KEGG   ORTHOLOGY: K08367
Entry
K08367                      KO                                     

Name
RUNX1, AML1
Definition
runt-related transcription factor 1
Pathway
ko04530  Tight junction
ko04659  Th17 cell differentiation
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05220  Chronic myeloid leukemia
ko05221  Acute myeloid leukemia
Disease
H00001  B-cell acute lymphoblastic leukemia
H00003  Acute myeloid leukemia
H00004  Chronic myeloid leukemia
H00978  Thrombocytopenia (THC)
H01481  Myelodysplastic syndrome
H02410  Myelodysplastic/myeloproliferative neoplasms
H02411  Chronic myelomonocytic leukemia
H02412  Atypical chronic myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09144 Cellular community - eukaryotes
   04530 Tight junction
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05202 Transcriptional misregulation in cancer
    K08367  RUNX1, AML1; runt-related transcription factor 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
   05220 Chronic myeloid leukemia
    K08367  RUNX1, AML1; runt-related transcription factor 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08367  RUNX1, AML1; runt-related transcription factor 1
Transcription factors [BR:ko03000]
 Eukaryotic type
  beta-Scaffold factors with minor groove contacts
   Runt
    K08367  RUNX1, AML1; runt-related transcription factor 1
Genes
HSA: 861(RUNX1)
PTR: 101058316(RUNX1)
PPS: 100985479(RUNX1)
GGO: 101124359(RUNX1)
PON: 100449725(RUNX1)
NLE: 100594110(RUNX1)
MCC: 696749(RUNX1)
MCF: 102145008(RUNX1)
CSAB: 103218488(RUNX1)
RRO: 104658772(RUNX1)
RBB: 108536870(RUNX1)
CJC: 100385071(RUNX1)
SBQ: 101047789(RUNX1)
MMU: 12394(Runx1)
MCAL: 110311558(Runx1)
MPAH: 110329713(Runx1)
RNO: 50662(Runx1)
MUN: 110542151(Runx1)
CGE: 100758283(Runx1)
NGI: 103736431(Runx1)
HGL: 101705852(Runx1)
CCAN: 109700411(Runx1)
OCU: 100358993(RUNX1)
TUP: 102496134(RUNX1)
CFA: 487746(RUNX1)
VVP: 112910264(RUNX1)
AML: 100484679(RUNX1)
UMR: 103673224(RUNX1)
UAH: 113262125(RUNX1)
ORO: 101367976(RUNX1)
ELK: 111155817
FCA: 101084898(RUNX1)
PPAD: 109249750(RUNX1)
AJU: 106966472(RUNX1)
BTA: 529631(RUNX1)
BOM: 102282115(RUNX1)
BIU: 109561422(RUNX1)
BBUB: 102392702(RUNX1)
CHX: 102178020(RUNX1)
OAS: 101108280(RUNX1)
SSC: 100512633(RUNX1)
CFR: 102521748(RUNX1)
CDK: 105089882(RUNX1)
BACU: 103006498(RUNX1)
LVE: 103074813(RUNX1)
OOR: 101288785(RUNX1)
DLE: 111163859(RUNX1)
PCAD: 102984857(RUNX1)
ECB: 100051950(RUNX1)
EPZ: 103549174(RUNX1)
EAI: 106832821(RUNX1)
MYB: 102247211(RUNX1)
MYD: 102768477(RUNX1)
MNA: 107533502(RUNX1)
HAI: 109391240(RUNX1)
DRO: 112305670(RUNX1)
PALE: 102879444(RUNX1)
RAY: 107520364(RUNX1)
MJV: 108384793(RUNX1)
LAV: 100665882(RUNX1)
TMU: 101357079
MDO: 100025525(RUNX1)
SHR: 100921236(RUNX1)
PCW: 110214791(RUNX1)
OAA: 100082553(RUNX1)
GGA: 396152(RUNX1)
MGP: 100540674(RUNX1)
CJO: 107323234(RUNX1)
NMEL: 110402700(RUNX1)
APLA: 101799657(RUNX1)
ACYG: 106043406(RUNX1)
TGU: 100222588(RUNX1)
LSR: 110475368(RUNX1)
GFR: 102042762
FAB: 101820379(RUNX1)
PHI: 102099092(RUNX1)
