KEGG   ORTHOLOGY: K06625
Entry
K06625                      KO                                     

Name
CDKN1A, P21, CIP1
Definition
cyclin-dependent kinase inhibitor 1A
Pathway
ko01522  Endocrine resistance
ko01524  Platinum drug resistance
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04115  p53 signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04218  Cellular senescence
ko04630  JAK-STAT signaling pathway
ko04921  Oxytocin signaling pathway
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05169  Epstein-Barr virus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05212  Pancreatic cancer
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05217  Basal cell carcinoma
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05222  Small cell lung cancer
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00030  Cervical cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04630 JAK-STAT signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04066 HIF-1 signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04068 FoxO signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04151 PI3K-Akt signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04115 p53 signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04218 Cellular senescence
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
 09150 Organismal Systems
  09152 Endocrine system
   04921 Oxytocin signaling pathway
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   04928 Parathyroid hormone synthesis, secretion and action
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05202 Transcriptional misregulation in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05206 MicroRNAs in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05205 Proteoglycans in cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05203 Viral carcinogenesis
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09162 Cancer: specific types
   05210 Colorectal cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05212 Pancreatic cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05225 Hepatocellular carcinoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05226 Gastric cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05214 Glioma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05216 Thyroid cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05220 Chronic myeloid leukemia
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05217 Basal cell carcinoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05218 Melanoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05211 Renal cell carcinoma
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05219 Bladder cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05215 Prostate cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05213 Endometrial cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05224 Breast cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05222 Small cell lung cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05223 Non-small cell lung cancer
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05161 Hepatitis B
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05160 Hepatitis C
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05163 Human cytomegalovirus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05167 Kaposi sarcoma-associated herpesvirus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05169 Epstein-Barr virus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   05165 Human papillomavirus infection
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
   01522 Endocrine resistance
