KEGG   ORTHOLOGY: K07203
Entry
K07203                      KO                                     

Name
MTOR, FRAP, TOR
Definition
serine/threonine-protein kinase mTOR [EC:2.7.11.1]
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04012  ErbB signaling pathway
ko04066  HIF-1 signaling pathway
ko04072  Phospholipase D signaling pathway
ko04113  Meiosis - yeast
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04139  Mitophagy - yeast
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04212  Longevity regulating pathway - worm
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04361  Axon regeneration
ko04371  Apelin signaling pathway
ko04630  JAK-STAT signaling pathway
ko04659  Th17 cell differentiation
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04935  Growth hormone synthesis, secretion and action
ko05010  Alzheimer disease
ko05014  Amyotrophic lateral sclerosis
ko05016  Huntington disease
ko05017  Spinocerebellar ataxia
ko05022  Pathways of neurodegeneration - multiple diseases
ko05131  Shigellosis
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05212  Pancreatic cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05221  Acute myeloid leukemia
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H01928  Smith-Kingsmore syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04371 Apelin signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04630 JAK-STAT signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04066 HIF-1 signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04072 Phospholipase D signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04151 PI3K-Akt signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04152 AMPK signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04150 mTOR signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04138 Autophagy - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04136 Autophagy - other
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04139 Mitophagy - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09143 Cell growth and death
   04113 Meiosis - yeast
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04218 Cellular senescence
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04920 Adipocytokine signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04935 Growth hormone synthesis, secretion and action
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04919 Thyroid hormone signaling pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09158 Development and regeneration
   04361 Axon regeneration
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09149 Aging
   04211 Longevity regulating pathway
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04212 Longevity regulating pathway - worm
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04213 Longevity regulating pathway - multiple species
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09159 Environmental adaptation
   04714 Thermogenesis
