KEGG   ORTHOLOGY: K06484
Entry
K06484                      KO                                     

Name
ITGA5, CD49e
Definition
integrin alpha 5
Pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04640  Hematopoietic cell lineage
ko04810  Regulation of actin cytoskeleton
ko05100  Bacterial invasion of epithelial cells
ko05131  Shigellosis
ko05133  Pertussis
ko05135  Yersinia infection
ko05165  Human papillomavirus infection
ko05168  Herpes simplex virus 1 infection
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K06484  ITGA5, CD49e; integrin alpha 5
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K06484  ITGA5, CD49e; integrin alpha 5
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K06484  ITGA5, CD49e; integrin alpha 5
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K06484  ITGA5, CD49e; integrin alpha 5
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K06484  ITGA5, CD49e; integrin alpha 5
 09150 Organismal Systems
  09151 Immune system
   04640 Hematopoietic cell lineage
    K06484  ITGA5, CD49e; integrin alpha 5
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K06484  ITGA5, CD49e; integrin alpha 5
   05205 Proteoglycans in cancer
    K06484  ITGA5, CD49e; integrin alpha 5
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K06484  ITGA5, CD49e; integrin alpha 5
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K06484  ITGA5, CD49e; integrin alpha 5
   05414 Dilated cardiomyopathy
    K06484  ITGA5, CD49e; integrin alpha 5
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K06484  ITGA5, CD49e; integrin alpha 5
   05135 Yersinia infection
    K06484  ITGA5, CD49e; integrin alpha 5
   05133 Pertussis
    K06484  ITGA5, CD49e; integrin alpha 5
   05100 Bacterial invasion of epithelial cells
    K06484  ITGA5, CD49e; integrin alpha 5
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K06484  ITGA5, CD49e; integrin alpha 5
   05165 Human papillomavirus infection
    K06484  ITGA5, CD49e; integrin alpha 5
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K06484  ITGA5, CD49e; integrin alpha 5
   04515 Cell adhesion molecules
    K06484  ITGA5, CD49e; integrin alpha 5
   04090 CD molecules
    K06484  ITGA5, CD49e; integrin alpha 5
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K06484  ITGA5, CD49e; integrin alpha 5
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin alpha subunits
   K06484  ITGA5, CD49e; integrin alpha 5
CD molecules [BR:ko04090]
 Proteins
  K06484  CD49e, ITGA5; integrin, alpha 5
Genes
HSA: 3678(ITGA5)
PTR: 451958(ITGA5)
PPS: 100968295(ITGA5)
GGO: 101134285(ITGA5)
PON: 100453984(ITGA5)
NLE: 100606925(ITGA5)
MCC: 574315(ITGA5)
MCF: 102114969(ITGA5)
CSAB: 103238438(ITGA5)
RRO: 104670562(ITGA5)
RBB: 108514611(ITGA5)
CJC: 100386674(ITGA5)
SBQ: 101043820(ITGA5)
MMU: 16402(Itga5)
MCAL: 110310456(Itga5)
MPAH: 110334621(Itga5)
RNO: 315346(Itga5)
MUN: 110557599(Itga5)
CGE: 100768174(Itga5)
NGI: 103738966(Itga5)
HGL: 101714885(Itga5)
CCAN: 109686653(Itga5)
OCU: 100009172(ITGA5)
TUP: 102467775(ITGA5)
CFA: 486493(ITGA5)
VVP: 112911311(ITGA5)
AML: 100479433(ITGA5)
UMR: 103675680(ITGA5)
UAH: 113257516(ITGA5)
ORO: 101380023(ITGA5)
ELK: 111157949
FCA: 101093870(ITGA5)
