KEGG   ORTHOLOGY: K07532
Entry
K07532                      KO                                     

Name
ARHGEF12, LARG
Definition
Rho guanine nucleotide exchange factor 12
Pathway
ko04270  Vascular smooth muscle contraction
ko04360  Axon guidance
ko04361  Axon regeneration
ko04611  Platelet activation
ko04625  C-type lectin receptor signaling pathway
ko04810  Regulation of actin cytoskeleton
ko05130  Pathogenic Escherichia coli infection
ko05135  Yersinia infection
ko05152  Tuberculosis
ko05163  Human cytomegalovirus infection
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 09150 Organismal Systems
  09151 Immune system
   04611 Platelet activation
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   04625 C-type lectin receptor signaling pathway
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  09153 Circulatory system
   04270 Vascular smooth muscle contraction
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  09158 Development and regeneration
   04360 Axon guidance
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   04361 Axon regeneration
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   05205 Proteoglycans in cancer
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  09171 Infectious disease: bacterial
   05130 Pathogenic Escherichia coli infection
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   05135 Yersinia infection
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
   05152 Tuberculosis
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
  09172 Infectious disease: viral
   05163 Human cytomegalovirus infection
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
Membrane trafficking [BR:ko04131]
 Others
  Rho GTPase associated proteins
   Rho guanine nucleotide exchange factors (GEFs)
    K07532  ARHGEF12, LARG; Rho guanine nucleotide exchange factor 12
Other DBs
GO: 0005089
Genes
HSA: 23365(ARHGEF12)
PTR: 451618(ARHGEF12)
PPS: 100981550(ARHGEF12)
GGO: 101150763(ARHGEF12)
PON: 100457621(ARHGEF12)
NLE: 100602658(ARHGEF12)
MCC: 712096(ARHGEF12)
MCF: 102118758(ARHGEF12)
CSAB: 103248653(ARHGEF12)
RRO: 104657228(ARHGEF12)
RBB: 108528604(ARHGEF12)
CJC: 100411450(ARHGEF12)
SBQ: 101040423(ARHGEF12)
MMU: 69632(Arhgef12)
MCAL: 110301221(Arhgef12)
MPAH: 110327439(Arhgef12)
RNO: 367072(Arhgef12)
MUN: 110548553(Arhgef12)
CGE: 100765006(Arhgef12)
NGI: 103727935(Arhgef12)
CCAN: 109688211(Arhgef12)
OCU: 100340118(ARHGEF12)
TUP: 102469549(ARHGEF12)
CFA: 479409(ARHGEF12)
VVP: 112920313(ARHGEF12)
AML: 100471078(ARHGEF12)
UMR: 103662491(ARHGEF12)
UAH: 113259947(ARHGEF12)
ORO: 101372821(ARHGEF12)
ELK: 111153798
FCA: 101085657(ARHGEF12)
PTG: 102949630(ARHGEF12)
PPAD: 109278500(ARHGEF12)
AJU: 106974771(ARHGEF12)
BTA: 503575(ARHGEF12)
BOM: 102277776(ARHGEF12)
BIU: 109569536(ARHGEF12)
BBUB: 102397446(ARHGEF12)
CHX: 102179302(ARHGEF12)
OAS: 101117190(ARHGEF12)
SSC: 100523324(ARHGEF12)
CFR: 102524302(ARHGEF12)
CDK: 105090126(ARHGEF12)
BACU: 103002190(ARHGEF12)
LVE: 103083833(ARHGEF12)
OOR: 101272295(ARHGEF12)
DLE: 111167479(ARHGEF12)
PCAD: 102996900(ARHGEF12)
ECB: 100071503(ARHGEF12)
EPZ: 103546845(ARHGEF12)
EAI: 106842382(ARHGEF12)
MYB: 102243603(ARHGEF12)
MYD: 102761091(ARHGEF12)
MNA: 107533084(ARHGEF12)
HAI: 109393895(ARHGEF12)
DRO: 112312981(ARHGEF12)
PALE: 102879072(ARHGEF12)
RAY: 107513342(ARHGEF12)
MJV: 108396063(ARHGEF12)
LAV: 100661002(ARHGEF12)
TMU: 101358090
MDO: 100030904(ARHGEF12)
SHR: 100913854(ARHGEF12)