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05206 MicroRNAs in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05205 Proteoglycans in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05230 Central carbon metabolism in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05231 Choline metabolism in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09162 Cancer: specific types
   05210 Colorectal cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05212 Pancreatic cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05225 Hepatocellular carcinoma
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05226 Gastric cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05214 Glioma
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05221 Acute myeloid leukemia
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05215 Prostate cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05224 Breast cancer
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05014 Amyotrophic lateral sclerosis
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05016 Huntington disease
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05017 Spinocerebellar ataxia
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05022 Pathways of neurodegeneration - multiple diseases
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   04931 Insulin resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09172 Infectious disease: viral
   05170 Human immunodeficiency virus 1 infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05168 Herpes simplex virus 1 infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05163 Human cytomegalovirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   05165 Human papillomavirus infection
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
   01522 Endocrine resistance
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PIKK family [OT]
   K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    K07203  MTOR, FRAP, TOR; serine/threonine-protein kinase mTOR
Other DBs
COG: COG5032
Genes
HSA: 2475(MTOR)
PTR: 457945(MTOR)
PPS: 100980204(MTOR)
GGO: 101138990(MTOR)
PON: 100456786(MTOR)
NLE: 100594291(MTOR)
MCC: 106992736(MTOR)
MCF: 102128371(MTOR)
CSAB: 103225615(MTOR)
RRO: 104654362(MTOR)
RBB: 108539366(MTOR)
CJC: 100406608(MTOR)
SBQ: 101047083(MTOR)
MMU: 56717(Mtor)
MCAL: 110292680(Mtor)
MPAH: 110323363(Mtor)
RNO: 56718(Mtor)
MUN: 110548161(Mtor)
CGE: 100755421(Mtor)
NGI: 103732897(Mtor)
HGL: 101725626(Mtor)
CCAN: 109689653 109689656(Mtor)
OCU: 100356164(MTOR)
TUP: 102485262(MTOR)
CFA: 478232(MTOR)
VVP: 112929738(MTOR)
AML: 100471122(MTOR)
UMR: 103666660(MTOR)
UAH: 113270510(MTOR)
ORO: 101363844(MTOR)
ELK: 111154883
FCA: 101098152(MTOR)
PTG: 102967196(MTOR)
PPAD: 109274103(MTOR)
AJU: 106984907(MTOR)
BTA: 100139219(MTOR)
BOM: 102281727(MTOR)
BIU: 109570401(MTOR)
BBUB: 102407977(MTOR)
CHX: 100860902(MTOR)
OAS: 100271659(MTOR)
SSC: 100127359(MTOR)
CFR: 102510836(MTOR)
CDK: 105107024(MTOR)
BACU: 103004460(MTOR)
LVE: 103083889(MTOR)
OOR: 101284249(MTOR)
DLE: 111187265(MTOR)
PCAD: 102991493(MTOR)
ECB: 100051341(MTOR)
EPZ: 103552237(MTOR)
EAI: 106836676(MTOR)
MYB: 102241670(MTOR)
MYD: 102766933(MTOR)
MNA: 107540994(MTOR)
