KEGG   ORTHOLOGY: K07365
Entry
K07365                      KO                                     

Name
NCK1
Definition
NCK adaptor protein 1
Pathway
ko04012  ErbB signaling pathway
ko04360  Axon guidance
ko04660  T cell receptor signaling pathway
ko05130  Pathogenic Escherichia coli infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K07365  NCK1; NCK adaptor protein 1
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K07365  NCK1; NCK adaptor protein 1
  09158 Development and regeneration
   04360 Axon guidance
    K07365  NCK1; NCK adaptor protein 1
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K07365  NCK1; NCK adaptor protein 1
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K07365  NCK1; NCK adaptor protein 1
Domain-containing proteins not elsewhere classified [BR:ko04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   K07365  NCK1; NCK adaptor protein 1
Other DBs
GO: 0005070
Genes
HSA: 4690(NCK1)
PTR: 460720(NCK1)
PPS: 100977379(NCK1)
GGO: 101140243(NCK1)
PON: 100171550(NCK1)
NLE: 100603655(NCK1)
MCC: 716807(NCK1)
MCF: 102120560(NCK1)
CSAB: 103241620(NCK1)
RRO: 104663559(NCK1)
RBB: 108531425(NCK1)
CJC: 100395287(NCK1)
SBQ: 101048338(NCK1) 101051752
MMU: 17973(Nck1)
MCAL: 110301899(Nck1)
MPAH: 110327568(Nck1)
RNO: 300955(Nck1)
MUN: 110555024(Nck1)
CGE: 100769675(Nck1)
NGI: 103740969(Nck1)
HGL: 101702437(Nck1)
CCAN: 109700191(Nck1)
OCU: 100358703(NCK1)
TUP: 102496748(NCK1)
CFA: 485677(NCK1)
VVP: 112932505(NCK1)
AML: 100471786(NCK1)
UMR: 103678792(NCK1)
UAH: 113253973(NCK1)
ORO: 101362290(NCK1)
ELK: 111155007
FCA: 101094695(NCK1)
PTG: 102966572(NCK1)
PPAD: 109259671(NCK1)
AJU: 106976791(NCK1)
BTA: 536154(NCK1)
BOM: 102279803(NCK1)
BIU: 109560012(NCK1)
BBUB: 102414972(NCK1)
CHX: 102189995(NCK1)
OAS: 100307045(NCK1)
SSC: 100192438(NCK1)
CFR: 102516504(NCK1)
CDK: 105085277(NCK1)
BACU: 103020651(NCK1)
LVE: 103084883(NCK1)
OOR: 101277943(NCK1)
DLE: 111179217(NCK1)
PCAD: 102981258(NCK1)
ECB: 100053397(NCK1)
EPZ: 103540015(NCK1)
EAI: 106838086(NCK1)
MYB: 102239473(NCK1)
MYD: 102755172(NCK1)
MNA: 107546111(NCK1)
HAI: 109389242(NCK1)
DRO: 112309536(NCK1)
PALE: 102882952(NCK1)
RAY: 107513946(NCK1)
MJV: 108393776(NCK1)
LAV: 100666870(NCK1)
TMU: 101355115
MDO: 100016740(NCK1)
SHR: 100925251(NCK1)
PCW: 110208205(NCK1)
OAA: 100079992(NCK1)
XLA: 399308(nck1.L) 779200(nck1.S)
XTR: 493463(nck1)
NPR: 108799848(NCK1)
DRE: 100334953(nck1b) 564584(nck1a)
IPU: 108272450(nck1)
PHYP: 113545402(nck1)
AMEX: 103027024(nck1)
EEE: 113584767
TRU: 101065074(nck1)
LCO: 104937188
MZE: 101479403(nck1)
ONL: 100702155(nck1)
OLA: 101169073(nck1)
XMA: 102232959(nck1)
XCO: 114136577(nck1)
PRET: 103456551(nck1)
CVG: 107096481(nck1)
NFU: 107382806(nck1)
KMR: 108230442(nck1)
ALIM: 106513369(nck1)
AOCE: 111579235(nck1)
CSEM: 103377266(nck1)
POV: 109629668(nck1)
LCF: 108881691(nck1)
SDU: 111220938(nck1)
SLAL: 111656230(nck1)
HCQ: 109519481(nck1)
BPEC: 110170092(nck1)
MALB: 109961474(nck1)
OTW: 112238631
ELS: 105026593(nck1)
SFM: 108927539 108935223(nck1)
PKI: 111840703 111850477(nck1)
LCM: 102363552(NCK1)
CMK: 103174820(nck1)
RTP: 109917774(nck1)
 » show all
Reference
  Authors
Lettau M, Pieper J, Gerneth A, Lengl-Janssen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, Janssen O
  Title
The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.
