KEGG   ORTHOLOGY: K07438
Entry
K07438                      KO                                     
Symbol
CYP27B1
Name
calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase) [EC:1.14.15.18]
Pathway
map00100  Steroid biosynthesis
map01100  Metabolic pathways
map04928  Parathyroid hormone synthesis, secretion and action
map05152  Tuberculosis
Module
M00103  Cholecalciferol biosynthesis
Disease
H00408  Type 1 diabetes mellitus
H01143  Vitamin D-dependent rickets
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09103 Lipid metabolism
   00100 Steroid biosynthesis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 09150 Organismal Systems
  09152 Endocrine system
   04928 Parathyroid hormone synthesis, secretion and action
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05152 Tuberculosis
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   00199 Cytochrome P450
    K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.14  Acting on paired donors, with incorporation or reduction of molecular oxygen
   1.14.15  With reduced iron-sulfur protein as one donor, and incorporation of one atom of oxygen into the other donor
    1.14.15.18  calcidiol 1-monooxygenase
     K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Cytochrome P450 [BR:ko00199]
 Cytochrome P450, animal type
  CYP27 family
   K07438  CYP27B1; calcidiol 1-monooxygenase (25-hydroxyvitamin D3 1alpha-hydroxylase)
Other DBs
RN: R03610 R11324
GO: 0004498
Genes
HSA: 1594(CYP27B1)
PTR: 452027(CYP27B1)
PPS: 100974264(CYP27B1)
GGO: 101146696
PON: 100443915
NLE: 100594622
MCC: 715747(CYP27B1)
MCF: 102117707(CYP27B1)
MTHB: 126930378
CSAB: 103238591(CYP27B1)
CATY: 105587234
PANU: 101009903
TGE: 112634833
RRO: 104682342
RBB: 108524407
TFN: 117089857
PTEH: 111541786
CJC: 100388588(CYP27B1)
SBQ: 101042462
CSYR: 103264442
MMUR: 105877998
LCAT: 123639587
OGA: 100961635
MMU: 13115(Cyp27b1)
MCAL: 110303958
MPAH: 110327080
RNO: 114700(Cyp27b1)
MCOC: 116075946
MUN: 110561784
CGE: 100760414
MAUA: 101840476
PLEU: 114704779
MORG: 121464015
MFOT: 126514764
AAMP: 119803686
NGI: 103742896
HGL: 101700851
CPOC: 100717678
CCAN: 109686086
DORD: 105990140
DSP: 122124179
NCAR: 124983979
OCU: 100341053
OPI: 101530921
TUP: 102492875
CFA: 481133(CYP27B1)
CLUD: 112677953
VVP: 112922328
VLG: 121491053
AML: 100481484
UMR: 103656705
UAH: 113256358
UAR: 123787194
ELK: 111160181
LLV: 125106498
MPUF: 101674682
ORO: 101363421
EJU: 114215050
ZCA: 113922553
MLX: 118008655
NSU: 110577862
FCA: 100750221(CYP27B1)
PYU: 121040851
PBG: 122473840
LRUF: 124501071
PTG: 102971063
PPAD: 109270394
AJU: 106975877
HHV: 120248015
BTA: 539630(CYP27B1)
BOM: 102278257
BIU: 109559305
BBUB: 102414554
CHX: 102170758
OAS: 101116039
ODA: 120857512
CCAD: 122427212
SSC: 397055(CYP27B1)
CFR: 102522811
CBAI: 105062143
CDK: 105100328
VPC: 102532825
BACU: 103001013
LVE: 103084276
OOR: 101284262
DLE: 111173817
PCAD: 102984886
PSIU: 116760774
ECB: 100034100(CYP27B1)
EPZ: 103553643
EAI: 106833020
MYB: 102262846
MYD: 102757775
MMYO: 118649575
MLF: 102431071
MNA: 107546167
PKL: 118730267
HAI: 109390756
DRO: 112319168
SHON: 118975885
AJM: 119065237
PDIC: 114513469
PHAS: 123812846
MMF: 118623548
RFQ: 117028656
PALE: 102894468