HAI: 109381262(MTOR)
DRO: 112299108(MTOR)
PALE: 102885092(MTOR)
RAY: 107513109(MTOR)
MJV: 108390746(MTOR) 108399184
LAV: 100660112(MTOR)
TMU: 101343808
MDO: 100619675(MTOR)
SHR: 100931480(MTOR)
PCW: 110199207(MTOR)
OAA: 100079751(MTOR)
GGA: 419455(MTOR)
MGP: 100547037(MTOR)
CJO: 107323407(MTOR)
NMEL: 110408585(MTOR)
APLA: 101802486(MTOR)
ACYG: 106040228(MTOR)
TGU: 100219695(MTOR)
LSR: 110474443(MTOR)
SCAN: 103820856(MTOR)
GFR: 102034190(MTOR)
FAB: 101820693(MTOR)
PHI: 102108233(MTOR)
PMAJ: 107213730(MTOR)
CCAE: 111938583(MTOR)
CCW: 104693234(MTOR)
ETL: 114056898(MTOR)
FPG: 101919512(MTOR)
FCH: 102051979(MTOR)
CLV: 102093827(MTOR)
EGZ: 104133077(MTOR)
NNI: 104008993(MTOR)
ACUN: 113487804(MTOR)
PADL: 103918043(MTOR)
AAM: 106482444(MTOR)
ASN: 102372197(MTOR)
AMJ: 102574334(MTOR)
PSS: 102451030(MTOR)
CMY: 102947284
CPIC: 101949839(MTOR)
ACS: 100565267(mtor)
PVT: 110073225(MTOR)
PBI: 103053332(MTOR)
PMUR: 107294607(MTOR)
TSR: 106548093(MTOR)
PMUA: 114602439(MTOR)
GJA: 107108920(MTOR)
XLA: 108696363
XTR: 100491970(mtor)
NPR: 108789092(MTOR) 108796319
DRE: 324254(mtor)
SANH: 107679101 107687131(mtor)
CCAR: 109052678 109094977(mtor)
IPU: 108265039(mtor)
PHYP: 113533236(mtor)
AMEX: 103042377(mtor)
EEE: 113584326(mtor)
TRU: 101074470(mtor)
LCO: 104919512(mtor)
NCC: 104956725
MZE: 101471360(mtor)
ONL: 100700382(mtor)
OLA: 101156248(mtor)
XMA: 102220301(mtor)
XCO: 114146827(mtor)
PRET: 103467091(mtor)
CVG: 107086709(mtor)
NFU: 107391286(mtor)
KMR: 108233102(mtor)
ALIM: 106518905(mtor)
AOCE: 111567358(mtor)
CSEM: 103384900(mtor)
POV: 109630582(mtor)
LCF: 108882623(mtor)
SDU: 111227586(mtor)
SLAL: 111656119(mtor)
HCQ: 109511770(mtor)
BPEC: 110157966(mtor)
MALB: 109967123(mtor)
SASA: 100380849(mtor)
SALP: 112068245
ELS: 105013925(mtor)
PKI: 111834305(mtor)
LCM: 102360124(MTOR)
CMK: 103181362(mtor)
RTP: 109914403
BFO: 118430523
CIN: 100178479
SPU: 580879
APLC: 110982650
SKO: 100329005(TOR)
DME: Dmel_CG5092(Tor)
DER: 6541133
DSE: 6617786
DSI: Dsimw501_GD23862(Dsim_GD23862)
DAN: 6497044
DPE: 6602261
DMN: 108162417
DWI: 6642343
DAZ: 108611317
DNV: 108649829
DHE: 111592907
DVI: 6627365
MDE: 101893055
LCQ: 111683351
AAG: 5565894
AALB: 109429896
AME: 409393
BIM: 100749875
BTER: 100649664
CCAL: 108631239
OBB: 114873371
SOC: 105193564
MPHA: 105830377
AEC: 105152845
ACEP: 105624966
PBAR: 105424520
VEM: 105566956
HST: 105190144
DQU: 106747690
CFO: 105256945
LHU: 105679357
PGC: 109859730
OBO: 105276125
PCF: 106789371
NVI: 100118360
CSOL: 105365573
MDL: 103576490
TCA: 660499
DPA: 109544499
ATD: 109608742
NVL: 108556975
BMOR: 100431180(TOR2)
PXY: 105390151
API: 100163481
DNX: 107162479
AGS: 114123865
RMD: 113555205
BTAB: 109043116
CLEC: 106669228
ZNE: 110840625
FCD: 110851607
PVM: 113820097
TUT: 107359769
DPTE: 113791191
CSCU: 111620923
PTEP: 107439010
CEL: CELE_B0261.2(let-363)
CBR: CBG12850(Cbr-let-363)
BMY: Bm1_48125
TSP: Tsp_04731
PCAN: 112557789
CRG: 105331599
MYI: 110448263
OBI: 106870424
SHX: MS3_06813
EGL: EGR_00240
NVE: 5517009
EPA: 110251691
AMIL: 114959968
PDAM: 113680191
SPIS: 111343488
DGT: 114516375
HMG: 100197178
AQU: 100633443
ATH: AT1G50030(TOR)
ALY: 9330289
