KEGG   ORTHOLOGY: K07828Help
Entry
K07828                      KO                                     

Name
NRAS
Definition
GTPase NRas
Pathway
ko01521  EGFR tyrosine kinase inhibitor resistance
ko01522  Endocrine resistance
ko04010  MAPK signaling pathway
ko04012  ErbB signaling pathway
ko04014  Ras signaling pathway
ko04015  Rap1 signaling pathway
ko04062  Chemokine signaling pathway
ko04068  FoxO signaling pathway
ko04071  Sphingolipid signaling pathway
ko04072  Phospholipase D signaling pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04150  mTOR signaling pathway
ko04151  PI3K-Akt signaling pathway
ko04210  Apoptosis
ko04211  Longevity regulating pathway
ko04213  Longevity regulating pathway - multiple species
ko04218  Cellular senescence
ko04360  Axon guidance
ko04370  VEGF signaling pathway
ko04371  Apelin signaling pathway
ko04540  Gap junction
ko04550  Signaling pathways regulating pluripotency of stem cells
ko04625  C-type lectin receptor signaling pathway
ko04650  Natural killer cell mediated cytotoxicity
ko04660  T cell receptor signaling pathway
ko04662  B cell receptor signaling pathway
ko04664  Fc epsilon RI signaling pathway
ko04714  Thermogenesis
ko04720  Long-term potentiation
ko04722  Neurotrophin signaling pathway
ko04725  Cholinergic synapse
ko04726  Serotonergic synapse
ko04730  Long-term depression
ko04810  Regulation of actin cytoskeleton
ko04910  Insulin signaling pathway
ko04912  GnRH signaling pathway
ko04915  Estrogen signaling pathway
ko04916  Melanogenesis
ko04917  Prolactin signaling pathway
ko04919  Thyroid hormone signaling pathway
ko04921  Oxytocin signaling pathway
ko04926  Relaxin signaling pathway
ko04933  AGE-RAGE signaling pathway in diabetic complications
ko05034  Alcoholism
ko05160  Hepatitis C
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05167  Kaposi sarcoma-associated herpesvirus infection
ko05170  Human immunodeficiency virus 1 infection
ko05200  Pathways in cancer
ko05203  Viral carcinogenesis
ko05205  Proteoglycans in cancer
ko05206  MicroRNAs in cancer
ko05210  Colorectal cancer
ko05211  Renal cell carcinoma
ko05213  Endometrial cancer
ko05214  Glioma
ko05215  Prostate cancer
ko05216  Thyroid cancer
ko05218  Melanoma
ko05219  Bladder cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
ko05223  Non-small cell lung cancer
ko05224  Breast cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
ko05230  Central carbon metabolism in cancer
ko05231  Choline metabolism in cancer
ko05235  PD-L1 expression and PD-1 checkpoint pathway in cancer
Disease
H00003  Acute myeloid leukemia
H00010  Multiple myeloma
H00016  Oral cancer
H00018  Gastric cancer
H00032  Thyroid cancer
H00033  Adrenal carcinoma
H00038  Melanoma
H00108  Autoimmune lymphoproliferative syndromes
H00523  Noonan syndrome and related disorders
H01481  Myelodysplastic syndrome
H01666  Angiosarcoma
H01738  Noonan syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04014 Ras signaling pathway
    K07828  NRAS; GTPase NRas
   04015 Rap1 signaling pathway
    K07828  NRAS; GTPase NRas
