KEGG   ORTHOLOGY: K07201
Entry
K07201                      KO                                     

Name
FOXO1
Definition
forkhead box protein O1
Pathway
ko04068  FoxO signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04922  Glucagon signaling pathway
ko04931  Insulin resistance
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05131  Shigellosis
ko05165  Human papillomavirus infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05215  Prostate cancer
Disease
H00037  Rhabdomyosarcoma
H02434  Diffuse large B-cell lymphoma, not otherwise specified
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04152 AMPK signaling pathway
    K07201  FOXO1; forkhead box protein O1
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K07201  FOXO1; forkhead box protein O1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04922 Glucagon signaling pathway
    K07201  FOXO1; forkhead box protein O1
   04919 Thyroid hormone signaling pathway
    K07201  FOXO1; forkhead box protein O1
  09149 Aging
   04211 Longevity regulating pathway
    K07201  FOXO1; forkhead box protein O1
   04213 Longevity regulating pathway - multiple species
    K07201  FOXO1; forkhead box protein O1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07201  FOXO1; forkhead box protein O1
   05202 Transcriptional misregulation in cancer
    K07201  FOXO1; forkhead box protein O1
  09162 Cancer: specific types
   05215 Prostate cancer
    K07201  FOXO1; forkhead box protein O1
  09167 Endocrine and metabolic disease
   04931 Insulin resistance
    K07201  FOXO1; forkhead box protein O1
   04933 AGE-RAGE signaling pathway in diabetic complications
    K07201  FOXO1; forkhead box protein O1
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K07201  FOXO1; forkhead box protein O1
  09172 Infectious disease: viral
   05165 Human papillomavirus infection
    K07201  FOXO1; forkhead box protein O1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K07201  FOXO1; forkhead box protein O1
Transcription factors [BR:ko03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix other regulators
    K07201  FOXO1; forkhead box protein O1
Genes
HSA: 2308(FOXO1)
PTR: 467352(FOXO1)
PPS: 100996020(FOXO1)
GGO: 101151399(FOXO1)
PON: 100460676(FOXO1)
NLE: 100594615(FOXO1)
MCC: 700030(FOXO1)
MCF: 102116712(FOXO1)
CSAB: 103214322(FOXO1)
RRO: 104671116(FOXO1)
RBB: 108514115(FOXO1)
CJC: 100397393(FOXO1)
SBQ: 101053657(FOXO1)
MMU: 56458(Foxo1)
MCAL: 110291168(Foxo1)
MPAH: 110319907(Foxo1)
RNO: 84482(Foxo1)
MUN: 110549421(Foxo1)
CGE: 100768647(Foxo1)
NGI: 103747066(Foxo1)
HGL: 101707441(Foxo1)
CCAN: 109688921(Foxo1)
OCU: 100358471(FOXO1)
TUP: 102489658(FOXO1)
CFA: 477295(FOXO1)
VVP: 112918703(FOXO1)
AML: 100471182(FOXO1)
UMR: 103677704(FOXO1)
UAH: 113251282(FOXO1)
ORO: 101373912(FOXO1)
ELK: 111158571
