 6599634
DMN: 108153002
DWI: 6639528
DAZ: 108613150
DNV: 108650495
DHE: 111603738
DVI: 6623182
MDE: 101892485
LCQ: 111682809
ACOZ: 120955156
AARA: 120899878
AAG: 5571016
CPII: 120418452
AME: 412172
ACER: 107999290
BIM: 100749343
BTER: 100648173
CCAL: 108631207
OBB: 114875845
MGEN: 117225490
NMEA: 116435014
CGIG: 122405552
SOC: 105193309
MPHA: 105830863
AEC: 105143333
ACEP: 105625063
PBAR: 105433457
VEM: 105565412
HST: 105188999
DQU: 106744347
CFO: 105252997
FEX: 115243693
LHU: 105677602
PGC: 109856287
OBO: 105277856
PCF: 106793282
NVI: 100118291
CSOL: 105368992
MDL: 103574093
TCA: 658971
DPA: 109532895
ATD: 109601124
AGB: 108907350
NVL: 108561427
APLN: 108742429
PPYR: 116165655
OTU: 111425320
BMOR: 101739196
BMAN: 114244875
MSEX: 115441692
BANY: 112056015
PMAC: 106714389
PXU: 106124802
PRAP: 110994846
ZCE: 119829580
HAW: 110383811
TNL: 113496933
PXY: 105391294
API: 100570104
DNX: 107173943
AGS: 114121289
RMD: 113556928
BTAB: 109037229
DCI: 103509874
CLEC: 106670456
NLU: 111050810
ZNE: 110830796
CSEC: 111862806
EAF: 111701949
DSV: 119449483
RSAN: 119387443
RMP: 119188301
VDE: 111254482
VJA: 111263891
DPTE: 113791645
CSCU: 111622033
CEL: CELE_F54A5.3(shc-1)
CBR: CBG05128(Cbr-shc-1)
PCAN: 112554149
BGT: 106071539
GAE: 121381149
CRG: 105331060
MYI: 110460076
PMAX: 117334706
OBI: 106871874
LAK: 106154724
NVE: 5518213
EPA: 110236258
AMIL: 114970949
PDAM: 113682635
SPIS: 111342706
DGT: 114533934
 » show all
Reference
  Authors
Audero E, Cascone I, Maniero F, Napione L, Arese M, Lanfrancone L, Bussolino F
  Title
Adaptor ShcA protein binds tyrosine kinase Tie2 receptor and regulates migration and sprouting but not survival of endothelial cells.
  Journal
J Biol Chem 279:13224-33 (2004)
DOI:10.1074/jbc.M307456200
  Sequence
[hsa:6464]
Reference
PMID:1623525
  Authors
Pelicci G, Lanfrancone L, Grignani F, McGlade J, Cavallo F, Forni G, Nicoletti I, Grignani F, Pawson T, Pelicci PG
  Title
A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction.
  Journal
Cell 70:93-104 (1992)
DOI:10.1016/0092-8674(92)90536-L
  Sequence
[hsa:6464]
LinkDB

KEGG   ORTHOLOGY: K17447
Entry
K17447                      KO                                     

Name
SHC2
Definition
SHC-transforming protein 2
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04370  VEGF signaling pathway
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05100  Bacterial invasion of epithelial cells
map05214  Glioma
map05220  Chronic myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04014 Ras signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04370 VEGF signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04072 Phospholipase D signaling pathway
    K17447  SHC2; SHC-transforming protein 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17447  SHC2; SHC-transforming protein 2