   04010 MAPK signaling pathway
    K07828  NRAS; GTPase NRas
   04012 ErbB signaling pathway
    K07828  NRAS; GTPase NRas
   04370 VEGF signaling pathway
    K07828  NRAS; GTPase NRas
   04371 Apelin signaling pathway
    K07828  NRAS; GTPase NRas
   04068 FoxO signaling pathway
    K07828  NRAS; GTPase NRas
   04072 Phospholipase D signaling pathway
    K07828  NRAS; GTPase NRas
   04071 Sphingolipid signaling pathway
    K07828  NRAS; GTPase NRas
   04151 PI3K-Akt signaling pathway
    K07828  NRAS; GTPase NRas
   04150 mTOR signaling pathway
    K07828  NRAS; GTPase NRas
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K07828  NRAS; GTPase NRas
   04137 Mitophagy - animal
    K07828  NRAS; GTPase NRas
  09143 Cell growth and death
   04210 Apoptosis
    K07828  NRAS; GTPase NRas
   04218 Cellular senescence
    K07828  NRAS; GTPase NRas
  09144 Cellular community - eukaryotes
   04540 Gap junction
    K07828  NRAS; GTPase NRas
   04550 Signaling pathways regulating pluripotency of stem cells
    K07828  NRAS; GTPase NRas
  09142 Cell motility
   04810 Regulation of actin cytoskeleton
    K07828  NRAS; GTPase NRas
 09150 Organismal Systems
  09151 Immune system
   04625 C-type lectin receptor signaling pathway
    K07828  NRAS; GTPase NRas
   04650 Natural killer cell mediated cytotoxicity
    K07828  NRAS; GTPase NRas
   04660 T cell receptor signaling pathway
    K07828  NRAS; GTPase NRas
   04662 B cell receptor signaling pathway
    K07828  NRAS; GTPase NRas
   04664 Fc epsilon RI signaling pathway
    K07828  NRAS; GTPase NRas
   04062 Chemokine signaling pathway
    K07828  NRAS; GTPase NRas
  09152 Endocrine system
   04910 Insulin signaling pathway
    K07828  NRAS; GTPase NRas
   04912 GnRH signaling pathway
    K07828  NRAS; GTPase NRas
   04915 Estrogen signaling pathway
    K07828  NRAS; GTPase NRas
   04917 Prolactin signaling pathway
    K07828  NRAS; GTPase NRas
   04921 Oxytocin signaling pathway
    K07828  NRAS; GTPase NRas
   04926 Relaxin signaling pathway
    K07828  NRAS; GTPase NRas
   04919 Thyroid hormone signaling pathway
    K07828  NRAS; GTPase NRas
   04916 Melanogenesis
    K07828  NRAS; GTPase NRas
  09156 Nervous system
   04725 Cholinergic synapse
    K07828  NRAS; GTPase NRas
   04726 Serotonergic synapse
    K07828  NRAS; GTPase NRas
   04720 Long-term potentiation
    K07828  NRAS; GTPase NRas
   04730 Long-term depression
    K07828  NRAS; GTPase NRas
   04722 Neurotrophin signaling pathway
    K07828  NRAS; GTPase NRas
  09158 Development
   04360 Axon guidance
    K07828  NRAS; GTPase NRas
  09149 Aging
   04211 Longevity regulating pathway
    K07828  NRAS; GTPase NRas
   04213 Longevity regulating pathway - multiple species
    K07828  NRAS; GTPase NRas
  09159 Environmental adaptation
   04714 Thermogenesis
    K07828  NRAS; GTPase NRas
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K07828  NRAS; GTPase NRas
   05206 MicroRNAs in cancer
    K07828  NRAS; GTPase NRas
   05205 Proteoglycans in cancer
    K07828  NRAS; GTPase NRas
   05203 Viral carcinogenesis