PTG: 102959936(ITGA5)
PPAD: 109249251(ITGA5)
AJU: 106989320(ITGA5)
BTA: 281873(ITGA5)
BOM: 102276200(ITGA5)
BIU: 109558343(ITGA5)
BBUB: 102404538(ITGA5)
CHX: 102176587(ITGA5)
OAS: 443140(ITGA5)
SSC: 100155091(ITGA5)
CFR: 102507691(ITGA5)
CDK: 105101003(ITGA5)
BACU: 103011640(ITGA5)
LVE: 103074553(ITGA5)
OOR: 101275353(ITGA5)
DLE: 111173917(ITGA5)
PCAD: 102983046(ITGA5)
ECB: 100064655(ITGA5)
EPZ: 103563237(ITGA5)
EAI: 106828260(ITGA5)
MYB: 102255900(ITGA5)
MYD: 102775400(ITGA5)
MNA: 107541067(ITGA5)
HAI: 109391860(ITGA5)
DRO: 112318448(ITGA5)
PALE: 102889111(ITGA5)
RAY: 107521082(ITGA5)
MJV: 108408507(ITGA5)
LAV: 100676951(ITGA5)
TMU: 101340808
SHR: 100923187(ITGA5)
PCW: 110194038(ITGA5)
OAA: 100090507(ITGA5)
TGU: 115491489
PHI: 102111964(ITGA5)
FPG: 101923738(ITGA5)
FCH: 102047845(ITGA5)
ASN: 102382434(ITGA5)
AMJ: 102563393(ITGA5)
PSS: 102445917(ITGA5)
CMY: 102942186(ITGA5)
CPIC: 101936839(ITGA5)
ACS: 100566243(itga5)
PVT: 110071758(ITGA5)
PBI: 103062319(ITGA5)
PMUR: 107288179(ITGA5)
PMUA: 114592908(ITGA5)
GJA: 107119049(ITGA5)
XLA: 394366(itga5.L) 397842(itga5.S)
XTR: 100492002(itga5)
NPR: 108797346(ITGA5)
DRE: 386787(itga5)
SRX: 107723722 107756357(itga5)
IPU: 108275658(itga5)
PHYP: 113530454(itga5)
AMEX: 103025198(itga5)
EEE: 113576413(itga5)
PRET: 103465419
PKI: 111851704(itga5)
LCM: 102364268
BFO: 118424962
AME: 724548
BIM: 100742360
BTER: 100649030
OBB: 114875919
LHU: 105670985
OBO: 105276232
EGL: EGR_09156
AQU: 105312393
 » show all
Reference
PMID:2958481
  Authors
Argraves WS, Suzuki S, Arai H, Thompson K, Pierschbacher MD, Ruoslahti E
  Title
Amino acid sequence of the human fibronectin receptor.
  Journal
J Cell Biol 105:1183-90 (1987)
DOI:10.1083/jcb.105.3.1183
  Sequence
[hsa:3678]
Reference
  Authors
Weigel-Kelley KA, Yoder MC, Srivastava A
  Title
Alpha5beta1 integrin as a cellular coreceptor for human parvovirus B19: requirement of functional activation of beta1 integrin for viral entry.
  Journal
Blood 102:3927-33 (2003)
DOI:10.1182/blood-2003-05-1522
LinkDB

KEGG   ORTHOLOGY: K05719
Entry
K05719                      KO                                     

Name
ITGB1, CD29
Definition
integrin beta 1
Pathway
ko04015  Rap1 signaling pathway
ko04145  Phagosome
ko04151  PI3K-Akt signaling pathway
ko04360  Axon guidance
ko04510  Focal adhesion
ko04512  ECM-receptor interaction
ko04514  Cell adhesion molecules
ko04530  Tight junction
ko04611  Platelet activation
ko04670  Leukocyte transendothelial migration
ko04810  Regulation of actin cytoskeleton
ko05100  Bacterial invasion of epithelial cells
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05133  Pertussis
ko05135  Yersinia infection
ko05140  Leishmaniasis
ko05145  Toxoplasmosis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05222  Small cell lung cancer
ko05410  Hypertrophic cardiomyopathy
ko05412  Arrhythmogenic right ventricular cardiomyopathy
ko05414  Dilated cardiomyopathy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K05719  ITGB1, CD29; integrin beta 1
   04151 PI3K-Akt signaling pathway
    K05719  ITGB1, CD29; integrin beta 1
  09133 Signaling molecules and interaction
   04512 ECM-receptor interaction
    K05719  ITGB1, CD29; integrin beta 1
