KEGG   ORTHOLOGY: K06641
Entry
K06641                      KO                                     

Name
CHEK2
Definition
serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
Pathway
ko04110  Cell cycle
ko04111  Cell cycle - yeast
ko04115  p53 signaling pathway
ko04218  Cellular senescence
ko05166  Human T-cell leukemia virus 1 infection
Disease
H00881  Li-Fraumeni syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04110 Cell cycle
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04111 Cell cycle - yeast
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04115 p53 signaling pathway
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
   04218 Cellular senescence
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
 09160 Human Diseases
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K06641  CHEK2; serine/threonine-protein kinase CHEK2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: CAMK group
  RAD53 family
   K06641  CHEK2; serine/threonine-protein kinase CHEK2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  Check point factors
   Other check point factors
    K06641  CHEK2; serine/threonine-protein kinase CHEK2
Other DBs
COG: COG0515
Genes
HSA: 11200(CHEK2)
PTR: 458733(CHEK2)
PPS: 100987687(CHEK2)
GGO: 101124618(CHEK2)
PON: 100461345(CHEK2)
NLE: 100594542(CHEK2)
MCC: 713668(CHEK2)
MCF: 102122988(CHEK2)
CSAB: 103223122(CHEK2)
RRO: 104658998(CHEK2)
RBB: 108517558(CHEK2)
CJC: 100404949(CHEK2)
SBQ: 101051768(CHEK2)
MMU: 50883(Chek2)
MCAL: 110294527(Chek2)
MPAH: 110312870(Chek2)
RNO: 114212(Chek2)
MUN: 110553166(Chek2)
CGE: 100769280(Chek2)
NGI: 103750875(Chek2)
HGL: 101721212(Chek2)
CCAN: 109690250(Chek2)
OCU: 100339430(CHEK2)
TUP: 102484993(CHEK2)
CFA: 486338(CHEK2)
VVP: 112906959(CHEK2)
AML: 100467146(CHEK2)
UMR: 103659236(CHEK2)
UAH: 113244997(CHEK2)
ORO: 101386368(CHEK2)
ELK: 111160086
FCA: 101085665(CHEK2)
PTG: 102960814(CHEK2)
PPAD: 109253543(CHEK2)
AJU: 106985461(CHEK2)
BTA: 518897(CHEK2)
BOM: 102283552(CHEK2)
BIU: 109571019(CHEK2)
BBUB: 102409445(CHEK2)
CHX: 102184180(CHEK2)
OAS: 101105532(CHEK2)
SSC: 100192447(CHEK2)
CFR: 102508820(CHEK2)
CDK: 105099476(CHEK2)
BACU: 103014798(CHEK2)
LVE: 103076926(CHEK2)
OOR: 101289528(CHEK2)
DLE: 111162720(CHEK2)
PCAD: 102986126(CHEK2)
ECB: 100059288(CHEK2)
EPZ: 103554111(CHEK2)
EAI: 106827624(CHEK2)
MYB: 102250232(CHEK2)
MYD: 102766522(CHEK2)
MNA: 107526210(CHEK2)
HAI: 109383036(CHEK2)
DRO: 112310842(CHEK2)
PALE: 102882358(CHEK2)
RAY: 107520494(CHEK2)
MJV: 108408453(CHEK2)
LAV: 100666208(CHEK2)
TMU: 101359759
MDO: 100030584(CHEK2)
SHR: 100932330(CHEK2)
PCW: 110215254(CHEK2)
OAA: 100077482(CHEK2)
GGA: 768913(CHEK2)
MGP: 100543068(CHEK2)
CJO: 107321227(CHEK2)
NMEL: 110406189(CHEK2)
ACYG: 106043894(CHEK2)
TGU: 100228558(CHEK2)
LSR: 110478117(CHEK2)
SCAN: 103818108(CHEK2)
GFR: 102038788(CHEK2)
FAB: 101811158(CHEK2)
PHI: 102110514(CHEK2)
PMAJ: 107211857(CHEK2)
CCAE: 111936476(CHEK2)
CCW: 104688640(CHEK2)
ETL: 114061540(CHEK2)
FPG: 101911493(CHEK2)
FCH: 102057640(CHEK2)
CLV: 102090751(CHEK2)
EGZ: 104122580(CHEK2)
NNI: 104015770(CHEK2)
ACUN: 113486115(CHEK2)
PADL: 103922582(CHEK2)
AAM: 106492744(CHEK2)
ASN: 102386466(CHEK2)
AMJ: 102574431(CHEK2)
PSS: 102461937(CHEK2)
CMY: 102947582(CHEK2)
CPIC: 101952469(CHEK2)
PVT: 110083425(CHEK2)
PBI: 103066019(CHEK2)
PMUR: 107287280(CHEK2)
TSR: 106550569(CHEK2)
PMUA: 114587126(CHEK2)
GJA: 107123921(CHEK2)
XLA: 398179(chek2.L)
XTR: 100144952(chek2)
