KEGG   ORTHOLOGY: K07515
Entry
K07515                      KO                                     

Name
HADHA
Definition
enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase [EC:4.2.1.17 1.1.1.211]
Pathway
ko00062  Fatty acid elongation
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko00410  beta-Alanine metabolism
ko00627  Aminobenzoate degradation
ko00640  Propanoate metabolism
ko00650  Butanoate metabolism
ko00930  Caprolactam degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01212  Fatty acid metabolism
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Disease
H00489  LCHAD deficiency
H00525  Disorders of mitochondrial fatty-acid oxidation
H01352  Mitochondrial trifunctional protein deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00650 Butanoate metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00071 Fatty acid degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00310 Lysine degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00380 Tryptophan metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
   00930 Caprolactam degradation
    K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.211  long-chain-3-hydroxyacyl-CoA dehydrogenase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07515  HADHA; enoyl-CoA hydratase / long-chain 3-hydroxyacyl-CoA dehydrogenase
Other DBs
RN: R01778 R02685 R03026 R03045 R04137 R04170 R04204 R04224 R04737 R04738 R04739 R04740 R04741 R04743 R04744 R04745 R04746 R04748 R04749 R05595 R06942
GO: 0004300 0016509
Genes
HSA: 3030(HADHA)
PTR: 459079(HADHA)
PPS: 100973698 100978217(HADHA)
GGO: 101143053(HADHA)
PON: 100172963(HADHA)
NLE: 100593214 100593233(HADHA)
MCC: 695975(HADHA)
MCF: 102142372(HADHA)
CSAB: 103220642(HADHA)
RRO: 104677892(HADHA)
RBB: 108532679(HADHA)
CJC: 100390439(HADHA)
SBQ: 101047074(HADHA)
MMU: 97212(Hadha)
MCAL: 110294690(Hadha)
MPAH: 110324206(Hadha)
RNO: 170670(Hadha)
MUN: 110547680(Hadha)
CGE: 100757947(Hadha)
NGI: 103735655(Hadha)
HGL: 101724137(Hadha)
CCAN: 109685831(Hadha)
OCU: 100355022(HADHA)
TUP: 102471941(HADHA) 102478660
CFA: 100856745(HADHA)
VVP: 112908532(HADHA)
AML: 100469654(HADHA)
UMR: 103671672(HADHA)
UAH: 113270772(HADHA)
ORO: 101364854(HADHA)
ELK: 111154088
FCA: 101084701(HADHA)
PTG: 102966470(HADHA)
PPAD: 109267284(HADHA)
AJU: 106967830(HADHA)
BTA: 281810(HADHA)
BOM: 102287426(HADHA)
BIU: 109566315(HADHA)
BBUB: 102398211(HADHA)
CHX: 102189046(HADHA)
OAS: 100192316(HADHA)
SSC: 397012(HADHA)
CFR: 102516648(HADHA)
CDK: 105098509(HADHA)
BACU: 103001885(HADHA)
LVE: 103086620(HADHA)
OOR: 101286957(HADHA)
DLE: 111174988(HADHA)
PCAD: 102996843(HADHA)
ECB: 100071381(HADHA)
EPZ: 103546462(HADHA)
EAI: 106840921(HADHA)
MYB: 102263028(HADHA)
MYD: 102751724(HADHA)
MNA: 107534200(HADHA)
HAI: 109383051(HADHA)
DRO: 112297764(HADHA)
PALE: 102889313(HADHA)
RAY: 107498535(HADHA)
MJV: 108392159(HADHA)
LAV: 100675857(HADHA)
TMU: 101353485
MDO: 100030776(HADHA)
SHR: 100928252(HADHA)
PCW: 110206510(HADHA)
OAA: 100077524(HADHA)
