KEGG   ORTHOLOGY: K07209Help
Entry
K07209                      KO                                     

Name
IKBKB, IKKB
Definition
inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
Pathway
ko01523  Antifolate resistance
ko04010  MAPK signaling pathway
ko04014  Ras signaling pathway
ko04062  Chemokine signaling pathway
ko04064  NF-kappa B signaling pathway
ko04068  FoxO signaling pathway
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04380  Osteoclast differentiation
ko04620  Toll-like receptor signaling pathway
ko04621  NOD-like receptor signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko04623  Cytosolic DNA-sensing pathway
ko04624  Toll and Imd signaling pathway
ko04625  C-type lectin receptor signaling pathway
ko04657  IL-17 signaling pathway
ko04658  Th1 and Th2 cell differentiation
ko04659  Th17 cell differentiation
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04668  TNF signaling pathway
ko04722  Neurotrophin signaling pathway
ko04910  Insulin signaling pathway
ko04920  Adipocytokine signaling pathway
ko04930  Type II diabetes mellitus
ko04931  Insulin resistance
ko04932  Non-alcoholic fatty liver disease (NAFLD)
ko05120  Epithelial cell signaling in Helicobacter pylori infection
ko05130  Pathogenic Escherichia coli infection
ko05131  Shigellosis
ko05132  Salmonella infection
ko05135  Yersinia infection
ko05142  Chagas disease (American trypanosomiasis)
ko05145  Toxoplasmosis
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05162  Measles
ko05163  Human cytomegalovirus infection
ko05164  Influenza A
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05168  Herpes simplex virus 1 infection
ko05169  Epstein-Barr virus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05206  MicroRNAs in cancer
ko05212  Pancreatic cancer
ko05215  Prostate cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05222  Small cell lung cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
ko05418  Fluid shear stress and atherosclerosis
Disease
H00093  Combined immunodeficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04010 MAPK signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04064 NF-kappa B signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04668 TNF signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04068 FoxO signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04151 PI3K-Akt signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04150 mTOR signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09150 Organismal Systems
  09151 Immune system
   04620 Toll-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04624 Toll and Imd signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04621 NOD-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04622 RIG-I-like receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04623 Cytosolic DNA-sensing pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04625 C-type lectin receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04660 T cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04658 Th1 and Th2 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04659 Th17 cell differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04657 IL-17 signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04662 B cell receptor signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04062 Chemokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04920 Adipocytokine signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09156 Nervous system
   04722 Neurotrophin signaling pathway