   04514 Cell adhesion molecules
    K05719  ITGB1, CD29; integrin beta 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04145 Phagosome
    K05719  ITGB1, CD29; integrin beta 1
  09144 Cellular community - eukaryotes
   04510 Focal adhesion
    K05719  ITGB1, CD29; integrin beta 1
   04530 Tight junction
    K05719  ITGB1, CD29; integrin beta 1
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K05719  ITGB1, CD29; integrin beta 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K05719  ITGB1, CD29; integrin beta 1
   04670 Leukocyte transendothelial migration
    K05719  ITGB1, CD29; integrin beta 1
  09158 Development and regeneration
   04360 Axon guidance
    K05719  ITGB1, CD29; integrin beta 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K05719  ITGB1, CD29; integrin beta 1
   05205 Proteoglycans in cancer
    K05719  ITGB1, CD29; integrin beta 1
  09162 Cancer: specific types
   05222 Small cell lung cancer
    K05719  ITGB1, CD29; integrin beta 1
  09166 Cardiovascular disease
   05410 Hypertrophic cardiomyopathy
    K05719  ITGB1, CD29; integrin beta 1
   05412 Arrhythmogenic right ventricular cardiomyopathy
    K05719  ITGB1, CD29; integrin beta 1
   05414 Dilated cardiomyopathy
    K05719  ITGB1, CD29; integrin beta 1
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K05719  ITGB1, CD29; integrin beta 1
   05131 Shigellosis
    K05719  ITGB1, CD29; integrin beta 1
   05135 Yersinia infection
    K05719  ITGB1, CD29; integrin beta 1
   05133 Pertussis
    K05719  ITGB1, CD29; integrin beta 1
   05100 Bacterial invasion of epithelial cells
    K05719  ITGB1, CD29; integrin beta 1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K05719  ITGB1, CD29; integrin beta 1
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K05719  ITGB1, CD29; integrin beta 1
   05140 Leishmaniasis
    K05719  ITGB1, CD29; integrin beta 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K05719  ITGB1, CD29; integrin beta 1
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K05719  ITGB1, CD29; integrin beta 1
   04515 Cell adhesion molecules
    K05719  ITGB1, CD29; integrin beta 1
   04090 CD molecules
    K05719  ITGB1, CD29; integrin beta 1
Membrane trafficking [BR:ko04131]
 Endocytosis
  Phagocytosis
   Integrins (complement receptors)
    K05719  ITGB1, CD29; integrin beta 1
Exosome [BR:ko04147]
 Exosomal proteins
  Proteins found in most exosomes
   K05719  ITGB1, CD29; integrin beta 1
Cell adhesion molecules [BR:ko04515]
 Integrins
  Integrin beta subunits
   K05719  ITGB1, CD29; integrin beta 1
CD molecules [BR:ko04090]
 Proteins
  K05719  CD29, ITGB1; integrin, beta 1
Genes
HSA: 3688(ITGB1)
PTR: 450396(ITGB1)
PPS: 100992059(ITGB1)
GGO: 101142683(ITGB1)
PON: 100172223(ITGB1)
NLE: 100595108(ITGB1)
MCC: 574312(ITGB1)
MCF: 102144610(ITGB1)
CSAB: 103238098(ITGB1)
RRO: 104663301(ITGB1)
RBB: 108529400(ITGB1)
CJC: 100394145(ITGB1)
SBQ: 101040620(ITGB1)
MMU: 16412(Itgb1)
MCAL: 110299930(Itgb1)
MPAH: 110337225(Itgb1)
RNO: 24511(Itgb1)
MUN: 110554841(Itgb1)
CGE: 100763033(Itgb1)
NGI: 103745645(Itgb1)
HGL: 101711253(Itgb1)
CCAN: 109697920(Itgb1)
OCU: 100008898(ITGB1)
TUP: 102489284(ITGB1)