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17447  SHC2; SHC-transforming protein 2
   04062 Chemokine signaling pathway
    K17447  SHC2; SHC-transforming protein 2
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04915 Estrogen signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04917 Prolactin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04926 Relaxin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
   04935 Growth hormone synthesis, secretion and action
    K17447  SHC2; SHC-transforming protein 2
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17447  SHC2; SHC-transforming protein 2
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17447  SHC2; SHC-transforming protein 2
   05226 Gastric cancer
    K17447  SHC2; SHC-transforming protein 2
   05214 Glioma
    K17447  SHC2; SHC-transforming protein 2
   05220 Chronic myeloid leukemia
    K17447  SHC2; SHC-transforming protein 2
   05224 Breast cancer
    K17447  SHC2; SHC-transforming protein 2
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17447  SHC2; SHC-transforming protein 2
  09165 Substance dependence
   05034 Alcoholism
    K17447  SHC2; SHC-transforming protein 2
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17447  SHC2; SHC-transforming protein 2
   01522 Endocrine resistance
    K17447  SHC2; SHC-transforming protein 2
Genes
HSA: 25759(SHC2)
PTR: 749831(SHC2)
PPS: 100974798(SHC2)
GGO: 101129046(SHC2)
PON: 100445042(SHC2)
NLE: 100591489(SHC2)
MCC: 721021(SHC2)
MCF: 102125325(SHC2)
CSAB: 103233559(SHC2)
CATY: 105591876(SHC2)
PANU: 101006054
RBB: 108531776(SHC2) 108533994
TFN: 117074894(SHC2)
PTEH: 111528883(SHC2)
CJC: 100415083(SHC2)
SBQ: 101048523(SHC2)
MMUR: 105860825(SHC2)
MMU: 216148(Shc2)
MCAL: 110303444(Shc2)
MPAH: 110326457(Shc2)
RNO: 314612(Shc2)
MCOC: 116076241(Shc2)
MUN: 110551355(Shc2)
CGE: 100761269(Shc2)
PLEU: 114684102(Shc2)
NGI: 103737407(Shc2)
HGL: 101723930(Shc2)
CCAN: 109686083(Shc2)
TUP: 102481863(SHC2)
CFA: 611955(SHC2)
VVP: 112935467(SHC2)
VLG: 121494261(SHC2)
AML: 100480694(SHC2)
UMR: 103681753(SHC2)
UAH: 113242690(SHC2)
ORO: 101384118(SHC2)
ELK: 111161808
MPUF: 101692343(SHC2)
EJU: 114226321(SHC2)
MLX: 118004996(SHC2)
FCA: 101083489(SHC2)
PTG: 102954336(SHC2)
PPAD: 109257730(SHC2)
AJU: 106978092(SHC2)
HHV: 120242345(SHC2)
BTA: 533455(SHC2)
BOM: 102281047(SHC2)
BIU: 109561056(SHC2)
BBUB: 102389953(SHC2)
CHX: 102169956(SHC2)
OAS: 101113847(SHC2)
ODA: 120864498(SHC2)
SSC: 110259382(SHC2)
CFR: 102506382(SHC2)
CDK: 105093416(SHC2)
BACU: 103006868(SHC2)
LVE: 103088833(SHC2)
OOR: 101275665(SHC2)
DLE: 111170483(SHC2)
PCAD: 102974315(SHC2)
ECB: 100146209(SHC2)
EPZ: 103542441(SHC2)
EAI: 106834253(SHC2)
MYB: 102251506(SHC2)
MYD: 102752087(SHC2)
MMYO: 118659254(SHC2)
MNA: 107538554(SHC2)
HAI: 109390676(SHC2)
DRO: 112312297(SHC2)
SHON: 118984370(SHC2)