  Journal
Protein Sci 19:658-69 (2010)
DOI:10.1002/pro.334
Reference
  Authors
Latreille M, Larose L
  Title
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
  Journal
J Biol Chem 281:26633-44 (2006)
DOI:10.1074/jbc.M513556200
  Sequence
[hsa:4690]
LinkDB

KEGG   ORTHOLOGY: K19862
Entry
K19862                      KO                                     

Name
NCK2, GRB4
Definition
NCK adaptor protein 2
Pathway
ko04012  ErbB signaling pathway
ko04360  Axon guidance
ko04361  Axon regeneration
ko04660  T cell receptor signaling pathway
ko05130  Pathogenic Escherichia coli infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04012 ErbB signaling pathway
    K19862  NCK2, GRB4; NCK adaptor protein 2
 09150 Organismal Systems
  09151 Immune system
   04660 T cell receptor signaling pathway
    K19862  NCK2, GRB4; NCK adaptor protein 2
  09158 Development and regeneration
   04360 Axon guidance
    K19862  NCK2, GRB4; NCK adaptor protein 2
   04361 Axon regeneration
    K19862  NCK2, GRB4; NCK adaptor protein 2
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K19862  NCK2, GRB4; NCK adaptor protein 2
 09180 Brite Hierarchies
  09183 Protein families: signaling and cellular processes
   04990 Domain-containing proteins not elsewhere classified
    K19862  NCK2, GRB4; NCK adaptor protein 2
Domain-containing proteins not elsewhere classified [BR:ko04990]
 Src homology (SH) domain-containing proteins
  Signal transducing adaptor proteins
   K19862  NCK2, GRB4; NCK adaptor protein 2
Other DBs
GO: 0005070
Genes
HSA: 8440(NCK2)
PTR: 459472(NCK2)
PPS: 100994701(NCK2)
GGO: 101150520(NCK2)
PON: 100452789(NCK2)
NLE: 100607084(NCK2)
MCC: 713287(NCK2)
MCF: 102135959(NCK2)
CSAB: 103241188(NCK2)
RRO: 104660581(NCK2)
RBB: 108512467(NCK2)
CJC: 100401429(NCK2)
SBQ: 101049638(NCK2)
MMU: 17974(Nck2)
MCAL: 110293782(Nck2)
MPAH: 110321651(Nck2)
RNO: 316369(Nck2)
MUN: 110559035(Nck2)
CGE: 100762895(Nck2)
NGI: 103726627(Nck2)
HGL: 101720865(Nck2)
CCAN: 109683294(Nck2)
OCU: 100353755(NCK2)
TUP: 102497440(NCK2)
CFA: 481319(NCK2)
VVP: 112915128(NCK2)
AML: 100475197(NCK2)
UMR: 103670625(NCK2)
UAH: 113267660(NCK2)
ORO: 101375416(NCK2)
ELK: 111155877
FCA: 101099871(NCK2)
PTG: 102953673(NCK2)
PPAD: 109254532(NCK2)
AJU: 106977958(NCK2)
BTA: 526430(NCK2)
BOM: 102279804(NCK2)
BIU: 109566126(NCK2)
BBUB: 102409945(NCK2)
CHX: 102180601(NCK2)
OAS: 101114255(NCK2)
SSC: 100192439(NCK2)
CFR: 102509285(NCK2)
CDK: 105099095(NCK2)
BACU: 103015169(NCK2)
LVE: 103074996(NCK2)
OOR: 101274780(NCK2)
DLE: 111187536(NCK2)
PCAD: 102977998(NCK2)
ECB: 100049884(NCK2)
EPZ: 103562116(NCK2)
EAI: 106832694(NCK2)
MYB: 102255056(NCK2)
MYD: 102772855(NCK2)
MNA: 107526881(NCK2)
HAI: 109374107(NCK2)
DRO: 112315145(NCK2)
PALE: 102887531(NCK2)
RAY: 107509617(NCK2)
MJV: 108402802(NCK2)
LAV: 100660400(NCK2)
TMU: 101356005
MDO: 100014693(NCK2)
SHR: 100931923(NCK2)
PCW: 110209420(NCK2)
OAA: 100077602(NCK2)
GGA: 418727(NCK2)
MGP: 100544012(NCK2)
CJO: 107306567(NCK2)
NMEL: 110406945(NCK2)
APLA: 101802828(NCK2)
ACYG: 106041651(NCK2)
TGU: 100222831(NCK2)
LSR: 110474599(NCK2)
SCAN: 103812376(NCK2)
GFR: 102038661(NCK2)
FAB: 101811171(NCK2)
PHI: 102108428(NCK2)
PMAJ: 107207170(NCK2)
CCAE: 111922680(NCK2)
CCW: 104686084(NCK2)
ETL: 114066596(NCK2)
FPG: 101914660(NCK2)
FCH: 102056394(NCK2)
CLV: 102087879(NCK2)
EGZ: 104126366(NCK2)