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05206 MicroRNAs in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05221 Acute myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05220 Chronic myeloid leukemia
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05215 Prostate cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05222 Small cell lung cancer
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09166 Cardiovascular disease
   05418 Fluid shear stress and atherosclerosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09167 Endocrine and metabolic disease
   04930 Type II diabetes mellitus
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04932 Non-alcoholic fatty liver disease (NAFLD)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   04931 Insulin resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09171 Infectious disease: bacterial
   05120 Epithelial cell signaling in Helicobacter pylori infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05130 Pathogenic Escherichia coli infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05132 Salmonella infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05131 Shigellosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05135 Yersinia infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05170 Human immunodeficiency virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05162 Measles
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05164 Influenza A
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05161 Hepatitis B
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05160 Hepatitis C
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05168 Herpes simplex virus 1 infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05163 Human cytomegalovirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05169 Epstein-Barr virus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05165 Human papillomavirus infection
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09174 Infectious disease: parasitic
   05145 Toxoplasmosis
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
   05142 Chagas disease (American trypanosomiasis)
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
  09176 Drug resistance: antineoplastic
   01523 Antifolate resistance
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.10  IkappaB kinase
     K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  IKK family [OT]
   K07209  IKBKB, IKKB; inhibitor of nuclear factor kappa-B kinase subunit beta
BRITE hierarchy
Other DBs
GO: 0008384
Genes
HSA: 3551(IKBKB)
PTR: 472749(IKBKB)
PPS: 100989390(IKBKB)
GGO: 101141659(IKBKB)
PON: 100440586(IKBKB)
NLE: 100588081(IKBKB)
MCC: 704683(IKBKB)
MCF: 102146604(IKBKB)
CSAB: 103215686(IKBKB)
RRO: 104666046(IKBKB)
RBB: 108540719(IKBKB)
CJC: 100393096(IKBKB)
SBQ: 101052971(IKBKB)
MMU: 16150(Ikbkb)
MCAL: 110300158(Ikbkb)
MPAH: 110336182(Ikbkb)
RNO: 84351(Ikbkb)
MUN: 110556613(Ikbkb)
CGE: 100750488(Ikbkb)
NGI: 103726621(Ikbkb)
HGL: 101711077(Ikbkb)
CCAN: 109696400(Ikbkb)
OCU: 100356401(IKBKB)
TUP: 102467954(IKBKB)
CFA: 482839(IKBKB)
VVP: 112916156(IKBKB)
AML: 100471679(IKBKB)
UMR: 103677059(IKBKB)
UAH: 113245546(IKBKB)
ORO: 101375346(IKBKB)
ELK: 111144397
FCA: 100142682(IKBKB)
PTG: 102963734(IKBKB)
PPAD: 109262264(IKBKB)
AJU: 106990012(IKBKB)
BTA: 281854(IKBKB)
BOM: 102281443(IKBKB)
BIU: 109553353(IKBKB)
BBUB: 102398886(IKBKB)
CHX: 102177406(IKBKB)
OAS: 780484(IKBKB)
SSC: 100101471(IKBKB)
CFR: 102508142(IKBKB)
CDK: 105086448(IKBKB)
BACU: 103015119(IKBKB)
LVE: 103088633(IKBKB)
OOR: 101285763(IKBKB)
