KEGG   ORTHOLOGY: K07206
Entry
K07206                      KO                                     

Name
TSC1
Definition
tuberous sclerosis 1
Pathway
ko04072  Phospholipase D signaling pathway
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04218  Cellular senescence
ko04714  Thermogenesis
ko04910  Insulin signaling pathway
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05168  Herpes simplex virus 1 infection
ko05231  Choline metabolism in cancer
Disease
H00896  Lymphangioleiomyomatosis
H00915  Tuberous sclerosis complex
H01251  Focal cortical dysplasia of Taylor
H01691  Renal angiomyolipoma
H01692  Subependymal giant cell astrocytoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04072 Phospholipase D signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04151 PI3K-Akt signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04152 AMPK signaling pathway
    K07206  TSC1; tuberous sclerosis 1
   04150 mTOR signaling pathway
    K07206  TSC1; tuberous sclerosis 1
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07206  TSC1; tuberous sclerosis 1
  09143 Cell growth and death
   04218 Cellular senescence
    K07206  TSC1; tuberous sclerosis 1
 09150 Organismal Systems
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07206  TSC1; tuberous sclerosis 1
  09149 Aging
   04211 Longevity regulating pathway
    K07206  TSC1; tuberous sclerosis 1
  09159 Environmental adaptation
   04714 Thermogenesis
    K07206  TSC1; tuberous sclerosis 1
 09160 Human Diseases
  09161 Cancer: overview
   05231 Choline metabolism in cancer
    K07206  TSC1; tuberous sclerosis 1
  09172 Infectious disease: viral
   05168 Herpes simplex virus 1 infection
    K07206  TSC1; tuberous sclerosis 1
   05163 Human cytomegalovirus infection
    K07206  TSC1; tuberous sclerosis 1
   05165 Human papillomavirus infection
    K07206  TSC1; tuberous sclerosis 1
Genes
HSA: 7248(TSC1)
PTR: 464818(TSC1)
PPS: 100975575(TSC1)
GGO: 101137273(TSC1)
PON: 100147742(TSC1)
NLE: 100587112(TSC1)
MCC: 714645(TSC1)
MCF: 102124229(TSC1)
CSAB: 103239711(TSC1)
RRO: 104669743(TSC1)
RBB: 108513580(TSC1)
CJC: 100407741(TSC1)
SBQ: 101028002(TSC1)
MMU: 64930(Tsc1)
MCAL: 110312162(Tsc1)  
MPAH: 110318637(Tsc1)
RNO: 60445(Tsc1)
MUN: 110550703(Tsc1)
CGE: 100767621(Tsc1)
NGI: 103742835(Tsc1)
HGL: 101708424(Tsc1)
CCAN: 109691000(Tsc1)
OCU: 100338695(TSC1)
TUP: 102483474(TSC1)
CFA: 480688(TSC1)
VVP: 112928006(TSC1)  
AML: 100471530(TSC1)
UMR: 103670250(TSC1)
UAH: 113266547(TSC1)
ORO: 101363167(TSC1)
ELK: 111145731
FCA: 101101514(TSC1)
PTG: 102953770(TSC1)  
PPAD: 109249982(TSC1)
AJU: 106985348(TSC1)
BTA: 533440(TSC1)
BOM: 102280709(TSC1)
BIU: 109566571(TSC1)
BBUB: 102401735(TSC1)
CHX: 102178739(TSC1)
OAS: 101119127(TSC1)
SSC: 100154726(TSC1)
CFR: 102504505(TSC1)
CDK: 105085191(TSC1)
BACU: 103010162(TSC1)
LVE: 103088278(TSC1)
OOR: 101275677(TSC1)
DLE: 111177090(TSC1)
PCAD: 102991442(TSC1)
ECB: 100066615(TSC1)
EPZ: 103553676(TSC1)
EAI: 106845368(TSC1)
MYB: 102245381(TSC1)
MYD: 102752713(TSC1)
MNA: 107524632(TSC1)
HAI: 109380979(TSC1)
DRO: 112306281(TSC1)
PALE: 102878835(TSC1)  
RAY: 107504576(TSC1)
MJV: 108386004(TSC1)
LAV: 100667008(TSC1)
TMU: 101347417
MDO: 100017591(TSC1)
SHR: 100918165(TSC1)
PCW: 110198888(TSC1)
OAA: 100080641(TSC1)
GGA: 417166(TSC1)
MGP: 100539473(TSC1)
CJO: 107321823(TSC1)
NMEL: 110406741(TSC1)  
APLA: 101798545(TSC1)
ACYG: 106044091(TSC1)