GGA: 395929(HADHA)
MGP: 100548080(HADHA)
CJO: 107312378(HADHA)
NMEL: 110397114(HADHA)
ACYG: 106048383(HADHA)
LSR: 110478445(HADHA)
SCAN: 103824695(HADHA)
GFR: 102032411(HADHA)
FAB: 101815112(HADHA)
PHI: 102103703(HADHA)
PMAJ: 107198787(HADHA)
CCAE: 111927468(HADHA)
CCW: 104683133(HADHA)
ETL: 114071979(HADHA)
FPG: 101918262(HADHA)
FCH: 102045684(HADHA)
CLV: 102093055(HADHA)
EGZ: 104130955(HADHA)
NNI: 104014780(HADHA)
ACUN: 113478819(HADHA)
PADL: 103923913(HADHA)
AAM: 106499621(HADHA)
ASN: 102387874(HADHA)
AMJ: 102559143(HADHA)
PSS: 102461507(HADHA)
CMY: 102938765(HADHA)
CPIC: 101942783(HADHA)
ACS: 100553746(hadha)
PVT: 110090547(HADHA)
PBI: 103053277(HADHA)
PMUR: 107291031(HADHA) 107300505
TSR: 106541761(HADHA)
PMUA: 114594987(HADHA)
GJA: 107113769(HADHA)
XLA: 108717268(hadha.L) 444044(hadha.S)
XTR: 394832(hadha)
NPR: 108803249(HADHA)
DRE: 553401(hadhaa) 793834(hadhab)
IPU: 100304971 108257474(hadha)
TRU: 101073662(hadha)
LCO: 104929997(hadha)
NCC: 104942173(hadha)
OLA: 101155646(hadha)
XMA: 102229661(hadha)
XCO: 114133804(hadha)
PRET: 103458382(hadha)
CVG: 107095825(hadha)
NFU: 107392010(hadha)
KMR: 108239107(hadha)
ALIM: 106529789(hadha)
CSEM: 103380450(hadha)
POV: 109636387(hadha)
LCF: 108874899(hadha)
SDU: 111225708(hadha)
SLAL: 111673117(hadha)
MALB: 109964597(hadha)
SASA: 106603767 106611334(ECHA)
ELS: 105026863(hadha)
PKI: 111851531(hadha) 111857967
LCM: 102350823(HADHA)
CMK: 103183149(hadha)
RTP: 109910714(hadha)
BFO: 118404846
CIN: 100181980
SPU: 585357
APLC: 110978691
SKO: 100369576(HADHA)
DME: Dmel_CG4389(Mtpalpha)
DER: 6541344
DSE: 6611826
DSI: Dsimw501_GD22351(Dsim_GD22351)
DAN: 6504621
DSR: 110176800
DPE: 6589537
DMN: 108161786
DWI: 6641563
DAZ: 108610802
DNV: 108649592
DHE: 111603880
DVI: 6634031
MDE: 101889137
LCQ: 111679665
AAG: 5572923
AME: 410325
BIM: 100741897
BTER: 100642892
CCAL: 108623987
OBB: 114875921
SOC: 105201374
MPHA: 105837947
AEC: 105152057
ACEP: 105621618
PBAR: 105434016
VEM: 105567443
HST: 105189285
DQU: 106748121
CFO: 105254374
LHU: 105673815
PGC: 109863893
OBO: 105279823
PCF: 106784609
NVI: 100121740
CSOL: 105361087
MDL: 103579736
TCA: 662336
ATD: 109603223
NVL: 108558831
BMOR: 692820
BMAN: 114248364
PMAC: 106719824
PRAP: 110999633
HAW: 110371935
TNL: 113493488
PXY: 105387328
API: 100165657
DNX: 107168916
AGS: 114130103
RMD: 113555782
BTAB: 109036133
CLEC: 106670657
ZNE: 110827146
FCD: 110854334
PVM: 113805029
TUT: 107359547
DPTE: 113799485
CSCU: 111616495
CEL: CELE_C29F3.1(ech-1.1) CELE_T08B2.7(ech-1.2)
CBR: CBG12562
BMY: Bm1_51120
PCAN: 112574360
CRG: 105342066
OBI: 106883270
LAK: 106173898
EPA: 110254396
ADF: 107334024
AMIL: 114957985
PDAM: 113673361
SPIS: 111326946
DGT: 114535097
HMG: 100197152(hadha)
AQU: 100631983
FCY: FRACYDRAFT_183437(ECH_HADH2)
SPAR: SPRG_06557
 » show all
Reference
PMID:8135828
  Authors
Kamijo T, Aoyama T, Komiyama A, Hashimoto T
  Title
Structural analysis of cDNAs for subunits of human mitochondrial fatty acid beta-oxidation trifunctional protein.
