KEGG   ORTHOLOGY: K06631
Entry
K06631                      KO                                     

Name
PLK1
Definition
polo-like kinase 1 [EC:2.7.11.21]
Pathway
ko04068  FoxO signaling pathway
ko04110  Cell cycle
ko04114  Oocyte meiosis
ko04914  Progesterone-mediated oocyte maturation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K06631  PLK1; polo-like kinase 1
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06631  PLK1; polo-like kinase 1
   04114 Oocyte meiosis
    K06631  PLK1; polo-like kinase 1
 09150 Organismal Systems
  09152 Endocrine system
   04914 Progesterone-mediated oocyte maturation
    K06631  PLK1; polo-like kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06631  PLK1; polo-like kinase 1
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K06631  PLK1; polo-like kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.21  polo kinase
     K06631  PLK1; polo-like kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PLK family [OT]
   K06631  PLK1; polo-like kinase 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centromeric chromatin formation proteins
   SAC (spindle assembly checkpoint) factors
    Protein kinases
     K06631  PLK1; polo-like kinase 1
  Centrosome formation and ciliogenesis proteins
   Kinases and associated factors
    K06631  PLK1; polo-like kinase 1
  Sister chromatid separation proteins
   Polo kinases
    K06631  PLK1; polo-like kinase 1
Genes
HSA: 5347(PLK1)
PTR: 453991(PLK1)
PPS: 100992499(PLK1)
GGO: 101142495(PLK1)
PON: 100437332(PLK1)
NLE: 100596287(PLK1)
MCC: 697686(PLK1)
MCF: 101865340(PLK1)
CSAB: 103229799(PLK1)
RRO: 104658253(PLK1)
RBB: 108517680 108538812(PLK1)
CJC: 100409054(PLK1)
SBQ: 101038450(PLK1)
MMU: 18817(Plk1)
MCAL: 110298205(Plk1)
MPAH: 110319327(Plk1)
RNO: 25515(Plk1)
MUN: 110550653(Plk1)
CGE: 100760676(Plk1)
NGI: 103746931(Plk1)
HGL: 101721399(Plk1)
CCAN: 109699641(Plk1)
OCU: 100356287(PLK1)
TUP: 102494746(PLK1)
CFA: 489971(PLK1)
VVP: 112908293(PLK1)
AML: 100478763(PLK1)
UMR: 103668898(PLK1)
UAH: 113267582(PLK1)
ORO: 101381651(PLK1)
ELK: 111162240
FCA: 101098508(PLK1)
PTG: 102953697(PLK1)
PPAD: 109255556(PLK1)
AJU: 106970495(PLK1)
BTA: 538238(PLK1)
BOM: 102272163(PLK1)
BIU: 109578571(PLK1)
BBUB: 102407714(PLK1)
CHX: 102171678(PLK1)
OAS: 101105713(PLK1)
SSC: 396953(PLK1)
CFR: 102512097(PLK1)
CDK: 105094832(PLK1)
BACU: 103012253(PLK1)
LVE: 103090008(PLK1)
OOR: 101276504(PLK1)
DLE: 111182235(PLK1)
PCAD: 102974840(PLK1)
ECB: 100068388(PLK1)
EPZ: 103562657(PLK1)
EAI: 106845827(PLK1)
MYB: 102260682(PLK1)
MYD: 102758132(PLK1)
MNA: 107544743(PLK1)
HAI: 109386529(PLK1)
DRO: 112304766(PLK1)
PALE: 102895334(PLK1)
RAY: 107516089(PLK1)
MJV: 108383431(PLK1)
LAV: 100675411(PLK1)
TMU: 101355942
MDO: 100027403(PLK1)
SHR: 100930498(PLK1)
PCW: 110202459(PLK1)
OAA: 100073533(PLK1)
GGA: 416575(PLK1)
MGP: 100539569(PLK1)
CJO: 107320693(PLK1)
NMEL: 110405608(PLK1)
APLA: 101800116(PLK1)
ACYG: 106046017(PLK1)
TGU: 100221581(PLK1)
LSR: 110479539(PLK1)
SCAN: 103817797(PLK1)
GFR: 102042745(PLK1)
FAB: 101821878(PLK1)
PHI: 102106048(PLK1)
PMAJ: 107210991(PLK1)
CCAE: 111936205(PLK1)
CCW: 104684984(PLK1)
ETL: 114061457(PLK1)
FPG: 101921429(PLK1)
FCH: 102046673(PLK1)
CLV: 102089372(PLK1)
EGZ: 104134547(PLK1)
NNI: 104015281(PLK1)
ACUN: 113485917(PLK1)
PADL: 103913915(PLK1)
AAM: 106486200(PLK1)
ASN: 102370156(PLK1)
AMJ: 102561861(PLK1)