CFA: 477956(ITGB1)
VVP: 112921568(ITGB1)
AML: 100482697(ITGB1)
UMR: 103656511(ITGB1)
UAH: 113244232(ITGB1)
ORO: 101385291(ITGB1)
ELK: 111155558
FCA: 751821(ITGB1)
PTG: 102967350(ITGB1)
PPAD: 109276308(ITGB1)
AJU: 106967340(ITGB1)
BTA: 281876(ITGB1)
BOM: 102273972(ITGB1)
BIU: 109567924(ITGB1)
BBUB: 102401423(ITGB1)
CHX: 102178060(ITGB1)
OAS: 443141(ITGB1)
SSC: 397019(ITGB1)
CFR: 102509512(ITGB1)
CDK: 105100650(ITGB1)
BACU: 103008019(ITGB1)
LVE: 103070821(ITGB1)
OOR: 101283510(ITGB1)
DLE: 111178037(ITGB1)
PCAD: 102984702(ITGB1)
ECB: 100055024(ITGB1)
EPZ: 103565316(ITGB1)
EAI: 106836617(ITGB1)
MYB: 102260978(ITGB1)
MYD: 102757018(ITGB1)
MNA: 107525073(ITGB1)
HAI: 109388160(ITGB1)
DRO: 112317701(ITGB1)
PALE: 102886785(ITGB1)
RAY: 107499295(ITGB1)
MJV: 108397161(ITGB1)
LAV: 100664978(ITGB1)
TMU: 101360881
MDO: 100018342(ITGB1)
SHR: 100913968(ITGB1)
PCW: 110211245(ITGB1)
OAA: 100073959(ITGB1)
GGA: 374058(ITGB1)
MGP: 100551464(ITGB1)
CJO: 107308921(ITGB1)
NMEL: 110393676(ITGB1)
APLA: 101792849(ITGB1)
ACYG: 106042674(ITGB1)
TGU: 100230947(ITGB1)
LSR: 110477312(ITGB1)
SCAN: 103813076(ITGB1)
GFR: 102039987(ITGB1)
FAB: 101810282(ITGB1)
PHI: 102112472(ITGB1)
PMAJ: 107200467(ITGB1)
CCAE: 111924368(ITGB1)
CCW: 104686529(ITGB1)
ETL: 114059485(ITGB1)
FPG: 101917395(ITGB1)
FCH: 102059641(ITGB1)
CLV: 102089491(ITGB1)
EGZ: 104133604(ITGB1)
NNI: 104022255(ITGB1)
ACUN: 113476425(ITGB1)
PADL: 103918264(ITGB1)
AAM: 106489947(ITGB1)
ASN: 102383871(ITGB1)
AMJ: 102575802(ITGB1)
PSS: 102452555(ITGB1)
CMY: 102946836(ITGB1)
CPIC: 101948025(ITGB1)
ACS: 100562954(itgb1)
PVT: 110082773(ITGB1)
PBI: 103060558(ITGB1)
PMUR: 107284025(ITGB1)
TSR: 106544187(ITGB1)
PMUA: 114607514 114607723(ITGB1)
GJA: 107125566(ITGB1)
XLA: 397755(itgb1.L) 399443(itgb1.S)
XTR: 394767(itgb1)
NPR: 108792462(ITGB1)
DRE: 405864(itgb1b.2) 556734(itgb1a) 566771(itgb1b.1) 570216(itgb1b)
IPU: 100304492(itgb1) 108271845(itgb1)
EEE: 113568006 113574768(itgb1)
NCC: 104965598(itgb1)
ONL: 100692535 100703183(itgb1)
OLA: 101154978 101175441(itgb1)
CVG: 107090367(itgb1) 107094308
NFU: 107382649(itgb1) 107383442
ALIM: 106521066(itgb1) 106522907
BPEC: 110165515(itgb1)
SASA: 106568844(ITB1) 106590025(ITB1) 106599515
LCM: 102348482(ITGB1) 102349081
RTP: 109934950(itgb1) 109935770
DME: Dmel_CG1560(mys) Dmel_CG1762(Itgbn)
DSI: Dsimw501_GD16875(Dsim_GD16875) Dsimw501_GD28212(Dsim_GD28212)
TCA: 656761 657674(mys)
DNX: 107165598
AGS: 114124922
RMD: 113555455
BTAB: 109031639
CEL: CELE_ZK1058.2(pat-3)
CBR: CBG03601(Cbr-pat-3)
BMY: Bm1_20780
SHX: MS3_05634
EGL: EGR_03922
 » show all
Reference
PMID:2958481
  Authors
Argraves WS, Suzuki S, Arai H, Thompson K, Pierschbacher MD, Ruoslahti E
  Title
Amino acid sequence of the human fibronectin receptor.
  Journal
J Cell Biol 105:1183-90 (1987)
DOI:10.1083/jcb.105.3.1183
  Sequence
[hsa:3688]
Reference
PMID:7523423
  Authors
Balzac F, Retta SF, Albini A, Melchiorri A, Koteliansky VE, Geuna M, Silengo L, Tarone G
  Title
Expression of beta 1B integrin isoform in CHO cells results in a dominant negative effect on cell adhesion and motility.
  Journal
J Cell Biol 127:557-65 (1994)
DOI:10.1083/jcb.127.2.557
LinkDB

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