KEGG   ORTHOLOGY: K08527
Entry
K08527                      KO                                     

Name
RARA, NR1B1
Definition
retinoic acid receptor alpha
Pathway
ko04659  Th17 cell differentiation
ko04915  Estrogen signaling pathway
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K08527  RARA, NR1B1; retinoic acid receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08527  RARA, NR1B1; retinoic acid receptor alpha
   05202 Transcriptional misregulation in cancer
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08527  RARA, NR1B1; retinoic acid receptor alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08527  RARA, NR1B1; retinoic acid receptor alpha
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08527  RARA, NR1B1; retinoic acid receptor alpha
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1B. Retinoic acid receptor (RAR)
   K08527  RARA, NR1B1; retinoic acid receptor alpha
Other DBs
GO: 0003708
Genes
HSA: 5914(RARA)
PTR: 454647(RARA)
PPS: 100967548(RARA)
GGO: 101149605(RARA)
PON: 100439672(RARA)
NLE: 100603497(RARA)
MCC: 700206(RARA)
MCF: 102132722(RARA)
CSAB: 103243515(RARA)
RRO: 104655108(RARA)
RBB: 108534716(RARA)
CJC: 100410811(RARA)
SBQ: 101036514(RARA)
MMU: 19401(Rara)
MCAL: 110304400(Rara)
MPAH: 110331544(Rara)
RNO: 24705(Rara)
MUN: 110558507(Rara)
CGE: 100771910(Rara)
NGI: 103731122(Rara)
HGL: 101722948(Rara)
CCAN: 109694431(Rara)
OCU: 100009009(RARA)
TUP: 102498662(RARA)
CFA: 480526(RARA)
VVP: 112917766(RARA)
AML: 100463678(RARA)
UMR: 103662226(RARA)
UAH: 113265491(RARA)
ORO: 101381332(RARA)
ELK: 111151320
FCA: 101083048(RARA)
PTG: 102969575(RARA)
PPAD: 109247445(RARA)
AJU: 106980526(RARA)
BTA: 534280(RARA)
BOM: 102274769(RARA)
BIU: 109574115(RARA)
BBUB: 102412210(RARA)
CHX: 102188350(RARA)
OAS: 101107973(RARA)
SSC: 396709(RARA)
CFR: 102503688(RARA)
CDK: 105099020(RARA)
BACU: 103009412(RARA)
LVE: 103082251(RARA)
OOR: 101269345(RARA)
DLE: 111166235(RARA)
PCAD: 102981217(RARA)
ECB: 100054274(RARA)
EPZ: 103550195(RARA)
EAI: 106826262(RARA)
MYB: 102260476(RARA)
MYD: 102755605(RARA)
MNA: 107528992(RARA)
HAI: 109380809(RARA)
DRO: 112316405(RARA)
PALE: 102880130(RARA)
RAY: 107520689(RARA)
MJV: 108392195(RARA)
LAV: 100666758(RARA)
TMU: 101340976
MDO: 100015353(RARA)
SHR: 100923612(RARA)
PCW: 110215735(RARA)
OAA: 100092826(RARA)
GGA: 395213(RARA)
CJO: 107325261(RARA)
NMEL: 110388413
APLA: 101792081(RARA)
TGU: 778445(RARA)
LSR: 110471901(RARA)
SCAN: 103821620(RARA)
GFR: 102041075(RARA)
FAB: 101814830(RARA)
PHI: 102111110(RARA)
PMAJ: 107215144(RARA)
CCAE: 111940005(RARA)
CCW: 104697796(RARA)
ETL: 114069278(RARA)
FPG: 101912143(RARA)
FCH: 102055030(RARA)
CLV: 102092082(RARA)
AAM: 106486419(RARA)
ASN: 102387253(RARA)
AMJ: 102560946(RARA)
PSS: 102449811(RARA)
ACS: 100562365(rara)
PVT: 110085568(RARA)
PBI: 103066803(RARA)
PMUR: 107295660 107303084(RARA)
TSR: 106555178(RARA)
PMUA: 114582798(RARA)
GJA: 107108914(RARA)
XLA: 108702480 399081(rara.L)
XTR: 100038052(rara)
NPR: 108795221(RARA)
DRE: 30680(raraa) 555364(rarab)
EEE: 113582193
TRU: 101070619 445948(rara)
LCO: 104923246(rara) 104931638(rarb) 104935789
NCC: 104949876
ONL: 100690706(rara) 100692530
OLA: 100049282
XMA: 102222808(rara)
XCO: 114150468(rara)
PRET: 103481985(rara)
CVG: 107091050(rara)
NFU: 107388099(rara)
KMR: 108237228(rara) 108248182
ALIM: 106517345(rara)
CSEM: 103393600
LCF: 108875743(rara) 108898567
SDU: 111219812(rara) 111223734
SLAL: 111650283(rara) 111662467
BPEC: 110162387
SFM: 108928193(rara)
PKI: 111848637
LCM: 102356597(RARA)
CMK: 103173071 103189277(rara)
RTP: 109921635
BFO: 118405347
CBR: CBG06735 CBG08259(Cbr-nhr-26) CBG16291
MYI: 110442192
LAK: 106171053
 » show all
Reference
PMID:2825036
  Authors
Giguere V, Ong ES, Segui P, Evans RM
  Title
Identification of a receptor for the morphogen retinoic acid.
  Journal
Nature 330:624-9 (1987)
DOI:10.1038/330624a0
  Sequence
[hsa:5914]
Reference
  Authors
Parmar S, Tallman MS
  Title
Acute promyelocytic leukaemia:a review.
  Journal
Expert Opin Pharmacother 4:1379-92 (2003)
DOI:10.1517/14656566.4.8.1379
Reference
  Authors
Zelent A, Guidez F, Melnick A, Waxman S, Licht JD
  Title
Translocations of the RARalpha gene in acute promyelocytic leukemia.
  Journal
Oncogene 20:7186-203 (2001)
DOI:10.1038/sj.onc.1204766
LinkDB

