KEGG   ORTHOLOGY: K06450
Entry
K06450                      KO                                     

Name
CD3D
Definition
T-cell surface glycoprotein CD3 delta chain
Pathway
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05142  Chagas disease
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04660 T cell receptor signaling pathway
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04658 Th1 and Th2 cell differentiation
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   04659 Th17 cell differentiation
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05170 Human immunodeficiency virus 1 infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05162 Measles
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
   05169 Epstein-Barr virus infection
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06450  CD3D; T-cell surface glycoprotein CD3 delta chain
CD molecules [BR:ko04090]
 Proteins
  K06450  CD3d; CD3D antigen, delta polypeptide (TiT3 complex)
Genes
HSA: 915(CD3D)
PTR: 451584(CD3D)
PPS: 100979946(CD3D)
GGO: 101150395(CD3D)
PON: 100440740(CD3D)
NLE: 100603907(CD3D)
MCC: 699582(CD3D)
MCF: 102133701(CD3D)
CSAB: 103248585(CD3D)
RRO: 104665574(CD3D)
RBB: 108536385(CD3D)
CJC: 100404313(CD3D)
SBQ: 101029738(CD3D)
MMU: 12500(Cd3d)
MCAL: 110302262(Cd3d)
MPAH: 110328514(Cd3d)
RNO: 25710(Cd3d)
MUN: 110549118(Cd3d)
CGE: 100756906(Cd3d)
NGI: 103748303(Cd3d)
HGL: 101712534(Cd3d)
CCAN: 109699106(Cd3d)
OCU: 100356153(CD3D)
TUP: 102498607(CD3D)
CFA: 479419(CD3D)
VVP: 112920226(CD3D)
AML: 100484718(CD3D)
UMR: 103662337(CD3D)
UAH: 113260002(CD3D)
ORO: 101385969(CD3D)
ELK: 111153823
FCA: 101083107(CD3D)
PTG: 102969057(CD3D)
PPAD: 109278564(CD3D)
AJU: 106966153(CD3D)
BTA: 281053(CD3D)
BOM: 102272573(CD3D)
BIU: 109569960(CD3D)
BBUB: 102390133(CD3D)
CHX: 102191154(CD3D)
OAS: 443397(CD3D)
SSC: 396661(CD3D)
CFR: 102505672(CD3D)
CDK: 105090171(CD3D)
BACU: 103003761(CD3D)
LVE: 103069825(CD3D)
OOR: 101279567(CD3D)
DLE: 111166923(CD3D)
PCAD: 102979567(CD3D)
ECB: 100062931(CD3D)
EPZ: 103546675(CD3D)
EAI: 106840277(CD3D)
MYB: 102240563(CD3D)
MYD: 102753304(CD3D)
MNA: 107530792(CD3D)
HAI: 109385283(CD3D)
DRO: 112314228(CD3D)
PALE: 102894486(CD3D)
RAY: 107516062(CD3D)
MJV: 108385099(CD3D)
LAV: 100661471(CD3D)
TMU: 101353008
MDO: 100031472(CD3D)
SHR: 100925080
PCW: 110207189(CD3D)
OAA: 100090811
GGA: 396518(CD3D)
MGP: 100543119
CJO: 107324150
NMEL: 110387606
APLA: 101792606
ACYG: 106039849(CD3D)
TGU: 100222416
LSR: 110470410
SCAN: 103822979
GFR: 102042200
FAB: 101820502
PHI: 102106764(CD3D)
PMAJ: 107214324
CCAE: 111939276
CCW: 104692179
FPG: 101916542(CD3D)
FCH: 102052093(CD3D)
CLV: 102092403(CD3D)
EGZ: 104124562
NNI: 104019039(CD3D)
ACUN: 113488514
PADL: 103921538(CD3D)
AAM: 106491545(CD3D)
ASN: 102382203(CD3D)
AMJ: 102572479(CD3D)
CPIC: 101940477
ACS: 103281391
GJA: 107112603(CD3G)
SRX: 107710511
SGH: 107557647
IPU: 100305122 108278320(cd3g)
TRU: 654302(cd3g/d)
MZE: 101473769(cd3g)
XMA: 111611912
XCO: 114133423
NFU: 107372866
ALIM: 106521072
CSEM: 103377691
SDU: 111232852
SALP: 111957658
CMK: 103191344(cd3g)
RTP: 109926251
 » show all
Reference
PMID:3488209
  Authors
Tunnacliffe A, Sims JE, Rabbitts TH
  Title
T3 delta pre-mRNA is transcribed from a non-TATA promoter and is alternatively spliced in human T cells.