    K07828  NRAS; GTPase NRas
   05230 Central carbon metabolism in cancer
    K07828  NRAS; GTPase NRas
   05231 Choline metabolism in cancer
    K07828  NRAS; GTPase NRas
   05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
    K07828  NRAS; GTPase NRas
  09162 Cancer: specific types
   05210 Colorectal cancer
    K07828  NRAS; GTPase NRas
   05225 Hepatocellular carcinoma
    K07828  NRAS; GTPase NRas
   05226 Gastric cancer
    K07828  NRAS; GTPase NRas
   05214 Glioma
    K07828  NRAS; GTPase NRas
   05216 Thyroid cancer
    K07828  NRAS; GTPase NRas
   05221 Acute myeloid leukemia
    K07828  NRAS; GTPase NRas
   05220 Chronic myeloid leukemia
    K07828  NRAS; GTPase NRas
   05218 Melanoma
    K07828  NRAS; GTPase NRas
   05211 Renal cell carcinoma
    K07828  NRAS; GTPase NRas
   05219 Bladder cancer
    K07828  NRAS; GTPase NRas
   05215 Prostate cancer
    K07828  NRAS; GTPase NRas
   05213 Endometrial cancer
    K07828  NRAS; GTPase NRas
   05224 Breast cancer
    K07828  NRAS; GTPase NRas
   05223 Non-small cell lung cancer
    K07828  NRAS; GTPase NRas
  09165 Substance dependence
   05034 Alcoholism
    K07828  NRAS; GTPase NRas
  09167 Endocrine and metabolic disease
   04933 AGE-RAGE signaling pathway in diabetic complications
    K07828  NRAS; GTPase NRas
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K07828  NRAS; GTPase NRas
   05170 Human immunodeficiency virus 1 infection
    K07828  NRAS; GTPase NRas
   05161 Hepatitis B
    K07828  NRAS; GTPase NRas
   05160 Hepatitis C
    K07828  NRAS; GTPase NRas
   05163 Human cytomegalovirus infection
    K07828  NRAS; GTPase NRas
   05167 Kaposi sarcoma-associated herpesvirus infection
    K07828  NRAS; GTPase NRas
   05165 Human papillomavirus infection
    K07828  NRAS; GTPase NRas
  09176 Drug resistance: antineoplastic
   01521 EGFR tyrosine kinase inhibitor resistance
    K07828  NRAS; GTPase NRas
   01522 Endocrine resistance
    K07828  NRAS; GTPase NRas
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K07828  NRAS; GTPase NRas
  09183 Protein families: signaling and cellular processes
   04147 Exosome
    K07828  NRAS; GTPase NRas
   04031 GTP-binding proteins
    K07828  NRAS; GTPase NRas
Membrane trafficking [BR:ko04131]
 Endocytosis
  Macropinocytosis
   Ras GTPases
    K07828  NRAS; GTPase NRas
Exosome [BR:ko04147]
 Exosomal proteins
  Exosomal proteins of haemopoietic cells  (B-cell, T-cell, DC-cell, reticulocyte, and mast cell)
   K07828  NRAS; GTPase NRas
  Exosomal proteins of other body fluids (saliva and urine)
   K07828  NRAS; GTPase NRas
  Exosomal proteins of breast cancer cells
   K07828  NRAS; GTPase NRas
  Exosomal proteins of colorectal cancer cells
   K07828  NRAS; GTPase NRas
GTP-binding proteins [BR:ko04031]
 Small (Monomeric) G-proteins
  Ras Family
   Ras [OT]
    K07828  NRAS; GTPase NRas
BRITE hierarchy
Genes
HSA: 4893(NRAS)
PTR: 742713(NRAS)
PPS: 100970465(NRAS)
GGO: 101146562(NRAS)
PON: 100174317(NRAS)
NLE: 100592103(NRAS)
MCC: 709089(NRAS)
MCF: 102137913(NRAS)
CSAB: 103224167(NRAS)