PMAJ: 107207834 107209383(RUNX1)
CCAE: 111929229(RUNX1)
FPG: 101916329(RUNX1) 106112951
FCH: 102053520(RUNX1)
CLV: 102087117(RUNX1)
EGZ: 104128174(RUNX1)
NNI: 104020181(RUNX1)
ACUN: 113478993(RUNX1)
PADL: 103920324(RUNX1)
AAM: 106494897(RUNX1)
ASN: 102385681(RUNX1)
AMJ: 102572910(RUNX1)
PSS: 102455885(RUNX1)
CMY: 102944269(RUNX1)
CPIC: 101938129(RUNX1)
ACS: 100564051(runx1)
PVT: 110076828(RUNX1)
PBI: 103055722(RUNX1)
PMUR: 107291521
TSR: 106549617(RUNX1)
PMUA: 114596073(RUNX1)
GJA: 107117549
XLA: 108709238 379657(runx1.L)
XTR: 100485449(runx1)
NPR: 108791098(RUNX1)
DRE: 58126(runx1)
SRX: 107709287(runx1) 107751097
CCAR: 109071062
IPU: 108259037(runx1)
PHYP: 113537666(runx1)
AMEX: 103025657
EEE: 113582633
TRU: 100049631(runx1)
LCO: 104936698
NCC: 104961881
MZE: 101482179
ONL: 100691239
OLA: 101173202
XMA: 102230567
XCO: 114140828
PRET: 103477443
CVG: 107098178
NFU: 107384523
ALIM: 106534917
AOCE: 111562778
CSEM: 103389730
POV: 109640042(runx1)
LCF: 108902563
SDU: 111232758
SLAL: 111670267
HCQ: 109528744
BPEC: 110156597
OTW: 112238382(runx1)
ELS: 105019777(runx1)
SFM: 108931706 108938311(runx1)
PKI: 111856070(runx1)
LCM: 102360635(RUNX1)
CMK: 103186755(runx1)
RTP: 109914103(runx1)
BFO: 118423548
CIN: 100178299
SPU: 373468(SpRunt-1) 576197
APLC: 110978851
SKO: 100302713(runt)
AGS: 114126750
NVE: 5504767
EPA: 110249929
ADF: 107351415
AMIL: 114961964
PDAM: 113676023
SPIS: 111342489
DGT: 114535050
AQU: 100638951
 » show all
Reference
PMID:1720541
  Authors
Miyoshi H, Shimizu K, Kozu T, Maseki N, Kaneko Y, Ohki M
  Title
t(8;21) breakpoints on chromosome 21 in acute myeloid leukemia are clustered within a limited region of a single gene, AML1.
  Journal
Proc Natl Acad Sci U S A 88:10431-4 (1991)
DOI:10.1073/pnas.88.23.10431
  Sequence
[hsa:861]
LinkDB

KEGG   ORTHOLOGY: K10053
Entry
K10053                      KO                                     

Name
RUNX1T1, CBFA2T1
Definition
CBFA2/RNUX1 translocation partner 1
Pathway
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10053  RUNX1T1, CBFA2T1; CBFA2/RNUX1 translocation partner 1
   05202 Transcriptional misregulation in cancer
    K10053  RUNX1T1, CBFA2T1; CBFA2/RNUX1 translocation partner 1
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K10053  RUNX1T1, CBFA2T1; CBFA2/RNUX1 translocation partner 1
Genes
HSA: 862(RUNX1T1)
PTR: 472816(RUNX1T1)
PPS: 100978930(RUNX1T1)
GGO: 101131502(RUNX1T1)
PON: 100456274(RUNX1T1)
NLE: 100590085(RUNX1T1)
MCC: 696934(RUNX1T1)
MCF: 102118526(RUNX1T1)
CSAB: 103237120(RUNX1T1)
RRO: 104654243(RUNX1T1)
RBB: 108512203(RUNX1T1)
CJC: 100409447(RUNX1T1)
SBQ: 101046150(RUNX1T1)
MMU: 12395(Runx1t1)
MCAL: 110292200(Runx1t1)
MPAH: 110338627(Runx1t1)
RNO: 362489(Runx1t1)
MUN: 110558721(Runx1t1)
CGE: 100768348(Runx1t1)
NGI: 103729546(Runx1t1)
CCAN: 109682056(Runx1t1)
OCU: 100354419(RUNX1T1)
TUP: 102487489(RUNX1T1)
CFA: 487044(RUNX1T1)
VVP: 112930994(RUNX1T1)
AML: 100478720(RUNX1T1)
UMR: 103661423(RUNX1T1)
UAH: 113252942(RUNX1T1)
ORO: 101379574(RUNX1T1)