  Journal
Biochem Biophys Res Commun 199:818-25 (1994)
DOI:10.1006/bbrc.1994.1302
  Sequence
[hsa:3030]
LinkDB

KEGG   ORTHOLOGY: K07514
Entry
K07514                      KO                                     

Name
EHHADH
Definition
enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase [EC:4.2.1.17 1.1.1.35 5.3.3.8]
Pathway
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko00410  beta-Alanine metabolism
ko00627  Aminobenzoate degradation
ko00640  Propanoate metabolism
ko00650  Butanoate metabolism
ko00930  Caprolactam degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01212  Fatty acid metabolism
ko03320  PPAR signaling pathway
ko04146  Peroxisome
Module
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00087  beta-Oxidation
Disease
H01198  Fanconi renotubular syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00650 Butanoate metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09103 Lipid metabolism
   00071 Fatty acid degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00310 Lysine degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00380 Tryptophan metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
   00930 Caprolactam degradation
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 09140 Cellular Processes
  09141 Transport and catabolism
   04146 Peroxisome
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.35  3-hydroxyacyl-CoA dehydrogenase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.3  Transposing C=C bonds
    5.3.3.8  Delta3-Delta2-enoyl-CoA isomerase
     K07514  EHHADH; enoyl-CoA hydratase / 3-hydroxyacyl-CoA dehydrogenase / 3,2-trans-enoyl-CoA isomerase
Other DBs
RN: R01975 R03026 R03045 R04137 R04170 R04203 R04204 R04224 R04737 R04738 R04739 R04740 R04741 R04743 R04744 R04745 R04746 R04748 R04749 R04756 R05066 R05595 R06941 R06942
GO: 0004300 0003857 0004165
Genes
HSA: 1962(EHHADH)
PTR: 460996(EHHADH)
PPS: 100985141(EHHADH)
GGO: 101130472(EHHADH)
PON: 100174685(EHHADH)
NLE: 100586768(EHHADH)
MCC: 701193(EHHADH)
MCF: 102118537(EHHADH)
CSAB: 103221115(EHHADH)
RRO: 104672740(EHHADH)
RBB: 108525336(EHHADH)
CJC: 100395397(EHHADH)
SBQ: 101049266(EHHADH)
MMU: 74147(Ehhadh)
MCAL: 110311920(Ehhadh)
MPAH: 110330110(Ehhadh)
RNO: 171142(Ehhadh)
MUN: 110561900(Ehhadh)
CGE: 100754698(Ehhadh)
NGI: 103732668(Ehhadh)
HGL: 101699730(Ehhadh)
CCAN: 109695163
OCU: 100346381(EHHADH)
TUP: 102502891(EHHADH)
CFA: 488110(EHHADH)
VVP: 112926276(EHHADH)
AML: 100468058(EHHADH)
UMR: 103676178(EHHADH)
UAH: 113254101(EHHADH)
ORO: 101370722(EHHADH)
ELK: 111150208
FCA: 101083876(EHHADH)
PTG: 102965690(EHHADH)
PPAD: 109275245(EHHADH)
AJU: 106967987(EHHADH)
BTA: 518852(EHHADH)
