KEGG   ORTHOLOGY: K08093Help
Entry
K08093                      KO                                     

Name
hxlA
Definition
3-hexulose-6-phosphate synthase [EC:4.1.2.43]
Pathway
ko00030  Pentose phosphate pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K08093  hxlA; 3-hexulose-6-phosphate synthase
  09102 Energy metabolism
   00680 Methane metabolism
    K08093  hxlA; 3-hexulose-6-phosphate synthase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K08093  hxlA; 3-hexulose-6-phosphate synthase
BRITE hierarchy
Other DBs
RN: R05338
COG: COG0269
GO: 0043801
Genes
EUM: ECUMN_2963
STM: STM2755
SEO: STM14_3320
SEV: STMMW_27231
SEY: SL1344_2739(hxlA)
SEM: STMDT12_C28070
SEJ: STMUK_2743
SEB: STM474_2890
SEF: UMN798_2989(hxlA)
SETU: STU288_13940
SENI: CY43_14395
SEH: SeHA_C2929(hxlA)
SHB: SU5_03243
ECLZ: LI64_16165
ECAN: CWI88_05395(hxlA)
KPN: KPN_02957
KLW: DA718_10170(hxlA)
SOD: Sant_0061
METL: U737_21900(hxlA)
MAH: MEALZ_3953(hps1)
MPSY: CEK71_00435(hxlA)
MMAI: sS8_1135
MEJ: Q7A_2498(hxlA) Q7A_2501(hxlA)
MEP: MPQ_0281(sgbH) MPQ_1561
MBAC: BN1209_0202(rmpA) BN1209_0771(rmpA)
MBAT: BN1208_0845(hps)
SDO: SD1155_05640(hxlA)
BSU: BSU03460(hxlA)
BSR: I33_0397(hxlA)
BSL: A7A1_1851
BSH: BSU6051_03460(hxlA)
BSUT: BSUB_00396(hxlA)
BSUL: BSUA_00396(hxlA)
BSUS: Q433_02070
BSS: BSUW23_01790(hxlA)
BST: GYO_0559(hxlA)
BSO: BSNT_06681(hxlA)
BSQ: B657_03460(hxlA)
BSX: C663_0338(hxlA)
BLI: BL02045(hxlA)
BLD: BLi02805(hxlA)
BLH: BaLi_c29000(hxlA)
BAY: RBAM_003630(hxlA)
BAQ: BACAU_0303(hxlA)
BYA: BANAU_0305(hxlA)
BAMP: B938_01575
BAML: BAM5036_0322(hxlA)
BAMA: RBAU_0337(hxlA)
BAMN: BASU_0321(hxlA)
BAMB: BAPNAU_0307(hxlA)
BAMT: AJ82_01980
BAMY: V529_03250(hxlA)
BMP: NG74_00345(hxlA)
BAO: BAMF_0310(hxlA)
BAZ: BAMTA208_01555(hxlA)
BQL: LL3_00318(hxlA)
BXH: BAXH7_00321(hxlA)
BQY: MUS_0325(hxlA)
BAMI: KSO_017855
BAMC: U471_03230
BAMF: U722_01860
BCL: ABC3351(hxlA)
BPU: BPUM_2333
BPUM: BW16_12650
BPUS: UP12_11780
BMQ: BMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)
BMD: BMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)
BMEG: BG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)
BAG: Bcoa_0968
BJS: MY9_0361
BMET: BMMGA3_06845(hps)
BACW: QR42_11740
BACP: SB24_07990
BACB: OY17_04480
BACY: QF06_00690
BACL: BS34A_04030(hxlA)
BALM: BsLM_0362
BGY: BGLY_3090(hxlA)
BKW: BkAM31D_07120(hxlA_1) BkAM31D_16315(hxlA_2)
BBEV: BBEV_0241(hxlA)
BALT: CFN77_12450(hxlA)
BACQ: DOE78_03635(hxlA)
OIH: OB2806
OCN: CUC15_15170(hxlA)
GTN: GTNG_1490
GGH: GHH_c21400(hxlA)
GEA: GARCT_00704(hxlA_1) GARCT_02004(hxlA_2)
ANM: GFC28_662
ANL: GFC29_964
HLI: HLI_12660
SAU: SA0528
SAV: SAV0570
SAW: SAHV_0568
SAM: MW0525
SAS: SAS0528
SAR: SAR0574
SAC: SACOL0617