AJM: 119044619(SHC2)
MMF: 118615745(SHC2)
PALE: 102885958(SHC2)
RAY: 107500961(SHC2)
MJV: 108391745(SHC2)
TOD: 119240463(SHC2)
TMU: 101359726
SHR: 100917745(SHC2)
PCW: 110223483(SHC2)
OAA: 100081397(SHC2)
GGA: 770341(SHC2)
PCOC: 116235831(SHC2)
MGP: 100538500(SHC2)
CJO: 107325668(SHC2)
NMEL: 110389019(SHC2)
APLA: 101803969(SHC2)
ACYG: 106049094(SHC2)
TGU: 100217581(SHC2)
LSR: 110475781(SHC2)
SCAN: 103822026(SHC2)
PMOA: 120496007(SHC2)
GFR: 102034643(SHC2)
FAB: 101815242(SHC2)
PHI: 102100749(SHC2)
PMAJ: 107215430(SHC2)
CCAE: 111940286(SHC2)
CCW: 104697005(SHC2)
ETL: 114066416(SHC2)
FPG: 101924524(SHC2)
FCH: 102049085(SHC2)
CLV: 102088882(SHC2)
EGZ: 104124436(SHC2)
NNI: 104016320(SHC2)
PADL: 103923470(SHC2)
AAM: 106486386(SHC2)
ASN: 102383911(SHC2)
AMJ: 102565747(SHC2)
GGN: 109294913(SHC2)
CMY: 102933759(SHC2)
CPIC: 101944228(SHC2)
TST: 117868957(SHC2)
CABI: 116814882(SHC2)
ACS: 100553545(shc2)
PVT: 110079278(SHC2)
PBI: 103061599(SHC2)
PMUR: 107298759
PGUT: 117668639(SHC2)
PMUA: 114588608(SHC2)
ZVI: 118087871(SHC2)
GJA: 107110440(SHC2)
XLA: 108706896(shc2.S) 108713169(shc2.L)
XTR: 100487416(shc2)
NPR: 108790334(SHC2)
DRE: 562011(shc2)
SANH: 107676975(shc2) 107699410
CCAR: 109096032
IPU: 108270761(shc2)
PHYP: 113547084(shc2)
AMEX: 103026451
EEE: 113587209(shc2)
TRU: 101071160(shc2)
LCO: 104918475(shc2)
NCC: 104958981(shc2)
ELY: 117254016(shc2)
PLEP: 121938139(shc2)
SLUC: 116055201(shc2)
ECRA: 117950057(shc2)
PFLV: 114561987(shc2)
GAT: 120823634(shc2)
MSAM: 119900775(shc2)
CUD: 121512814(shc2)
MZE: 101463941
ONL: 100696779
OAU: 116317325(shc2)
OLA: 101156242(shc2)
OML: 112150934(shc2)
XMA: 102216631
XCO: 114150293
XHE: 116726316
PRET: 103463557(shc2)
CVG: 107085719(shc2)
CTUL: 119794273(shc2)
NFU: 107393200(shc2)
KMR: 108230757(shc2)
ALIM: 106530194(shc2)
AOCE: 111573492(shc2)
CSEM: 103398231
POV: 109625730(shc2)
LCF: 108881424(shc2)
SDU: 111232138
SLAL: 111654285
XGL: 120790651(shc2)
HCQ: 109532226
BPEC: 110167820(shc2)
MALB: 109964050
OMY: 110521457 110524319(shc2)
ELS: 105011583(shc2)
SFM: 108919768(shc2)
PKI: 111860152(shc2)
LOC: 102690296
PSPA: 121301327(shc2)
LCM: 102355047(SHC2)
CMK: 103182043(shc2)
RTP: 109937865(shc2)
ATEN: 116299283
 » show all
Reference
PMID:9507002
  Authors
Nakamura T, Muraoka S, Sanokawa R, Mori N
  Title
N-Shc and Sck, two neuronally expressed Shc adapter homologs. Their differential regional expression in the brain and roles in neurotrophin and Src signaling.
  Journal
J Biol Chem 273:6960-7 (1998)
DOI:10.1074/jbc.273.12.6960
  Sequence
[hsa:25759]
Reference
  Authors
Sasaki H, Emi M, Iijima H, Ito N, Sato H, Yabe I, Kato T, Utsumi J, Matsubara K
  Title
Copy number loss of (src homology 2 domain containing)-transforming protein 2 (SHC2) gene: discordant loss in monozygotic twins and frequent loss in patients with multiple system atrophy.