TGU: 100228268(TSC1)
LSR: 110477611(TSC1)
SCAN: 103818978(TSC1)
GFR: 102040493(TSC1)
FAB: 101806512(TSC1)
PHI: 102103020(TSC1)
PMAJ: 107212076(TSC1)
CCAE: 111937022(TSC1)
CCW: 104688322(TSC1)
ETL: 114073788(TSC1)
FPG: 101921096(TSC1)
FCH: 102050812(TSC1)
CLV: 102094746(TSC1)
EGZ: 104128282(TSC1)
NNI: 104023182(TSC1)
ACUN: 113486658(TSC1)
PADL: 103915274(TSC1)
AAM: 106483762(TSC1)
ASN: 102383470(TSC1)
AMJ: 102560300(TSC1)
PSS: 102453047(TSC1)
CMY: 102939516(TSC1)
CPIC: 101947761(TSC1)
ACS: 100560493(tsc1)
PVT: 110079595(TSC1)
PBI: 103052506(TSC1)
PMUR: 107296501(TSC1)
TSR: 106554224(TSC1)
PMUA: 114589564(TSC1)
GJA: 107112796(TSC1)
XLA: 108698219(tsc1.L) 108699932(tsc1.S)
XTR: 100380126(tsc1)
NPR: 108794671(TSC1)
DRE: 100330617(tsc1b) 337167(tsc1a)
AMEX: 103023802 103025705(tsc1)
EEE: 113573747(tsc1) 113577927
TRU: 101064275(tsc1) 101070860
LCO: 104923614(tsc1)
NCC: 104947658(tsc1)
OLA: 101174436 101175335(tsc1)
PRET: 103473966(tsc1)
ALIM: 106513555(tsc1) 106527806
AOCE: 111567968
POV: 109640306(tsc1) 109645786
SLAL: 111646396 111650122(tsc1)
HCQ: 109525278 109530634(tsc1)
SASA: 100380649(tsc1) 106565454 106587014(tsc1)
OTW: 112219359 112248911(tsc1)
ELS: 105024185(tsc1) 105027820
SFM: 108922678 108938614(tsc1)
LCM: 102358393(TSC1)
CMK: 103184683(tsc1)  
RTP: 109916041(tsc1)
BFO: 118420790
CIN: 100187265
SPU: 583100
APLC: 110976296
SKO: 100378717
DME: Dmel_CG6147(Tsc1)
DER: 6554977
DSE: 6607685
DSI: Dsimw501_GD21066(Dsim_GD21066)
DAN: 6498902
DSR: 110191130
DPE: 6587274
DMN: 108153938
DWI: 6647663
DAZ: 108612252
DNV: 108658894
DHE: 111596495
MDE: 101894607
LCQ: 111683384
AAG: 5580190
AALB: 109425317
AME: 724223
BIM: 100742364
BTER: 100647028
CCAL: 108633075
OBB: 114882646
SOC: 105200235
MPHA: 105832281
AEC: 105149474
ACEP: 105626702
PBAR: 105432913
VEM: 105558282
HST: 105188459
DQU: 106744506
CFO: 105253445
LHU: 105675360
PGC: 109853729
OBO: 105280381
PCF: 106789129
NVI: 100117824
CSOL: 105360272
MDL: 103577328
TCA: 662868
DPA: 109538899
ATD: 109601668
NVL: 108561625
BMAN: 114247029
PRAP: 111000914
API: 100164018
DNX: 107169785
AGS: 114132822
RMD: 113551645
BTAB: 109032568
ZNE: 110828006
FCD: 110849974
DPTE: 113790448
PTEP: 107448053
BMY: Bm1_31440
PCAN: 112575235
CRG: 105327465
MYI: 110458194
OBI: 106876567
LAK: 106177516
NVE: 5519398
EPA: 110245765
ADF: 107357403
AMIL: 114950473
PDAM: 113686705
SPIS: 111323659
DGT: 114530212
HMG: 100204754
AQU: 109586668
 » show all
Reference
PMID:9242607
  Authors
van Slegtenhorst M, de Hoogt R, Hermans C, Nellist M, Janssen B, Verhoef S, Lindhout D, van den Ouweland A, Halley D, Young J, Burley M, Jeremiah S, Woodward K, Nahmias J, Fox M, Ekong R, Osborne J, Wolfe J, Povey S, Snell RG, Cheadle JP, Jones AC, Tachataki M, Ravine D, Sampson JR, Reeve MP, Richardson P, Wilmer F, Munro C, Hawkins TL, Sepp T, Ali JB, Ward S, Green AJ, Yates JR, Kwiatkowska J, Henske EP, Short MP, Haines JH, Jozwiak S, Kwiatkowski DJ
  Title
Identification of the tuberous sclerosis gene TSC1 on chromosome 9q34.
  Journal
Science 277:805-8 (1997)
DOI:10.1126/science.277.5327.805
  Sequence
[hsa:7248]
Reference
  Authors
Tee AR, Fingar DC, Manning BD, Kwiatkowski DJ, Cantley LC, Blenis J
  Title
Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling.
  Journal
Proc Natl Acad Sci U S A 99:13571-6 (2002)
DOI:10.1073/pnas.202476899
  Sequence
[hsa:7248]
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