PCW: 110207237(ARHGEF12)
OAA: 100073922(ARHGEF12)
GGA: 419752(ARHGEF12)
MGP: 100548723(ARHGEF12)
CJO: 107324215(ARHGEF12)
NMEL: 110387798(ARHGEF12)
APLA: 101801214(ARHGEF12)
ACYG: 106039779(ARHGEF12)
TGU: 100222469(ARHGEF12)
LSR: 110477541(ARHGEF12)
SCAN: 103823048(ARHGEF12)
GFR: 102044369(ARHGEF12)
FAB: 101809691(ARHGEF12)
PHI: 102099232(ARHGEF12)
PMAJ: 107214410(ARHGEF12)
CCAE: 111939314(ARHGEF12)
CCW: 104692104(ARHGEF12)
ETL: 114066793(ARHGEF12)
FPG: 101920266(ARHGEF12)
FCH: 102057692(ARHGEF12)
CLV: 102085287(ARHGEF12)
EGZ: 104125926(ARHGEF12)
NNI: 104016617(ARHGEF12)
ACUN: 113488517(ARHGEF12)
PADL: 103922296(ARHGEF12)
AAM: 106487853(ARHGEF12)
ASN: 102372630(ARHGEF12)
AMJ: 102569441(ARHGEF12)
PSS: 102463682(ARHGEF12)
CMY: 102938930(ARHGEF12)
CPIC: 101932178(ARHGEF12)
ACS: 100566171(arhgef12)
PVT: 110078466(ARHGEF12)
PBI: 103067299(ARHGEF12)
PMUR: 107285540(ARHGEF12)
TSR: 106545978(ARHGEF12)
PMUA: 114585904(ARHGEF12)
GJA: 107108209(ARHGEF12)
XLA: 108696425(arhgef12.L) 398710(arhgef12.S)
XTR: 779951(arhgef12)
NPR: 108796163(ARHGEF12)
DRE: 562455(arhgef12a) 571031(arhgef12b)
CCAR: 109103913
IPU: 108260059
PHYP: 113531117
AMEX: 103030748(arhgef12)
EEE: 113580997(arhgef12)
TRU: 101078165(arhgef12)
LCO: 104918032(arhgef12)
MZE: 101464277(arhgef12)
ONL: 100699405(arhgef12)
OLA: 101169798(arhgef12)
XMA: 102235138(arhgef12)
XCO: 114161924(arhgef12)
PRET: 103476288
CVG: 107088318(arhgef12)
NFU: 107380349(arhgef12)
KMR: 108243522(arhgef12)
ALIM: 106515458(arhgef12)
AOCE: 111576229
CSEM: 103378423(arhgef12) 103395343
POV: 109630279
LCF: 108886392(arhgef12)
SDU: 111228040(arhgef12)
SLAL: 111652622(arhgef12)
HCQ: 109526407(arhgef12)
BPEC: 110154066(arhgef12)
MALB: 109960212(arhgef12)
SFM: 108936187(arhgef12)
PKI: 111846252(arhgef12)
LCM: 102353846(ARHGEF12)
CMK: 103190752
RTP: 109910615(arhgef12)
BFO: 118420976
SPU: 576882
APLC: 110989335
SKO: 100374488
DME: Dmel_CG9635(RhoGEF2)
DER: 6548163
DSE: 6609537
DSI: Dsimw501_GD11240(Dsim_GD11240)
DAN: 6494294
DSR: 110181167
DPE: 6590830
DMN: 108159292
DWI: 6640155
DAZ: 108617010
DNV: 108652930
DHE: 111599722
DVI: 6635406
MDE: 101890835
AAG: 5577203
AME: 410127
BIM: 100745717
BTER: 100644321
CCAL: 108627563
OBB: 114870954
SOC: 105193747
MPHA: 105834570
AEC: 105155064
ACEP: 105622945
VEM: 105558344
DQU: 106746314
CFO: 105251006
LHU: 105670701
PGC: 109855783
OBO: 105276513
PCF: 106792462
NVI: 100124202
CSOL: 105361613
MDL: 103576614
TCA: 656249
DPA: 109534322
NVL: 108568340
BMOR: 101742925
BMAN: 114247845
HAW: 110379761
DNX: 107165164
AGS: 114129304
RMD: 113556838
BTAB: 109039735
CLEC: 106666708
ZNE: 110828140
FCD: 110844861
PVM: 113804129
TUT: 107359640
DPTE: 113798594
CEL: CELE_F13E6.6(rhgf-1)
CBR: CBG04522(Cbr-rhgf-1)
BMY: Bm1_27245
TSP: Tsp_00331
PCAN: 112567754
CRG: 105330610
MYI: 110465684
OBI: 106875720
SHX: MS3_02253
EGL: EGR_02095
NVE: 5504909
EPA: 110251207
ADF: 107329530
AMIL: 114954433
PDAM: 113665708
SPIS: 111343037
HMG: 100206897
AQU: 100636411
 » show all
Reference
  Authors
Kourlas PJ, Strout MP, Becknell B, Veronese ML, Croce CM, Theil KS, Krahe R, Ruutu T, Knuutila S, Bloomfield CD, Caligiuri MA
  Title
Identification of a gene at 11q23 encoding a guanine nucleotide exchange factor: evidence for its fusion with MLL in acute myeloid leukemia.
  Journal
Proc Natl Acad Sci U S A 97:2145-50 (2000)
DOI:10.1073/pnas.040569197
  Sequence
[hsa:23365]
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