  Journal
Mol Brain 4:24 (2011)
DOI:10.1186/1756-6606-4-24
  Sequence
[hsa:25759]
LinkDB

KEGG   ORTHOLOGY: K17448
Entry
K17448                      KO                                     

Name
SHC3
Definition
SHC-transforming protein 3
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05100  Bacterial invasion of epithelial cells
map05214  Glioma
map05220  Chronic myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04014 Ras signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04072 Phospholipase D signaling pathway
    K17448  SHC3; SHC-transforming protein 3
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17448  SHC3; SHC-transforming protein 3
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17448  SHC3; SHC-transforming protein 3
   04062 Chemokine signaling pathway
    K17448  SHC3; SHC-transforming protein 3
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04915 Estrogen signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04917 Prolactin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04926 Relaxin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
   04935 Growth hormone synthesis, secretion and action
    K17448  SHC3; SHC-transforming protein 3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17448  SHC3; SHC-transforming protein 3
 09160 Human Diseases
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17448  SHC3; SHC-transforming protein 3
   05226 Gastric cancer
    K17448  SHC3; SHC-transforming protein 3
   05214 Glioma
    K17448  SHC3; SHC-transforming protein 3
   05220 Chronic myeloid leukemia
    K17448  SHC3; SHC-transforming protein 3
   05224 Breast cancer
    K17448  SHC3; SHC-transforming protein 3
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17448  SHC3; SHC-transforming protein 3
  09165 Substance dependence
   05034 Alcoholism
    K17448  SHC3; SHC-transforming protein 3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17448  SHC3; SHC-transforming protein 3
   01522 Endocrine resistance
    K17448  SHC3; SHC-transforming protein 3
Genes
HSA: 53358(SHC3)
PTR: 450176(SHC3)
PPS: 100972624(SHC3)
GGO: 101127418(SHC3)
PON: 100462011(SHC3)
NLE: 100589484(SHC3)
MCC: 574275(SHC3)
MCF: 102130150(SHC3)
CSAB: 103219725(SHC3)
CATY: 105584282(SHC3)
PANU: 101024393(SHC3)
RRO: 104668515(SHC3)
RBB: 108532239(SHC3)
TFN: 117098366(SHC3)
PTEH: 111527961(SHC3)
CJC: 100402406(SHC3)
SBQ: 101028764(SHC3)
MMUR: 105876163(SHC3)
MMU: 20418(Shc3)
MCAL: 110308134(Shc3)
MPAH: 110333751(Shc3)
RNO: 114858(Shc3)
MCOC: 116081462(Shc3)
MUN: 110559069(Shc3)
CGE: 100760879(Shc3)
PLEU: 114689488(Shc3)
NGI: 103726215(Shc3)
HGL: 101715363(Shc3)
CCAN: 109675955(Shc3)
OCU: 100353992(SHC3)
TUP: 102472295(SHC3)
CFA: 476352(SHC3)
VVP: 112908627(SHC3)
VLG: 121485154(SHC3)
AML: 100468080(SHC3)
UMR: 103663185(SHC3)
UAH: 113270120(SHC3)
ORO: 101375500(SHC3)
ELK: 111153623
MPUF: 101676109(SHC3)
EJU: 114219804(SHC3)
MLX: 118026255(SHC3)
FCA: 101095865(SHC3)
PTG: 102965813(SHC3)
PPAD: 109275536(SHC3)
AJU: 106987970(SHC3)