KEGG   ORTHOLOGY: K10054
Entry
K10054                      KO                                     

Name
PML, TRIM19
Definition
probable transcription factor PML
Pathway
ko04120  Ubiquitin mediated proteolysis
ko04144  Endocytosis
ko05164  Influenza A
ko05168  Herpes simplex virus 1 infection
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Disease
H00003  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10054  PML, TRIM19; probable transcription factor PML
 09140 Cellular Processes
  09141 Transport and catabolism
   04144 Endocytosis
    K10054  PML, TRIM19; probable transcription factor PML
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10054  PML, TRIM19; probable transcription factor PML
   05202 Transcriptional misregulation in cancer
    K10054  PML, TRIM19; probable transcription factor PML
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K10054  PML, TRIM19; probable transcription factor PML
  09172 Infectious disease: viral
   05164 Influenza A
    K10054  PML, TRIM19; probable transcription factor PML
   05168 Herpes simplex virus 1 infection
    K10054  PML, TRIM19; probable transcription factor PML
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10054  PML, TRIM19; probable transcription factor PML
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRIM/RBCC proteins
    K10054  PML, TRIM19; probable transcription factor PML
Genes
HSA: 5371(PML)
PTR: 453736(PML)
PPS: 100993007(PML)
GGO: 101145052(PML)
PON: 100445630(PML)
NLE: 100607016(PML)
MCC: 700379(PML)
MCF: 102135847(PML)
CSAB: 103245348(PML)
RRO: 104678056 115891998 115897517 115897528
RBB: 108524152(PML)
CJC: 100388843(PML)
SBQ: 101042469(PML)
MMU: 18854(Pml)
MCAL: 110301964(Pml)
MPAH: 110327943(Pml)
RNO: 315713(Pml)
CGE: 100757598(Pml)
NGI: 103736862(Pml)
HGL: 101707749(Pml)
CCAN: 109687659
OCU: 100351382(PML)
TUP: 102474405(PML)
CFA: 487641(PML)
VVP: 112918012(PML)
AML: 100475070(PML)
UMR: 103679001(PML)
UAH: 113240956(PML)
ORO: 101365827(PML)
ELK: 111153323
FCA: 101086975(PML)
PTG: 102963011(PML)
PPAD: 109262710(PML)
AJU: 106979429(PML)
BTA: 100138545(PML)
BOM: 102286043(PML)
BIU: 109575524(PML)
BBUB: 102394614(PML)
CHX: 102173973(PML)
OAS: 101111580(PML)
SSC: 100157336(PML)
CFR: 102504760(PML)
CDK: 105087276(PML)
BACU: 103013991(PML)
LVE: 103090340(PML)
OOR: 101283102(PML)
DLE: 111177808(PML)
PCAD: 102983450(PML)
ECB: 100062744(PML)
EPZ: 103560966(PML)
MYB: 102242938(PML)
MYD: 102775373(PML)
MNA: 107528565(PML)
HAI: 109396273(PML)
DRO: 112301759(PML)
PALE: 102895190(PML)
RAY: 107500111(PML)
MJV: 108390543(PML)
LAV: 100663907(PML)
TMU: 101356208
MDO: 100029464(PML)
SHR: 100925902(PML)
PCW: 110214069(PML)
OAA: 100076474(PML)
GGA: 100857563(PMLL) 415302(PML)
MGP: 104912756(PML) 104912761
CJO: 107318588 107318590(PML)
NMEL: 110403842(PML) 110403910
APLA: 101796105 113844857(PML)
ACYG: 106044181(PML)
LSR: 110482659(PML)
PHI: 102107893(PML)
PMAJ: 107209110(PML)
ETL: 114059791(PML) 114060460
FPG: 101910511(PML) 101910853
ACUN: 113483848 113483936(PML)
PADL: 103922051 103922053(PML)
AAM: 106500165(PML) 106500166
AMJ: 102575005(PML)
PSS: 102454618(PML) 106731873
CMY: 102944212(PML) 102947589
CPIC: 101946293(PML) 101948754
PVT: 110084440(PML)
TSR: 106552979(PML)
GJA: 107109157
CMK: 103190730
 » show all
Reference
  Authors
Guo A, Salomoni P, Luo J, Shih A, Zhong S, Gu W, Pandolfi PP
  Title
The function of PML in p53-dependent apoptosis.
  Journal
Nat Cell Biol 2:730-6 (2000)
DOI:10.1038/35036365
  Sequence
[hsa:5371]
Reference
  Authors
Lin HK, Bergmann S, Pandolfi PP
  Title
Cytoplasmic PML function in TGF-beta signalling.
  Journal
Nature 431:205-11 (2004)
DOI:10.1038/nature02783
  Sequence
[hsa:5371] [mmu:18854]
Reference
PMID:1652369
  Authors
de The H, Lavau C, Marchio A, Chomienne C, Degos L, Dejean A
  Title
The PML-RAR alpha fusion mRNA generated by the t(15;17) translocation in acute promyelocytic leukemia encodes a functionally altered RAR.
  Journal
Cell 66:675-84 (1991)
DOI:10.1016/0092-8674(91)90113-D
  Sequence
[hsa:5371]
LinkDB

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