KEGG   ORTHOLOGY: K06622
Entry
K06622                      KO                                     

Name
CDKN2C, P18, INK4C
Definition
cyclin-dependent kinase inhibitor 2C
Pathway
ko01522  Endocrine resistance
ko04110  Cell cycle
ko04934  Cushing syndrome
ko05166  Human T-cell leukemia virus 1 infection
ko05202  Transcriptional misregulation in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
 09160 Human Diseases
  09161 Cancer: overview
   05202 Transcriptional misregulation in cancer
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K06622  CDKN2C, P18, INK4C; cyclin-dependent kinase inhibitor 2C
Other DBs
GO: 0004861
Genes
HSA: 1031(CDKN2C)
PTR: 469319(CDKN2C)
PPS: 100992391(CDKN2C)
GGO: 101125732(CDKN2C)
PON: 100459088(CDKN2C)
NLE: 100606274(CDKN2C)
MCC: 711877(CDKN2C)
MCF: 102132965(CDKN2C)
CSAB: 103224834(CDKN2C)
RRO: 104672737(CDKN2C)
RBB: 108531808(CDKN2C)
CJC: 100395956(CDKN2C)
SBQ: 101041782(CDKN2C)
MMU: 12580(Cdkn2c)
MCAL: 110292857(Cdkn2c)
MPAH: 110323411(Cdkn2c)
RNO: 54238(Cdkn2c)
MUN: 110563557(Cdkn2c)
CGE: 100774733(Cdkn2c)
NGI: 103733571(Cdkn2c)
HGL: 101721834(Cdkn2c)
CCAN: 109700012(Cdkn2c)
OCU: 100358955(CDKN2C)
TUP: 102484147(CDKN2C)
CFA: 475359(CDKN2C)
VVP: 112914731(CDKN2C)
AML: 100470950(CDKN2C)
UMR: 103670732(CDKN2C)
UAH: 113254692(CDKN2C)
ORO: 101379422(CDKN2C)
ELK: 111143151
FCA: 101086582(CDKN2C)
PTG: 102961641(CDKN2C)
PPAD: 109266897(CDKN2C)
AJU: 106973704(CDKN2C)
BTA: 505691(CDKN2C)
BOM: 102272454(CDKN2C)
BIU: 109556313(CDKN2C)
BBUB: 102396473(CDKN2C)
CHX: 102169723(CDKN2C)
OAS: 101109224(CDKN2C)
SSC: 100515210(CDKN2C)
CFR: 102507152(CDKN2C)
CDK: 105092949(CDKN2C)
BACU: 103019317(CDKN2C)
LVE: 103075084(CDKN2C)
OOR: 101287647(CDKN2C)
DLE: 111175798(CDKN2C)
PCAD: 102986788(CDKN2C)
ECB: 100051195(CDKN2C)
EPZ: 103550643(CDKN2C)
EAI: 106826063(CDKN2C)
MYB: 102257630(CDKN2C)
MYD: 102756495(CDKN2C)
MNA: 107538025(CDKN2C)
HAI: 109390269(CDKN2C)
DRO: 112314586(CDKN2C)
PALE: 102878098(CDKN2C)
RAY: 107497964(CDKN2C)
MJV: 108404720(CDKN2C)
LAV: 100669475(CDKN2C)
TMU: 101341387
MDO: 100020812(CDKN2C)
SHR: 100927420(CDKN2C)
PCW: 110209335(CDKN2C)
OAA: 114805449(CDKN2C)
GGA: 429104(CDKN2C)
MGP: 104912502(CDKN2C)
CJO: 107317588(CDKN2C)
NMEL: 110402276(CDKN2C)
APLA: 101794566(CDKN2C)
ACYG: 106032943(CDKN2C)
TGU: 100220326(CDKN2C)
LSR: 110470604(CDKN2C)
SCAN: 103815007(CDKN2C)
GFR: 102034516(CDKN2C)
FAB: 101815473(CDKN2C)
PHI: 102101327(CDKN2C)
PMAJ: 107208495(CDKN2C)
CCAE: 111943841(CDKN2C)
CCW: 104695210(CDKN2C)
ETL: 114062544(CDKN2C)
FPG: 101916167(CDKN2C)
FCH: 102051318(CDKN2C)
CLV: 102090072(CDKN2C)
EGZ: 104131493(CDKN2C)
NNI: 104009364(CDKN2C)
ACUN: 113483155(CDKN2C)
PADL: 103912449(CDKN2C)
AAM: 106491607(CDKN2C)
ASN: 102370721(CDKN2C)
AMJ: 102571103(CDKN2C)
PSS: 102448899(CDKN2C)
CMY: 102940829(CDKN2C)
CPIC: 101931916(CDKN2C)
ACS: 100556777(cdkn2c)
PVT: 110076178(CDKN2C)
PBI: 103053459(CDKN2C)
PMUR: 107283071(CDKN2C)
TSR: 106541820(CDKN2C)
PMUA: 114599020(CDKN2C)
GJA: 107116289(CDKN2C)
XLA: 108714312(cdkn2c.L) 108715590(cdkn2c.S)
XTR: 100144705(cdkn2c)
NPR: 108783816(CDKN2C)
DRE: 555797(cdkn2c)
CCAR: 109058083(cdkn2c)
IPU: 108265004(cdkn2c)
PHYP: 113527280(cdkn2c)
AMEX: 103024048(cdkn2c)
EEE: 113572097(cdkn2c)
LCO: 104925255(cdkn2c)
OLA: 101163481(cdkn2c)
XMA: 102230397(cdkn2c)
XCO: 114151621(cdkn2c)
PRET: 103464068(cdkn2c) 103464190
CVG: 107084055
NFU: 107393153(cdkn2c)
ALIM: 106530509
AOCE: 111571419
CSEM: 103397432(cdkn2c)
LCF: 108881373(cdkn2c)
SDU: 111239825(cdkn2c)
SLAL: 111651876
HCQ: 109531898(cdkn2c)
BPEC: 110160228(cdkn2c)
MALB: 109967446(cdkn2c)
OTW: 112251012(cdkn2c)
SALP: 111976075
ELS: 105026377(cdkn2c)
SFM: 108919037(cdkn2c)
PKI: 111848953(cdkn2c)
LCM: 102367385(CDKN2C)
RTP: 109914995(cdkn2c)
BFO: 118431772
SPU: 100893594
APLC: 110985161
SKO: 102806482
NVI: 116416336
 » show all
Reference
  Authors
Canepa ET, Scassa ME, Ceruti JM, Marazita MC, Carcagno AL, Sirkin PF, Ogara MF
  Title
INK4 proteins, a family of mammalian CDK inhibitors with novel biological functions.
  Journal
IUBMB Life 59:419-26 (2007)
DOI:10.1080/15216540701488358
Reference
  Authors
Blais A, Monte D, Pouliot F, Labrie C
  Title
Regulation of the human cyclin-dependent kinase inhibitor p18INK4c by the transcription factors E2F1 and Sp1.
  Journal
J Biol Chem 277:31679-93 (2002)
DOI:10.1074/jbc.M204554200
  Sequence
[hsa:1031]
Reference
PMID:8001816
  Authors
Guan KL, Jenkins CW, Li Y, Nichols MA, Wu X, O'Keefe CL, Matera AG, Xiong Y
  Title
Growth suppression by p18, a p16INK4/MTS1- and p14INK4B/MTS2-related CDK6 inhibitor, correlates with wild-type pRb function.
  Journal
Genes Dev 8:2939-52 (1994)
DOI:10.1101/gad.8.24.2939
  Sequence
[hsa:1031]
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