HHV: 120237954(SHC3)
BTA: 512696(SHC3)
BOM: 102268950(SHC3)
BIU: 109562580(SHC3)
BBUB: 102411865(SHC3)
CHX: 102189677(SHC3)
OAS: 101107936(SHC3)
ODA: 120861915(SHC3)
SSC: 102164918(SHC3)
CFR: 102508169(SHC3)
CDK: 105086410(SHC3)
BACU: 103017986(SHC3)
LVE: 103078122(SHC3)
OOR: 101280480(SHC3)
DLE: 111167641(SHC3)
PCAD: 102977456(SHC3)
ECB: 100061926(SHC3)
EPZ: 103552516(SHC3)
EAI: 106841633(SHC3)
MYB: 102245983(SHC3)
MYD: 102772432(SHC3)
MMYO: 118652528(SHC3)
MNA: 107529164(SHC3)
HAI: 109376923(SHC3)
DRO: 112307260(SHC3)
SHON: 118993733(SHC3)
AJM: 119040940(SHC3)
MMF: 118629877(SHC3)
PALE: 102879956(SHC3)
RAY: 107504308(SHC3)
MJV: 108404902
TOD: 119231849(SHC3)
LAV: 100659669(SHC3)
TMU: 101360084
MDO: 100024603(SHC3)
SHR: 100914800(SHC3)
PCW: 110223827(SHC3)
GGA: 431265(SHC3)
PCOC: 116236693(SHC3)
CJO: 107306293(SHC3)
NMEL: 110390178(SHC3)
APLA: 101792705(SHC3)
ACYG: 106045108(SHC3)
TGU: 100221851(SHC3)
LSR: 110470634(SHC3)
SCAN: 103821251(SHC3)
PMOA: 120509461(SHC3)
GFR: 102039603(SHC3)
FAB: 101820104(SHC3)
PHI: 102110162(SHC3)
PMAJ: 107216331(SHC3)
CCAE: 111941731(SHC3)
CCW: 104689719(SHC3)
ETL: 114061143(SHC3)
FPG: 101913271(SHC3)
FCH: 102053453(SHC3)
CLV: 102091397(SHC3)
EGZ: 104126913(SHC3)
NNI: 104009737(SHC3)
ACUN: 113490173(SHC3)
PADL: 103921606(SHC3)
AAM: 106495478(SHC3)
ASN: 102374227(SHC3)
AMJ: 102574737(SHC3)
CPOO: 109323712(SHC3)
GGN: 109297521(SHC3)
PSS: 102449148(SHC3)
CMY: 102938973(SHC3)
CPIC: 101943152(SHC3)
TST: 117879421(SHC3)
CABI: 116820123(SHC3)
ACS: 100560033(shc3)
PVT: 110080566(SHC3)
PBI: 103061531(SHC3)
PMUR: 107293823(SHC3)
TSR: 106543844(SHC3)
PGUT: 117661352(SHC3)
PMUA: 114606494(SHC3)
ZVI: 118076970(SHC3)
GJA: 107108634(SHC3)
XTR: 100101768(shc3)
NPR: 108792509(SHC3)
DRE: 100332111(shc3)
SRX: 107713521(shc3) 107731079
CCAR: 109108077
IPU: 108279345
PHYP: 113535807
AMEX: 103034159
EEE: 113573720
TRU: 101074404
LCO: 104928532(shc3)
NCC: 104940972(shc3)
ELY: 117269992(shc3)
PLEP: 121960165(shc3)
SLUC: 116062835(shc3)
ECRA: 117959810(shc3)
PFLV: 114571470(shc3)
GAT: 120831599(shc3)
MSAM: 119914153(shc3) 119915020
CUD: 121525455(shc3)
MZE: 101471658
ONL: 100703092
OAU: 116331844(shc3)
OLA: 101174847(shc3)
OML: 112163126(shc3)
XMA: 102217649
XCO: 114149224(shc3)
XHE: 116724009(shc3)
PRET: 103473860
CVG: 107085834(shc3)
CTUL: 119789839(shc3)
NFU: 107374683(shc3)
KMR: 108231103(shc3)
ALIM: 106534007(shc3)
AOCE: 111585351(shc3)
CSEM: 103390284(shc3)
POV: 109642612
LCF: 108874038(shc3)
SDU: 111234683(shc3)
SLAL: 111664807(shc3)
XGL: 120806701(shc3)
HCQ: 109523621(shc3)
BPEC: 110160455
MALB: 109960608
SASA: 106568489(shc3)
OTW: 112257355
OMY: 110536941(shc3)
SALP: 111980239
ELS: 105031363(shc3)
SFM: 108932838(shc3)
PKI: 111833617(shc3)
LOC: 102685302(shc3)
LCM: 102362793(SHC3)
CMK: 103182842(shc3)
 » show all
Reference
PMID:8808684
  Authors
Nakamura T, Sanokawa R, Sasaki Y, Ayusawa D, Oishi M, Mori N
  Title
N-Shc: a neural-specific adapter molecule that mediates signaling from neurotrophin/Trk to Ras/MAPK pathway.