NNI: 104019351(NCK2)
ACUN: 113483788(NCK2)
PADL: 103918839(NCK2)
AAM: 106494037(NCK2)
ASN: 102370411(NCK2)
AMJ: 102566343(NCK2)
PSS: 102454769(NCK2)
CMY: 102947414
CPIC: 101931052(NCK2)
ACS: 100557091(nck2)
PVT: 110074140(NCK2)
PBI: 103048957(NCK2)
PMUR: 107288838(NCK2)
TSR: 106547107(NCK2)
PMUA: 114596419(NCK2)
GJA: 107125087(NCK2)
XLA: 108709700(nck2.S) 398861(nck2.L)
XTR: 493349(nck2)
NPR: 108785115(NCK2)
DRE: 393972(nck2a) 445098(nck2b)
IPU: 108266513(nck2) 108273233
PHYP: 113526141(nck2) 113538147
AMEX: 103023033(nck2) 103038818
TRU: 101074912(nck2)
LCO: 104932099
NCC: 104956509
MZE: 101465176(nck2)
ONL: 100704988(nck2)
OLA: 101174471(nck2)
XMA: 102221197(nck2)
XCO: 114148531(nck2)
PRET: 103480013(nck2)
CVG: 107096904(nck2)
NFU: 107389799(nck2)
KMR: 108232338(nck2)
ALIM: 106519829(nck2)
AOCE: 111572180(nck2)
CSEM: 103391712(nck2)
POV: 109637996(nck2)
SDU: 111218770(nck2)
SLAL: 111654366(nck2)
HCQ: 109530583(nck2)
BPEC: 110173156(nck2)
MALB: 109965359(nck2)
ELS: 105016578(nck2) 105022090
LCM: 102359773(NCK2)
CMK: 103172274(nck2)
RTP: 109936440(nck2)
BFO: 118427244
CIN: 100175158
SPU: 578833
APLC: 110983577
SKO: 100373180
DME: Dmel_CG3727(dock)
DER: 6542349
DSE: 6617305
DSI: Dsimw501_GD23050(Dsim_GD23050)
DAN: 6497891
DSR: 110177024
DPE: 6589520
DMN: 108162101
DWI: 6643917
DAZ: 108610589
DNV: 108658357
DHE: 111599069
DVI: 6628724
MDE: 101891988
LCQ: 111685382
AAG: 5578157
AME: 551892
BIM: 100742497
BTER: 100644764
CCAL: 108631613
OBB: 114883222
SOC: 105202299
MPHA: 105831384
AEC: 105152808
ACEP: 105625086
PBAR: 105427789
VEM: 105567000
HST: 105182194
DQU: 106747767
CFO: 105256967
LHU: 105667937
PGC: 109861548
OBO: 105284559
PCF: 106793108
NVI: 100119748
CSOL: 105359930
MDL: 103571431
TCA: 658201
NVL: 108567995
BMOR: 101739261
BMAN: 114247100
PMAC: 106719249
PRAP: 110999976
HAW: 110381585
TNL: 113493064
PXY: 105384796
API: 100161543
DNX: 107161514
RMD: 113556007
BTAB: 109031734
CLEC: 106668760
ZNE: 110837752
FCD: 110844078
PVM: 113803558
TUT: 107363123
DPTE: 113795105
CEL: CELE_ZK470.5(nck-1)
CBR: CBG14353(Cbr-nck-1)
TSP: Tsp_06779
PCAN: 112555927
CRG: 105341452
MYI: 110465906
OBI: 106874504
LAK: 106180240
SHX: MS3_00363
EGL: EGR_00334
NVE: 116619864
EPA: 110232077
ADF: 107351112
AMIL: 114977558
PDAM: 113680711
SPIS: 111339101
DGT: 114531977
AQU: 100641856
 » show all
Reference
  Authors
Braverman LE, Quilliam LA
  Title
Identification of Grb4/Nckbeta, a src homology 2 and 3 domain-containing adapter protein having similar binding and biological properties to Nck.
  Journal
J Biol Chem 274:5542-9 (1999)
DOI:10.1074/jbc.274.9.5542
  Sequence
[hsa:8440]
Reference
  Authors
Latreille M, Larose L
  Title
Nck in a complex containing the catalytic subunit of protein phosphatase 1 regulates eukaryotic initiation factor 2alpha signaling and cell survival to endoplasmic reticulum stress.
  Journal
J Biol Chem 281:26633-44 (2006)
DOI:10.1074/jbc.M513556200
  Sequence
[hsa:8440]
Reference
  Authors
Lettau M, Pieper J, Gerneth A, Lengl-Janssen B, Voss M, Linkermann A, Schmidt H, Gelhaus C, Leippe M, Kabelitz D, Janssen O
  Title
The adapter protein Nck: role of individual SH3 and SH2 binding modules for protein interactions in T lymphocytes.
  Journal
Protein Sci 19:658-69 (2010)
DOI:10.1002/pro.334
LinkDB

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