PGIG: 120604970
PVP: 105307396
RAY: 107501490
MJV: 108387803
TOD: 119248104
SARA: 101536895
LAV: 100657886
TMU: 101355020
DNM: 101414278
MDO: 100031497
GAS: 123250198
SHR: 100913970
PCW: 110210991
OAA: 114814717
LSR: 110473893
SCAN: 103824978
PMOA: 120499536
OTC: 121334301
PRUF: 121356351
FAB: 101816678
PHI: 102103763
PMAJ: 107199279
CBRC: 103611929
ACHL: 103807649
NNI: 104021543
ACHC: 115350948
DPUB: 104304660
AROW: 112972148
NPD: 112952263
ASN: 102386966
AMJ: 102574984
CPOO: 109324487
PSS: 102443605
CMY: 102946801
CPIC: 101954100
TST: 117888845
CABI: 116828443
MRV: 120391239
ACS: 100559713
PVT: 110074451
SUND: 121920838
PBI: 103060795
PMUR: 107291644
CTIG: 120297684
TSR: 106552999
PGUT: 117662682
VKO: 123029856
PMUA: 114593032
ZVI: 118078986
GJA: 107119675
STOW: 125427926
XLA: 108708601(cyp27b1.L) 108709871(cyp27b1.S)
XTR: 448754(cyp27b1)
NPR: 108791588
RTEM: 120929439
BBUF: 120996179
BGAR: 122931986
DRE: 793309(cyp27b1)
SRX: 107747831
SANH: 107684010
SGH: 107561793
CCAR: 109089182
CAUA: 113068164
PPRM: 120467743
IPU: 108254794
SMEO: 124402328
TFD: 113639045
AMEX: 103035224
EEE: 113572450
TRU: 101062641
LCO: 109142364
NCC: 104955571
CGOB: 115008521
ELY: 117257290
EFO: 125895893
PLEP: 121956007
SLUC: 116066246
ECRA: 117942881
PFLV: 114554512
GAT: 120835315
PPUG: 119194159
MSAM: 119886596
CUD: 121528681
ALAT: 119021281
MZE: 101476393
ONL: 100706100
OAU: 116326616
OLA: 101172325
OML: 112145670
XMA: 102222483
XCO: 114134887
XHE: 116709734
PRET: 103465325
PFOR: 103129584
PLAI: 106935833
PMEI: 106929457
GAF: 122834207
CVG: 107082096
CTUL: 119795482
GMU: 124856373
NFU: 107385653
KMR: 108235620
ALIM: 106518084
NWH: 119412594
AOCE: 111587639
MCEP: 125007137
CSEM: 103386049
POV: 109628943
SSEN: 122767755
HHIP: 117761420
HSP: 118104984
LCF: 108898968
SDU: 111221905
SLAL: 111667688
XGL: 120806983
HCQ: 109522134
BPEC: 110171326
MALB: 109956137
BSPL: 114856290
ELS: 105017033
PKI: 111854850
AANG: 118210837
LOC: 102685924
PSPA: 121308962
LCM: 102346327
CMK: 103191415
RTP: 109925523
PPOT: 106099942
BGT: 106053581
GAE: 121389521
CRG: 105346613
MMER: 123550682
OSN: 115209661
 » show all
Reference
  Authors
Huang DC, Papavasiliou V, Rhim JS, Horst RL, Kremer R
  Title
Targeted disruption of the 25-hydroxyvitamin D3 1alpha-hydroxylase gene in ras-transformed keratinocytes demonstrates that locally produced 1alpha,25-dihydroxyvitamin D3 suppresses growth and induces differentiation in an autocrine fashion.
  Journal
Mol Cancer Res 1:56-67 (2002)
  Sequence
[hsa:1594]
Reference
PMID:9344864
  Authors
Monkawa T, Yoshida T, Wakino S, Shinki T, Anazawa H, Deluca HF, Suda T, Hayashi M, Saruta T
  Title
Molecular cloning of cDNA and genomic DNA for human 25-hydroxyvitamin D3 1 alpha-hydroxylase.
  Journal
Biochem Biophys Res Commun 239:527-33 (1997)
DOI:10.1006/bbrc.1997.7508
  Sequence
[hsa:1594]
Reference
  Authors
Sawada N, Sakaki T, Kitanaka S, Takeyama K, Kato S, Inouye K
  Title
Enzymatic properties of human 25-hydroxyvitamin D3 1alpha-hydroxylase coexpression with adrenodoxin and NADPH-adrenodoxin reductase in Escherichia coli.
  Journal
Eur J Biochem 265:950-6 (1999)
DOI:10.1046/j.1432-1327.1999.00794.x
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