BOM: 102285943(EHHADH)
BIU: 109557289(EHHADH)
BBUB: 102404255(EHHADH)
CHX: 102179598(EHHADH)
OAS: 101117635(EHHADH)
SSC: 448846(EHHADH)
CFR: 102519802(EHHADH)
CDK: 105085864(EHHADH)
BACU: 102997304(EHHADH)
LVE: 103073756(EHHADH)
OOR: 101277611(EHHADH)
DLE: 111173099(EHHADH)
PCAD: 102985760(EHHADH)
ECB: 100067714(EHHADH)
EPZ: 103565918(EHHADH)
EAI: 106834502(EHHADH)
MYB: 102240784(EHHADH)
MYD: 102771761(EHHADH)
MNA: 107527318(EHHADH)
HAI: 109396830(EHHADH)
DRO: 112308135(EHHADH)
PALE: 102880064(EHHADH)
RAY: 107518255(EHHADH)
MJV: 108410174(EHHADH)
LAV: 100677184(EHHADH)
TMU: 101352903
MDO: 100026751(EHHADH)
SHR: 100913272(EHHADH)
PCW: 110221285(EHHADH)
OAA: 100082172(EHHADH)
GGA: 424877(EHHADH)
MGP: 100551164(EHHADH)
CJO: 107317934(EHHADH)
NMEL: 110398159(EHHADH)
APLA: 101795970(EHHADH)
ACYG: 106039208(EHHADH)
TGU: 100229171(EHHADH)
LSR: 110474075(EHHADH)
SCAN: 103815479(EHHADH)
GFR: 102040622(EHHADH)
FAB: 101818793(EHHADH)
PHI: 102112202(EHHADH)
PMAJ: 107208675(EHHADH)
CCAE: 111945334(EHHADH)
CCW: 104696695(EHHADH)
ETL: 114054815(EHHADH)
FPG: 101918474(EHHADH)
FCH: 102057870(EHHADH)
CLV: 102091542(EHHADH)
EGZ: 104131306(EHHADH)
NNI: 104010666(EHHADH)
ACUN: 113483679(EHHADH)
PADL: 103916934(EHHADH)
AAM: 106493091(EHHADH)
ASN: 102381971(EHHADH)
AMJ: 102558567(EHHADH)
PSS: 102453335(EHHADH)
CMY: 102939101(EHHADH)
CPIC: 101941626(EHHADH)
ACS: 100558466(ehhadh)
PVT: 110075819(EHHADH)
PBI: 103052873(EHHADH)
PMUR: 107285887(EHHADH)
TSR: 106540162(EHHADH)
PMUA: 114597690(EHHADH)
GJA: 107123582(EHHADH)
XLA: 108703045(ehhadh.S)
XTR: 100216115(ehhadh)
NPR: 108795601(EHHADH)
DRE: 100000859(ehhadh)
SRX: 107749878(ehhadh)
SANH: 107663901(ehhadh)
SGH: 107596516
IPU: 108266325(ehhadh)
PHYP: 113525435(ehhadh)
AMEX: 103032907(ehhadh)
EEE: 113574639(ehhadh)
TRU: 101073728(ehhadh)
LCO: 104919050(ehhadh)
NCC: 104957955(ehhadh)
MZE: 101484421(ehhadh)
ONL: 100709434(ehhadh)
OLA: 101170799(ehhadh)
XMA: 102219640(ehhadh)
XCO: 114148066(ehhadh)
PRET: 103461662(ehhadh)
CVG: 107087127(ehhadh)
NFU: 107390106(ehhadh)
KMR: 108240797(ehhadh)
ALIM: 106523328(ehhadh)
AOCE: 111588505(ehhadh)
CSEM: 103392204(ehhadh)
POV: 109631473(ehhadh)
LCF: 108901033(ehhadh)
SDU: 111218377(ehhadh)
SLAL: 111651262(ehhadh)
HCQ: 109523309(ehhadh)
BPEC: 110166609(ehhadh)
MALB: 109957167(ehhadh)
SASA: 100195275(ehhadh)
OTW: 112218409(ehhadh)
SALP: 112072998(ehhadh)
ELS: 105029884(ehhadh)
SFM: 108928073(ehhadh)
PKI: 111841633(ehhadh)
LCM: 102356308(EHHADH)
APLC: 110973407
PCAN: 112564830
MYI: 110465017
LAK: 106165251
 » show all
Reference
PMID:8188243
  Authors
Hoefler G, Forstner M, McGuinness MC, Hulla W, Hiden M, Krisper P, Kenner L, Ried T, Lengauer C, Zechner R, et al.
