KEGG   ORTHOLOGY: K08074Help
Entry
K08074                      KO                                     

Name
ADPGK
Definition
ADP-dependent glucokinase [EC:2.7.1.147]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K08074  ADPGK; ADP-dependent glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.147  ADP-specific glucose/glucosamine kinase
     K08074  ADPGK; ADP-dependent glucokinase
BRITE hierarchy
Other DBs
RN: R05804 R09085 R09086 R12594
GO: 0043843
Genes
HSA: 83440(ADPGK)
PTR: 748791(ADPGK)
PPS: 100988588(ADPGK)
GGO: 101140731(ADPGK)
PON: 100173850(ADPGK)
NLE: 100596634(ADPGK)
MCC: 699257(ADPGK)
MCF: 101866506(ADPGK)
CSAB: 103245364(ADPGK)
RRO: 104673839(ADPGK)
CJC: 100385481(ADPGK)
SBQ: 101050870(ADPGK)
MMU: 72141(Adpgk)
MCAL: 110301455(Adpgk)
MPAH: 110327365(Adpgk)
RNO: 315722(Adpgk)
MUN: 110549574(Adpgk)
CGE: 100754978(Adpgk)
NGI: 103736851(Adpgk)
HGL: 101717458(Adpgk)
CCAN: 109687654(Adpgk)
OCU: 100347024(ADPGK)
TUP: 102498911(ADPGK)
CFA: 478360(ADPGK)
VVP: 112935284(ADPGK)
AML: 100473629(ADPGK)
UMR: 103679135(ADPGK)
UAH: 113240943(ADPGK)
ORO: 101378614(ADPGK)
ELK: 111153171
FCA: 101088581(ADPGK)
PTG: 102961110(ADPGK)
PPAD: 109262726(ADPGK)
AJU: 106974196(ADPGK)
BTA: 518158(ADPGK)
BOM: 102286604(ADPGK)
BIU: 109564750(ADPGK)
BBUB: 102410724(ADPGK)
CHX: 102181503(ADPGK)
OAS: 101116836(ADPGK)
SSC: 100623786(ADPGK)
CFR: 102523920(ADPGK)
CDK: 105087286(ADPGK)
BACU: 103021058(ADPGK)
LVE: 103082058(ADPGK)
OOR: 101278987(ADPGK)
DLE: 111177800(ADPGK)
PCAD: 102996053(ADPGK)
ECB: 100052166(ADPGK)
EPZ: 103555465(ADPGK)
EAI: 106836645(ADPGK)
MYB: 102260287(ADPGK)
MYD: 102775076(ADPGK)
MNA: 107528420(ADPGK)
HAI: 109391764(ADPGK)
DRO: 112301941(ADPGK)
PALE: 102897483(ADPGK)
RAY: 107501104(ADPGK)
MJV: 108394720(ADPGK)
LAV: 100662497(ADPGK)
TMU: 101353805
MDO: 100016323(ADPGK)
SHR: 100921460(ADPGK)
PCW: 110213901(ADPGK)
OAA: 100077123(ADPGK)
GGA: 415317(ADPGK)
MGP: 100544507(ADPGK)
CJO: 107318502(ADPGK)
NMEL: 110403602(ADPGK)
APLA: 101797470(ADPGK)
ACYG: 106044200(ADPGK)
TGU: 100230242(ADPGK)
LSR: 110483973(ADPGK)
SCAN: 103816150(ADPGK)
GFR: 102040116(ADPGK)
FAB: 101814955(ADPGK)
PHI: 102108989(ADPGK)
PMAJ: 107209369(ADPGK)
CCAE: 111933914(ADPGK)
CCW: 104697511(ADPGK)
ETL: 114059930(ADPGK)
FPG: 101912436(ADPGK)
FCH: 102052366(ADPGK)
CLV: 102093047(ADPGK)
EGZ: 104130704(ADPGK)
NNI: 104016789(ADPGK)
ACUN: 113483794(ADPGK)
PADL: 103913426(ADPGK)
AAM: 106486110(ADPGK)
ASN: 102369271(ADPGK)
AMJ: 102576175(ADPGK)
PSS: 102444452(ADPGK)
CMY: 102945709(ADPGK)
CPIC: 101937495(ADPGK)
ACS: 100567625(adpgk)
PVT: 110084388(ADPGK)
PBI: 103059020(ADPGK)
PMUR: 107297693(ADPGK)
TSR: 106551694(ADPGK)
GJA: 107116940(ADPGK)
XTR: 100216148 100489920(adpgkl) 100495684(adpgk)
NPR: 108784070(ADPGK) 108792739
DRE: 557919(adpgk) 566398(adpgk2)
IPU: 108269756 108275069(adpgk)
PHYP: 113529880(adpgk) 113538789
AMEX: 103040241 103047422(adpgk)
EEE: 113578613 113583561(adpgk)
TRU: 101076196(adpgk) 101076203
LCO: 104920148 104929546(adpgk)
ONL: 100698586(adpgk) 100699774
OLA: 101160066(adpgk) 101160396
XMA: 102225042(adpgk) 102232621
XCO: 114143454 114153348(adpgk)
PRET: 103461108(adpgk) 103462836
CVG: 107092158 107093211(adpgk)
NFU: 107381177 107395420(adpgk)
KMR: 108237299 108248323(adpgk)
ALIM: 106523670 106531205(adpgk)
AOCE: 111583744(adpgk) 111585860
