KEGG   ORTHOLOGY: K07376
Entry
K07376                      KO                                     

Name
PRKG1
Definition
cGMP-dependent protein kinase 1 [EC:2.7.11.12]
Pathway
map04022  cGMP-PKG signaling pathway
map04270  Vascular smooth muscle contraction
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04730  Long-term depression
map04740  Olfactory transduction
map04923  Regulation of lipolysis in adipocytes
map04970  Salivary secretion
Disease
H00801  Familial thoracic aortic aneurysm and dissection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K07376  PRKG1; cGMP-dependent protein kinase 1
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K07376  PRKG1; cGMP-dependent protein kinase 1
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07376  PRKG1; cGMP-dependent protein kinase 1
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K07376  PRKG1; cGMP-dependent protein kinase 1
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K07376  PRKG1; cGMP-dependent protein kinase 1
  09154 Digestive system
   04970 Salivary secretion
    K07376  PRKG1; cGMP-dependent protein kinase 1
  09156 Nervous system
   04730 Long-term depression
    K07376  PRKG1; cGMP-dependent protein kinase 1
  09157 Sensory system
   04740 Olfactory transduction
    K07376  PRKG1; cGMP-dependent protein kinase 1
  09159 Environmental adaptation
   04713 Circadian entrainment
    K07376  PRKG1; cGMP-dependent protein kinase 1
   04714 Thermogenesis
    K07376  PRKG1; cGMP-dependent protein kinase 1
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K07376  PRKG1; cGMP-dependent protein kinase 1
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.12  cGMP-dependent protein kinase
     K07376  PRKG1; cGMP-dependent protein kinase 1
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  PKG family
   K07376  PRKG1; cGMP-dependent protein kinase 1
Other DBs
GO: 0004692
Genes
HSA: 5592(PRKG1)
PTR: 744467(PRKG1)
PPS: 100975252(PRKG1)
PON: 100437791(PRKG1)
NLE: 100597697(PRKG1)
MCC: 703356(PRKG1)
MCF: 102122483(PRKG1)
CSAB: 103216192(PRKG1)
CATY: 105587190(PRKG1)
RRO: 104676729(PRKG1)
TFN: 117085919(PRKG1)
PTEH: 111551296(PRKG1) 113220965
CJC: 100388016(PRKG1)
SBQ: 101043597(PRKG1)
MMUR: 105870362(PRKG1)
MMU: 19091(Prkg1)
MCAL: 110285294(Prkg1)
MPAH: 110313055(Prkg1)
RNO: 54286(Prkg1)
MCOC: 116103727(Prkg1)
CGE: 100768615(Prkg1)
PLEU: 114710735(Prkg1)
NGI: 103732508(Prkg1)
HGL: 101708361(Prkg1)
OCU: 100008694(PRKG1)
CFA: 609616(PRKG1)
VVP: 112931969(PRKG1)
VLG: 121475369(PRKG1)
AML: 100481505(PRKG1)
UMR: 103661993(PRKG1)
UAH: 113258870(PRKG1)
ELK: 111145213
MPUF: 101687177(PRKG1)
EJU: 114210308(PRKG1)
MLX: 118012977(PRKG1)
FCA: 101097420(PRKG1)
PTG: 102969150(PRKG1)
PPAD: 109255410(PRKG1)
AJU: 106969513(PRKG1)
HHV: 120235955(PRKG1)
BTA: 282004(PRKG1)
BOM: 102279305(PRKG1)
BBUB: 102407722(PRKG1)
CHX: 102182753(PRKG1)
OAS: 443010(PRKG1)
ODA: 120873771(PRKG1)
SSC: 733640(PRKG1)
CFR: 102509252(PRKG1)
CDK: 105085256(PRKG1)
BACU: 103012801(PRKG1)
LVE: 103071917(PRKG1)
OOR: 101279276(PRKG1)
DLE: 111172539(PRKG1)
PCAD: 102991499(PRKG1)
ECB: 100071872(PRKG1)
EAI: 106847454(PRKG1)
MYB: 102255009(PRKG1)
MMYO: 118670010(PRKG1)