  Title
cDNA cloning of the human peroxisomal enoyl-CoA hydratase: 3-hydroxyacyl-CoA dehydrogenase bifunctional enzyme and localization to chromosome 3q26.3-3q28: a free left Alu Arm is inserted in the 3' noncoding region.
  Journal
Genomics 19:60-7 (1994)
DOI:10.1006/geno.1994.1013
  Sequence
[hsa:1962]
Reference
  Authors
Zhao S, Xu W, Jiang W, Yu W, Lin Y, Zhang T, Yao J, Zhou L, Zeng Y, Li H, Li Y, Shi J, An W, Hancock SM, He F, Qin L, Chin J, Yang P, Chen X, Lei Q, Xiong Y, Guan KL
  Title
Regulation of cellular metabolism by protein lysine acetylation.
  Journal
Science 327:1000-4 (2010)
DOI:10.1126/science.1179689
LinkDB

KEGG   ORTHOLOGY: K07511
Entry
K07511                      KO                                     

Name
ECHS1
Definition
enoyl-CoA hydratase [EC:4.2.1.17]
Pathway
ko00062  Fatty acid elongation
ko00071  Fatty acid degradation
ko00280  Valine, leucine and isoleucine degradation
ko00310  Lysine degradation
ko00380  Tryptophan metabolism
ko00410  beta-Alanine metabolism
ko00627  Aminobenzoate degradation
ko00640  Propanoate metabolism
ko00650  Butanoate metabolism
ko00930  Caprolactam degradation
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01212  Fatty acid metabolism
Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
M00032  Lysine degradation, lysine => saccharopine => acetoacetyl-CoA
M00085  Fatty acid elongation in mitochondria
M00087  beta-Oxidation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K07511  ECHS1; enoyl-CoA hydratase
   00650 Butanoate metabolism
    K07511  ECHS1; enoyl-CoA hydratase
  09103 Lipid metabolism
   00062 Fatty acid elongation
    K07511  ECHS1; enoyl-CoA hydratase
   00071 Fatty acid degradation
    K07511  ECHS1; enoyl-CoA hydratase
  09105 Amino acid metabolism
   00280 Valine, leucine and isoleucine degradation
    K07511  ECHS1; enoyl-CoA hydratase
   00310 Lysine degradation
    K07511  ECHS1; enoyl-CoA hydratase
   00380 Tryptophan metabolism
    K07511  ECHS1; enoyl-CoA hydratase
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K07511  ECHS1; enoyl-CoA hydratase
  09111 Xenobiotics biodegradation and metabolism
   00627 Aminobenzoate degradation
    K07511  ECHS1; enoyl-CoA hydratase
   00930 Caprolactam degradation
    K07511  ECHS1; enoyl-CoA hydratase
Enzymes [BR:ko01000]
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.17  enoyl-CoA hydratase
     K07511  ECHS1; enoyl-CoA hydratase
Other DBs
RN: R02685 R03026 R03045 R04137 R04170 R04204 R04224 R04738 R04740 R04744 R04746 R04749 R05595 R06942