CSEM: 103379410(adpgk) 103379918
POV: 109624554(adpgk) 109625024
LCF: 108877019 108883016(adpgk)
SDU: 111219002 111229922(adpgk)
SLAL: 111650379(adpgk) 111668843
BPEC: 110169162(adpgk) 110172923
MALB: 109954478 109974965(adpgk)
ELS: 105016080 105018670(adpgk)
SFM: 108923988 108942355(adpgk)
LCM: 102354033 102364267(ADPGK)
CMK: 103178909 103188726(adpgk)
RTP: 109915605(adpgk)
DME: Dmel_CG6650(CG6650)
DER: 6545532
DSE: 6605634
DSI: Dsimw501_GD14473(Dsim_GD14473)
DAN: 6507219
DSR: 110190186
DPE: 6595753
DMN: 108153097
DWI: 6638735
DAZ: 108613311
DNV: 108651233
DVI: 6622989
MDE: 101896047
LCQ: 111681213
AAG: 110676244
AME: 413336
BIM: 100749517
BTER: 100652288
CCAL: 108623529
OBB: 114877764
SOC: 105205417
MPHA: 105829982
AEC: 105145579
ACEP: 105620980
PBAR: 105429499
VEM: 105566163
HST: 105183903
DQU: 106741608
CFO: 105249194
LHU: 105674879
PGC: 109855885
OBO: 105280856
PCF: 106792050
NVI: 100118248
CSOL: 105367804
MDL: 103576353
BMOR: 101746527
BMAN: 114244333
PMAC: 106711958
PRAP: 111001851
HAW: 110372149
BTAB: 109044175
CLEC: 106661214
ZNE: 110841380
TUT: 107361191
DPTE: 113796635
CSCU: 111624497
PTEP: 107447833
CEL: CELE_C50D2.7(C50D2.7)
CBR: CBG06989
BMY: Bm1_43195
TSP: Tsp_05422
EGL: EGR_09230
NVE: 5506810
EPA: 110250152
ADF: 107332063
AMIL: 114973522
SPIS: 111320563
DGT: 114515678
DDI: DDB_G0287631(glk)
SPAR: SPRG_15821
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Ronimus RS, Morgan HW
  Title
Cloning and biochemical characterization of a novel mouse ADP-dependent glucokinase.
  Journal
Biochem Biophys Res Commun 315:652-8 (2004)
DOI:10.1016/j.bbrc.2004.01.103
LinkDB All DBs

KEGG   ORTHOLOGY: K00918Help
Entry
K00918                      KO                                     

Name
pfkC
Definition
ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
Pathway
ko00010  Glycolysis / Gluconeogenesis
ko00030  Pentose phosphate pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00010 Glycolysis / Gluconeogenesis
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
   00030 Pentose phosphate pathway
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
  09102 Energy metabolism
   00680 Methane metabolism
    K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.1  Phosphotransferases with an alcohol group as acceptor
    2.7.1.146  ADP-specific phosphofructokinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
    2.7.1.147  ADP-specific glucose/glucosamine kinase
     K00918  pfkC; ADP-dependent phosphofructokinase/glucokinase
BRITE hierarchy
Other DBs
RN: R05805 R09084 R09085 R09086
COG: COG4809
GO: 0043844 0043843
Genes
SAME: SAMCFNEI73_pA0085
RLT: Rleg2_4979
PLEO: OHA_2_00048
GRC: GI584_20260
TCO: Theco_1176
CSH: Closa_0608
LUA: D4A81_12730
HALS: D7D81_07845
LPIL: LIP_1021 LIP_1249 LIP_3330
MIM: AKG07_17120
TPYO: X956_09010
MBAS: ALGA_3097
ASAC: ATHSA_0704
MJA: MJ_1604
MMP: MMP1296(pfkC)
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
PHO: PH0589(PH0589) PH1645(PH1645)
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
MAC: MA_3562(glkA) MA_3563(pfk)
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
NMG: Nmag_3826
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Verhees CH, Kengen SW, Tuininga JE, Schut GJ, Adams MW, De Vos WM, Van Der Oost J
  Title
The unique features of glycolytic pathways in Archaea.