CRB: 17897805
CSAT: 104777927
THJ: 104826500
CPAP: 110821135
CIT: 102618367
TCC: 18608126
DZI: 111309034
EGR: 104419800
VRA: 106777509
VAR: 108319939
VUN: 114173244
CCAJ: 109800697
CAM: 101499541
LJA: Lj1g3v0052210.1(Lj1g3v0052210.1) Lj1g3v0052210.2(Lj1g3v0052210.2) Lj1g3v0052210.3(Lj1g3v0052210.3)
ADU: 107488658
AIP: 107643288
FVE: 101310491
RCN: 112168819
PPER: 18766256
PMUM: 103335031
PAVI: 110760196
PXB: 103928072
ZJU: 107427093
CSV: 101212051
CMO: 103495325
MCHA: 111017367
CMAX: 111471047
CMOS: 111454906
CPEP: 111811251
RCU: 8258060
JCU: 105650837
HBR: 110648417
MESC: 110618927
VVI: 100249713
SLY: 101259295
SPEN: 107002769
SOT: 102604383
CANN: 107879481
NTA: 107776741(TOR) 107799667
NSY: 104242814
NTO: 104118002
NAU: 109208101
INI: 109178500
SIND: 105169347
LSV: 111891370
CCAV: 112515141
BVG: 104904834
NNU: 104589114
OSA: 4338174
DOSA: Os05t0235300-01(Os05g0235300)
OBR: 102706940
BDI: 100835842
ATS: 109783936(LOC109783936)
SBI: 8084725
ZMA: 542211(cl3114_1(600))
SITA: 101780377
PDA: 103698521
EGU: 105056261
MUS: 103980358
DCT: 110111565
PEQ: 110022180
AOF: 109833837
ATR: 18423738
PPP: 112284079
CRE: CHLREDRAFT_176480(TOR1)
APRO: F751_1983
MIS: MICPUN_88899(TOR)
SCE: YJR066W(TOR1) YKL203C(TOR2)
ERC: Ecym_3152
KMX: KLMA_30046(TOR2)
NCS: NCAS_0G03440(NCAS0G03440)
NDI: NDAI_0D01470(NDAI0D01470)
TPF: TPHA_0F03570(TPHA0F03570)
TBL: TBLA_0D03670(TBLA0D03670)
TDL: TDEL_0F00460(TDEL0F00460)
KAF: KAFR_0A08100(KAFR0A08100) KAFR_0E00310(KAFR0E00310)
PIC: PICST_33151(TOR2)
CAL: CAALFM_C207330WA(TOR1)
SLB: AWJ20_2811(TOR1)
NCR: NCU05608
NTE: NEUTE1DRAFT148627(NEUTE1DRAFT_148627)
MGR: MGG_15156
SSCK: SPSK_06845
MAW: MAC_01551
MAJ: MAA_02388
CMT: CCM_04900
MBE: MBM_05946
ANI: AN5982.2
ANG: ANI_1_672144(An16g04720)
ABE: ARB_05798
TVE: TRV_04550
PNO: SNOG_08246(SNOG_08245)
PTE: PTT_08717
ZTR: MYCGRDRAFT_67795(TOR1)
PFJ: MYCFIDRAFT_205476(TOR2)
SPO: SPBC216.07c(tor2) SPBC30D10.10c(tor1)
TASA: A1Q1_03117
ABP: AGABI1DRAFT126075(AGABI1DRAFT_126075) AGABI1DRAFT35543(AGABI1DRAFT_35543)
ABV: AGABI2DRAFT151451(AGABI2DRAFT_151451) AGABI2DRAFT151460(AGABI2DRAFT_151460)
MGL: MGL_2920
MRT: MRET_3521
DDI: DDB_G0281569(tor)
DFA: DFA_09983(tor)
EHI: EHI_169320(177.t00028)
SPAR: SPRG_13345
EHX: EMIHUDRAFT_99823(TOR1)
LMA: LMJF_34_3940(TOR3) LMJF_34_4530(TOR2) LMJF_36_6320(TOR1)
LIF: LINJ_34_3750(TOR3) LINJ_34_4160(TOR2) LINJ_36_6580(TOR1)
LBZ: LBRM_20_3550(TOR3) LBRM_20_3990(TOR2) LBRM_35_6620(TOR1)
 » show all
Reference
PMID:8008069
  Authors
Brown EJ, Albers MW, Shin TB, Ichikawa K, Keith CT, Lane WS, Schreiber SL
  Title
A mammalian protein targeted by G1-arresting rapamycin-receptor complex.
  Journal
Nature 369:756-8 (1994)
DOI:10.1038/369756a0
  Sequence
[hsa:2475]
Reference
  Authors
Jiang Y, Broach JR
  Title
Tor proteins and protein phosphatase 2A reciprocally regulate Tap42 in controlling cell growth in yeast.
  Journal
EMBO J 18:2782-92 (1999)
DOI:10.1093/emboj/18.10.2782
LinkDB

KEGG   ORTHOLOGY: K07204
Entry
K07204                      KO                                     

Name
RAPTOR
Definition
regulatory associated protein of mTOR
Pathway