  Journal
EMBO J 5:1245-52 (1986)
DOI:10.1002/j.1460-2075.1986.tb04353.x
  Sequence
[hsa:915]
Reference
  Authors
de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F
  Title
Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.
  Journal
J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588
LinkDB

KEGG   ORTHOLOGY: K06451
Entry
K06451                      KO                                     

Name
CD3E
Definition
T-cell surface glycoprotein CD3 epsilon chain
Pathway
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05142  Chagas disease
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05340  Primary immunodeficiency
Disease
H00091  T-B+Severe combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04660 T cell receptor signaling pathway
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04658 Th1 and Th2 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   04659 Th17 cell differentiation
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09163 Immune disease
   05340 Primary immunodeficiency
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05170 Human immunodeficiency virus 1 infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05162 Measles
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
   05169 Epstein-Barr virus infection
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06451  CD3E; T-cell surface glycoprotein CD3 epsilon chain
CD molecules [BR:ko04090]
 Proteins
  K06451  CD3e; CD3E antigen, epsilon polypeptide (TiT3 complex)
Genes
HSA: 916(CD3E)
PTR: 742330(CD3E)
PPS: 100978919(CD3E)
GGO: 101149676(CD3E)
PON: 100440004(CD3E)
NLE: 100582516(CD3E)
MCC: 699467(CD3E)
MCF: 102133065(CD3E)
CSAB: 103248584(CD3E)
RRO: 104665572(CD3E)
RBB: 108536387(CD3E)
CJC: 100403944(CD3E)
SBQ: 101030803(CD3E)
MMU: 12501(Cd3e)
MCAL: 110302127(Cd3e)
MPAH: 110328560(Cd3e)
RNO: 315609(Cd3e)
MUN: 110549111(Cd3e)
CGE: 100757488(Cd3e)
NGI: 103728619(Cd3e)
HGL: 101711464(Cd3e)
CCAN: 109684407(Cd3e)
OCU: 100008616(CD3E) 100339529
TUP: 102499022(CD3E)
CFA: 442981(CD3E)
VVP: 112920227(CD3E)
AML: 100482462(CD3E)
UMR: 103662338(CD3E)
UAH: 113260003(CD3E)
ORO: 101385667(CD3E)
ELK: 111153962
FCA: 493936(CD3E)
PTG: 102969557(CD3E)
PPAD: 109278561(CD3E)
AJU: 106966166(CD3E)
BTA: 281054(CD3E)
BOM: 102272861(CD3E)
BIU: 109569940(CD3E)
BBUB: 102390460(CD3E)
CHX: 102190711(CD3E)
OAS: 443437(CD3E)
SSC: 397455(CD3E)
CFR: 102518964(CD3E)
CDK: 105090174(CD3E)
BACU: 103003476(CD3E)
LVE: 103070290(CD3E)