  Journal
Biochem J 375:231-46 (2003)
DOI:10.1042/BJ20021472
Reference
  Authors
Sakuraba H, Yoshioka I, Koga S, Takahashi M, Kitahama Y, Satomura T, Kawakami R, Ohshima T
  Title
ADP-dependent glucokinase/phosphofructokinase, a novel bifunctional enzyme from the hyperthermophilic archaeon Methanococcus jannaschii.
  Journal
J Biol Chem 277:12495-8 (2002)
DOI:10.1074/jbc.C200059200
LinkDB All DBs

KEGG   ENZYME: 2.7.1.147Help
Entry
EC 2.7.1.147                Enzyme                                 

Name
ADP-specific glucose/glucosamine kinase;
ADP-specific glucokinase;
ADP-dependent glucokinase
Class
Transferases;
Transferring phosphorus-containing groups;
Phosphotransferases with an alcohol group as acceptor
BRITE hierarchy
Sysname
ADP:D-glucose/D-glucosamine 6-phosphotransferase
Reaction(IUBMB)
(1) ADP + D-glucose = AMP + D-glucose 6-phosphate [RN:R05804];
(2) ADP + D-glucosamine = AMP + D-glucosamine 6-phosphate [RN:R12594]
Reaction(KEGG)
Substrate
ADP [CPD:C00008];
D-glucose [CPD:C00031];
D-glucosamine [CPD:C00329]
Product
AMP [CPD:C00020];
D-glucose 6-phosphate [CPD:C00092];
D-glucosamine 6-phosphate [CPD:C00352]
Comment
Requires Mg2+. The enzyme, characterized from a number of hyperthermophilic archaeal species, is highly specific for ADP. No activity is detected when ADP is replaced by ATP, GDP, phosphoenolpyruvate, diphosphate or polyphosphate.
History
EC 2.7.1.147 created 2001, modified 2020
Pathway
ec00010  Glycolysis / Gluconeogenesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
ec01120  Microbial metabolism in diverse environments
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase
K08074  ADP-dependent glucokinase
Genes
HSA: 83440(ADPGK)
PTR: 748791(ADPGK)
PPS: 100988588(ADPGK)
GGO: 101140731(ADPGK)
PON: 100173850(ADPGK)
NLE: 100596634(ADPGK)
MCC: 699257(ADPGK)
MCF: 101866506(ADPGK)
CSAB: 103245364(ADPGK)
RRO: 104673839(ADPGK)
CJC: 100385481(ADPGK)
SBQ: 101050870(ADPGK)
MMU: 72141(Adpgk)
MCAL: 110301455(Adpgk)
MPAH: 110327365(Adpgk)
RNO: 315722(Adpgk)
MUN: 110549574(Adpgk)
CGE: 100754978(Adpgk)
NGI: 103736851(Adpgk)
HGL: 101717458(Adpgk)
CCAN: 109687654(Adpgk)
OCU: 100347024(ADPGK)
TUP: 102498911(ADPGK)
CFA: 478360(ADPGK)
VVP: 112935284(ADPGK)
AML: 100473629(ADPGK)
UMR: 103679135(ADPGK)
UAH: 113240943(ADPGK)
ORO: 101378614(ADPGK)
ELK: 111153171
FCA: 101088581(ADPGK)
PTG: 102961110(ADPGK)
PPAD: 109262726(ADPGK)
AJU: 106974196(ADPGK)
BTA: 518158(ADPGK)
BOM: 102286604(ADPGK)
BIU: 109564750(ADPGK)
BBUB: 102410724(ADPGK)
CHX: 102181503(ADPGK)
OAS: 101116836(ADPGK)
SSC: 100623786(ADPGK)
CFR: 102523920(ADPGK)
CDK: 105087286(ADPGK)
BACU: 103021058(ADPGK)
LVE: 103082058(ADPGK)
OOR: 101278987(ADPGK)
DLE: 111177800(ADPGK)
PCAD: 102996053(ADPGK)