GO: 0004300
Genes
HSA: 1892(ECHS1)
PTR: 747936(ECHS1)
PPS: 100991484(ECHS1)
GGO: 101144756(ECHS1)
PON: 100173612(ECHS1)
NLE: 100590909(ECHS1) 115834410
MCC: 722723(ECHS1)
MCF: 101925228(ECHS1)
CSAB: 103245970(ECHS1)
RRO: 104677652(ECHS1)
RBB: 108543377(ECHS1)
CJC: 100390793(ECHS1)
SBQ: 101047632(ECHS1)
MMU: 93747(Echs1)
MCAL: 110298759(Echs1)
MPAH: 110325026(Echs1)
RNO: 100911186 140547(Echs1)
MUN: 110549035(Echs1)
CGE: 100754654(Echs1)
NGI: 103725841(Echs1)
HGL: 101697414(Echs1)
CCAN: 109698398(Echs1)
OCU: 100341040(ECHS1)
TUP: 102493494(ECHS1)
CFA: 480828(ECHS1)
VVP: 112928847(ECHS1)
AML: 100467523(ECHS1)
UMR: 103659639(ECHS1)
UAH: 113252096(ECHS1)
ORO: 101366734(ECHS1)
FCA: 101089898(ECHS1)
PTG: 102968257(ECHS1)
PPAD: 109256705(ECHS1)
AJU: 106987505(ECHS1)
BTA: 281748(ECHS1)
BOM: 102281121(ECHS1)
BIU: 109553027(ECHS1)
BBUB: 102391502(ECHS1)
CHX: 102185243(ECHS1)
OAS: 101112867(ECHS1)
SSC: 100156927(ECHS1)
CFR: 102513232(ECHS1)
CDK: 105104592(ECHS1)
BACU: 103020372(ECHS1)
LVE: 103087811(ECHS1)
OOR: 101276913(ECHS1)
DLE: 111172160(ECHS1)
PCAD: 102978046(ECHS1)
ECB: 100066748(ECHS1)
EPZ: 103556388(ECHS1)
EAI: 106841083(ECHS1)
MYB: 102259446(ECHS1)
MYD: 102761160(ECHS1)
MNA: 107532104(ECHS1)
HAI: 109383526(ECHS1)
DRO: 112300231(ECHS1)
PALE: 102884409(ECHS1)
RAY: 107517164(ECHS1)
MJV: 108395404(ECHS1)
LAV: 100655867(ECHS1)
TMU: 101361856
MDO: 100028122(ECHS1)
SHR: 100934811(ECHS1)
PCW: 110214032(ECHS1)
OAA: 100082869(ECHS1)
GGA: 770828(ECHS1)
MGP: 100541406(ECHS1)
CJO: 107315631(ECHS1)
NMEL: 110390486(ECHS1)
APLA: 101801447(ECHS1)
ACYG: 106030578(ECHS1)
TGU: 100219304(ECHS1)
LSR: 110474016(ECHS1)
SCAN: 103814229(ECHS1)
GFR: 102041591(ECHS1)
FAB: 101807384(ECHS1)
PHI: 102107261(ECHS1)
PMAJ: 107206554(ECHS1)
CCAE: 111942727(ECHS1)
CCW: 104695097(ECHS1)
ETL: 114067586(ECHS1)
FPG: 101911475(ECHS1)
FCH: 102054014(ECHS1)
CLV: 102084289(ECHS1)
EGZ: 104125143(ECHS1)
NNI: 104013578(ECHS1)
PADL: 103924293(ECHS1)
AAM: 106495293(ECHS1)
ASN: 102379077(ECHS1)
AMJ: 102559204(ECHS1)
PSS: 102444046(ECHS1)
CMY: 102934831
CPIC: 101934752(ECHS1)
ACS: 100558325(echs1)
PVT: 110072287(ECHS1)
PBI: 103058375(ECHS1)
PMUR: 107288287(ECHS1)
TSR: 106545789(ECHS1)
PMUA: 114590918(ECHS1)
GJA: 107106993(ECHS1)
XLA: 733431(echs1.L)
XTR: 448019(echs1)
NPR: 108793157(ECHS1)
DRE: 368912(echs1)
SGH: 107552936(echs1) 107601864
IPU: 100528847(echs1)
PHYP: 113537820(echs1)
AMEX: 103039905(echs1)
EEE: 113582079(echs1)
TRU: 101064906(echs1)
LCO: 104924259(echs1)
NCC: 104961349(echs1)
MZE: 101487381(echs1)