NPR: 108788045(CHEK2)
DRE: 336998(chek2)
SRX: 107723314(chek2) 107751420
IPU: 108255821(chek2)
PHYP: 113525110(chek2)
AMEX: 103034962(chek2)
EEE: 113572926(chek2)
TRU: 101063164(chek2)
MZE: 101485707(chek2)
ONL: 100708289(chek2)
OLA: 101170645(chek2)
XMA: 102224037
XCO: 114154787
PRET: 103460387(chek2)
CVG: 107105136
NFU: 107386179(chek2)
KMR: 108248076
ALIM: 106536288(chek2)
AOCE: 111573057(chek2)
CSEM: 103397943(chek2)
POV: 109645723
LCF: 108894515(chek2)
SDU: 111237444(chek2)
SLAL: 111649055(chek2)
HCQ: 109525295(chek2)
BPEC: 110169250(chek2)
MALB: 109957388
ELS: 105014423(chek2)
SFM: 108927301(chek2)
PKI: 111852734(chek2)
LCM: 102362683(CHEK2)
CMK: 103184008(chek2)
RTP: 109911275(chek2)
BFO: 118426647
CIN: 100175326
APLC: 110976646
SKO: 100372241
DME: Dmel_CG10895(lok)
DER: 6549116
DSE: 6614767
DSI: Dsimw501_GD24241(Dsim_GD24241)
DAN: 6497269
DPE: 6596561
DMN: 108162747
DWI: 6646756
DAZ: 108609925
DNV: 108650024
DHE: 111600369
DVI: 6634353
MDE: 101896859
LCQ: 111686974
AAG: 5569344
AME: 551949
BIM: 100745014
BTER: 100649762
CCAL: 108628555
OBB: 114871747
MPHA: 105833500
AEC: 105151042
ACEP: 105619804
PBAR: 105422193
VEM: 105566545
HST: 105181538
DQU: 106746783
CFO: 105258386
LHU: 105668387
PGC: 109861563
OBO: 105285139
PCF: 106793397
NVI: 100117742
CSOL: 105366519
MDL: 103568664
TCA: 661264
DPA: 109538347
ATD: 109608704
NVL: 108558766
BMOR: 692482(Chk2)
BMAN: 114252597
PMAC: 106717857
PRAP: 111003433
HAW: 110374774
TNL: 113498960
PXY: 105381643
API: 100163511
DNX: 107174043
AGS: 114123755
RMD: 113547984
BTAB: 109031651
CLEC: 106664898
PVM: 113829798
CSCU: 111617872
CEL: CELE_T08D2.7(T08D2.7) CELE_Y60A3A.12(chk-2)
CBR: CBG20512(Cbr-chk-2)
PCAN: 112561834
CRG: 105318723
MYI: 110445255
OBI: 106878443
LAK: 106155701
SHX: MS3_02323
EGL: EGR_00376
NVE: 5516550
EPA: 110232754
ADF: 107341547
AMIL: 114959893
PDAM: 113686167
SPIS: 111336580
DGT: 114520644
HMG: 100207948
SCE: YDL101C(DUN1)
ERC: Ecym_5624
KMX: KLMA_20647(DUN1)
NCS: NCAS_0B05910(NCAS0B05910)
NDI: NDAI_0B03190(NDAI0B03190)
TPF: TPHA_0C04570(TPHA0C04570)
TBL: TBLA_0B07330(TBLA0B07330)
TDL: TDEL_0G02820(TDEL0G02820)
KAF: KAFR_0K02450(KAFR0K02450)
CAL: CAALFM_C505100CA(DUN1)
NCR: NCU02814(prd-4)
NTE: NEUTE1DRAFT133979(NEUTE1DRAFT_133979)
MGR: MGG_01596
SSCK: SPSK_05999
MAW: MAC_01056
MAJ: MAA_05678
CMT: CCM_01421
MBE: MBM_06218
ANI: AN4279.2
ANG: ANI_1_520114(An13g00100)
ABE: ARB_00949
TVE: TRV_00735
PNO: SNOG_03701(SNOG_03700)
PTE: PTT_12246
MBR: MONBRDRAFT_15828(Cds1)
DDI: DDB_G0281567(fhkC)
DFA: DFA_05550(fhkA)
EHI: EHI_011510(90.t00001)
 » show all
Reference
  Authors
Lovly CM, Yan L, Ryan CE, Takada S, Piwnica-Worms H
  Title
Regulation of Chk2 ubiquitination and signaling through autophosphorylation of serine 379.
  Journal
Mol Cell Biol 28:5874-85 (2008)
DOI:10.1128/MCB.00821-08
  Sequence
[hsa:11200]
Reference
  Authors
Bahassi EM, Ovesen JL, Riesenberg AL, Bernstein WZ, Hasty PE, Stambrook PJ
  Title
The checkpoint kinases Chk1 and Chk2 regulate the functional associations between hBRCA2 and Rad51 in response to DNA damage.
  Journal
Oncogene 27:3977-85 (2008)
DOI:10.1038/onc.2008.17
  Sequence
[hsa:11200]
Reference
PMID:9836640
  Authors
Matsuoka S, Huang M, Elledge SJ
  Title
Linkage of ATM to cell cycle regulation by the Chk2 protein kinase.
  Journal
Science 282:1893-7 (1998)
DOI:10.1126/science.282.5395.1893
  Sequence
[hsa:11200]
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