SAE: NWMN_0533
SAD: SAAV_0533(hxlA)
SUU: M013TW_0558(hxlA)
SUE: SAOV_0605
SUJ: SAA6159_00524(hxlA)
SUK: SAA6008_00578(hxlA)
SUC: ECTR2_524(hxlA)
SUQ: HMPREF0772_12618(hxlA)
SUZ: MS7_0560(hxlA)
SUG: SAPIG0645(hxlA)
SAUA: SAAG_00991
SAUE: RSAU_000524(hps)
SAUS: SA40_0511
SAUU: SA957_0526
SAUG: SA268_0524
SAUF: X998_0612(hxlA)
SAB: SAB0520
SAUB: C248_0645
SAUM: BN843_5640
SAUC: CA347_586(hxlA)
SAUR: SABB_00621
SAUI: AZ30_02885
SAUD: CH52_02905
SAMS: NI36_02840
SEP: SE0341
SER: SERP0216
SEPP: SEB_00262
SEPS: DP17_1647(hxlA)
SHA: SH2420
SHH: ShL2_02215(hxlA)
SDT: SPSE_2213(hxlA)
SPAS: STP1_1658
SHU: SHYC_10795(hxlA)
SSCH: LH95_10395
SSCZ: RN70_11130
SAGQ: EP23_11365
SSIF: AL483_08720(hxlA)
SPET: CEP67_09865(hxlA)
SSCU: CEP64_01020(hxlA)
SKL: C7J89_12605(hxlA)
SFQ: C7J90_01805(hxlA)
SHOM: EGX58_03330(hxlA)
MCL: MCCL_0037
MCAK: MCCS_00640
ESI: Exig_2372
EAN: Eab7_2216
PPY: PPE_04673
PPM: PPSC2_24305(hxlA)
PPO: PPM_4826(hxlA)
PPOL: X809_40845
PPQ: PPSQR21_049250(sgbH)
PPOY: RE92_12975
PMS: KNP414_07885(hxlA)
PMW: B2K_37330
PRI: PRIO_3567 PRIO_6499(hxlA)
PSWU: SY83_08105
PDH: B9T62_30300(hxlA)
PLW: D5F53_10835(hxlA)
SACA: FFV09_02170(hxlA)
PLX: CW734_09535(hxlA) CW734_13380(hxlA)
LBR: LVIS_0442
LPAP: LBPC_0348
LBN: LBUCD034_0077(hxlA)
LSN: LSA_03490
PCE: PECL_1750
TOO: C7K38_07925(hxlA)
OOE: OEOE_0131
LMM: MI1_09731
WSO: WSWS_00759(hxlA)
AUR: HMPREF9243_0240(hxlA)
CAC: CA_C0396
CAE: SMB_G0404(sgbH)
CAY: CEA_G0406
CBE: Cbei_4647
CBZ: Cbs_4647
CBEI: LF65_06885
ROB: CK5_18950
PFT: JBW_00828
EUC: EC1_08720
CDX: CDES_00570(rmpA)
CMI: CMM_1123(sgaH)
CMS: CMS1443(hps)
CMC: CMN_01092(sgaH)
PLAP: EAO79_07240(hxlA)
ART: Arth_3708
ARR: ARUE_c04640(rmpA)
ARN: CGK93_01940(hxlA)
ARX: ARZXY2_3983(hxlA)
ARTH: C3B78_00800(hxlA)
AAU: AAur_0494(hps)
AAI: AARI_06580(rmpA)
AMQ: AMETH_4519(hps) AMETH_4538(hps)
BDE: BDP_0013
BDN: BBDE_0013
BANG: BBAG_0932
TTR: Tter_2273
RBA: RB5319
PIR: VN12_13465(hxlA)
RUL: UC8_20370(hxlA)
GMR: GmarT_59230(hxlA)
ABAC: LuPra_03104(hxlA)
CPI: Cpin_5671
FLN: FLA_3348
ZPR: ZPR_1061
MARM: YQ22_17840
CBAL: M667_16185
CBAT: M666_16170
ZGA: ZOBELLIA_3942(hxlA)
AALG: AREALGSMS7_04556(hxlA)
MJA: MJ_0644
MAE: Maeo_1123
MTH: MTH_888
METC: MTCT_0805
MWO: MWSIV6_1262(hpsA)
METE: tca_00853(proA)
MST: Msp_1358
MSI: Msm_0426
MRU: mru_0712
MEB: Abm4_0441
MMIL: sm9_0586
MEYE: TL18_02745
MOL: YLM1_0353
METH: MBMB1_0388
MFC: BRM9_1874
MCUB: MCBB_0344(hpsA)
MFV: Mfer_0465
MKA: MK0153(sgbH) MK1449(menG)
APE: APE_0952.1(hxlA)
ACJ: ACAM_0624(hxlA)
SMR: Smar_0492
IHO: Igni_0269
IIS: EYM_01130
DKA: DKAM_1456
TAG: Tagg_1068
IAG: Igag_1921
HBU: Hbut_0129
STO: STK_02380(hxlA)
SSO: SSO0202(hpS-2)
SOL: Ssol_1184
SSOA: SULA_1220
SSOL: SULB_1221
SSOF: SULC_1219