ko04136  Autophagy - other
ko04138  Autophagy - yeast
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko05131  Shigellosis
ko05206  MicroRNAs in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K07204  RAPTOR; regulatory associated protein of mTOR
   04152 AMPK signaling pathway
    K07204  RAPTOR; regulatory associated protein of mTOR
   04150 mTOR signaling pathway
    K07204  RAPTOR; regulatory associated protein of mTOR
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07204  RAPTOR; regulatory associated protein of mTOR
   04138 Autophagy - yeast
    K07204  RAPTOR; regulatory associated protein of mTOR
   04136 Autophagy - other
    K07204  RAPTOR; regulatory associated protein of mTOR
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07204  RAPTOR; regulatory associated protein of mTOR
  09149 Aging
   04211 Longevity regulating pathway
    K07204  RAPTOR; regulatory associated protein of mTOR
   04213 Longevity regulating pathway - multiple species
    K07204  RAPTOR; regulatory associated protein of mTOR
  09159 Environmental adaptation
   04714 Thermogenesis
    K07204  RAPTOR; regulatory associated protein of mTOR
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K07204  RAPTOR; regulatory associated protein of mTOR
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K07204  RAPTOR; regulatory associated protein of mTOR
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07204  RAPTOR; regulatory associated protein of mTOR
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    K07204  RAPTOR; regulatory associated protein of mTOR
Other DBs
COG: COG2319
Genes
HSA: 57521(RPTOR)
PTR: 454949(RPTOR)
PPS: 100976440(RPTOR)
GGO: 101137206(RPTOR)
PON: 100434731(RPTOR)
NLE: 100587259(RPTOR)
MCC: 712848(RPTOR)
MCF: 102116460(RPTOR)
CSAB: 103243701(RPTOR)
RRO: 104654941(RPTOR)
RBB: 108534267(RPTOR)
CJC: 100413313(RPTOR)
SBQ: 101039601(RPTOR)
MMU: 74370(Rptor)
MCAL: 110304213(Rptor)
MPAH: 110331504(Rptor)
RNO: 287871(Rptor)
MUN: 110550003(Rptor)
CGE: 100761529(Rptor)
NGI: 103730533(Rptor)
HGL: 101724257(Rptor)
CCAN: 109689889(Rptor)
OCU: 103346553
TUP: 102470795(RPTOR)
CFA: 608378(RPTOR)
VVP: 112920880(RPTOR)
AML: 100478081(RPTOR)
UMR: 103665983(RPTOR)
UAH: 113244532(RPTOR)
ORO: 101384799(RPTOR)
ELK: 111160429
FCA: 101086862(RPTOR)
PTG: 102958566(RPTOR)
PPAD: 109276800(RPTOR)
AJU: 106981870(RPTOR)
BTA: 507056(RPTOR)
BOM: 102285390(RPTOR)
BIU: 109573755(RPTOR)
BBUB: 102412399(RPTOR)
CHX: 102173122(RPTOR)
OAS: 101119321(RPTOR)
SSC: 100512677(RPTOR)
CFR: 102512403(RPTOR)
CDK: 105106263(RPTOR)
BACU: 103001225(RPTOR)
LVE: 103088660(RPTOR)
OOR: 101290397(RPTOR)
DLE: 111182724(RPTOR)
PCAD: 102990076(RPTOR)
ECB: 100056244(RPTOR)
EPZ: 103547320(RPTOR)
EAI: 106845645(RPTOR)
MYB: 102240594(RPTOR)
MYD: 102754661(RPTOR)
MNA: 107532063(RPTOR)
HAI: 109393012(RPTOR)
DRO: 112298706(RPTOR)
PALE: 102885334(RPTOR)
RAY: 107510093(RPTOR)
MJV: 108398121(RPTOR)
LAV: 100657753
TMU: 101343081
MDO: 100026103(RPTOR)
SHR: 100930970(RPTOR)
PCW: 110218186(RPTOR)
GGA: 428674(RPTOR)
MGP: 100549898(RPTOR)
CJO: 107322223(RPTOR)
NMEL: 110407207(RPTOR)