OOR: 101279986(CD3E)
DLE: 111166898(CD3E)
PCAD: 102979279(CD3E)
ECB: 100629532(CD3E)
EPZ: 103546676(CD3E)
EAI: 106840276(CD3E)
MYB: 102240865(CD3E)
MYD: 102753033(CD3E)
MNA: 107530780(CD3E)
HAI: 109385284(CD3E)
DRO: 112314382(CD3E)
PALE: 102894744(CD3E)
RAY: 107516045(CD3E)
MJV: 108385087(CD3E)
LAV: 100654724(CD3E)
TMU: 101359660
MDO: 100031478(CD3E)
SHR: 100919058(CD3E)
PCW: 110207187(CD3E)
OAA: 103164647(CD3E)
GGA: 396062(CD3E)
MGP: 100542967(CD3E)
CJO: 107324151(CD3E)
NMEL: 110387607(CD3E)
APLA: 101792798(CD3E)
ACYG: 106039831(CD3E)
TGU: 115498349(CD3E)
LSR: 110470447(CD3E)
SCAN: 103822978(CD3E)
GFR: 102033069(CD3E)
FAB: 101805814(CD3E)
PHI: 102100748(CD3E)
PMAJ: 107214303(CD3E)
CCAE: 111939275(CD3E)
CCW: 104692070(CD3E)
ETL: 114056274(CD3E)
FPG: 101916374(CD3E)
FCH: 102052256(CD3E)
CLV: 102092091(CD3E)
EGZ: 104124563(CD3E)
NNI: 104019038(CD3E)
ACUN: 113488553(CD3E)
PADL: 103921537(CD3E)
AAM: 106491550(CD3E)
ASN: 102385481(CD3E)
AMJ: 102572715(CD3E)
PSS: 102444605(CD3E)
CMY: 102940609(CD3E)
CPIC: 101932898(CD3E)
ACS: 103281392(cd3e)
PVT: 110079214(CD3E)
PBI: 103063950(CD3E)
PMUR: 107284819(CD3E)
TSR: 106540658(CD3E)
PMUA: 114585624(CD3E)
XLA: 108696460(cd3e.L) 108697598(cd3e.S)
XTR: 100101735(cd3e)
NPR: 108792155(CD3E)
SRX: 107710512(cd3e) 107757322
SGH: 107557646(cd3e) 107575792
CCAR: 109113691(cd3e)
IPU: 108278371(cd3e)
PHYP: 113544469(cd3e)
EEE: 113581196(cd3e)
TRU: 654301(cd3e)
NCC: 104958452(cd3e)
MZE: 101473479(cd3e)
ONL: 100699580(cd3e)
XMA: 111612026(cd3e)
XCO: 114162006(cd3e)
PRET: 108166815(cd3e)
CVG: 107080969 107102557(cd3e)
NFU: 107372865(cd3e)
AOCE: 111574529(cd3e)
CSEM: 103377690
POV: 109634477(cd3e)
LCF: 108890654(cd3e)
SDU: 111232876(cd3e)
SLAL: 111650651(cd3e)
HCQ: 109529377(cd3e)
MALB: 109951826(cd3e)
SASA: 100136516(cd3e)
OTW: 112265197(cd3e)
SFM: 108932125(cd3e) 108932308
LCM: 102349686(CD3E)
RTP: 109922585
 » show all
Reference
PMID:3012357
  Authors
Gold DP, Puck JM, Pettey CL, Cho M, Coligan J, Woody JN, Terhorst C
  Title
Isolation of cDNA clones encoding the 20K non-glycosylated polypeptide chain of the human T-cell receptor/T3 complex.
  Journal
Nature 321:431-4 (1986)
DOI:10.1038/321431a0
  Sequence
[hsa:916]
Reference
  Authors
de Saint Basile G, Geissmann F, Flori E, Uring-Lambert B, Soudais C, Cavazzana-Calvo M, Durandy A, Jabado N, Fischer A, Le Deist F
  Title
Severe combined immunodeficiency caused by deficiency in either the delta or the epsilon subunit of CD3.