SAI: Saci_0802
SID: M164_1939
SII: LD85_2191
SIH: SiH_1876
SIR: SiRe_1804
SIC: SiL_1785
MSE: Msed_0227
MCN: Mcup_1845
AHO: Ahos_0599
PAI: PAE1679
PIS: Pisl_1686
PCL: Pcal_0568
PAS: Pars_1830
PYR: P186_0040
POG: Pogu_0300
TNE: Tneu_0708
CMA: Cmaq_1871
TUZ: TUZN_2015
TTN: TTX_1521(hps)
VDI: Vdis_1817
VMO: VMUT_0258
TPE: Tpen_0372
ASC: ASAC_0959
ACIA: SE86_04960
KCR: Kcr_1307
AG: BAA19967(rmpA)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Yasueda H, Kawahara Y, Sugimoto S.
  Title
Bacillus subtilis yckG and yckF encode two key enzymes of the ribulose monophosphate pathway used by methylotrophs, and yckH is required for their expression.
  Journal
J Bacteriol 181:7154-60 (1999)
LinkDB All DBs

KEGG   ORTHOLOGY: K13812Help
Entry
K13812                      KO                                     

Name
fae-hps
Definition
bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
Pathway
ko00030  Pentose phosphate pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13812  fae-hps; bifunctional enzyme Fae/Hps
  09102 Energy metabolism
   00680 Methane metabolism
    K13812  fae-hps; bifunctional enzyme Fae/Hps
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
  4.2  Carbon-oxygen lyases
   4.2.1  Hydro-lyases
    4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase
     K13812  fae-hps; bifunctional enzyme Fae/Hps
BRITE hierarchy
Other DBs
RN: R05338 R08058
COG: COG1795 COG0269
Genes
MJA: MJ_1447
MFE: Mefer_1012
MVU: Metvu_1176
MFS: MFS40622_0906
MIF: Metin_1286
MJH: JH146_0570
MIG: Metig_0664
MAE: Maeo_0614
MOK: Metok_1249
METF: CFE53_04300
MTH: MTH_1474
MMG: MTBMA_c00570(fae_hps)
METC: MTCT_1339
MWO: MWSIV6_0011(fae-hps)
METE: tca_01421(fae)
MST: Msp_1498
MSI: Msm_1213
MRU: mru_2131
MEB: Abm4_0046
MMIL: sm9_0074
MEYE: TL18_10355
MOL: YLM1_1686
METH: MBMB1_0009(fae-hps)
MFC: BRM9_0060
MFI: DSM1535_1378(fae-hps)
MCUB: MCBB_0021(fae-hps_1)
METT: CIT01_05685(fae)
METO: CIT02_07030(fae)
MFV: Mfer_0572
AFU: AF_1305
FPL: Ferp_2129
GAC: GACE_2158
GAH: GAH_00575
MAC: MA_4608
MBAR: MSBR2_2313
MBAK: MSBR3_2375
MMA: MM_1279
MMAC: MSMAC_0037
METM: MSMTP_0040
MTHE: MSTHC_1499
MTHR: MSTHT_1787
MHOR: MSHOH_0037
MBU: Mbur_1994(fae-hps)
MMET: MCMEM_0222
MMH: Mmah_0234
MPY: Mpsy_1425
MTP: Mthe_0988
MCJ: MCON_1383
MHI: Mhar_0019
MHU: Mhun_1628
MLA: Mlab_0996
MEMA: MMAB1_1386(fae-hps)
MPI: Mpet_0801
MBN: Mboo_0772
MPL: Mpal_1036
MPD: MCP_2904(fae_hps)
MEZ: Mtc_0381(fae)
RCI: RCIX775(fae-hps)
BARC: AOA65_1083(faeB-hpsB)
BARB: AOA66_1278
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Grochowski LL, Xu H, White RH
  Title
Ribose-5-phosphate biosynthesis in Methanocaldococcus jannaschii occurs in the absence of a pentose-phosphate pathway.