ELK: 111146561
FCA: 101080942(RUNX1T1)
PTG: 102970421(RUNX1T1)
PPAD: 109269481(RUNX1T1)
AJU: 106974898(RUNX1T1)
BTA: 538628(RUNX1T1)
BOM: 102274988(RUNX1T1)
BIU: 109568483(RUNX1T1)
BBUB: 102390205(RUNX1T1)
CHX: 102171993(RUNX1T1)
OAS: 101113340(RUNX1T1)
SSC: 100155449(RUNX1T1)
CFR: 102516825(RUNX1T1)
CDK: 105085729(RUNX1T1)
BACU: 103005533
LVE: 103077217
OOR: 101271315(RUNX1T1)
DLE: 111180430(RUNX1T1)
PCAD: 102974126(RUNX1T1)
ECB: 100050630(RUNX1T1)
EPZ: 103553228(RUNX1T1)
EAI: 106824235(RUNX1T1)
MYB: 102243741(RUNX1T1)
MYD: 102756572(RUNX1T1)
MNA: 107534139(RUNX1T1)
HAI: 109372090(RUNX1T1)
DRO: 112315439(RUNX1T1)
PALE: 102888477(RUNX1T1)
RAY: 107512357(RUNX1T1)
MJV: 108408780
LAV: 100665783(RUNX1T1)
TMU: 101344188
MDO: 100022190(RUNX1T1)
SHR: 100922016(RUNX1T1)
PCW: 110198542(RUNX1T1)
OAA: 100073405(RUNX1T1)
GGA: 395503(RUNX1T1)
CJO: 107310364(RUNX1T1)
NMEL: 110394118(RUNX1T1)
APLA: 101800818(RUNX1T1)
ACYG: 106030524(RUNX1T1)
TGU: 100229704(RUNX1T1)
LSR: 110477431(RUNX1T1)
SCAN: 103813468(RUNX1T1)
GFR: 102040893(RUNX1T1)
FAB: 101821449(RUNX1T1)
PHI: 102099067(RUNX1T1)
PMAJ: 107200377(RUNX1T1)
CCAE: 111924553(RUNX1T1)
CCW: 104692752(RUNX1T1)
ETL: 114061745(RUNX1T1)
FPG: 101915609(RUNX1T1)
FCH: 102048856(RUNX1T1)
CLV: 102098210(RUNX1T1)
EGZ: 104125847(RUNX1T1)
NNI: 104016412(RUNX1T1)
ACUN: 113476598(RUNX1T1)
PADL: 103917305(RUNX1T1)
AAM: 106496278(RUNX1T1)
ASN: 102371887(RUNX1T1)
AMJ: 106737062(RUNX1T1)
PSS: 102455992(RUNX1T1)
CMY: 102938445(RUNX1T1)
CPIC: 101938633(RUNX1T1)
ACS: 100567064(runx1t1)
PVT: 110090578(RUNX1T1)
PMUR: 107285752(RUNX1T1)
TSR: 106538969(RUNX1T1)
PMUA: 114600431(RUNX1T1)
GJA: 107111652(RUNX1T1)
XLA: 100337515 108695382 733153(runx1t1.L)
XTR: 100491944(runx1t1)
NPR: 108800260(RUNX1T1)
DRE: 767809(runx1t1)
SRX: 107710231(runx1t1)
IPU: 108273286(runx1t1)
PHYP: 113543809(runx1t1)
AMEX: 103035738(runx1t1)
EEE: 113572313(runx1t1)
TRU: 101078656(runx1t1)
LCO: 104923114
NCC: 104953321(runx1t1)
MZE: 101478103(runx1t1)
ONL: 100701721(runx1t1)
OLA: 101159684(runx1t1)
XMA: 102222077(runx1t1)
XCO: 114156233(runx1t1)
PRET: 103472358(runx1t1)
CVG: 107100819(runx1t1)
NFU: 107394762(runx1t1)
KMR: 108240981(runx1t1)
ALIM: 106515789(runx1t1)
AOCE: 111563744(runx1t1)
CSEM: 103394450(runx1t1)
POV: 109631521(runx1t1)
LCF: 108897851(runx1t1)
SDU: 111223088(runx1t1)
SLAL: 111659311(runx1t1)
BPEC: 110167267(runx1t1)
MALB: 109963964(runx1t1)
ELS: 105006707(runx1t1)
PKI: 111848289(runx1t1)
LCM: 102358617(RUNX1T1)
CMK: 103184601(runx1t1)
RTP: 109913365
BFO: 118417968
SPU: 576535
DME: Dmel_CG3385(nvy)
DER: 6548294
DSI: Dsimw501_GD11849(Dsim_GD11849)
DSR: 110177432
DPE: 6601320
DAZ: 108616872
DHE: 111599688
NVI: 100680285
ZNE: 110830833
FCD: 110843270
HMG: 100200803
 » show all
Reference
PMID:9661669
  Authors
Wolford JK, Prochazka M
  Title
Structure and expression of the human MTG8/ETO gene.
  Journal
Gene 212:103-9 (1998)
DOI:10.1016/S0378-1119(98)00141-3
  Sequence
[hsa:862]
LinkDB

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