ECB: 100052166(ADPGK)
EPZ: 103555465(ADPGK)
EAI: 106836645(ADPGK)
MYB: 102260287(ADPGK)
MYD: 102775076(ADPGK)
MNA: 107528420(ADPGK)
HAI: 109391764(ADPGK)
DRO: 112301941(ADPGK)
PALE: 102897483(ADPGK)
RAY: 107501104(ADPGK)
MJV: 108394720(ADPGK)
LAV: 100662497(ADPGK)
TMU: 101353805
MDO: 100016323(ADPGK)
SHR: 100921460(ADPGK)
PCW: 110213901(ADPGK)
OAA: 100077123(ADPGK)
GGA: 415317(ADPGK)
MGP: 100544507(ADPGK)
CJO: 107318502(ADPGK)
NMEL: 110403602(ADPGK)
APLA: 101797470(ADPGK)
ACYG: 106044200(ADPGK)
TGU: 100230242(ADPGK)
LSR: 110483973(ADPGK)
SCAN: 103816150(ADPGK)
GFR: 102040116(ADPGK)
FAB: 101814955(ADPGK)
PHI: 102108989(ADPGK)
PMAJ: 107209369(ADPGK)
CCAE: 111933914(ADPGK)
CCW: 104697511(ADPGK)
ETL: 114059930(ADPGK)
FPG: 101912436(ADPGK)
FCH: 102052366(ADPGK)
CLV: 102093047(ADPGK)
EGZ: 104130704(ADPGK)
NNI: 104016789(ADPGK)
ACUN: 113483794(ADPGK)
PADL: 103913426(ADPGK)
AAM: 106486110(ADPGK)
ASN: 102369271(ADPGK)
AMJ: 102576175(ADPGK)
PSS: 102444452(ADPGK)
CMY: 102945709(ADPGK)
CPIC: 101937495(ADPGK)
ACS: 100567625(adpgk)
PVT: 110084388(ADPGK)
PBI: 103059020(ADPGK)
PMUR: 107297693(ADPGK)
TSR: 106551694(ADPGK)
GJA: 107116940(ADPGK)
XTR: 100216148 100489920(adpgkl) 100495684(adpgk)
NPR: 108784070(ADPGK) 108792739
DRE: 557919(adpgk) 566398(adpgk2)
IPU: 108269756 108275069(adpgk)
PHYP: 113529880(adpgk) 113538789
AMEX: 103040241 103047422(adpgk)
EEE: 113578613 113583561(adpgk)
TRU: 101076196(adpgk) 101076203
LCO: 104920148 104929546(adpgk)
ONL: 100698586(adpgk) 100699774
OLA: 101160066(adpgk) 101160396
XMA: 102225042(adpgk) 102232621
XCO: 114143454 114153348(adpgk)
PRET: 103461108(adpgk) 103462836
CVG: 107092158 107093211(adpgk)
NFU: 107381177 107395420(adpgk)
KMR: 108237299 108248323(adpgk)
ALIM: 106523670 106531205(adpgk)
AOCE: 111583744(adpgk) 111585860
CSEM: 103379410(adpgk) 103379918
POV: 109624554(adpgk) 109625024
LCF: 108877019 108883016(adpgk)
SDU: 111219002 111229922(adpgk)
SLAL: 111650379(adpgk) 111668843
BPEC: 110169162(adpgk) 110172923
MALB: 109954478 109974965(adpgk)
ELS: 105016080 105018670(adpgk)
SFM: 108923988 108942355(adpgk)
LCM: 102354033 102364267(ADPGK)
CMK: 103178909 103188726(adpgk)
RTP: 109915605(adpgk)
DME: Dmel_CG6650(CG6650)
DER: 6545532
DSE: 6605634
DSI: Dsimw501_GD14473(Dsim_GD14473)
DAN: 6507219
DSR: 110190186
DPE: 6595753
DMN: 108153097
DWI: 6638735
DAZ: 108613311
DNV: 108651233
DVI: 6622989
MDE: 101896047
LCQ: 111681213
AAG: 110676244
AME: 413336
BIM: 100749517
BTER: 100652288
CCAL: 108623529
OBB: 114877764
SOC: 105205417
MPHA: 105829982
AEC: 105145579
ACEP: 105620980
PBAR: 105429499
VEM: 105566163
HST: 105183903
DQU: 106741608
CFO: 105249194
LHU: 105674879
PGC: 109855885
OBO: 105280856
PCF: 106792050
NVI: 100118248
