KEGG   ORTHOLOGY: K08014
Entry
K08014                      KO                                     

Name
RAPGEF3, EPAC1
Definition
Rap guanine nucleotide exchange factor 3
Pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04670  Leukocyte transendothelial migration
ko04720  Long-term potentiation
ko04726  Serotonergic synapse
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04072 Phospholipase D signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04024 cAMP signaling pathway
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
  09156 Nervous system
   04726 Serotonergic synapse
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
   04720 Long-term potentiation
    K08014  RAPGEF3, EPAC1; Rap guanine nucleotide exchange factor 3
Genes
HSA: 10411(RAPGEF3)
PTR: 467198(RAPGEF3)
PPS: 100979763(RAPGEF3)
GGO: 101153785(RAPGEF3)
PON: 100174087(RAPGEF3)
NLE: 100592347(RAPGEF3)
MCC: 703967(RAPGEF3)
MCF: 101865707(RAPGEF3)
CSAB: 103238211(RAPGEF3)
RRO: 104654834(RAPGEF3)
RBB: 108515949(RAPGEF3)
CJC: 100399583(RAPGEF3)
SBQ: 101043933(RAPGEF3)
MMU: 223864(Rapgef3)
MCAL: 110310170(Rapgef3)
MPAH: 110334708(Rapgef3)
RNO: 59326(Rapgef3)
MUN: 110546167(Rapgef3)
CGE: 100767619(Rapgef3)
NGI: 103740631(Rapgef3)
HGL: 101711127(Rapgef3)
CCAN: 109691611(Rapgef3)
OCU: 100356363(RAPGEF3)
TUP: 102502265(RAPGEF3)
CFA: 486591(RAPGEF3)
VVP: 112921075(RAPGEF3)
AML: 100473947(RAPGEF3)
UMR: 103675595(RAPGEF3)
UAH: 113257686(RAPGEF3)
ORO: 101371953(RAPGEF3)
ELK: 111157928
FCA: 101085387(RAPGEF3)
PTG: 102966186(RAPGEF3)
PPAD: 109249020(RAPGEF3)
AJU: 106969310(RAPGEF3)
BTA: 535383(RAPGEF3)
BOM: 102282215(RAPGEF3)
BIU: 109559177(RAPGEF3)
BBUB: 102407658(RAPGEF3)
CHX: 102178145(RAPGEF3)
OAS: 101109786(RAPGEF3)
SSC: 100620989(RAPGEF3)
CFR: 102524040(RAPGEF3)
CDK: 105103807(RAPGEF3)
BACU: 103005728(RAPGEF3)
LVE: 103080613(RAPGEF3)
OOR: 101278657(RAPGEF3)
DLE: 111174075(RAPGEF3)
PCAD: 102987186
ECB: 100050541(RAPGEF3)
EPZ: 103546793(RAPGEF3)
EAI: 106836844(RAPGEF3)
MYB: 102257237(RAPGEF3)
MYD: 102768579(RAPGEF3)
MNA: 107528219(RAPGEF3)
HAI: 109372517
DRO: 112318292(RAPGEF3)
PALE: 102895678(RAPGEF3)
RAY: 107499884(RAPGEF3)
MJV: 108392459(RAPGEF3)
LAV: 100655802(RAPGEF3)
TMU: 101344659
SHR: 100925807(RAPGEF3)
PCW: 110201486(RAPGEF3)
OAA: 100680839(RAPGEF3)
GGA: 426888(RAPGEF3)
MGP: 100539538(RAPGEF3)
CJO: 107325717(RAPGEF3)
NMEL: 110389221(RAPGEF3)
APLA: 101791788
ACYG: 106047705(RAPGEF3)
TGU: 115491504(RAPGEF3)
LSR: 110481646(RAPGEF3)
SCAN: 115483875
GFR: 102039560(RAPGEF3)
FAB: 101814980(RAPGEF3)
PHI: 102110109(RAPGEF3)
PMAJ: 107198895
FPG: 101924930(RAPGEF3)
FCH: 102048878(RAPGEF3)
CLV: 102094087(RAPGEF3)
EGZ: 104132693(RAPGEF3)
NNI: 104011982(RAPGEF3)
ACUN: 113491036(RAPGEF3)
PADL: 103914893(RAPGEF3)
AAM: 106485098(RAPGEF3)
ASN: 102381678(RAPGEF3)
AMJ: 102574517(RAPGEF3)
PSS: 102443863(RAPGEF3)
CMY: 102939607
CPIC: 101931835(RAPGEF3)
ACS: 100560594(rapgef3)
PVT: 110071318(RAPGEF3)
PBI: 103063904(RAPGEF3)
PMUR: 107288970(RAPGEF3)
TSR: 106556124
PMUA: 114592897(RAPGEF3)
GJA: 107109551(RAPGEF3)
XLA: 108708626(rapgef3.L) 108709885(Epac) 733186(rapgef3.S)
XTR: 100491495(rapgef3)