ACYG: 106046774(RPTOR)
TGU: 100225993(RPTOR)
LSR: 110472422(RPTOR)
SCAN: 103819746(RPTOR)
GFR: 102035893(RPTOR)
FAB: 101813847(RPTOR)
PHI: 102110286(RPTOR)
PMAJ: 107212280(RPTOR)
CCAE: 111937466(RPTOR)
CCW: 104698217(RPTOR)
ETL: 114068210(RPTOR)
FPG: 101914030(RPTOR)
FCH: 102056258(RPTOR)
CLV: 102083854(RPTOR)
EGZ: 104130570(RPTOR)
NNI: 104014273(RPTOR)
ACUN: 113486697(RPTOR)
PADL: 103917403(RPTOR)
AAM: 106485995(RPTOR)
ASN: 102388292(RPTOR)
AMJ: 102566392(RPTOR)
PSS: 102450550(RPTOR)
CMY: 102940371(RPTOR)
CPIC: 101943607(RPTOR)
ACS: 100560434(rptor)
PVT: 110090060(RPTOR)
PBI: 103048711(RPTOR)
PMUR: 107286684(RPTOR)
TSR: 106545772
PMUA: 114588922(RPTOR)
GJA: 107108212(RPTOR)
XLA: 108700989
XTR: 100170605(rptor)
NPR: 108795291(RPTOR)
DRE: 560455(rptor)
SRX: 107710275(rptor) 107728013
SANH: 107669526 107701211(rptor)
SGH: 107553319 107591918(rptor)
CCAR: 109080016
IPU: 108272627(rptor)
PHYP: 113523684(rptor)
AMEX: 103025211(rptor)
EEE: 113578854(rptor)
TRU: 115253237(rptor)
LCO: 104921544(rptor)
MZE: 101472178(rptor)
ONL: 100703173(rptor)
OLA: 101156464(rptor)
XMA: 102218020(rptor)
XCO: 114144230(rptor)
PRET: 103463551(rptor)
CVG: 107085497(rptor)
NFU: 107390202(rptor)
KMR: 108248226(rptor)
ALIM: 106526906
AOCE: 111567444(rptor)
CSEM: 103384286(rptor)
POV: 109627313(rptor)
LCF: 108884551(rptor)
SDU: 111217934(rptor)
SLAL: 111655458(rptor)
HCQ: 109527445(rptor)
BPEC: 110173825(rptor)
MALB: 109956793(rptor)
SALP: 111982470(rptor) 112080951
ELS: 105021612(rptor)
SFM: 108940088(rptor)
PKI: 111832912(rptor)
LCM: 102347131(RPTOR)
CMK: 103175567(rptor)
RTP: 109929749(rptor)
BFO: 118429076
CIN: 100176030
SPU: 586135
APLC: 110980200
SKO: 100329056(Rptor)
DME: Dmel_CG4320(raptor)
DER: 26526319
DSE: 116801997
DSI: Dsimw501_GD16213(Dsim_GD16213)
DAN: 26513892
DSR: 110182073
DPE: 113566507
DMN: 108158608
DWI: 26529589
DNV: 115562295
MDE: 109611603
LCQ: 111677467
AALB: 109622875
AME: 551668
BIM: 100747046
BTER: 100646513
CCAL: 108625095
OBB: 114875182
SOC: 105205268
AEC: 105143266
ACEP: 105622426
PBAR: 105427154
VEM: 105560656
HST: 105188175
DQU: 106743346
CFO: 105255545
LHU: 105671423
PGC: 109858433
OBO: 105279550
PCF: 106792114
NVI: 100121829
CSOL: 105362360
MDL: 103574178
TCA: 658299
DPA: 109544960
ATD: 109608878
NVL: 108567042
BMOR: 100463495(rptor)
BMAN: 114244624
PMAC: 106721370
PRAP: 111002364
HAW: 110381466
TNL: 113508095
PXY: 105383216
API: 100167375
DNX: 107168561
AGS: 114120868
RMD: 113550891
BTAB: 109037964
CLEC: 106673798
ZNE: 110832472
FCD: 110848463
PVM: 113809344
TUT: 107368329
DPTE: 113798080
CSCU: 111634668
PTEP: 107450389
CEL: CELE_C10C5.6(daf-15)
CBR: CBG21644(Cbr-daf-15)
BMY: Bm1_20705
PCAN: 112558153
CRG: 105317543
MYI: 110448552
OBI: 106869827
EGL: EGR_07620
NVE: 5520151
EPA: 110238896
ADF: 107355961
AMIL: 114957656
PDAM: 113667746
SPIS: 111325425
DGT: 114519261
HMG: 100213041
AQU: 100638632
ATH: AT3G08850(RAPTOR1) AT5G01770(RAPTOR2)
CRB: 17890879
CPAP: 110811611
CIT: 102614941
TCC: 18602269
VRA: 106759187
VAR: 108328977
VUN: 114183537
CAM: 101514864
LJA: Lj1g3v2442920.1(Lj1g3v2442920.1) Lj1g3v2442920.2(Lj1g3v2442920.2) Lj1g3v2442920.4(Lj1g3v2442920.4)