  Journal
J Clin Invest 114:1512-7 (2004)
DOI:10.1172/JCI22588
LinkDB

KEGG   ORTHOLOGY: K06452
Entry
K06452                      KO                                     

Name
CD3G
Definition
T-cell surface glycoprotein CD3 gamma chain
Pathway
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05142  Chagas disease
ko05162  Measles
ko05166  Human T-cell leukemia virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
   04660 T cell receptor signaling pathway
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
   04658 Th1 and Th2 cell differentiation
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
   04659 Th17 cell differentiation
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
   05170 Human immunodeficiency virus 1 infection
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
   05162 Measles
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
   05169 Epstein-Barr virus infection
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
  09174 Infectious disease: parasitic
   05142 Chagas disease
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06452  CD3G; T-cell surface glycoprotein CD3 gamma chain
CD molecules [BR:ko04090]
 Proteins
  K06452  CD3g; CD3G antigen, gamma polypeptide (TiT3 complex)
Genes
HSA: 917(CD3G)
PTR: 451585(CD3G)
PPS: 100979261(CD3G)
GGO: 101151025(CD3G)
PON: 100440370(CD3G)
NLE: 100582184(CD3G)
MCC: 705270(CD3G)
MCF: 102134381(CD3G)
CSAB: 103248587(CD3G)
RRO: 104665573(CD3G)
RBB: 108536388(CD3G)
CJC: 100404679(CD3G)
SBQ: 101029105(CD3G)
MMU: 12502(Cd3g)
MCAL: 110302182(Cd3g)
MPAH: 110328470(Cd3g)
RNO: 300678(Cd3g)
MUN: 110549119(Cd3g)
CGE: 100757196(Cd3g)
NGI: 103748301(Cd3g)
HGL: 101712197(Cd3g)
CCAN: 109699105(Cd3g)
OCU: 100352809(CD3G) 100355340
TUP: 102498196(CD3G)
CFA: 489383(CD3G)
VVP: 112920225(CD3G)
AML: 100484468(CD3G)
UMR: 103662336(CD3G)
UAH: 113260001(CD3G)
ORO: 101386261(CD3G)
ELK: 111153842
FCA: 101089292(CD3G)
PTG: 102968170(CD3G)
PPAD: 109278562(CD3G)
AJU: 106966124(CD3G)
BTA: 281055(CD3G)
BOM: 102272288(CD3G)
BIU: 109569992(CD3G)
BBUB: 102388922(CD3G)
CHX: 102191440(CD3G)
OAS: 443398(CD3G)
SSC: 494013(CD3G)
CFR: 102518706(CD3G)
CDK: 105090170(CD3G)
BACU: 103004030(CD3G)
LVE: 103069546(CD3G)
OOR: 101279311(CD3G)
DLE: 111166936(CD3G)
PCAD: 102980039(CD3G)
ECB: 100062960(CD3G)
EPZ: 103546674(CD3G)
EAI: 106840278(CD3G)
MYB: 102240258(CD3G)
MYD: 102753586(CD3G)
MNA: 107530779(CD3G)
HAI: 109385282(CD3G)
DRO: 112314387(CD3G)
PALE: 102894240(CD3G)
RAY: 107516027(CD3G)
MJV: 108385007(CD3G)
LAV: 100661940(CD3G)
TMU: 101352744
MDO: 100031464(CD3G)
SHR: 100924822
PCW: 110207190(CD3G)
OAA: 100090795
CMY: 102940831
XLA: 373582(cd3g.S)
XTR: 100216101(cd3g)
NPR: 108794983(CD3G)
ONL: 102080392
OLA: 101161323
KMR: 108244437(cd3g)
AOCE: 111574541(cd3g)
POV: 109634482
LCF: 108890653(cd3g)
BPEC: 110161941
LCM: 102349401
 » show all
Reference
PMID:2944745
  Authors
Krissansen GW, Owen MJ, Verbi W, Crumpton MJ
  Title
Primary structure of the T3 gamma subunit of the T3/T cell antigen receptor complex deduced from cDNA sequences: evolution of the T3 gamma and delta subunits.
  Journal
EMBO J 5:1799-808 (1986)
DOI:10.1002/j.1460-2075.1986.tb04429.x
  Sequence
[hsa:917]
Reference
  Authors
Gokturk B, Keles S, Kirac M, Artac H, Tokgoz H, Guner SN, Caliskan U, Caliskaner Z, van der Burg M, van Dongen J, Morgan NV, Reisli I
  Title
CD3G gene defects in familial autoimmune thyroiditis.
  Journal
Scand J Immunol 80:354-61 (2014)
DOI:10.1111/sji.12200
LinkDB

DBGET integrated database retrieval system