FCA: 101096628(FOXO1)
PTG: 102969147(FOXO1)
PPAD: 109266009(FOXO1)
AJU: 106972644(FOXO1)
BTA: 506618(FOXO1)
BOM: 102284612(FOXO1)
BIU: 109566997(FOXO1)
BBUB: 102396402(FOXO1)
CHX: 102184915(FOXO1)
OAS: 101107877(FOXO1)
SSC: 397077(FOXO1)
CFR: 102511562(FOXO1)
CDK: 105091004(FOXO1)
BACU: 103020667(FOXO1)
LVE: 103086905(FOXO1)
OOR: 101285637(FOXO1)
DLE: 111175267(FOXO1)
PCAD: 102980680(FOXO1)
ECB: 100050481(FOXO1)
EPZ: 103552024(FOXO1)
EAI: 106848479(FOXO1)
MYB: 102253962(FOXO1)
MYD: 102766094(FOXO1)
MNA: 107537551(FOXO1)
HAI: 109387667(FOXO1)
DRO: 112312153(FOXO1)
PALE: 102892244(FOXO1)
RAY: 107497776(FOXO1)
MJV: 108409638(FOXO1)
LAV: 100655740(FOXO1)
TMU: 101340503
MDO: 100021587(FOXO1)
SHR: 100928882(FOXO1)
PCW: 110196617(FOXO1)
OAA: 100082288(FOXO1)
GGA: 374231(FOXO1)
MGP: 100540055(FOXO1)
CJO: 107308196(FOXO1)
NMEL: 110388188(FOXO1)
APLA: 101795447(FOXO1)
ACYG: 106035078(FOXO1)
TGU: 100217629(FOXO1)
LSR: 110468577(FOXO1)
SCAN: 103812564(FOXO1)
GFR: 102039410(FOXO1)
FAB: 101809090(FOXO1)
PHI: 102099738(FOXO1)
PMAJ: 107210372(FOXO1)
CCAE: 111944362(FOXO1)
CCW: 104689938(FOXO1)
ETL: 114059362(FOXO1)
FPG: 101915696(FOXO1)
FCH: 102057600(FOXO1)
CLV: 102086772(FOXO1)
EGZ: 104129682(FOXO1)
NNI: 104010936(FOXO1)
ACUN: 113482931(FOXO1)
PADL: 103913472(FOXO1)
AAM: 106489240(FOXO1)
ASN: 102388853(FOXO1)
AMJ: 102576430(FOXO1)
PSS: 102449767(FOXO1)
CMY: 102939461(FOXO1)
CPIC: 101940772(FOXO1)
ACS: 100557662(foxo1)
PVT: 110076126(FOXO1)
PBI: 103062993(FOXO1)
PMUR: 107289857(FOXO1)
TSR: 106545297(FOXO1)
PMUA: 114593612(FOXO1)
GJA: 107110257(FOXO1)
XLA: 108709932(foxo1.S) 444991(foxo1.L)
XTR: 493378(foxo1)
NPR: 108787037(FOXO1)
DRE: 567969(foxo1b) 768121(foxo1a)
IPU: 108277356 108277791(foxo1)
PHYP: 113524179 113539229(foxo1)
AMEX: 103032706(foxo1) 103046520
EEE: 113578626(foxo1) 113590924
NCC: 104957347(foxo1) 104967635
OLA: 100301620(foxo1) 101164740
XMA: 102236896(foxo1) 102237615
XCO: 114153516 114161639(foxo1)
PRET: 103475003 103475797(foxo1)
NFU: 107380205(foxo1) 107386483
KMR: 108236025(foxo1) 108245221
CSEM: 103378152(foxo1) 103395707
BPEC: 110158469 110164373(foxo1)
MALB: 109959485 109968458(foxo1)
ELS: 105007737 105008116(foxo1)
LCM: 102347273(FOXO1)
CMK: 103177236(foxo1)
RTP: 109926926(foxo1)
SPU: 585334
DGT: 114535699
 » show all
Reference
  Authors
Bois PR, Izeradjene K, Houghton PJ, Cleveland JL, Houghton JA, Grosveld GC
  Title
FOXO1a acts as a selective tumor suppressor in alveolar rhabdomyosarcoma.
  Journal
J Cell Biol 170:903-12 (2005)
DOI:10.1083/jcb.200501040
Reference
  Authors
Zhang X, Gan L, Pan H, Guo S, He X, Olson ST, Mesecar A, Adam S, Unterman TG
  Title
Phosphorylation of serine 256 suppresses transactivation by FKHR (FOXO1) by multiple mechanisms. Direct and indirect effects on nuclear/cytoplasmic shuttling and DNA binding.