CSOL: 105367804
MDL: 103576353
BMOR: 101746527
BMAN: 114244333
PMAC: 106711958
PRAP: 111001851
HAW: 110372149
BTAB: 109044175
CLEC: 106661214
ZNE: 110841380
TUT: 107361191
DPTE: 113796635
CSCU: 111624497
PTEP: 107447833
CEL: CELE_C50D2.7(C50D2.7)
CBR: CBG06989
BMY: Bm1_43195
TSP: Tsp_05422
EGL: EGR_09230
NVE: 5506810
EPA: 110250152
ADF: 107332063
AMIL: 114973522
SPIS: 111320563
DGT: 114515678
DDI: DDB_G0287631(glk)
SPAR: SPRG_15821
TPYO: X956_09010
MBAS: ALGA_3097
ASAC: ATHSA_0704
MJA: MJ_1604
MMP: MMP1296(pfkC)
MMD: GYY_07315
MMAK: MMKA1_15210(pfkC)
MMAO: MMOS7_14030(pfkC)
MMAD: MMJJ_15470
MAE: Maeo_0005
PHO: PH0589(PH0589) PH1645(PH1645)
TGA: TGAM_0818(glkA) TGAM_1465(pfkC)
MAC: MA_3562(glkA) MA_3563(pfk)
MTP: Mthe_1214
MCJ: MCON_0234(pfkC)
MBN: Mboo_1525
NMG: Nmag_3826
 » show all
Taxonomy
Reference
1  [PMID:8530474]
  Authors
Kengen SW, Tuininga JE, de Bok FA, Stams AJ, de Vos WM.
  Title
Purification and characterization of a novel ADP-dependent glucokinase from the hyperthermophilic archaeon Pyrococcus furiosus.
  Journal
J Biol Chem 270:30453-7 (1995)
DOI:10.1074/jbc.270.51.30453
  Sequence
[pfu:PF0312]
Reference
2  [PMID:11098152]
  Authors
Koga S, Yoshioka I, Sakuraba H, Takahashi M, Sakasegawa S, Shimizu S, Ohshima T
  Title
Biochemical characterization, cloning, and sequencing of ADP-dependent (AMP-forming) glucokinase from two hyperthermophilic archaea, Pyrococcus furiosus and Thermococcus litoralis.
  Journal
J Biochem 128:1079-85 (2000)
DOI:10.1093/oxfordjournals.jbchem.a022836
Reference
3  [PMID:29146530]
  Authors
Aslam M, Takahashi N, Matsubara K, Imanaka T, Kanai T, Atomi H
  Title
Identification of the glucosamine kinase in the chitinolytic pathway of Thermococcus kodakarensis.
  Journal
J Biosci Bioeng 125:320-326 (2018)
DOI:10.1016/j.jbiosc.2017.10.005
Other DBs
ExplorEnz - The Enzyme Database: 2.7.1.147
IUBMB Enzyme Nomenclature: 2.7.1.147
ExPASy - ENZYME nomenclature database: 2.7.1.147
BRENDA, the Enzyme Database: 2.7.1.147
CAS: 173585-07-4
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KEGG   REACTION: R09085Help
Entry
R09085                      Reaction                               

Name
ADP:D-glucose 6-phosphotransferase
Definition
alpha-D-Glucose + ADP <=> alpha-D-Glucose 6-phosphate + AMP
Equation
Reaction class
RC00002  C00008_C00020
RC00017  C00267_C00668
Enzyme
Pathway
rn00010  Glycolysis / Gluconeogenesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00001  Glycolysis (Embden-Meyerhof pathway), glucose => pyruvate
Orthology
K00918  ADP-dependent phosphofructokinase/glucokinase [EC:2.7.1.146 2.7.1.147]
K08074  ADP-dependent glucokinase [EC:2.7.1.147]
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