KEGG   ORTHOLOGY: K08018
Entry
K08018                      KO                                     

Name
RAPGEF2, PDZGEF1
Definition
Rap guanine nucleotide exchange factor 2
Pathway
ko04010  MAPK signaling pathway
ko04015  Rap1 signaling pathway
ko04530  Tight junction
Disease
H02213  Familial adult myoclonic epilepsy
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04010 MAPK signaling pathway
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
   04015 Rap1 signaling pathway
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08018  RAPGEF2, PDZGEF1; Rap guanine nucleotide exchange factor 2
Genes
HSA: 9693(RAPGEF2)
PTR: 461577(RAPGEF2)
PPS: 100972977(RAPGEF2)
GGO: 101154294(RAPGEF2)
PON: 100444094(RAPGEF2)
NLE: 100594311(RAPGEF2)
MCC: 704717(RAPGEF2)
MCF: 102145680(RAPGEF2)
CSAB: 103236456(RAPGEF2)
RRO: 104677918(RAPGEF2)
RBB: 108520366
CJC: 100388886(RAPGEF2)
SBQ: 101033151(RAPGEF2)
MMU: 76089(Rapgef2)
MCAL: 110290848(Rapgef2)
RNO: 310533(Rapgef2)
CGE: 100754995(Rapgef2)
NGI: 103751016(Rapgef2)
HGL: 101718791(Rapgef2)
CCAN: 109689106
OCU: 100346752(RAPGEF2)
TUP: 102476593(RAPGEF2)
CFA: 100856359(RAPGEF2)
VVP: 112926924(RAPGEF2)
AML: 100484273(RAPGEF2)
UMR: 103658068(RAPGEF2)
UAH: 113255808(RAPGEF2)
ORO: 101373494(RAPGEF2)
ELK: 111155074
FCA: 101084954(RAPGEF2)
PTG: 102950679(RAPGEF2)
PPAD: 109262464(RAPGEF2)
AJU: 106967455(RAPGEF2)
BTA: 100139484(RAPGEF2)
BOM: 102275520(RAPGEF2)
BIU: 109571167(RAPGEF2)
BBUB: 102405471(RAPGEF2)
CHX: 102187973(RAPGEF2)
OAS: 101111578(RAPGEF2)
SSC: 100517409(RAPGEF2)
CFR: 102510135(RAPGEF2)
CDK: 105094767(RAPGEF2)
BACU: 103005459
LVE: 103076487(RAPGEF2)
OOR: 101274731(RAPGEF2)
DLE: 111179022(RAPGEF2)
PCAD: 102982227(RAPGEF2)
ECB: 100069003(RAPGEF2)
EPZ: 103545519(RAPGEF2)
EAI: 106823789(RAPGEF2)
MYB: 102244394(RAPGEF2)
MYD: 102762387(RAPGEF2)
MNA: 107527478(RAPGEF2)
HAI: 109395998(RAPGEF2)
DRO: 112312369(RAPGEF2)
PALE: 102879764(RAPGEF2)
RAY: 107511410(RAPGEF2)
MJV: 108392300(RAPGEF2)
LAV: 100670174(RAPGEF2)
TMU: 101340649
MDO: 100023159(RAPGEF2)
SHR: 100923893(RAPGEF2)
PCW: 110196451(RAPGEF2)
OAA: 100079239(RAPGEF2)
GGA: 422418(RAPGEF2)
MGP: 100549357(RAPGEF2)
CJO: 107313022(RAPGEF2)
NMEL: 110398765(RAPGEF2)
APLA: 101802476(RAPGEF2)
ACYG: 106032300
TGU: 100224541(RAPGEF2)
LSR: 110473752(RAPGEF2)
SCAN: 103825944(RAPGEF2)
GFR: 102042003(RAPGEF2)
FAB: 101805788(RAPGEF2)
PHI: 102109398(RAPGEF2)
PMAJ: 107203090(RAPGEF2)
CCAE: 111927874(RAPGEF2)
CCW: 104697194(RAPGEF2)
ETL: 114057051(RAPGEF2)
FPG: 101920342(RAPGEF2)
FCH: 102060194(RAPGEF2)
CLV: 102086538(RAPGEF2)
EGZ: 104124157(RAPGEF2)
NNI: 104021249(RAPGEF2)
ACUN: 113479525(RAPGEF2)
PADL: 103917939(RAPGEF2)
AAM: 106491974
ASN: 102382228(RAPGEF2)
AMJ: 102563879(RAPGEF2)