  Journal
J Biol Chem 277:45276-84 (2002)
DOI:10.1074/jbc.M208063200
  Sequence
[hsa:2308]
Reference
PMID:9479491
  Authors
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC
  Title
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
  Journal
Genomics 47:187-99 (1998)
DOI:10.1006/geno.1997.5122
  Sequence
[hsa:2308]
LinkDB

KEGG   ORTHOLOGY: K09408
Entry
K09408                      KO                                     

Name
FOXO3
Definition
forkhead box protein O3
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04137  Mitophagy - animal
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04361  Axon regeneration
ko04722  Neurotrophin signaling pathway
ko04917  Prolactin signaling pathway
ko05131  Shigellosis
ko05213  Endometrial cancer
ko05223  Non-small cell lung cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04068 FoxO signaling pathway
    K09408  FOXO3; forkhead box protein O3
   04151 PI3K-Akt signaling pathway
    K09408  FOXO3; forkhead box protein O3
   04152 AMPK signaling pathway
    K09408  FOXO3; forkhead box protein O3
 09140 Cellular Processes
  09141 Transport and catabolism
   04137 Mitophagy - animal
    K09408  FOXO3; forkhead box protein O3
  09143 Cell growth and death
   04218 Cellular senescence
    K09408  FOXO3; forkhead box protein O3
 09150 Organismal Systems
  09151 Immune system
   04062 Chemokine signaling pathway
    K09408  FOXO3; forkhead box protein O3
  09152 Endocrine system
   04917 Prolactin signaling pathway
    K09408  FOXO3; forkhead box protein O3
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K09408  FOXO3; forkhead box protein O3
  09158 Development and regeneration
   04361 Axon regeneration
    K09408  FOXO3; forkhead box protein O3
  09149 Aging
   04211 Longevity regulating pathway
    K09408  FOXO3; forkhead box protein O3
   04212 Longevity regulating pathway - worm
    K09408  FOXO3; forkhead box protein O3
   04213 Longevity regulating pathway - multiple species
    K09408  FOXO3; forkhead box protein O3
 09160 Human Diseases
  09162 Cancer: specific types
   05213 Endometrial cancer
    K09408  FOXO3; forkhead box protein O3
   05223 Non-small cell lung cancer
    K09408  FOXO3; forkhead box protein O3
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K09408  FOXO3; forkhead box protein O3
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K09408  FOXO3; forkhead box protein O3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09408  FOXO3; forkhead box protein O3
Transcription factors [BR:ko03000]
 Eukaryotic type
  Helix-turn-helix
   Fork head/winged helix other regulators
    K09408  FOXO3; forkhead box protein O3
Genes
HSA: 2309(FOXO3)
PTR: 462921(FOXO3)
PPS: 100976373(FOXO3)
GGO: 101153605(FOXO3)
PON: 100451077(FOXO3)
NLE: 100600519(FOXO3)
MCC: 700731(FOXO3)
MCF: 101925779(FOXO3)
CSAB: 103240621(FOXO3)
RRO: 104677475(FOXO3)
RBB: 108533814(FOXO3)
CJC: 100406446(FOXO3)
SBQ: 101039948(FOXO3)
MMU: 56484(Foxo3)
MCAL: 110302833(Foxo3)
MPAH: 110326428(Foxo3)
RNO: 294515(Foxo3)
MUN: 110555699(Foxo3)
CGE: 100770315(Foxo3)
NGI: 103749566(Foxo3)
HGL: 101699251(Foxo3)
CCAN: 109700754(Foxo3)
OCU: 100343573(FOXO3)
TUP: 102479628(FOXO3)
CFA: 481954(FOXO3)
VVP: 112925120(FOXO3)
AML: 100480992(FOXO3)
UMR: 103675835(FOXO3)
UAH: 113264764(FOXO3)
ORO: 101376741
ELK: 111158279
FCA: 101081548(FOXO3)
PTG: 102961930(FOXO3)
PPAD: 109263506(FOXO3)
AJU: 106986643(FOXO3)
BTA: 535530(FOXO3)
BOM: 102287014(FOXO3)
BIU: 109563845(FOXO3)
BBUB: 102391543(FOXO3)
CHX: 102188676(FOXO3)
OAS: 100913151(FOXO3)
SSC: 733621(FOXO3)
CFR: 102513603(FOXO3)
CDK: 105097118(FOXO3)
BACU: 102999779(FOXO3)
LVE: 103084467(FOXO3)