    K06625  CDKN1A, P21, CIP1; cyclin-dependent kinase inhibitor 1A
Other DBs
GO: 0004861
Genes
HSA: 1026(CDKN1A)
PTR: 104001067(CDKN1A)
PPS: 100977916(CDKN1A)
GGO: 101126640(CDKN1A)
PON: 100453682(CDKN1A)
NLE: 100599083(CDKN1A)
MCC: 719199(CDKN1A)
MCF: 102136063(CDKN1A)
CSAB: 103221583(CDKN1A)
RRO: 104682880(CDKN1A)
RBB: 108528336(CDKN1A)
CJC: 100894215(CDKN1A)
SBQ: 101041919(CDKN1A)
MMU: 12575(Cdkn1a)
MCAL: 110283679(Cdkn1a)
MPAH: 110338236(Cdkn1a)
RNO: 114851(Cdkn1a)
MUN: 110546586(Cdkn1a)
CGE: 103160601(Cdkn1a)
NGI: 103739652(Cdkn1a)
HGL: 101710552(Cdkn1a)
CCAN: 109696503(Cdkn1a)
OCU: 100348489(CDKN1A)
TUP: 102490159(CDKN1A)
CFA: 474890(CDKN1A)
VVP: 112913942(CDKN1A)
AML: 100484923(CDKN1A)
UMR: 103665536(CDKN1A)
UAH: 113243864(CDKN1A)
ORO: 101375107(CDKN1A)
ELK: 111147618
FCA: 493943(CDKN1A)
PTG: 102964051(CDKN1A)
PPAD: 109271531(CDKN1A)
AJU: 106972797(CDKN1A)
BTA: 513497(CDKN1A)
BOM: 102268672(CDKN1A)
BIU: 109577247(CDKN1A)
BBUB: 102403077(CDKN1A)
CHX: 102179898(CDKN1A)
OAS: 100302083(CDKN1A)
SSC: 100152215(CDKN1A)
CFR: 102509404(CDKN1A)
CDK: 105101330(CDKN1A)
BACU: 103005082(CDKN1A)
LVE: 103080733(CDKN1A)
OOR: 101288384(CDKN1A)
DLE: 111178743(CDKN1A)
PCAD: 102995437(CDKN1A)
ECB: 100064022(CDKN1A)
EPZ: 103564535(CDKN1A)
EAI: 106824579(CDKN1A)
MYB: 102245891(CDKN1A)
MYD: 102773038(CDKN1A)
MNA: 107545578(CDKN1A)
HAI: 109395991(CDKN1A)
DRO: 112302262(CDKN1A)
PALE: 102894049(CDKN1A)
RAY: 107514682(CDKN1A)
MJV: 108385913(CDKN1A)
LAV: 100671706(CDKN1A)
TMU: 101342008
MDO: 100029103(CDKN1A)
SHR: 100926666(CDKN1A)
PCW: 110217257(CDKN1A)
OAA: 114813305(CDKN1A)
GGA: 378914(CDKN1A)
MGP: 104914505(CDKN1A)
CJO: 107324690(CDKN1A)
NMEL: 110388091(CDKN1A)
APLA: 101796138(CDKN1A)
ACYG: 106031068 106048467(CDKN1A)
TGU: 105759380(CDKN1A)
LSR: 110473068(CDKN1A)
SCAN: 103822335(CDKN1A)
GFR: 102041135(CDKN1A)
FAB: 101811025(CDKN1A)
PHI: 102112135(CDKN1A)
PMAJ: 107214716(CDKN1A)
CCAE: 111944648(CDKN1A)
CCW: 104692419(CDKN1A)
ETL: 114064409(CDKN1A)
FCH: 114014226(CDKN1A)
CLV: 102096820(CDKN1A)
NNI: 104010373(CDKN1A) 104012649
ACUN: 113488931(CDKN1A) 113491306(CDKN1B)
PADL: 103917239 103925936(CDKN1A)
AAM: 106484396(CDKN1A) 106488969
ASN: 102368723(CDKN1B) 102379358(CDKN1A)
AMJ: 102567302(CDKN1D) 102568235(CDKN1A)
PSS: 102450716(CDKN1A) 102453637
CMY: 102939737(CDKN1A) 102940507
CPIC: 101938764(CDKN1A) 101953786
ACS: 100555337(cdkn1a)
PVT: 110075002 110079972(CDKN1A)
PBI: 103052025(CDKN1A) 103053360
PMUR: 107287054(CDKN1A)
TSR: 106541210(CDKN1A)
PMUA: 114599215(CDKN1A)
GJA: 107111179 107117358(CDKN1A)
XLA: 108709405 492305(cdkn1a.L)
XTR: 100038054(cdkn1a)
DRE: 100151416(cdkn1a)
IPU: 108281086(cdkn1a)
PHYP: 113539506
AMEX: 103041774 103047217(cdkn1a)
EEE: 113573558 113586971(cdkn1a)
TRU: 105417819
NCC: 104948695
PRET: 103465183
CVG: 107085617
NFU: 107385762
AOCE: 111574372
CSEM: 103385882
POV: 109629024
BPEC: 110168634
LCM: 102361382(CDKN1A)
CMK: 103179079(cdkn1a) 103179335
RTP: 109923052(cdkn1b)
AME: 725144
BIM: 100740661
BTER: 100643680
OBB: 114872802
CFO: 105258549
TCA: 107397827
DPA: 109533541
ATD: 109594574
PTEP: 107443706
PCAN: 112566296
LAK: 106178439
PDAM: 113675332
 » show all
Reference
  Authors
Abbas T, Dutta A
  Title
p21 in cancer: intricate networks and multiple activities.
  Journal
Nat Rev Cancer 9:400-14 (2009)
DOI:10.1038/nrc2657
Reference
PMID:8242751
  Authors
Harper JW, Adami GR, Wei N, Keyomarsi K, Elledge SJ
  Title
The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin-dependent kinases.
  Journal
Cell 75:805-16 (1993)
DOI:10.1016/0092-8674(93)90499-G
  Sequence
[hsa:1026]
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