  Journal
J Bacteriol 187:7382-9 (2005)
DOI:10.1128/JB.187.21.7382-7389.2005
  Sequence
[mja:MJ_1447]
LinkDB All DBs

KEGG   ORTHOLOGY: K13831Help
Entry
K13831                      KO                                     

Name
hps-phi
Definition
3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
Pathway
ko00030  Pentose phosphate pathway
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
ko01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00030 Pentose phosphate pathway
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
  09102 Energy metabolism
   00680 Methane metabolism
    K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Enzymes [BR:ko01000]
 4. Lyases
  4.1  Carbon-carbon lyases
   4.1.2  Aldehyde-lyases
    4.1.2.43  3-hexulose-6-phosphate synthase
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
 5. Isomerases
  5.3  Intramolecular oxidoreductases
   5.3.1  Interconverting aldoses and ketoses, and related compounds
    5.3.1.27  6-phospho-3-hexuloisomerase
     K13831  hps-phi; 3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
BRITE hierarchy
Other DBs
RN: R05338 R05339 R09780
COG: COG0269 COG0684
GO: 0043801 0043800
Genes
MCA: MCA2738
MAH: MEALZ_1912(hpsi2)
MBUR: EQU24_11340(hxlA)
MPSY: CEK71_18985
MMAI: sS8_1148
DAO: Desac_1176
COHN: KCTCHS21_15480
KST: KSMBR1_1055
MMP: MMP1270
MMQ: MmarC5_0321
MMD: GYY_07185
AFU: AF_0861
FPL: Ferp_2198
GAC: GACE_0250
GAH: GAH_00051
MEAR: Mpt1_c14440(faeB)
MARC: AR505_0014
ABI: Aboo_0457
PHO: PH1938(PH1938)
PAB: PAB1222
PFU: PF0220
PFI: PFC_00160
PYN: PNA2_0868
PYS: Py04_0376
TKO: TK0475
TON: TON_0336
TGA: TGAM_1891(hps)
TSI: TSIB_0428
THE: GQS_03555
THA: TAM4_82
THM: CL1_0365
TLT: OCC_09933
THS: TES1_0756
TNU: BD01_0222
TEU: TEU_06790
PPAC: PAP_05755
MAC: MA_4504
MBAR: MSBR2_3345
MBAK: MSBR3_3372
MMA: MM_1215
MMAC: MSMAC_0105
METM: MSMTP_0201
MTHE: MSTHC_1625
MTHR: MSTHT_1664
MHOR: MSHOH_0117
MMET: MCMEM_0644
MMH: Mmah_1222
MPY: Mpsy_1396
MTP: Mthe_0455
MCJ: MCON_0429
MHI: Mhar_1869
MHU: Mhun_0647
MLA: Mlab_1453
MEMA: MMAB1_1456(hpsA)
MPI: Mpet_0679
MBN: Mboo_0707
MPL: Mpal_2121
MPD: MCP_0861
MEZ: Mtc_1411
RCI: RCIX1492
NCV: NCAV_0256
BARB: AOA66_0495
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
  Sequence
[pho:PH1938]
Reference
  Authors
Orita I, Sato T, Yurimoto H, Kato N, Atomi H, Imanaka T, Sakai Y
  Title
The ribulose monophosphate pathway substitutes for the missing pentose phosphate pathway in the archaeon Thermococcus kodakaraensis.