MNA: 107543282(PRKG1)
HAI: 109387521(PRKG1)
DRO: 112307314(PRKG1)
SHON: 119001529(PRKG1)
AJM: 119057172
MMF: 118632751(PRKG1)
PALE: 102884723(PRKG1)
RAY: 107515478(PRKG1)
LAV: 100662471(PRKG1)
MDO: 100023016(PRKG1)
SHR: 100928746(PRKG1)
PCW: 110199927(PRKG1)
OAA: 100073431(PRKG1)
GGA: 423682(PRKG1)
PCOC: 116234759(PRKG1)
MGP: 100540173(PRKG1)
CJO: 107315639(PRKG1)
NMEL: 110390491(PRKG1)
APLA: 101802614(PRKG1)
ACYG: 106030263(PRKG1)
TGU: 100229896(PRKG1)
LSR: 110474019(PRKG1)
SCAN: 103823826(PRKG1)
PMOA: 120507265(PRKG1)
GFR: 102041315(PRKG1)
FAB: 101816835(PRKG1)
PHI: 102105641(PRKG1)
PMAJ: 107207071(PRKG1)
CCW: 104695105(PRKG1)
ETL: 114065114(PRKG1)
FPG: 101914750(PRKG1)
FCH: 102051167(PRKG1)
CLV: 102098659(PRKG1)
EGZ: 104125151(PRKG1)
NNI: 104013515(PRKG1)
ACUN: 113481922(PRKG1)
ASN: 102385836(PRKG1)
AMJ: 102573015(PRKG1)
CPOO: 109312524(PRKG1)
GGN: 109290935(PRKG1)
CMY: 102942713(PRKG1)
CPIC: 101953224(PRKG1)
TST: 117879767(PRKG1)
PGUT: 117670643(PRKG1)
PMUA: 114597269(PRKG1)
ZVI: 118096161(PRKG1)
XLA: 108696071 108697357(prkg1.S)
XTR: 100494278(prkg1)
NPR: 108797031(PRKG1)
DRE: 394005(prkg1a) 566430(prkg1b)
SRX: 107708873
SGH: 107557353(prkg1)
IPU: 108274270(prkg1)
PHYP: 113527432
AMEX: 103047830(prkg1)
EEE: 113577006(prkg1)
TRU: 101061256(prkg1)
LCO: 104927466
NCC: 104955830
ELY: 117247991
PLEP: 121954489 121959293(prkg1b)
SLUC: 116055147
ECRA: 117960504
MSAM: 119917222
MZE: 101466538
ONL: 100694992
OAU: 116333752
OLA: 100049290(prkg1)
OML: 112161974(prkg1b) 112163367
XMA: 102235247
XCO: 114138474
XHE: 116713518
PRET: 103476798
CVG: 107098368
NFU: 107376029
KMR: 108242381
ALIM: 106513507(prkg1) 106528217
AOCE: 111575530(prkg1)
CSEM: 103387682(prkg1)
POV: 109632737
LCF: 108897326
SDU: 111235208
SLAL: 111670023(prkg1)
XGL: 120796378
HCQ: 109528789
BPEC: 110157105
MALB: 109962157(prkg1)
SFM: 108932765 108939676(prkg1)
PKI: 111853690(prkg1)
LOC: 102684201(prkg1) 102689239
LCM: 102357627
CMK: 103180883(prkg1)
RTP: 109927508
CIN: 100184124
SPU: 589462
DME: Dmel_CG10033(for) Dmel_CG3324(Pkg21D) Dmel_CG4839(CG4839)
DSI: Dsimw501_GD22740(Dsim_GD22740) Dsimw501_GD22942(Dsim_GD22942) Dsimw501_GD23660(Dsim_GD23660)
AME: 406092(For) 551714
BIM: 100744786
BTER: 100628631
CCAL: 108631693
OBB: 114878681
MGEN: 117221657
NMEA: 116428630
SOC: 105202008
MPHA: 105835361
AEC: 105148710
ACEP: 105627059
PBAR: 105427696
VEM: 105562546
HST: 105180461
DQU: 106741445
CFO: 105255628
LHU: 105678094
PGC: 109861390
OBO: 105280702
PCF: 106784179
CSOL: 105361340
MDL: 103578414
TCA: 657149
BMOR: 692605(PKG-I)
BMAN: 114250737
PMAC: 106712155
PRAP: 110996662
HAW: 110376116
TNL: 113492093
PXY: 105381837
API: 100168151
DNX: 107170171
AGS: 114124896
RMD: 113560773
FCD: 110847879
PVM: 113813818
VDE: 111243669
VJA: 111266620
TUT: 107363105
CSCU: 111625343
CEL: CELE_F55A8.2(egl-4)
BGT: 106065352
NVE: 5509991
EPA: 110249033
AMIL: 114960266
PDAM: 113677276
SPIS: 111344883
HMG: 100201371(prkg1)
PCB: PCHAS_100910(PC000298.03.0)
TAN: TA04955
TPV: TP03_0511
CPV: cgd8_750
 » show all
Reference
  Authors
Sausbier M, Schubert R, Voigt V, Hirneiss C, Pfeifer A, Korth M, Kleppisch T, Ruth P, Hofmann F
  Title
Mechanisms of NO/cGMP-dependent vasorelaxation.