NPR: 108800976(RAPGEF3)
DRE: 101886094(rapgef3)
IPU: 108275659
PHYP: 113530617
AMEX: 103025506
EEE: 113576412(rapgef3)
TRU: 101068679
LCO: 104919939
MZE: 101480994
ONL: 100711715
OLA: 101158525
XMA: 102222768
XCO: 114140440
PRET: 103467797
CVG: 107091899
NFU: 107390402
KMR: 108237632
ALIM: 106522985
AOCE: 111581117
CSEM: 103385263
POV: 109643141
LCF: 108886373
SDU: 111235101
SLAL: 111661896
HCQ: 109513787(rapgef3)
BPEC: 110164588
MALB: 109970308
ELS: 105022286
SFM: 108939388
PKI: 111840326(rapgef3)
 » show all
Reference
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:10411]
LinkDB

KEGG   ORTHOLOGY: K04351
Entry
K04351                      KO                                     

Name
RAPGEF4, EPAC2
Definition
Rap guanine nucleotide exchange factor 4
Pathway
ko04015  Rap1 signaling pathway
ko04024  cAMP signaling pathway
ko04072  Phospholipase D signaling pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04670  Leukocyte transendothelial migration
ko04911  Insulin secretion
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04072 Phospholipase D signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
   04024 cAMP signaling pathway
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
 09150 Organismal Systems
  09151 Immune system
   04670 Leukocyte transendothelial migration
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09152 Endocrine system
   04911 Insulin secretion
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Membrane trafficking [BR:ko04131]
 Endoplasmic reticulum (ER) - Golgi transport
  Forward pathways
   Rab associated proteins
    K04351  RAPGEF4, EPAC2; Rap guanine nucleotide exchange factor 4
Genes
HSA: 11069(RAPGEF4)
PTR: 459744(RAPGEF4)
PPS: 100995002(RAPGEF4)
GGO: 101151388(RAPGEF4)
PON: 100189911(RAPGEF4)
NLE: 100602878(RAPGEF4)
MCC: 698148(RAPGEF4)
MCF: 101865166(RAPGEF4)
CSAB: 103217330(RAPGEF4)
RRO: 104673512(RAPGEF4)
RBB: 108518542(RAPGEF4)
CJC: 100401754(RAPGEF4)
SBQ: 101043595(RAPGEF4)
MMU: 56508(Rapgef4)
MCAL: 110289761(Rapgef4)
MPAH: 110318780(Rapgef4)
RNO: 252857(Rapgef4)
CGE: 100774346
NGI: 103751742(Rapgef4)
HGL: 101706913(Rapgef4)
CCAN: 109687932(Rapgef4)
OCU: 100348394(RAPGEF4)
TUP: 102485451(RAPGEF4)
CFA: 488402(RAPGEF4)
VVP: 112916400(RAPGEF4)
AML: 100480097(RAPGEF4)
UMR: 103659569
UAH: 113250770(RAPGEF4)
ORO: 101382059(RAPGEF4)
ELK: 111158917
FCA: 101092955(RAPGEF4)
PTG: 102959994(RAPGEF4)
PPAD: 109273039
AJU: 106987935(RAPGEF4)
BTA: 537312(RAPGEF4)
BOM: 102264805(RAPGEF4)
BIU: 109566435(RAPGEF4)
BBUB: 102396497(RAPGEF4)
CHX: 102184383(RAPGEF4)
OAS: 101112196(RAPGEF4)
SSC: 100511786(RAPGEF4)
CFR: 102519185(RAPGEF4)
CDK: 105091096(RAPGEF4)
BACU: 103018315(RAPGEF4)
LVE: 103078675(RAPGEF4)
OOR: 101271995(RAPGEF4)
DLE: 111172871(RAPGEF4)
PCAD: 102985646(RAPGEF4)
ECB: 100064121(RAPGEF4)
EPZ: 103559592(RAPGEF4)
EAI: 106834741(RAPGEF4)
MYB: 102262528(RAPGEF4)
MYD: 102765492(RAPGEF4)
MNA: 107531114(RAPGEF4)
HAI: 109388735(RAPGEF4)
DRO: 112305728(RAPGEF4)
PALE: 102884268
RAY: 107505164(RAPGEF4)
MJV: 108395539(RAPGEF4)
LAV: 100660747(RAPGEF4)
TMU: 101341572
MDO: 100025283(RAPGEF4)
SHR: 100933298(RAPGEF4)