RRO: 104669078(NRAS)
RBB: 108528122(NRAS)
CJC: 100414782(NRAS)
SBQ: 101036877(NRAS)
MMU: 18176(Nras)
MCAL: 110290873(Nras)
MPAH: 110320340(Nras)
RNO: 24605(Nras)
MUN: 110544642 110558448(Nras)
CGE: 100757614(Nras)
NGI: 103734938(Nras)
HGL: 101719269(Nras)
CCAN: 109696062(Nras)
OCU: 100344241(NRAS)
TUP: 102496534(NRAS)
CFA: 403872(NRAS)
VVP: 112916766(NRAS)
AML: 100464196(NRAS)
UMR: 103669422(NRAS)
UAH: 113244394(NRAS)
ORO: 101363525(NRAS)
FCA: 751105(NRAS)
PTG: 102952980(NRAS)
AJU: 106969596(NRAS)
BTA: 506322(NRAS)
BOM: 102269203(NRAS)
BIU: 109555890(NRAS)
BBUB: 102399487(NRAS)
PHD: 102316943(NRAS)
CHX: 102187180(NRAS)
OAS: 101102438(NRAS)
SSC: 100739349(NRAS)
CFR: 102509562(NRAS)
CDK: 105089630(NRAS)
BACU: 103004931(NRAS)
LVE: 103068734(NRAS)
OOR: 101276138(NRAS)
DLE: 111179996(NRAS)
ECB: 100059469(NRAS)
EPZ: 103552675(NRAS)
EAI: 106835678(NRAS)
MYB: 102247606(NRAS)
MYD: 102761492(NRAS)
MNA: 107545303(NRAS)
HAI: 109377015(NRAS)
RSS: 109446693(NRAS)
DRO: 112313707(NRAS)
PALE: 102885950(NRAS)
LAV: 100659051(NRAS)
TMU: 101344230
MDO: 554197(NRAS)
SHR: 100928986(NRAS)
OAA: 100074671(NRAS)
GGA: 419885(NRAS)
MGP: 104914532(NRAS)
CJO: 107324818(NRAS)
APLA: 101804733(NRAS)
ACYG: 106041320(NRAS)
TGU: 100222058(NRAS)
LSR: 110473049(NRAS)
SCAN: 103822405(NRAS)
GFR: 102039955(NRAS)
FAB: 101813585(NRAS)
PHI: 102110285(NRAS)
PMAJ: 107214761(NRAS)
CCAE: 111939625(NRAS)
CCW: 104692410(NRAS)
ETL: 114064402(NRAS)
FPG: 101921486(NRAS)
FCH: 102054942(NRAS)
CLV: 102098728(NRAS)
EGZ: 104126779(NRAS)
NNI: 104010364(NRAS)
ACUN: 113488912(NRAS)
AAM: 106485268(NRAS)
ASN: 102382019(NRAS)
AMJ: 102566357(NRAS)
PSS: 102447991(NRAS)
CMY: 102933328(NRAS)
CPIC: 101949923(NRAS)
ACS: 100565176(nras)
PVT: 110072322(NRAS)
PBI: 103066291(NRAS)
PMUR: 107284053(NRAS)
XLA: 399446(nras.L)
XTR: 549517(nras)
NPR: 108799544(NRAS)
DRE: 30380(nras)
IPU: 100305071(nras)
PHYP: 113535014(nras)
AMEX: 103039914(nras)
EEE: 113577375(nras)
SFM: 108928283(nras)
PKI: 111853914(nras)
LCM: 102361045(NRAS)
CMK: 103189723(nras)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:6616621
  Authors
Taparowsky E, Shimizu K, Goldfarb M, Wigler M
  Title
Structure and activation of the human N-ras gene.
  Journal
Cell 34:581-6 (1983)
DOI:10.1016/0092-8674(83)90390-2
  Sequence
[hsa:4893]
Reference
  Authors
Kwong LN, Costello JC, Liu H, Jiang S, Helms TL, Langsdorf AE, Jakubosky D, Genovese G, Muller FL, Jeong JH, Bender RP, Chu GC, Flaherty KT, Wargo JA, Collins JJ, Chin L
  Title
Oncogenic NRAS signaling differentially regulates survival and proliferation in melanoma.
  Journal
Nat Med 18:1503-10 (2012)
DOI:10.1038/nm.2941
Reference
  Authors
Eisfeld AK, Schwind S, Hoag KW, Walker CJ, Liyanarachchi S, Patel R, Huang X, Markowitz J, Duan W, Otterson GA, Carson WE 3rd, Marcucci G, Bloomfield CD, de la Chapelle A
  Title
NRAS isoforms differentially affect downstream pathways, cell growth, and cell transformation.
  Journal
Proc Natl Acad Sci U S A 111:4179-84 (2014)
DOI:10.1073/pnas.1401727111
  Sequence
[hsa:4893]
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