FVE: 101302666
RCN: 112192223
PPER: 18774912
PMUM: 103343577
PAVI: 110768387
ZJU: 107431283
CSV: 101210550
MCHA: 111013788
JCU: 105648064
VVI: 100261889
SPEN: 107031079
CANN: 107842546
INI: 109181636
OEU: 111407995
LSV: 111898220
CCAV: 112518569
BVG: 104898214
SOE: 110790221
DOSA: Os11t0109933-01(Os11g0109933) Os12t0110000-00(Os12g0110000)
OBR: 102700397
BDI: 100844309
ATS: 109780879(LOC109780879)
PEQ: 110035938
ATR: 18433549
MNG: MNEG_4146
APRO: F751_5412
SCE: YHR186C(KOG1)
KMX: KLMA_10476(KOG1)
NCS: NCAS_0F02050(NCAS0F02050)
NDI: NDAI_0C03540(NDAI0C03540)
TPF: TPHA_0L02130(TPHA0L02130)
TBL: TBLA_0B04680(TBLA0B04680)
TDL: TDEL_0G00730(TDEL0G00730)
KAF: KAFR_0B01580(KAFR0B01580)
PIC: PICST_74320(KOG1)
CAL: CAALFM_C105460WA(KOG1)
SLB: AWJ20_4695(KOG1)
NCR: NCU00621
NTE: NEUTE1DRAFT74339(NEUTE1DRAFT_74339)
MGR: MGG_02874
SSCK: SPSK_08295
MAW: MAC_00869
MAJ: MAA_07359
CMT: CCM_03247
BFU: BCIN_06g02850(Bckog1)
MBE: MBM_09848
ANI: AN4639.2
ANG: ANI_1_1874064(An07g06130)
ABE: ARB_03447
TVE: TRV_06101
PNO: SNOG_00356(SNOG_00357)
PTE: PTT_09949
SPO: SPAC57A7.11(mip1)
TASA: A1Q1_02297
ABP: AGABI1DRAFT67693(AGABI1DRAFT_67693)
ABV: AGABI2DRAFT147275(AGABI2DRAFT_147275)
MGL: MGL_3387
MRT: MRET_1849
DDI: DDB_G0270398(raptor)
DFA: DFA_05671(raptor)
EHI: EHI_040260(144.t00022)
NGD: NGA_0699600(RAPTOR)
 » show all
Reference
  Authors
Kim DH, Sarbassov DD, Ali SM, King JE, Latek RR, Erdjument-Bromage H, Tempst P, Sabatini DM
  Title
mTOR interacts with raptor to form a nutrient-sensitive complex that signals to the cell growth machinery.
  Journal
Cell 110:163-75 (2002)
DOI:10.1016/S0092-8674(02)00808-5
  Sequence
[hsa:57521]
Reference
  Authors
Hara K, Maruki Y, Long X, Yoshino K, Oshiro N, Hidayat S, Tokunaga C, Avruch J, Yonezawa K
  Title
Raptor, a binding partner of target of rapamycin (TOR), mediates TOR action.
  Journal
Cell 110:177-89 (2002)
DOI:10.1016/S0092-8674(02)00833-4
  Sequence
[hsa:57521]
LinkDB

KEGG   ORTHOLOGY: K16184
Entry
K16184                      KO                                     

Name
AKT1S1, PRAS40
Definition
proline-rich AKT1 substrate 1
Pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04714  Thermogenesis
ko05131  Shigellosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
   04150 mTOR signaling pathway
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
   04213 Longevity regulating pathway - multiple species
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
Membrane trafficking [BR:ko04131]
 Autophagy
  Other autophagy associated proteins
   mTORC1 complex
    K16184  AKT1S1, PRAS40; proline-rich AKT1 substrate 1
Genes
HSA: 84335(AKT1S1)
PTR: 456218(AKT1S1)
PPS: 100981524(AKT1S1)
GGO: 101151809(AKT1S1)
PON: 100449244(AKT1S1)
NLE: 100606336(AKT1S1)
MCC: 719101(AKT1S1)
MCF: 102139860(AKT1S1)
CSAB: 103235060(AKT1S1)
RRO: 104667216(AKT1S1)
RBB: 108535813(AKT1S1)
CJC: 100385926(AKT1S1)
SBQ: 101035426(AKT1S1)
MMU: 67605(Akt1s1)
MCAL: 110299208(Akt1s1)
MPAH: 110324411(Akt1s1)
RNO: 292887(Akt1s1)
CGE: 100768286(Akt1s1)
NGI: 103743684(Akt1s1)
HGL: 101712955(Akt1s1)