  Journal
J Bacteriol 188:4698-704 (2006)
DOI:10.1128/JB.00492-06
LinkDB All DBs

KEGG   ENZYME: 4.1.2.43Help
Entry
EC 4.1.2.43                 Enzyme                                 

Name
3-hexulose-6-phosphate synthase;
D-arabino-3-hexulose 6-phosphate formaldehyde-lyase;
3-hexulosephosphate synthase;
3-hexulose phosphate synthase;
HPS
Class
Lyases;
Carbon-carbon lyases;
Aldehyde-lyases
BRITE hierarchy
Sysname
D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
Reaction(IUBMB)
D-arabino-hex-3-ulose 6-phosphate = D-ribulose 5-phosphate + formaldehyde [RN:R05338]
Reaction(KEGG)
Substrate
D-arabino-hex-3-ulose 6-phosphate [CPD:C06019]
Product
D-ribulose 5-phosphate [CPD:C00199];
formaldehyde [CPD:C00067]
Comment
Requires Mg2+ or Mn2+ for maximal activity [1]. The enzyme is specific for D-ribulose 5-phosphate as substrate as ribose 5-phosphate, xylulose 5-phosphate, allulose 6-phosphate and fructose 6-phosphate cannot act as substrate. In addition to formaldehyde, the enzyme can also use glycolaldehyde and methylglyoxal [7]. This enzyme, along with EC 5.3.1.27, 6-phospho-3-hexuloisomerase, plays a key role in the ribulose-monophosphate cycle of formaldehyde fixation, which is present in many microorganisms that are capable of utilizing C1-compounds [1]. The hyperthermophilic and anaerobic archaeon Pyrococcus horikoshii OT3 constitutively produces a bifunctional enzyme that sequentially catalyses the reactions of this enzyme and EC 5.3.1.27, 6-phospho-3-hexuloisomerase [6]. This enzyme is a member of the orotidine 5'-monophosphate decarboxylase (OMPDC) suprafamily [5].
History
EC 4.1.2.43 created 2008
Pathway
ec00030  Pentose phosphate pathway
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08093  3-hexulose-6-phosphate synthase
K13812  bifunctional enzyme Fae/Hps
K13831  3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase
Genes
EUM: ECUMN_2963
STM: STM2755
SEO: STM14_3320
SEV: STMMW_27231
SEY: SL1344_2739(hxlA)
SEM: STMDT12_C28070
SEJ: STMUK_2743
SEB: STM474_2890
SEF: UMN798_2989(hxlA)
SETU: STU288_13940
SENI: CY43_14395
SEH: SeHA_C2929(hxlA)
SHB: SU5_03243
ECLZ: LI64_16165
ECAN: CWI88_05395(hxlA)
KPN: KPN_02957
KLW: DA718_10170(hxlA)
SOD: Sant_0061
METL: U737_21900(hxlA)
MAH: MEALZ_1912(hpsi2) MEALZ_3953(hps1)
MBUR: EQU24_11340(hxlA)
MEJ: Q7A_2498(hxlA) Q7A_2501(hxlA)
MEP: MPQ_0281(sgbH) MPQ_1561
MBAC: BN1209_0202(rmpA) BN1209_0771(rmpA)
MBAT: BN1208_0845(hps)
SDO: SD1155_05640(hxlA)
BSU: BSU03460(hxlA)
BSR: I33_0397(hxlA)
BSL: A7A1_1851
BSH: BSU6051_03460(hxlA)
BSUT: BSUB_00396(hxlA)
BSUL: BSUA_00396(hxlA)
BSUS: Q433_02070
BSS: BSUW23_01790(hxlA)