PSS: 102457114(RAPGEF2)
CMY: 102941224(RAPGEF2)
CPIC: 101940840(RAPGEF2)
ACS: 100561833(rapgef2)
PVT: 110072791(RAPGEF2)
PBI: 103066867
PMUR: 107286040(RAPGEF2)
TSR: 106550917(RAPGEF2)
PMUA: 114603804(RAPGEF2)
GJA: 107109403
XLA: 108706643 447229(rapgef2.L)
XTR: 100145659(rapgef2)
NPR: 108791705(RAPGEF2)
DRE: 557693(rapgef2) 793952(si:dkey-253i9.4)
PHYP: 113542715(rapgef2) 113544331
AMEX: 103034322(rapgef2) 103036243
EEE: 113570740(rapgef2) 113586113
TRU: 101068626(rapgef2)
LCO: 104932582(rapgef2)
NCC: 104941952(rapgef2)
MZE: 101469290(rapgef2)
ONL: 100709689(rapgef2)
OLA: 101158677(rapgef2)
XMA: 102216833(rapgef2)
XCO: 114139721(rapgef2)
PRET: 103471849(rapgef2)
CVG: 107095759
NFU: 107380014(rapgef2)
KMR: 108236655(rapgef2)
ALIM: 106513263(rapgef2)
AOCE: 111574983(rapgef2)
CSEM: 103390684(rapgef2)
POV: 109640036(rapgef2)
LCF: 108885198(rapgef2)
SDU: 111232429(rapgef2)
SLAL: 111655148(rapgef2)
HCQ: 109526251(rapgef2)
BPEC: 110153676(rapgef2)
MALB: 109973331(rapgef2)
SASA: 106604533(rapgef2) 106611555
ELS: 105027765(rapgef2)
SFM: 108924469(rapgef2) 108930833
PKI: 111833211 111837306(rapgef2)
LCM: 102349377(RAPGEF2)
CMK: 103182258(rapgef2)
RTP: 109927844(rapgef2)
BFO: 118411352
SPU: 591190
APLC: 110987331
DME: Dmel_CG9491(PDZ-GEF)
DER: 6542976
DSE: 6613608
DSI: Dsimw501_GD23402(Dsim_GD23402)
DAN: 6497338
DSR: 110185630
DPE: 6593934
DMN: 108161852
DWI: 6642759
DAZ: 108610898
DNV: 115563719
DHE: 111602206
DVI: 6628617
MDE: 101891421
LCQ: 111687387
AAG: 5566803
AME: 408810
BIM: 100745022
BTER: 100648358
OBB: 114872640
SOC: 105203629
MPHA: 105831101
AEC: 105143272
ACEP: 105623391
PBAR: 105426200
VEM: 105569329
HST: 105185384
DQU: 106746305
CFO: 105248938
LHU: 105678707
PGC: 109856330
OBO: 105276339
PCF: 106785252
NVI: 100119820
CSOL: 105363782
MDL: 103578822
TCA: 655931
DPA: 109534373
NVL: 108564103
BMOR: 101747113
BMAN: 114240391
PMAC: 106721665
PRAP: 110997433
HAW: 110373392
TNL: 113504713
PXY: 105382413
API: 100162402
DNX: 107163614
AGS: 114123378
RMD: 113550608
BTAB: 109034095
CLEC: 106668129
ZNE: 110841549
FCD: 110845730
TUT: 107371050
DPTE: 113793219
CEL: CELE_T14G10.2(pxf-1)
CBR: CBG03403(Cbr-pxf-1)
BMY: Bm1_36455
PCAN: 112563321
CRG: 105329799
MYI: 110447077
OBI: 106881120
SHX: MS3_07678
EGL: EGR_03501
EPA: 110254157
AMIL: 114954505
PDAM: 113666422
SPIS: 111328912
DGT: 114530055
 » show all
Reference
  Authors
Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ
  Title
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
  Journal
Biochim Biophys Acta 1593:141-9 (2003)
DOI:10.1016/S0167-4889(02)00365-8
Reference
  Authors
de Rooij J, Boenink NM, van Triest M, Cool RH, Wittinghofer A, Bos JL
  Title
PDZ-GEF1, a guanine nucleotide exchange factor specific for Rap1 and Rap2.