ONL: 100689827(echs1)
OLA: 101170209(echs1)
XMA: 102230327(echs1)
XCO: 114138350(echs1)
PRET: 103476967(echs1)
CVG: 107086575(echs1)
NFU: 107375617(echs1)
KMR: 108233980(echs1)
ALIM: 106522436(echs1)
AOCE: 111577443(echs1)
CSEM: 103387345(echs1)
POV: 109629600(echs1)
SDU: 111235312(echs1)
SLAL: 111658168(echs1)
HCQ: 109516213(echs1)
BPEC: 110157192(echs1)
MALB: 109961037(echs1)
SASA: 100194570(echs1)
OTW: 112252753(echs1)
SALP: 112070945(echs1)
ELS: 105010688(echs1)
SFM: 108942687(echs1)
PKI: 111850363(echs1)
LCM: 102356614(ECHS1)
CMK: 103182105(echs1)
RTP: 109917478(echs1)
BFO: 118416087
CIN: 100186995
SPU: 575690(Echs1)
APLC: 110986119
SKO: 100377615
DME: Dmel_CG6543(Echs1)
DER: 6549156
DSE: 6609058
DSI: Dsimw501_GD25738(Dsim_GD25738)
DAN: 6494025
DSR: 110189403
DPE: 6592438
DWI: 6646026
DAZ: 108616337
DNV: 108652848
DHE: 111595530
DVI: 6625142
MDE: 101889661
AAG: 5563904
AME: 409150
BIM: 100746130
BTER: 100643996
OBB: 114879751
SOC: 105193004
MPHA: 105834505
AEC: 105149968
ACEP: 105621218
PBAR: 105424853
VEM: 105562654
HST: 105191417
DQU: 106750322
CFO: 105258707
LHU: 105679764
PGC: 109861597
OBO: 105275362
PCF: 106793617
NVI: 100121569
CSOL: 105365636
MDL: 103578406
TCA: 660433
DPA: 109544658
NVL: 108560585
BMOR: 101745599
BMAN: 114241323
PMAC: 106718227
PRAP: 110994734
HAW: 110377936
TNL: 113492184
API: 100159954
DNX: 107167990
AGS: 114119477
RMD: 113553127
BTAB: 109038129
CLEC: 106663057
ZNE: 110826630
FCD: 110858299
PVM: 113811244
TUT: 107360075
DPTE: 113793051
CSCU: 111620854
PTEP: 107457312
CEL: CELE_T05G5.6(ech-6) CELE_Y105E8A.4(ech-7)
CBR: CBG08743(Cbr-ech-7) CBG09979 CBG10003(Cbr-ech-6)
BMY: Bm1_30520
TSP: Tsp_06325
PCAN: 112570641
CRG: 105341094
MYI: 110448572
OBI: 106872368
LAK: 106169615
NVE: 5511716
EPA: 110251759
AMIL: 114964711
PDAM: 113678566
SPIS: 111340302
DGT: 114530725
HMG: 100211063
AQU: 100633933
PPP: 112286081
SLB: AWJ20_1054(EHD3)
NCR: NCU06448
NTE: NEUTE1DRAFT121907(NEUTE1DRAFT_121907)
SSCK: SPSK_09558
MBE: MBM_08197
ANG: ANI_1_378024(An02g02820)
ABE: ARB_06519
TVE: TRV_06208
CNE: CNI00240
CNB: CNBH0240
TASA: A1Q1_02505
LBC: LACBIDRAFT_234621(ECH-3)
ABP: AGABI1DRAFT112523(AGABI1DRAFT_112523)
ABV: AGABI2DRAFT192491(AGABI2DRAFT_192491)
MRT: MRET_2237
DFA: DFA_05297(echs1) DFA_08632
SMIN: v1.2.030139.t1(symbB.v1.2.030139.t1)
SPAR: SPRG_06729
 » show all
Reference
PMID:9073515
  Authors
Janssen U, Davis EM, Le Beau MM, Stoffel W
  Title
Human mitochondrial enoyl-CoA hydratase gene (ECHS1): structural organization and assignment to chromosome 10q26.2-q26.3.