BST: GYO_0559(hxlA)
BSO: BSNT_06681(hxlA)
BSQ: B657_03460(hxlA)
BSX: C663_0338(hxlA)
BLI: BL02045(hxlA)
BLD: BLi02805(hxlA)
BLH: BaLi_c29000(hxlA)
BAY: RBAM_003630(hxlA)
BAQ: BACAU_0303(hxlA)
BYA: BANAU_0305(hxlA)
BAMP: B938_01575
BAML: BAM5036_0322(hxlA)
BAMA: RBAU_0337(hxlA)
BAMN: BASU_0321(hxlA)
BAMB: BAPNAU_0307(hxlA)
BAMT: AJ82_01980
BAMY: V529_03250(hxlA)
BMP: NG74_00345(hxlA)
BAO: BAMF_0310(hxlA)
BAZ: BAMTA208_01555(hxlA)
BQL: LL3_00318(hxlA)
BXH: BAXH7_00321(hxlA)
BQY: MUS_0325(hxlA)
BAMI: KSO_017855
BAMC: U471_03230
BAMF: U722_01860
BCL: ABC3351(hxlA)
BPU: BPUM_2333
BPUM: BW16_12650
BPUS: UP12_11780
BMQ: BMQ_0891(hxlA) BMQ_1538(hxlA) BMQ_2942(hxlA)
BMD: BMD_0891(hxlA) BMD_1519(hxlA) BMD_2971(hxlA)
BMEG: BG04_3186(hxlA) BG04_3830(hxlA) BG04_4896(hxlA) BG04_5472 BG04_5588(hxlA) BG04_5930(hxlA)
BAG: Bcoa_0968
BJS: MY9_0361
BMET: BMMGA3_06845(hps)
BACW: QR42_11740
BACP: SB24_07990
BACB: OY17_04480
BACY: QF06_00690
BACL: BS34A_04030(hxlA)
BALM: BsLM_0362
BGY: BGLY_3090(hxlA)
BKW: BkAM31D_07120(hxlA_1) BkAM31D_16315(hxlA_2)
BBEV: BBEV_0241(hxlA)
BALT: CFN77_12450(hxlA)
BACQ: DOE78_03635(hxlA)
OIH: OB2806
OCN: CUC15_15170(hxlA)
GTN: GTNG_1490
GGH: GHH_c21400(hxlA)
GEA: GARCT_00704(hxlA_1) GARCT_02004(hxlA_2)
ANM: GFC28_662
ANL: GFC29_964
HLI: HLI_12660
SAU: SA0528
SAV: SAV0570
SAW: SAHV_0568
SAM: MW0525
SAS: SAS0528
SAR: SAR0574
SAC: SACOL0617
SAE: NWMN_0533
SAD: SAAV_0533(hxlA)
SUU: M013TW_0558(hxlA)
SUE: SAOV_0605
SUJ: SAA6159_00524(hxlA)
SUK: SAA6008_00578(hxlA)
SUC: ECTR2_524(hxlA)
SUQ: HMPREF0772_12618(hxlA)
SUZ: MS7_0560(hxlA)
SUG: SAPIG0645(hxlA)
SAUA: SAAG_00991
SAUE: RSAU_000524(hps)
SAUS: SA40_0511
SAUU: SA957_0526
SAUG: SA268_0524
SAUF: X998_0612(hxlA)
SAB: SAB0520
SAUB: C248_0645
SAUM: BN843_5640
SAUC: CA347_586(hxlA)
SAUR: SABB_00621
SAUI: AZ30_02885
SAUD: CH52_02905
SAMS: NI36_02840
SEP: SE0341
SER: SERP0216
SEPP: SEB_00262
SEPS: DP17_1647(hxlA)
SHA: SH2420
SHH: ShL2_02215(hxlA)
SDT: SPSE_2213(hxlA)
SPAS: STP1_1658
SHU: SHYC_10795(hxlA)
SSCH: LH95_10395
SSCZ: RN70_11130
SAGQ: EP23_11365
SSIF: AL483_08720(hxlA)
SPET: CEP67_09865(hxlA)
SSCU: CEP64_01020(hxlA)
SKL: C7J89_12605(hxlA)
SFQ: C7J90_01805(hxlA)
SHOM: EGX58_03330(hxlA)
MCL: MCCL_0037
MCAK: MCCS_00640
ESI: Exig_2372
EAN: Eab7_2216
PPY: PPE_04673
PPM: PPSC2_24305(hxlA)
PPO: PPM_4826(hxlA)
PPOL: X809_40845
PPQ: PPSQR21_049250(sgbH)
PPOY: RE92_12975
PMS: KNP414_07885(hxlA)
PMW: B2K_37330
PRI: PRIO_3567 PRIO_6499(hxlA)
PSWU: SY83_08105
PDH: B9T62_30300(hxlA)
PLW: D5F53_10835(hxlA)
SACA: FFV09_02170(hxlA)
PLX: CW734_09535(hxlA) CW734_13380(hxlA)
LBR: LVIS_0442
LPAP: LBPC_0348