PSS: 102446825(PLK1)
CMY: 102931153(PLK1)
CPIC: 101943364(PLK1)
ACS: 100558384(plk1)
PVT: 110084996(PLK1)
PBI: 103059922(PLK1)
TSR: 106553451(PLK1)
GJA: 107126199(PLK1)
XLA: 108701628(plk1.L) 380481(plk1.S)
XTR: 407937(plk1)
NPR: 108790758(PLK1)
DRE: 280649(plk1)
SRX: 107722962 107725406(plk1)
SANH: 107692656(plk1) 107702528
SGH: 107564476(plk1) 107590713
IPU: 108258666(plk1)
PHYP: 113535688(plk1)
AMEX: 103034005(plk1)
EEE: 113580908(plk1)
TRU: 101072492(plk1)
LCO: 104921165(plk1)
NCC: 104943728(plk1)
MZE: 101467664(plk1)
ONL: 100698269(plk1)
OLA: 101170155(plk1)
XMA: 102218913(plk1)
XCO: 114143902(plk1)
PRET: 103462043(plk1)
CVG: 107099337(plk1)
NFU: 107389935(plk1)
KMR: 108243614(plk1)
ALIM: 106522726(plk1)
AOCE: 111566256(plk1)
CSEM: 103383451(plk1)
POV: 109646908(plk1)
LCF: 108894767(plk1)
SDU: 111216631(plk1)
SLAL: 111672930(plk1)
HCQ: 109511272(plk1)
BPEC: 110153514(plk1)
MALB: 109973323(plk1)
SASA: 106590979 106592455(plk1)
OTW: 112241904
ELS: 105029645(plk1)
PKI: 111845541(plk1) 111849137
LCM: 102348600(PLK1)
CMK: 103186623(plk1)
RTP: 109910478(plk1)
BFO: 118407845
CIN: 100177145
SPU: 587774
APLC: 110981126
SKO: 100375057(PLK1)
DME: Dmel_CG12306(polo)
DER: 6545229
DSE: 6616273
DSI: Dsimw501_GD14871(Dsim_GD14871)
DAN: 6492926
DSR: 110184654
DWI: 6638839
DAZ: 108612879
DNV: 108650551
DHE: 111592326
DVI: 6622842
MDE: 101895764
LCQ: 111680103
AAG: 5577816
AALB: 109429192
AME: 413261
BIM: 100745573
BTER: 100645092
CCAL: 108631225
OBB: 114879203
SOC: 105195386
MPHA: 105830341
AEC: 105153306
ACEP: 105625390
PBAR: 105426410
VEM: 105567455
HST: 105182847
DQU: 106740832
CFO: 105249967
LHU: 105676765
PGC: 109855515
OBO: 105287695
PCF: 106790885
NVI: 100120719
CSOL: 105359294
MDL: 103575130
TCA: 660822(polo)
DPA: 109536032
ATD: 109604358
NVL: 108567985
BMOR: 101740671(PLK1)
BMAN: 114250344
PMAC: 106712452
PRAP: 110997850
HAW: 110371560
TNL: 113492842
DNX: 107164321
BTAB: 109043875
CLEC: 106669672
ZNE: 110839445
TUT: 107366765
PTEP: 107450227
CEL: CELE_C14B9.4(plk-1) CELE_F55G1.8(plk-3) CELE_Y71F9B.7(plk-2)
CBR: CBG04120(Cbr-plk-2) CBG09233(Cbr-plk-1)
TSP: Tsp_02561
PCAN: 112560388
CRG: 105341494
MYI: 110442904
OBI: 106875068
LAK: 106169017
SHX: MS3_06674
EGL: EGR_01044
NVE: 5509390
EPA: 110240168
ADF: 107345140
AMIL: 114954501
PDAM: 113666440
AQU: 100641743
CNE: CNK02500
CNB: CNBK1050
DDI: DDB_G0274503(plk)
DFA: DFA_03393(plk)
EHI: EHI_008410(114.t00009)
SPAR: SPRG_00035
 » show all
Reference
  Authors
McMillin DW, Delmore J, Negri J, Ooi M, Klippel S, Miduturu CV, Gray NS, Richardson PG, Anderson KC, Kung AL, Mitsiades CS
  Title
Microenvironmental influence on pre-clinical activity of polo-like kinase inhibition in multiple myeloma: implications for clinical translation.
  Journal
PLoS One 6:e20226 (2011)
DOI:10.1371/journal.pone.0020226
  Sequence
[hsa:5347]
Reference
  Authors
Lee K, Rhee K
  Title
PLK1 phosphorylation of pericentrin initiates centrosome maturation at the onset of mitosis.
  Journal
J Cell Biol 195:1093-101 (2011)
DOI:10.1083/jcb.201106093
  Sequence
[hsa:5347]
Reference
  Authors
Chase D, Serafinas C, Ashcroft N, Kosinski M, Longo D, Ferris DK, Golden A
  Title
The polo-like kinase PLK-1 is required for nuclear envelope breakdown and the completion of meiosis in Caenorhabditis elegans.
  Journal
  Sequence
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