  Journal
J Biol Chem 274:38125-30 (1999)
DOI:10.1074/jbc.274.53.38125
  Sequence
[hsa:9693]
LinkDB

KEGG   ORTHOLOGY: K08020
Entry
K08020                      KO                                     

Name
RAPGEF6, PDZGEF2
Definition
Rap guanine nucleotide exchange factor 6
Pathway
ko04015  Rap1 signaling pathway
ko04530  Tight junction
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04015 Rap1 signaling pathway
    K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08020  RAPGEF6, PDZGEF2; Rap guanine nucleotide exchange factor 6
Genes
HSA: 51735(RAPGEF6)
PTR: 743392(RAPGEF6)
PPS: 100968786(RAPGEF6)
GGO: 101129664(RAPGEF6)
PON: 103890710(RAPGEF6)
NLE: 100591273(RAPGEF6)
MCC: 706541(RAPGEF6)
MCF: 102143429(RAPGEF6)
CSAB: 103244498(RAPGEF6)
RRO: 104676678(RAPGEF6)
RBB: 108512577(RAPGEF6)
CJC: 100386485(RAPGEF6)
SBQ: 101041774
MMU: 192786(Rapgef6)
MCAL: 110304183(Rapgef6)
MPAH: 110331568(Rapgef6)
RNO: 303141(Rapgef6)
CGE: 100763755(Rapgef6)
HGL: 101697165(Rapgef6)
CCAN: 109680796(Rapgef6) 109690621
OCU: 100358155(RAPGEF6)
TUP: 102502097(RAPGEF6)
CFA: 609521(RAPGEF6)
VVP: 112917094(RAPGEF6)
AML: 100482379(RAPGEF6)
UMR: 103670508(RAPGEF6)
UAH: 113261696(RAPGEF6)
ORO: 101378373(RAPGEF6)
ELK: 111140881
FCA: 101093077(RAPGEF6)
PTG: 102968394(RAPGEF6)
PPAD: 109250902(RAPGEF6)
AJU: 106970717(RAPGEF6)
BTA: 789597(RAPGEF6)
BOM: 102276794(RAPGEF6)
BIU: 109561827(RAPGEF6)
BBUB: 102396435(RAPGEF6)
CHX: 102191417(RAPGEF6)
OAS: 101102808(RAPGEF6)
SSC: 100521255(RAPGEF6)
CFR: 102524531(RAPGEF6)
CDK: 105089950(RAPGEF6)
BACU: 103001438(RAPGEF6)
LVE: 103088658(RAPGEF6)
OOR: 101284854(RAPGEF6)
DLE: 111182398(RAPGEF6)
PCAD: 102989906(RAPGEF6)
ECB: 100063392(RAPGEF6)
EPZ: 103565155
EAI: 106822220(RAPGEF6)
MYB: 102240423(RAPGEF6)
MYD: 102769591(RAPGEF6)
MNA: 107525016(RAPGEF6)
HAI: 109382579(RAPGEF6)
DRO: 112301608(RAPGEF6)
PALE: 102893941(RAPGEF6)
RAY: 107497019(RAPGEF6)
MJV: 108398447(RAPGEF6)
LAV: 100677695(RAPGEF6)
TMU: 101359307
MDO: 100015023(RAPGEF6)
SHR: 100931445(RAPGEF6)
PCW: 110211712(RAPGEF6)
OAA: 100079932(RAPGEF6)
GGA: 101751943(RAPGEF6)
MGP: 100546920(RAPGEF6)
CJO: 107320073(RAPGEF6)
NMEL: 110405204(RAPGEF6)
APLA: 101804493(RAPGEF6)
ACYG: 106032759(RAPGEF6)
TGU: 100231632(RAPGEF6)
LSR: 110481078(RAPGEF6)
SCAN: 103817468(RAPGEF6)
GFR: 102036412(RAPGEF6)
FAB: 101805681(RAPGEF6)
PHI: 102114600(RAPGEF6)
PMAJ: 107210682(RAPGEF6)
CCAE: 111935616
CCW: 104697988(RAPGEF6)
ETL: 114065701(RAPGEF6)
FPG: 101919848(RAPGEF6)
FCH: 102058727(RAPGEF6)
CLV: 102095625(RAPGEF6)
EGZ: 104133480(RAPGEF6)
NNI: 104012007(RAPGEF6)
ACUN: 113485264(RAPGEF6)
PADL: 103915794(RAPGEF6)
AAM: 106487219(RAPGEF6)
ASN: 102387493(RAPGEF6)
AMJ: 102557740(RAPGEF6)
PSS: 102452799(RAPGEF6)
CMY: 102934455(RAPGEF6)
CPIC: 101941486(RAPGEF6)
ACS: 100553829(rapgef6)
PVT: 110079410
PBI: 103064011(RAPGEF6)
PMUR: 107285994
PMUA: 114589738 114591262(RAPGEF6)
GJA: 107126038(RAPGEF6)
XLA: 108712621
XTR: 733941(rapgef6)
DRE: 335032(rapgef6)
IPU: 108278772
PHYP: 113543032(rapgef6)
AMEX: 103043076
EEE: 113578024
TRU: 101075836(rapgef6)
LCO: 104921050(rapgef6)
NCC: 104943230(rapgef6)
MZE: 101467019(rapgef6)
ONL: 100709723
OLA: 101165993(rapgef6)
XMA: 102224759(rapgef6)
XCO: 114153362(rapgef6)
PRET: 103475327(rapgef6)
CVG: 107104672
NFU: 107386829
KMR: 108238065(rapgef6)
ALIM: 106533947
AOCE: 111583549(rapgef6)
CSEM: 103394770(rapgef6)
POV: 109628648(rapgef6)
LCF: 108893518(rapgef6)
SDU: 111234286
SLAL: 111657380(rapgef6)
HCQ: 109515650(rapgef6)
BPEC: 110169267
MALB: 109966822
ELS: 105028267(rapgef6)
SFM: 108929682 108934339(rapgef6)
LCM: 102351728(RAPGEF6)
CMK: 103183673(rapgef6)
RTP: 109927338
 » show all
Reference
  Authors
Rebhun JF, Castro AF, Quilliam LA
  Title
Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction.
  Journal
J Biol Chem 275:34901-8 (2000)
DOI:10.1074/jbc.M005327200
Reference
  Authors
Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ
  Title
Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2.
  Journal
Biochim Biophys Acta 1593:141-9 (2003)
DOI:10.1016/S0167-4889(02)00365-8
  Sequence
[hsa:51735]
LinkDB

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