  Journal
Circ Res 87:825-30 (2000)
DOI:10.1161/01.RES.87.9.825
  Sequence
[mmu:19091]
LinkDB

KEGG   ORTHOLOGY: K19477
Entry
K19477                      KO                                     

Name
PRKG2
Definition
cGMP-dependent protein kinase 2 [EC:2.7.11.12]
Pathway
map04022  cGMP-PKG signaling pathway
map04540  Gap junction
map04611  Platelet activation
map04713  Circadian entrainment
map04714  Thermogenesis
map04730  Long-term depression
map04740  Olfactory transduction
map04923  Regulation of lipolysis in adipocytes
map04924  Renin secretion
map04970  Salivary secretion
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04022 cGMP-PKG signaling pathway
    K19477  PRKG2; cGMP-dependent protein kinase 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K19477  PRKG2; cGMP-dependent protein kinase 2
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09152 Endocrine system
   04923 Regulation of lipolysis in adipocytes
    K19477  PRKG2; cGMP-dependent protein kinase 2
   04924 Renin secretion
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09154 Digestive system
   04970 Salivary secretion
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09156 Nervous system
   04730 Long-term depression
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09157 Sensory system
   04740 Olfactory transduction
    K19477  PRKG2; cGMP-dependent protein kinase 2
  09159 Environmental adaptation
   04713 Circadian entrainment
    K19477  PRKG2; cGMP-dependent protein kinase 2
   04714 Thermogenesis
    K19477  PRKG2; cGMP-dependent protein kinase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K19477  PRKG2; cGMP-dependent protein kinase 2
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.12  cGMP-dependent protein kinase
     K19477  PRKG2; cGMP-dependent protein kinase 2
Protein kinases [BR:ko01001]
 Serine/threonine kinases: AGC group
  PKG family
   K19477  PRKG2; cGMP-dependent protein kinase 2
Other DBs
GO: 0004692
Genes
HSA: 5593(PRKG2)
PTR: 461217(PRKG2)
PPS: 100978260(PRKG2)
GGO: 101139285(PRKG2)
PON: 100438589(PRKG2)
NLE: 100584834(PRKG2)
MCC: 696308(PRKG2)
MCF: 102142098(PRKG2)
CSAB: 103235875(PRKG2)
CATY: 105576820(PRKG2)
PANU: 101021599(PRKG2)
RRO: 104654813(PRKG2)
RBB: 108543451(PRKG2)
TFN: 117085403(PRKG2)
PTEH: 111549391(PRKG2)
CJC: 100384937(PRKG2)
SBQ: 101033123(PRKG2)
MMUR: 105880962(PRKG2)
MMU: 19092(Prkg2)
MCAL: 110294464(Prkg2)
MPAH: 110330505(Prkg2)
RNO: 25523(Prkg2)
MCOC: 116067909(Prkg2)
MUN: 110562188(Prkg2)
CGE: 100765312(Prkg2)
PLEU: 114695723(Prkg2)
NGI: 103735969(Prkg2)
HGL: 101697843(Prkg2)
CCAN: 109702659(Prkg2)
OCU: 100008781(PRKG2)
TUP: 102489899(PRKG2)
CFA: 100855930(PRKG2)
VVP: 112919705(PRKG2)
VLG: 121493652(PRKG2)
AML: 100467892(PRKG2)
UMR: 103665352(PRKG2)
UAH: 113263226(PRKG2)
ORO: 101381093(PRKG2)
ELK: 111149130
MPUF: 101673181(PRKG2)
EJU: 114224927(PRKG2)
MLX: 118010403(PRKG2)
FCA: 101091618(PRKG2)
PTG: 102949245(PRKG2)
PPAD: 109276981(PRKG2)
AJU: 106976911(PRKG2)
HHV: 120222860(PRKG2)
BTA: 533330(PRKG2)
BOM: 102269763(PRKG2) 102270503
BIU: 109560622(PRKG2)
BBUB: 102405676(PRKG2)
CHX: 102172135(PRKG2)
OAS: 101113758(PRKG2)
ODA: 120861498(PRKG2)
SSC: 100512796(PRKG2)
CFR: 102519263(PRKG2)
CDK: 105091814(PRKG2)
BACU: 103013933(PRKG2)
LVE: 103091057(PRKG2)
OOR: 101280012(PRKG2)
DLE: 111187663(PRKG2)
PCAD: 102985621(PRKG2)
ECB: 100060358(PRKG2)
EPZ: 103549039(PRKG2)