  Journal
Genomics 40:470-5 (1997)
DOI:10.1006/geno.1996.4597
  Sequence
[hsa:1892]
LinkDB

KEGG   ORTHOLOGY: K14729
Entry
K14729                      KO                                     

Name
FOX2
Definition
multifunctional beta-oxidation protein [EC:4.2.1.- 1.1.1.-]
Pathway
ko00410  beta-Alanine metabolism
ko00640  Propanoate metabolism
ko01100  Metabolic pathways
ko01200  Carbon metabolism
Module
M00013  Malonate semialdehyde pathway, propanoyl-CoA => acetyl-CoA
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00640 Propanoate metabolism
    K14729  FOX2; multifunctional beta-oxidation protein
  09106 Metabolism of other amino acids
   00410 beta-Alanine metabolism
    K14729  FOX2; multifunctional beta-oxidation protein
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.1  Acting on the CH-OH group of donors
   1.1.1  With NAD+ or NADP+ as acceptor
    1.1.1.-  
     K14729  FOX2; multifunctional beta-oxidation protein
 4. Lyases
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.-  
     K14729  FOX2; multifunctional beta-oxidation protein
Other DBs
RN: R03045
COG: COG1028 COG2030
Genes
DSI: Dsimw501_GD19595(Dsim_GD19595)
AME: 724838
OBB: 114878274 114878275
SOC: 105208032
MPHA: 105834316 105834317
AEC: 105154611
ACEP: 105622498
PBAR: 105433932
VEM: 105570344
HST: 105191596 105191605
PCF: 106785155
DPA: 109535108
HAW: 110384310
TNL: 113503534
CLEC: 106667264
CSCU: 111629167
PCAN: 112554400
SCE: YKR009C(FOX2)
ERC: Ecym_7267
KMX: KLMA_70426(FOX2)
NCS: NCAS_0A04880(NCAS0A04880)
NDI: NDAI_0K01940(NDAI0K01940)
TPF: TPHA_0G03440(TPHA0G03440)
TBL: TBLA_0I00610(TBLA0I00610)
TDL: TDEL_0A02960(TDEL0A02960)
KAF: KAFR_0D03550(KAFR0D03550)
CAL: CAALFM_C300810CA(FOX2)
SLB: AWJ20_765(FOX2)
NCR: NCU08828(fox-2)
NTE: NEUTE1DRAFT116654(NEUTE1DRAFT_116654)
MGR: MGG_06148
SSCK: SPSK_01415
MAW: MAC_08073
MAJ: MAA_05113
CMT: CCM_04217
MBE: MBM_01704
ANI: AN7111.2
ANG: ANI_1_170124(An14g00990)
ABE: ARB_05825
TVE: TRV_00992
PTE: PTT_10630
CNE: CNF02530
CNB: CNBF2170
LBC: LACBIDRAFT_234865(MFP-1)
ABP: AGABI1DRAFT100749(AGABI1DRAFT_100749)
ABV: AGABI2DRAFT149505(AGABI2DRAFT_149505)
MGL: MGL_3316
MRT: MRET_2377
 » show all
Reference
PMID:1551874
  Authors
Hiltunen JK, Wenzel B, Beyer A, Erdmann R, Fossa A, Kunau WH
  Title
Peroxisomal multifunctional beta-oxidation protein of Saccharomyces cerevisiae. Molecular analysis of the fox2 gene and gene product.
  Journal
J Biol Chem 267:6646-53 (1992)
Reference
  Authors
Otzen C, Bardl B, Jacobsen ID, Nett M, Brock M
  Title
Candida albicans utilizes a modified beta-oxidation pathway for the degradation of toxic propionyl-CoA.
  Journal
J Biol Chem 289:8151-69 (2014)
DOI:10.1074/jbc.M113.517672
  Sequence
LinkDB

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