OOR: 101288204(FOXO3)
DLE: 111164348(FOXO3)
PCAD: 102980970(FOXO3)
ECB: 100066558(FOXO3)
EPZ: 103551216(FOXO3)
EAI: 106829766(FOXO3)
MYB: 102246728(FOXO3)
MYD: 102751393(FOXO3)
MNA: 107540694(FOXO3)
HAI: 109391421(FOXO3)
DRO: 112296999
PALE: 102890472(FOXO3)
RAY: 107518480(FOXO3)
MJV: 108390100
LAV: 100657588(FOXO3)
TMU: 101354741
MDO: 100021705(FOXO3)
SHR: 100917083(FOXO3)
PCW: 110222927(FOXO3)
OAA: 100080284(FOXO3)
GGA: 421769(FOXO3)
MGP: 100545873(FOXO3)
CJO: 107311812(FOXO3)
NMEL: 110395473(FOXO3)
APLA: 101799850(FOXO3)
ACYG: 106032604(FOXO3)
TGU: 100217648(FOXO3)
LSR: 110483710(FOXO3)
SCAN: 103822215(FOXO3)
GFR: 102034329(FOXO3)
FAB: 101810105(FOXO3)
PHI: 102100166(FOXO3)
PMAJ: 107201324(FOXO3)
CCAE: 111927133(FOXO3)
CCW: 104691645(FOXO3)
ETL: 114063307(FOXO3)
FPG: 101911781(FOXO3)
FCH: 102052285(FOXO3)
CLV: 102095969(FOXO3)
EGZ: 104131578(FOXO3)
NNI: 104011146(FOXO3)
ACUN: 113478153(FOXO3)
PADL: 103918984(FOXO3)
AAM: 106489614(FOXO3)
ASN: 102373584(FOXO3)
AMJ: 106737273(FOXO3)
PSS: 102455970(FOXO3)
CMY: 102942736(FOXO3)
CPIC: 101940984(FOXO3)
ACS: 100561938(foxo3)
PVT: 110083133(FOXO3)
PBI: 103053115(FOXO3) 103066631
PMUR: 107292237
TSR: 106556341(FOXO3)
PMUA: 114594024(FOXO3)
GJA: 107105443(FOXO3)
XLA: 108717943(foxo3.S) 444992(foxo3.L)
XTR: 100125025(foxo3)
NPR: 108792872(FOXO3)
DRE: 30296(foxo3b) 494532(foxo3a)
IPU: 108270398 108279058(foxo3)
PHYP: 113529099(foxo3) 113538547
AMEX: 103022904(foxo3) 103026113
EEE: 113567534 113580767(foxo3)
NCC: 104963488 104966138(foxo3)
OLA: 100301621(foxo3) 101155614
XMA: 102217263(foxo3) 102225439
NFU: 107377534(foxo3) 107391983
KMR: 108239076 108240108(foxo3)
SDU: 111226193 111236596(foxo3)
ELS: 105015400 105017479(foxo3)
SFM: 108920401(foxo3) 108921079
PKI: 111856450(foxo3) 111857894
LCM: 102359675(FOXO3)
CMK: 103178343(foxo3)
RTP: 109921049 109928072(foxo3)
BFO: 118422433
CIN: 100186156(foxo)
APLC: 110974374
SKO: 100303473(foxO3)
DME: Dmel_CG3143(foxo)
DER: 6552842
DSE: 6606448
DSI: Dsimw501_GD18943(Dsim_GD18943)
DAN: 6499030
DSR: 110190953
DPE: 6588468
DMN: 108156556
DWI: 6649777
DAZ: 108611366
DNV: 108659209
DHE: 111599783
DVI: 6635144
LCQ: 111690641
AAG: 5576867
AME: 727091
BIM: 100745007
BTER: 100643217
CCAL: 108630793
OBB: 114872156
SOC: 105196024
AEC: 105151192
ACEP: 105624987
PBAR: 105431952
VEM: 105568396
HST: 105183293
DQU: 106748843
CFO: 105254925
LHU: 105678422
PGC: 109856359
OBO: 105279112
PCF: 106789772
TCA: 664090
DPA: 109540202
ATD: 109603279
BMOR: 100529235(foxO)
BMAN: 114240768
PMAC: 106720323
PRAP: 111004181
HAW: 110373652
TNL: 113500648
PXY: 105382304
API: 100168097
DNX: 107165145
AGS: 114129032
RMD: 113550905
BTAB: 109037412
CLEC: 106669476
ZNE: 110839185
FCD: 110859825
DPX: DAPPUDRAFT_109005(FOXO)
PVM: 113820016
TUT: 107366353
PTEP: 107449813
CEL: CELE_R13H8.1(daf-16)
CBR: CBG12825(Cbr-daf-16)
BMY: Bm1_50095
TSP: Tsp_10373
PCAN: 112565983
CRG: 105318783
MYI: 110465698
NVE: 5509924
EPA: 110234656
SPIS: 111329204
HMG: 100202184
AQU: 109586425
 » show all
Reference
PMID:9479491
  Authors
Anderson MJ, Viars CS, Czekay S, Cavenee WK, Arden KC
  Title
Cloning and characterization of three human forkhead genes that comprise an FKHR-like gene subfamily.
  Journal
Genomics 47:187-99 (1998)
DOI:10.1006/geno.1997.5122
  Sequence
[hsa:2309]
Reference
  Authors
Lehtinen MK, Yuan Z, Boag PR, Yang Y, Villen J, Becker EB, DiBacco S, de la Iglesia N, Gygi S, Blackwell TK, Bonni A
  Title
A conserved MST-FOXO signaling pathway mediates oxidative-stress responses and extends life span.
  Journal
Cell 125:987-1001 (2006)
DOI:10.1016/j.cell.2006.03.046
  Sequence
[hsa:2309]
LinkDB

DBGET integrated database retrieval system