LBN: LBUCD034_0077(hxlA)
LSN: LSA_03490
PCE: PECL_1750
TOO: C7K38_07925(hxlA)
OOE: OEOE_0131
LMM: MI1_09731
WSO: WSWS_00759(hxlA)
AUR: HMPREF9243_0240(hxlA)
CAC: CA_C0396
CAE: SMB_G0404(sgbH)
CAY: CEA_G0406
CBE: Cbei_4647
CBZ: Cbs_4647
CBEI: LF65_06885
ROB: CK5_18950
PFT: JBW_00828
EUC: EC1_08720
CDX: CDES_00570(rmpA)
CMI: CMM_1123(sgaH)
CMS: CMS1443(hps)
CMC: CMN_01092(sgaH)
PLAP: EAO79_07240(hxlA)
ART: Arth_3708
ARR: ARUE_c04640(rmpA)
ARN: CGK93_01940(hxlA)
ARX: ARZXY2_3983(hxlA)
ARTH: C3B78_00800(hxlA)
AAU: AAur_0494(hps)
AAI: AARI_06580(rmpA)
AMQ: AMETH_4519(hps) AMETH_4538(hps)
BDE: BDP_0013
BDN: BBDE_0013
BANG: BBAG_0932
TTR: Tter_2273
RBA: RB5319
PIR: VN12_13465(hxlA)
RUL: UC8_20370(hxlA)
GMR: GmarT_59230(hxlA)
ABAC: LuPra_03104(hxlA)
CPI: Cpin_5671
FLN: FLA_3348
ZPR: ZPR_1061
MARM: YQ22_17840
CBAL: M667_16185
CBAT: M666_16170
ZGA: ZOBELLIA_3942(hxlA)
AALG: AREALGSMS7_04556(hxlA)
MMP: MMP1270
MMD: GYY_07185
MMG: MTBMA_c00570(fae_hps) MTBMA_c12830
MWO: MWSIV6_0011(fae-hps) MWSIV6_1262(hpsA)
METE: tca_00853(proA) tca_01421(fae)
METH: MBMB1_0009(fae-hps) MBMB1_0388
MFI: DSM1535_0057 DSM1535_1378(fae-hps)
MCUB: MCBB_0021(fae-hps_1) MCBB_0344(hpsA)
METT: CIT01_05685(fae)
MKA: MK0153(sgbH) MK1449(menG)
MEAR: Mpt1_c14440(faeB)
MARC: AR505_0014
ABI: Aboo_0457
PHO: PH1938(PH1938)
PAB: PAB1222
PFU: PF0220
PFI: PFC_00160
PYN: PNA2_0868
PYS: Py04_0376
TKO: TK0475
TON: TON_0336
TGA: TGAM_1891(hps)
TSI: TSIB_0428
THE: GQS_03555
THA: TAM4_82
THM: CL1_0365
TLT: OCC_09933
THS: TES1_0756
TNU: BD01_0222
TEU: TEU_06790
PPAC: PAP_05755
MBU: Mbur_1994(fae-hps)
MEMA: MMAB1_1386(fae-hps) MMAB1_1456(hpsA)
MPD: MCP_0861 MCP_2904(fae_hps)
MEZ: Mtc_0381(fae) Mtc_1411
RCI: RCIX1492 RCIX775(fae-hps)
APE: APE_0952.1(hxlA)
ACJ: ACAM_0624(hxlA)
SMR: Smar_0492
IHO: Igni_0269
IIS: EYM_01130
DKA: DKAM_1456
TAG: Tagg_1068
IAG: Igag_1921
HBU: Hbut_0129
STO: STK_02380(hxlA)
SSO: SSO0202(hpS-2)
SOL: Ssol_1184
SSOA: SULA_1220
SSOL: SULB_1221
SSOF: SULC_1219
SAI: Saci_0802
SID: M164_1939
SII: LD85_2191
SIH: SiH_1876
SIR: SiRe_1804
SIC: SiL_1785
MSE: Msed_0227
MCN: Mcup_1845
AHO: Ahos_0599
PAI: PAE1679
PIS: Pisl_1686
PCL: Pcal_0568
PAS: Pars_1830
PYR: P186_0040
POG: Pogu_0300
TNE: Tneu_0708
CMA: Cmaq_1871
TUZ: TUZN_2015
TTN: TTX_1521(hps)
VDI: Vdis_1817
VMO: VMUT_0258
TPE: Tpen_0372
ASC: ASAC_0959
ACIA: SE86_04960
NCV: NCAV_0256
KCR: Kcr_1307
BARC: AOA65_1083(faeB-hpsB)
 » show all
Taxonomy
Reference
1  [PMID:4219834]
  Authors
Ferenci T, Strom T, Quayle JR
  Title
Purification and properties of 3-hexulose phosphate synthase and phospho-3-hexuloisomerase from Methylococcus capsulatus.