CCAN: 109683918(Akt1s1)
TUP: 102485528(AKT1S1)
CFA: 610130(AKT1S1)
VVP: 112931404(AKT1S1)
AML: 109489401(AKT1S1)
UMR: 103657265(AKT1S1)
UAH: 113243278(AKT1S1)
ORO: 101366130(AKT1S1)
ELK: 111160809
FCA: 101100932(AKT1S1)
PPAD: 109253038(AKT1S1)
AJU: 106983118(AKT1S1)
BTA: 514859(AKT1S1)
BOM: 102264796(AKT1S1)
BIU: 109572134(AKT1S1)
BBUB: 102395301(AKT1S1)
CHX: 102186333(AKT1S1)
OAS: 101109114(AKT1S1)
SSC: 100519715(AKT1S1)
CFR: 102515969(AKT1S1)
CDK: 105100186(AKT1S1)
BACU: 103005941(AKT1S1)
LVE: 103075856(AKT1S1)
OOR: 101289949(AKT1S1)
DLE: 111180592(AKT1S1)
PCAD: 102990917(AKT1S1)
ECB: 100052282(AKT1S1)
EPZ: 103558294(AKT1S1)
EAI: 106824154(AKT1S1)
MYB: 102243802(AKT1S1)
MYD: 102758931(AKT1S1)
MNA: 107531871(AKT1S1)
HAI: 109391032(AKT1S1)
DRO: 112310069(AKT1S1)
PALE: 102897877(AKT1S1)
RAY: 107498836(AKT1S1)
MJV: 108383352(AKT1S1)
LAV: 100671446(AKT1S1)
TMU: 101345300
MDO: 100030158(AKT1S1)
SHR: 100928550(AKT1S1)
PCW: 110219791(AKT1S1)
OAA: 114814792(AKT1S1)
ASN: 102367984(AKT1S1)
AMJ: 102558199(AKT1S1)
CPIC: 101938133(AKT1S1)
ACS: 100557925(akt1s1)
PVT: 110078574(AKT1S1)
PBI: 103049186(AKT1S1)
TSR: 106549271(AKT1S1) 106556088
PMUA: 114608013(AKT1S1)
GJA: 107116605(AKT1S1)
XLA: 431814(akt1s1.S) 495075(akt1s1.L)
XTR: 496515(akt1s1)
NPR: 108792627(AKT1S1)
DRE: 566559(akt1s1)
CCAR: 109109154
IPU: 108280807(akt1s1)
PHYP: 113528230(akt1s1)
AMEX: 111193360(akt1s1)
EEE: 113587138(akt1s1)
LCO: 104939070(akt1s1)
NCC: 104954396(akt1s1)
MZE: 101481934(akt1s1)
ONL: 100689736(akt1s1)
OLA: 101169289(akt1s1)
XMA: 102221079(akt1s1)
XCO: 114159983(akt1s1)
PRET: 103468981(akt1s1)
CVG: 107097127(akt1s1)
NFU: 107378483(akt1s1)
KMR: 108237767(akt1s1)
AOCE: 111572742(akt1s1)
CSEM: 103392853(akt1s1)
POV: 109634335(akt1s1)
LCF: 108880633(akt1s1)
SDU: 111217583(akt1s1)
SLAL: 111660518(akt1s1)
HCQ: 109527791(akt1s1)
BPEC: 110161314(akt1s1)
MALB: 109963177(akt1s1)
OTW: 112258995
ELS: 105012938(akt1s1)
SFM: 108941800(akt1s1)
PKI: 111836870(akt1s1)
LCM: 102354837(AKT1S1)
CMK: 103173667(akt1s1)
RTP: 109923030(akt1s1)
BFO: 118412296
CIN: 100176540
APLC: 110975487
SKO: 100379062
AME: 551512
BIM: 100746742
BTER: 100645428
CCAL: 108622323
OBB: 114874712
SOC: 105198761
ACEP: 105618850
PBAR: 105427247
HST: 105189811
DQU: 106747449
CFO: 105249652
LHU: 105673603
PGC: 109853289
NVI: 100217361(Lobe)
CSOL: 105365101
NVL: 108559757
BTAB: 109043844
CLEC: 106669992
TUT: 107362660
PTEP: 107444734
MYI: 110449090
OBI: 106873180
NVE: 5508361
EPA: 110245043
AMIL: 114958534
SPIS: 111326006
DGT: 114533702
HMG: 100206382
 » show all
Reference
  Authors
Sancak Y, Thoreen CC, Peterson TR, Lindquist RA, Kang SA, Spooner E, Carr SA, Sabatini DM
  Title
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase.
  Journal
Mol Cell 25:903-15 (2007)
DOI:10.1016/j.molcel.2007.03.003
Reference
  Authors
Kovacina KS, Park GY, Bae SS, Guzzetta AW, Schaefer E, Birnbaum MJ, Roth RA
  Title
Identification of a proline-rich Akt substrate as a 14-3-3 binding partner.
  Journal
J Biol Chem 278:10189-94 (2003)
DOI:10.1074/jbc.M210837200
  Sequence
[hsa:84335]
LinkDB

DBGET integrated database retrieval system