DLE: 111173552(IKBKB)
PCAD: 102976706(IKBKB)
ECB: 100050167(IKBKB)
EPZ: 103562903(IKBKB)
EAI: 106828957(IKBKB)
MYB: 102261405(IKBKB)
MYD: 102773824(IKBKB)
MNA: 107523913(IKBKB)
HAI: 109386279(IKBKB)
DRO: 112321547(IKBKB)
PALE: 102893261(IKBKB)
RAY: 107501353(IKBKB)
MJV: 108399795(IKBKB)
LAV: 100657363(IKBKB)
TMU: 101351256
MDO: 100033031(IKBKB)
SHR: 100928932(IKBKB)
PCW: 110196387(IKBKB)
OAA: 100078925(IKBKB)
GGA: 426792(IKBKB)
MGP: 100542558(IKBKB)
CJO: 107323740(IKBKB)
NMEL: 110387184(IKBKB)
APLA: 101790255(IKBKB)
ACYG: 106044397(IKBKB)
TGU: 100225072(IKBKB)
LSR: 110473406(IKBKB)
SCAN: 103822735(IKBKB)
GFR: 102035648(IKBKB)
FAB: 101809821(IKBKB)
PHI: 102100562(IKBKB)
PMAJ: 107213912(IKBKB)
CCAE: 111938770(IKBKB)
CCW: 104694916(IKBKB)
ETL: 114066442(IKBKB)
FPG: 101922064(IKBKB)
FCH: 102058892(IKBKB)
CLV: 102087238(IKBKB)
EGZ: 104135306(IKBKB)
NNI: 104016028(IKBKB)
ACUN: 113488090(IKBKB)
PADL: 103920554(IKBKB)
AAM: 106487776(IKBKB)
ASN: 102377560(IKBKB)
AMJ: 102561936(IKBKB)
PSS: 102454676(IKBKB)
CMY: 102932073(IKBKB)
CPIC: 101945515(IKBKB)
ACS: 100551699(ikbkb)
PVT: 110072148(IKBKB)
PBI: 103052688(IKBKB)
PMUR: 107287960(IKBKB)
TSR: 106550867
PMUA: 114602842(IKBKB)
GJA: 107107812(IKBKB)
XLA: 432200(ikbkb.L)
XTR: 448125(ikbkb)
NPR: 108791446(IKBKB)
DRE: 563560(ikbkb)
SANH: 107671012
SGH: 107559596(ikbkb)
CCAR: 109095150(ikbkb)
IPU: 108265675(ikbkb)
PHYP: 113533569(ikbkb)
AMEX: 103040024(ikbkb)
EEE: 113584916(ikbkb)
TRU: 101062431(ikbkb)
LCO: 104921662(ikbkb)
NCC: 104956687(ikbkb)
MZE: 101472803(ikbkb)
ONL: 100698072(ikbkb)
OLA: 101170684(ikbkb)
XMA: 102223773(ikbkb)
XCO: 114154613(ikbkb)
PRET: 103470025(ikbkb)
CVG: 107089660(ikbkb)
NFU: 107394259(ikbkb)
KMR: 108233707(ikbkb)
ALIM: 106536414(ikbkb)
AOCE: 111577292(ikbkb)
CSEM: 103397763(ikbkb)
POV: 109637101(ikbkb)
LCF: 108881598(ikbkb)
SDU: 111236497(ikbkb)
SLAL: 111665990(ikbkb)
HCQ: 109525796
BPEC: 110155462(ikbkb)
MALB: 109956664(ikbkb)
SASA: 106580426(ikbkb)
OTW: 112263933
SALP: 111958214
ELS: 105014298(ikbkb)
SFM: 108920198(ikbkb)
PKI: 111854363(ikbkb)
LCM: 102358966(IKBKB)
RTP: 109927975(ikbkb)
CIN: 778921
DME: Dmel_CG4201(IKKbeta)
DER: 6553147
DSI: Dsimw501_GD20310(Dsim_ird5)
DYA: Dyak_GE26340(Dyak_ird5)
DSR: 110191738
DPE: 6594219
DMN: 108156166
DWI: 26529178
DAZ: 108621533
DNV: 108659762
DHE: 111604649
MDE: 101888056
AGA: AgaP_AGAP009166(IKK1)
AAG: 5577620
AME: 726760
BIM: 100744732
BTER: 100642917
CCAL: 108632449
OBB: 114871896
SOC: 105197895
MPHA: 105831917
AEC: 105147535
ACEP: 105623150
VEM: 105563455
HST: 105186757
DQU: 106748819
CFO: 105251219
LHU: 105679052
PGC: 109861528
OBO: 105277074
NVI: 100116284
MDL: 103578013
TCA: 655324 658393(ikkb)
DPA: 109540103
NVL: 108569535
BMOR: 101747125
BMAN: 114244430
PMAC: 106711966
PRAP: 111001847
HAW: 110372140
TNL: 113503695
PXY: 105396222
CLEC: 106666374
DPTE: 113792695
CSCU: 111632902
PTEP: 107440477
OBI: 106868427
AMIL: 114963622
SPIS: 111319765
DGT: 114531073
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Hu MC, Lee DF, Xia W, Golfman LS, Ou-Yang F, Yang JY, Zou Y, Bao S, Hanada N, Saso H, Kobayashi R, Hung MC
  Title
IkappaB kinase promotes tumorigenesis through inhibition of forkhead FOXO3a.
  Journal
Cell 117:225-37 (2004)
DOI:10.1016/S0092-8674(04)00302-2
Reference
PMID:9346485
  Authors
Woronicz JD, Gao X, Cao Z, Rothe M, Goeddel DV
  Title
IkappaB kinase-beta: NF-kappaB activation and complex formation with IkappaB kinase-alpha and NIK.
  Journal
Science 278:866-9 (1997)
DOI:10.1126/science.278.5339.866
  Sequence
[hsa:3551]
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