  Journal
Biochem J 144:477-86 (1974)
Reference
2  [PMID:564713]
  Authors
Kato N, Ohashi H, Tani Y, Ogata K
  Title
3-Hexulosephosphate synthase from Methylomonas aminofaciens 77a. Purification, properties and kinetics.
  Journal
Biochim Biophys Acta 523:236-44 (1978)
DOI:10.1016/0005-2744(78)90026-8
Reference
3  [PMID:8595859]
  Authors
Yanase H, Ikeyama K, Mitsui R, Ra S, Kita K, Sakai Y, Kato N
  Title
Cloning and sequence analysis of the gene encoding 3-hexulose-6-phosphate synthase from the methylotrophic bacterium, Methylomonas aminofaciens 77a, and its expression in Escherichia coli.
  Journal
FEMS Microbiol Lett 135:201-5 (1996)
DOI:10.1111/j.1574-6968.1996.tb07990.x
  Sequence
Reference
4  [PMID:16278835]
  Authors
Yurimoto H, Kato N, Sakai Y
  Title
Assimilation, dissimilation, and detoxification of formaldehyde, a central metabolic intermediate of methylotrophic metabolism.
  Journal
Chem Rec 5:367-75 (2005)
DOI:10.1002/tcr.20056
Reference
5  [PMID:16428816]
  Authors
Kato N, Yurimoto H, Thauer RK
  Title
The physiological role of the ribulose monophosphate pathway in bacteria and archaea.
  Journal
Biosci Biotechnol Biochem 70:10-21 (2006)
DOI:10.1271/bbb.70.10
Reference
6  [PMID:15901685]
  Authors
Orita I, Yurimoto H, Hirai R, Kawarabayasi Y, Sakai Y, Kato N
  Title
The archaeon Pyrococcus horikoshii possesses a bifunctional enzyme for formaldehyde fixation via the ribulose monophosphate pathway.
  Journal
J Bacteriol 187:3636-42 (2005)
DOI:10.1128/JB.187.11.3636-3642.2005
  Sequence
[pho:PH1938]
Reference
7
  Authors
Kato, N., Miyamoto, N., Shimao, M. and Sakazawa, C.
  Title
3-Hexulose phosphate pynthase from a new facultative methylotroph, Mycobacterium gastri MB19.
  Journal
Agric Biol Chem 52:2659-2661 (1988)
Other DBs
ExplorEnz - The Enzyme Database: 4.1.2.43
IUBMB Enzyme Nomenclature: 4.1.2.43
ExPASy - ENZYME nomenclature database: 4.1.2.43
BRENDA, the Enzyme Database: 4.1.2.43
LinkDB All DBs

KEGG   REACTION: R05338Help
Entry
R05338                      Reaction                               

Name
D-arabino-hex-3-ulose-6-phosphate formaldehyde-lyase (D-ribulose-5-phosphate-forming)
Definition
D-Ribulose 5-phosphate + Formaldehyde <=> D-arabino-Hex-3-ulose 6-phosphate
Equation
Reaction class
RC00421  C00067_C06019
RC00422  C00199_C06019
Enzyme
Pathway
rn00030  Pentose phosphate pathway
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
rn01230  Biosynthesis of amino acids
Module
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00345  Formaldehyde assimilation, ribulose monophosphate pathway
M00580  Pentose phosphate pathway, archaea, fructose 6P => ribose 5P
Orthology
K08093  3-hexulose-6-phosphate synthase [EC:4.1.2.43]
K13812  bifunctional enzyme Fae/Hps [EC:4.2.1.147 4.1.2.43]
K13831  3-hexulose-6-phosphate synthase / 6-phospho-3-hexuloisomerase [EC:4.1.2.43 5.3.1.27]
Other DBs
RHEA: 25204
LinkDB All DBs

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