KEGG   ORTHOLOGY: K06454
Entry
K06454                      KO                                     

Name
CD4
Definition
T-cell surface glycoprotein CD4
Pathway
ko04060  Cytokine-cytokine receptor interaction
ko04514  Cell adhesion molecules
ko04612  Antigen processing and presentation
ko04640  Hematopoietic cell lineage
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko05135  Yersinia infection
ko05166  Human T-cell leukemia virus 1 infection
ko05170  Human immunodeficiency virus 1 infection
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05340  Primary immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09133 Signaling molecules and interaction
   04060 Cytokine-cytokine receptor interaction
    K06454  CD4; T-cell surface glycoprotein CD4
   04514 Cell adhesion molecules
    K06454  CD4; T-cell surface glycoprotein CD4
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06454  CD4; T-cell surface glycoprotein CD4
   04612 Antigen processing and presentation
    K06454  CD4; T-cell surface glycoprotein CD4
   04660 T cell receptor signaling pathway
    K06454  CD4; T-cell surface glycoprotein CD4
   04658 Th1 and Th2 cell differentiation
    K06454  CD4; T-cell surface glycoprotein CD4
   04659 Th17 cell differentiation
    K06454  CD4; T-cell surface glycoprotein CD4
 09160 Human Diseases
  09161 Cancer: overview
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K06454  CD4; T-cell surface glycoprotein CD4
  09163 Immune disease
   05340 Primary immunodeficiency
    K06454  CD4; T-cell surface glycoprotein CD4
  09171 Infectious disease: bacterial
   05135 Yersinia infection
    K06454  CD4; T-cell surface glycoprotein CD4
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06454  CD4; T-cell surface glycoprotein CD4
   05170 Human immunodeficiency virus 1 infection
    K06454  CD4; T-cell surface glycoprotein CD4
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04090 CD molecules
    K06454  CD4; T-cell surface glycoprotein CD4
CD molecules [BR:ko04090]
 Proteins
  K06454  CD4; CD4 antigen (p55)
Genes
HSA: 920(CD4)
PTR: 450124(CD4)
PPS: 100970574(CD4)
GGO: 101130322(CD4)
PON: 100452381(CD4)
NLE: 100591806(CD4)
MCC: 713807(CD4)
MCF: 101864991(CD4)
CSAB: 103218480(CD4)
RRO: 104680099(CD4)
RBB: 108542050(CD4)
CJC: 100385000(CD4)
SBQ: 101028824(CD4)
MMU: 12504(Cd4)
MCAL: 110296921(Cd4)
MPAH: 110317139(Cd4)
RNO: 24932(Cd4)
MUN: 110548574(Cd4)
CGE: 100766761(Cd4)
NGI: 103727506(Cd4)
HGL: 101716842(Cd4)
CCAN: 109682769(Cd4)
OCU: 100009152(CD4)
TUP: 102469339(CD4)
CFA: 403931(CD4)
VVP: 112917336(CD4)
AML: 100482689(CD4)
UMR: 103656225(CD4)
UAH: 113257962(CD4)
ORO: 101370279(CD4)
ELK: 111159821
FCA: 493775(CD4)
PTG: 102954103(CD4)
PPAD: 109276110(CD4) 109276152
AJU: 106965350(CD4)
BTA: 407098(CD4)
BOM: 102281198(CD4)
BIU: 109558922(CD4)
BBUB: 102413723(CD4)
CHX: 102170124(CD4)
OAS: 443509(CD4)
SSC: 404704(CD4)
CFR: 102506854(CD4)
CDK: 105098206(CD4)
BACU: 103010726(CD4)
LVE: 103090277(CD4)
OOR: 101285114(CD4)
DLE: 111176687(CD4)
PCAD: 102981471(CD4)
ECB: 100052502(CD4)
EPZ: 103547015(CD4)
EAI: 106847327(CD4)
MYB: 102262721(CD4)
MYD: 102760024(CD4)
MNA: 107544013(CD4)
HAI: 109373637(CD4)
DRO: 112322003(CD4)
MJV: 108403555(CD4)
LAV: 100675007(CD4)
TMU: 101343648
MDO: 100016045(CD4)
SHR: 100923185(CD4)
PCW: 110213788(CD4)
OAA: 103165339(CD4)
GGA: 395362(CD4)
MGP: 100126554(CD4)
CJO: 107318700
NMEL: 110398410(CD4)
APLA: 101790140(CD4)
ACYG: 106047858(CD4)
TGU: 100227917(CD4)
LSR: 110480811(CD4)
SCAN: 103812453(CD4)
GFR: 102039868(CD4)
FAB: 101811036(CD4)
PHI: 102112871(CD4)
PMAJ: 107203925(CD4)
CCAE: 111938276(CD4)
CCW: 104687125(CD4)
ETL: 114058187
FPG: 101918856(CD4)
FCH: 102056138
CLV: 102084034(CD4)
EGZ: 104126598(CD4)
NNI: 104022494
ACUN: 113476745(CD4)
PADL: 103921966
AAM: 106497174
ASN: 102380067(CD4)
AMJ: 102572958(CD4)
PSS: 102461725(CD4)
CMY: 102933832(CD4)
CPIC: 101943745(CD4)
ACS: 100567219(cd4)
PVT: 110084638
PBI: 112540361
PMUR: 114922421
TSR: 106547473
PMUA: 114588021
GJA: 107108191
XTR: 100491070
NPR: 108795996
DRE: 799982(cd4-1)
CCAR: 109070695
IPU: 100304978
PHYP: 113542643
AMEX: 103041570
EEE: 113570626
TRU: 778001(cd4)
LCO: 104922282
MZE: 101464216
ONL: 100709183
OLA: 100125525
XMA: 102226965
XCO: 114142260
PRET: 103477977
CVG: 107082188
NFU: 107379481
KMR: 108235418
ALIM: 106521019
AOCE: 111569482
CSEM: 103388025
POV: 109633355
LCF: 108880732
SDU: 111230068
SLAL: 111669902
HCQ: 109515260
MALB: 109966202
SASA: 100136501 100136502(CD4)
ELS: 105028237
SFM: 108922084
PKI: 111834638
 » show all
Reference
PMID:2990730
  Authors
Maddon PJ, Littman DR, Godfrey M, Maddon DE, Chess L, Axel R
  Title
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family.
  Journal
Cell 42:93-104 (1985)
DOI:10.1016/S0092-8674(85)80105-7
  Sequence
[hsa:920]
Reference
PMID:2214026
  Authors
Crise B, Buonocore L, Rose JK
  Title
CD4 is retained in the endoplasmic reticulum by the human immunodeficiency virus type 1 glycoprotein precursor.
  Journal
J Virol 64:5585-93 (1990)
DOI:10.1128/JVI.64.11.5585-5593.1990
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