  Journal
Oncogene 13:1111-21 (1996)
  Sequence
[hsa:53358]
LinkDB

KEGG   ORTHOLOGY: K17449
Entry
K17449                      KO                                     

Name
SHC4
Definition
SHC-transforming protein 4
Pathway
map01521  EGFR tyrosine kinase inhibitor resistance
map01522  Endocrine resistance
map04012  ErbB signaling pathway
map04014  Ras signaling pathway
map04062  Chemokine signaling pathway
map04072  Phospholipase D signaling pathway
map04510  Focal adhesion
map04650  Natural killer cell mediated cytotoxicity
map04722  Neurotrophin signaling pathway
map04910  Insulin signaling pathway
map04915  Estrogen signaling pathway
map04917  Prolactin signaling pathway
map04926  Relaxin signaling pathway
map04935  Growth hormone synthesis, secretion and action
map05034  Alcoholism
map05100  Bacterial invasion of epithelial cells
map05206  MicroRNAs in cancer
map05214  Glioma
map05220  Chronic myeloid leukemia
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04014 Ras signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04072 Phospholipase D signaling pathway
    K17449  SHC4; SHC-transforming protein 4
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K17449  SHC4; SHC-transforming protein 4
 09150 Organismal Systems
  09151 Immune system
   04650 Natural killer cell mediated cytotoxicity
    K17449  SHC4; SHC-transforming protein 4
   04062 Chemokine signaling pathway
    K17449  SHC4; SHC-transforming protein 4
  09152 Endocrine system
   04910 Insulin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04915 Estrogen signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04917 Prolactin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04926 Relaxin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
   04935 Growth hormone synthesis, secretion and action
    K17449  SHC4; SHC-transforming protein 4
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K17449  SHC4; SHC-transforming protein 4
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K17449  SHC4; SHC-transforming protein 4
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K17449  SHC4; SHC-transforming protein 4
   05226 Gastric cancer
    K17449  SHC4; SHC-transforming protein 4
   05214 Glioma
    K17449  SHC4; SHC-transforming protein 4
   05220 Chronic myeloid leukemia
    K17449  SHC4; SHC-transforming protein 4
   05224 Breast cancer
    K17449  SHC4; SHC-transforming protein 4
  09171 Infectious disease: bacterial
   05100 Bacterial invasion of epithelial cells
    K17449  SHC4; SHC-transforming protein 4
  09165 Substance dependence
   05034 Alcoholism
    K17449  SHC4; SHC-transforming protein 4
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K17449  SHC4; SHC-transforming protein 4
   01522 Endocrine resistance
    K17449  SHC4; SHC-transforming protein 4
Genes
HSA: 399694(SHC4)
PTR: 453414(SHC4)
PPS: 100991042(SHC4)
GGO: 101154420(SHC4)
PON: 100431574(SHC4)
NLE: 100591644(SHC4)
MCC: 714611(SHC4)
MCF: 102130383(SHC4)
CSAB: 103245659(SHC4)
CATY: 105588205(SHC4)
RRO: 104657941(SHC4)
RBB: 108530104(SHC4)
TFN: 117070688(SHC4)
PTEH: 111552722(SHC4)
CJC: 100392220(SHC4)
SBQ: 101032627(SHC4)
MMUR: 105870730(SHC4)
MMU: 271849(Shc4)
MCAL: 110289726(Shc4)
MPAH: 110318126(Shc4)
RNO: 679845(Shc4)
MCOC: 116090849(Shc4)
MUN: 110550937(Shc4)
CGE: 100763505(Shc4)
PLEU: 114683897(Shc4)
NGI: 103733036(Shc4)
HGL: 101717788(Shc4)
CCAN: 109684252(Shc4)
OCU: 100350676(SHC4)
TUP: 102479734(SHC4)
CFA: 487546(SHC4)