EAI: 106828068(PRKG2)
MYB: 102258852(PRKG2)
MYD: 102770749(PRKG2)
MMYO: 118670506(PRKG2)
MNA: 107537152(PRKG2)
HAI: 109387927(PRKG2)
DRO: 112319697(PRKG2)
SHON: 118990410(PRKG2)
AJM: 119056901(PRKG2)
MMF: 118635511(PRKG2)
PALE: 102894554(PRKG2)
RAY: 107516479(PRKG2)
MJV: 108396587(PRKG2)
TOD: 119260972(PRKG2)
LAV: 100657163(PRKG2)
TMU: 101346076
MDO: 100014568(PRKG2)
SHR: 100927283(PRKG2)
PCW: 110209720(PRKG2)
OAA: 100082499(PRKG2)
GGA: 100859181(PRKACA) 428753(PRKG2)
PCOC: 116230675 116231090(PRKG2)
MGP: 100541294(PRKG2) 100544740
CJO: 107312321 107313465(PRKG2)
NMEL: 110396408 110397428(PRKG2)
APLA: 101790644(PRKG2)
ACYG: 106041906(PRKG2)
TGU: 100232260(PRKG2)
LSR: 110480895(PRKG2)
SCAN: 103826056(PRKG2)
PMOA: 120502746(PRKG2)
GFR: 102042278(PRKG2)
FAB: 101813345(PRKG2)
PHI: 102108417(PRKG2)
PMAJ: 107203574(PRKG2)
CCAE: 111928808(PRKG2)
CCW: 104697218(PRKG2)
ETL: 114059161(PRKG2)
FPG: 101916682 101918759(PRKG2)
FCH: 102055004(PRKG2) 106631485
CLV: 102089346(PRKG2)
EGZ: 104133983(PRKG2)
NNI: 104021251(PRKG2)
ACUN: 113479638(PRKG2)
PADL: 103913713(PRKG2)
AAM: 106491038(PRKG2)
ASN: 102372581 102375122(PRKG2)
AMJ: 102560332(PRKACA) 102570800(PRKG2)
CPOO: 109309532(PRKG2)
GGN: 109297118(PRKG2)
CPIC: 103305918(PRKG2)
ACS: 100561246(prkg2) 103282038
PVT: 110084111(PRKG2) 110087006
PMUR: 107286453 107303184(PRKG2)
TSR: 106545902 106547680(PRKG2)
PGUT: 117667640 117673681(PRKG2)
PMUA: 114595005 114604385(PRKG2)
ZVI: 118083662(PRKG2)
GJA: 107114871(PRKG2)
XLA: 108696263 108697216 444025(prkg2.L)
XTR: 100497736(prkg2) 100498055
NPR: 108789074(PRKG2)
DRE: 100125912(prkg2) 326020(si:dkey-121j17.5) 556339
ELY: 117252905(prkg2) 117270421(prkg3)
PLEP: 121944718(prkg2) 121954433 121956012(prkg3)
SLUC: 116050373 116054106(prkg2) 116066486(prkg3)
ECRA: 117945406(prkg2) 117960788 117961240(prkg3)
PFLV: 114555686(prkg2) 114572507
GAT: 120807891(prkg3) 120813110
MSAM: 119892004(prkg2) 119908424(prkg3)
CUD: 121510051(prkg2) 121511336 121521080(prkg3)
MZE: 101471197(prkg2) 101479945
ONL: 100699113(prkg2) 100708987
OAU: 116310793(prkg3) 116333376(prkg2)
OML: 112137683(prkg2) 112158429(prkg3) 112161926
XMA: 102216397 102230306(prkg2)
XCO: 114153990(prkg2) 114158207
XHE: 116729132(prkg2) 116733691
PRET: 103457572 103469805(prkg2)
CVG: 107083363 107083975(prkg2)
CTUL: 119785128(prkg3) 119785444(prkg2)
KMR: 108239119 108240136(prkg3) 108244533(prkg2)
POV: 109629155
SDU: 111216303 111228005(prkg2)
XGL: 120789174(prkg3) 120796544 120805415(prkg2)
MALB: 109952723 109957341(prkg2)
PSPA: 121300010(prkg2) 121317145(prkg3) 121318794 121325426
LCM: 102345412 102361824(PRKG2)
CMK: 103180874(prkg2) 103181471
ATD: 109601774
BGT: 106067606
APRO: F751_6750
MIS: MICPUN_104866(CL-PK2)
SMAZ: LH19_17420
SPHU: SPPYR_2707
 » show all
Reference
PMID:9788971
  Authors
Wagner C, Pfeifer A, Ruth P, Hofmann F, Kurtz A
  Title
Role of cGMP-kinase II in the control of renin secretion and renin expression.
  Journal
J Clin Invest 102:1576-82 (1998)
DOI:10.1172/JCI4044
Reference
PMID:8607838
  Authors
Orstavik S, Solberg R, Tasken K, Nordahl M, Altherr MR, Hansson V, Jahnsen T, Sandberg M
  Title
Molecular cloning, cDNA structure, and chromosomal localization of the human type II cGMP-dependent protein kinase.
  Journal
Biochem Biophys Res Commun 220:759-65 (1996)
DOI:10.1006/bbrc.1996.0477
  Sequence
[hsa:5593]
LinkDB

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