PCW: 110211578(RAPGEF4)
OAA: 100084234(RAPGEF4)
GGA: 429022(RAPGEF4)
CJO: 107316695(RAPGEF4)
NMEL: 110399900(RAPGEF4)
APLA: 101803499(RAPGEF4)
ACYG: 106029998(RAPGEF4)
TGU: 100231316(RAPGEF4)
LSR: 110482918(RAPGEF4)
SCAN: 103814439(RAPGEF4)
GFR: 102033413(RAPGEF4)
FAB: 101808736(RAPGEF4)
PHI: 102102247(RAPGEF4)
PMAJ: 107207670(RAPGEF4)
CCAE: 111932077(RAPGEF4)
CCW: 104693870(RAPGEF4)
ETL: 114054913(RAPGEF4)
FPG: 101910581(RAPGEF4)
FCH: 102051155(RAPGEF4)
CLV: 102085464(RAPGEF4)
EGZ: 104128060(RAPGEF4)
NNI: 104010004(RAPGEF4)
ACUN: 113482011(RAPGEF4)
PADL: 103924207(RAPGEF4)
AAM: 106499302(RAPGEF4)
ASN: 102376494(RAPGEF4)
AMJ: 102568614(RAPGEF4)
PSS: 102444117(RAPGEF4)
CMY: 102944298(RAPGEF4)
CPIC: 101939565(RAPGEF4)
ACS: 100567156(rapgef4)
PVT: 110088585(RAPGEF4)
PBI: 103053910(RAPGEF4)
PMUR: 107290439(RAPGEF4)
TSR: 106551336(RAPGEF4)
PMUA: 114606886(RAPGEF4)
GJA: 107107055(RAPGEF4)
XLA: 108701373(rapgef4.L) 108702995(rapgef4.S)
XTR: 100497690(rapgef4)
NPR: 108800352(RAPGEF4)
DRE: 559170(rapgef4)
IPU: 108266644(rapgef4)
PHYP: 113525881(rapgef4)
AMEX: 103032232 103034068(rapgef4)
EEE: 113580024 113588392(rapgef4)
TRU: 101065114(rapgef4) 101070245
LCO: 104927784(rapgef4) 104932605
ONL: 100689894 100695746(rapgef4)
XMA: 102217330 102228535(rapgef4)
CVG: 107085744 107091853(rapgef4)
NFU: 107384114 107390013(rapgef4)
KMR: 108239540 108239698(rapgef4)
LCF: 108883636 108888702(rapgef4)
SDU: 111218206(rapgef4) 111228847
SLAL: 111668523(rapgef4) 111671130
HCQ: 109507461 109507910(rapgef4)
BPEC: 110166573(rapgef4) 110173508
MALB: 109958072(rapgef4) 109969253
ELS: 105007217 105016205(rapgef4)
SFM: 108920347 108920713(rapgef4)
LCM: 102366727(RAPGEF4)
CMK: 103176454(rapgef4)
RTP: 109921268
BFO: 118424000
CIN: 100186896
SPU: 579050
APLC: 110973481
SKO: 100373735
DME: Dmel_CG34392(Epac)
DER: 6540983
DSI: Dsimw501_GD10302(Dsim_GD10302)
DSR: 110189781
DPE: 6590280
DMN: 108160374
DWI: 6643336
DAZ: 108614880
DNV: 108653799
DHE: 111601122
MDE: 101899941
LCQ: 111681708
AAG: 5573236
AALB: 109423294
TCA: 661613
DPA: 109539619
ATD: 109609621
NVL: 108564753
API: 100162065
DNX: 107163321
AGS: 114131920
RMD: 113551411
BTAB: 109044228
CLEC: 106668425
ZNE: 110836465
FCD: 110846921
PVM: 113819322
TUT: 107363025
DPTE: 113792243
CSCU: 111621959
PTEP: 107457381
CEL: CELE_T20G5.5(epac-1)
CBR: CBG09801(Cbr-epac-1)
BMY: Bm1_41585
TSP: Tsp_01532
PCAN: 112564521
CRG: 105320113
MYI: 110442375
OBI: 106867327
SHX: MS3_00093
NVE: 5508916
EPA: 110238364
ADF: 107350554
AMIL: 114946958
PDAM: 113675988
SPIS: 111323510
DGT: 114538354
AQU: 100638923
 » show all
Reference
  Authors
Gloerich M, Bos JL
  Title
Epac: defining a new mechanism for cAMP action.
  Journal
Annu Rev Pharmacol Toxicol 50:355-75 (2010)
DOI:10.1146/annurev.pharmtox.010909.105714
Reference
PMID:9856955
  Authors
Kawasaki H, Springett GM, Mochizuki N, Toki S, Nakaya M, Matsuda M, Housman DE, Graybiel AM
  Title
A family of cAMP-binding proteins that directly activate Rap1.
  Journal
Science 282:2275-9 (1998)
DOI:10.1126/science.282.5397.2275
  Sequence
[hsa:11069]
LinkDB

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