VVP: 112920045(SHC4)
VLG: 121485135(SHC4)
AML: 100475137(SHC4)
UMR: 103676722(SHC4)
UAH: 113269597(SHC4)
ORO: 101375729(SHC4)
ELK: 111162137
MPUF: 101689202(SHC4)
EJU: 114206514(SHC4)
MLX: 118002971(SHC4)
FCA: 101099050(SHC4)
PTG: 102955115(SHC4)
PPAD: 109263016(SHC4)
AJU: 106967221(SHC4)
HHV: 120220858(SHC4)
BTA: 524734(SHC4)
BOM: 102284488(SHC4)
BIU: 109565147(SHC4)
BBUB: 102406154(SHC4)
CHX: 102179773(SHC4)
OAS: 101110241(SHC4)
ODA: 120852962(SHC4)
SSC: 100526147(SHC4)
CFR: 102517753(SHC4)
CDK: 105104832(SHC4)
BACU: 102999132(SHC4)
LVE: 103088900(SHC4)
OOR: 101289594(SHC4)
DLE: 111181617(SHC4)
PCAD: 102988652(SHC4)
ECB: 100055699(SHC4)
EPZ: 103551857(SHC4)
EAI: 106838625(SHC4)
MYB: 102239285(SHC4)
MYD: 102762219(SHC4)
MMYO: 118651538(SHC4)
MNA: 107535558(SHC4)
HAI: 109394486(SHC4)
DRO: 112311774(SHC4)
SHON: 118992600(SHC4)
AJM: 119057612(SHC4)
MMF: 118631532(SHC4)
PALE: 102888926(SHC4)
RAY: 107519965(SHC4)
MJV: 108402352(SHC4)
TOD: 119238599(SHC4)
LAV: 100654827(SHC4)
TMU: 101355900
MDO: 100031128(SHC4)
SHR: 100927458(SHC4)
PCW: 110201503(SHC4)
GGA: 426482(SHC4)
PCOC: 116225316(SHC4)
MGP: 100541111(SHC4)
CJO: 107318783(SHC4)
NMEL: 110403695(SHC4)
APLA: 101797165(SHC4)
ACYG: 106033799(SHC4)
TGU: 100226451(SHC4)
LSR: 110474245(SHC4)
SCAN: 103816021(SHC4)
PMOA: 120509194(SHC4)
GFR: 102037367(SHC4)
FAB: 101809679(SHC4)
PHI: 102103363(SHC4)
PMAJ: 107209575(SHC4)
CCAE: 111934113(SHC4)
CCW: 104683990(SHC4)
ETL: 114059944(SHC4)
FPG: 101914295(SHC4)
FCH: 102053624(SHC4)
CLV: 102088829(SHC4)
EGZ: 104130918(SHC4)
NNI: 104017130(SHC4)
ACUN: 113484090(SHC4)
PADL: 103922748(SHC4)
AAM: 106496580(SHC4)
ASN: 102383468(SHC4)
AMJ: 102568049(SHC4)
CPOO: 109309042(SHC4)
GGN: 109288589(SHC4)
PSS: 102455357(SHC4)
CMY: 102934651(SHC4)
CPIC: 101946426(SHC4)
TST: 117884252(SHC4)
CABI: 116814983(SHC4)
ACS: 100560740(shc4)
PVT: 110077281(SHC4)
PBI: 103055438(SHC4)
PMUR: 107287682(SHC4)
PGUT: 117675742(SHC4)
PMUA: 114584523(SHC4)
ZVI: 118092793(SHC4)
GJA: 107124453(SHC4)
XLA: 108711398(shc4.L) 108712318(shc4.S)
XTR: 100490718(shc4)
NPR: 108792188(SHC4)
LCO: 109136640(shc4)
ELY: 117251476
PLEP: 121945679
SLUC: 116054708
ECRA: 117944463
PFLV: 114556819(shc4)
GAT: 120832530
MSAM: 119890775
CUD: 121512365
MZE: 101474172(shc4)
ONL: 100701320(shc4)
OAU: 116311729
OLA: 101170912(shc4)
OML: 112160361
XMA: 102222349(shc4)
XCO: 114142814(shc4)
XHE: 116719254(shc4)
PRET: 103462081(shc4)
CVG: 107085339(shc4)
CTUL: 119782435
NFU: 107381724(shc4)
AOCE: 111565759(shc4)
CSEM: 103379110(shc4)
POV: 109637245(shc4)
LCF: 108887900(shc4)
SDU: 111238681(shc4)
SLAL: 111661140(shc4)
XGL: 120792101
HCQ: 109525729(shc4)
SFM: 108940860
PKI: 111844965(shc4)
LOC: 102684593(shc4)
LCM: 102354432(SHC4)
CMK: 103187006(shc4)
 » show all
Reference
  Authors
Fagiani E, Giardina G, Luzi L, Cesaroni M, Quarto M, Capra M, Germano G, Bono M, Capillo M, Pelicci P, Lanfrancone L
  Title
RaLP, a new member of the Src homology and collagen family, regulates cell migration and tumor growth of metastatic melanomas.
  Journal
Cancer Res 67:3064-73 (2007)
DOI:10.1158/0008-5472.CAN-06-2301
  Sequence
[hsa:399694]
Reference
  Authors
Jones N, Hardy WR, Friese MB, Jorgensen C, Smith MJ, Woody NM, Burden SJ, Pawson T
  Title
Analysis of a Shc family adaptor protein, ShcD/Shc4, that associates with muscle-specific kinase.
  Journal
Mol Cell Biol 27:4759-73 (2007)
DOI:10.1128/MCB.00184-07
  Sequence
[hsa:399694]
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