KEGG   ORTHOLOGY: K08527
Entry
K08527                      KO                                     

Name
RARA, NR1B1
Definition
retinoic acid receptor alpha
Pathway
ko04659  Th17 cell differentiation
ko04915  Estrogen signaling pathway
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K08527  RARA, NR1B1; retinoic acid receptor alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08527  RARA, NR1B1; retinoic acid receptor alpha
   05202 Transcriptional misregulation in cancer
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K08527  RARA, NR1B1; retinoic acid receptor alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08527  RARA, NR1B1; retinoic acid receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08527  RARA, NR1B1; retinoic acid receptor alpha
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08527  RARA, NR1B1; retinoic acid receptor alpha
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1B. Retinoic acid receptor (RAR)
   K08527  RARA, NR1B1; retinoic acid receptor alpha
Other DBs
GO: 0003708
Genes
HSA: 5914(RARA)
PTR: 454647(RARA)
PPS: 100967548(RARA)
GGO: 101149605(RARA)
PON: 100439672(RARA)
NLE: 100603497(RARA)
MCC: 700206(RARA)
MCF: 102132722(RARA)
CSAB: 103243515(RARA)
RRO: 104655108(RARA)
RBB: 108534716(RARA)
CJC: 100410811(RARA)
SBQ: 101036514(RARA)
MMU: 19401(Rara)
MCAL: 110304400(Rara)
MPAH: 110331544(Rara)
RNO: 24705(Rara)
MUN: 110558507(Rara)
CGE: 100771910(Rara)
NGI: 103731122(Rara)
HGL: 101722948(Rara)
CCAN: 109694431(Rara)
OCU: 100009009(RARA)
TUP: 102498662(RARA)
CFA: 480526(RARA)
VVP: 112917766(RARA)
AML: 100463678(RARA)
UMR: 103662226(RARA)
UAH: 113265491(RARA)
ORO: 101381332(RARA)
ELK: 111151320
FCA: 101083048(RARA)
PTG: 102969575(RARA)
PPAD: 109247445(RARA)
AJU: 106980526(RARA)
BTA: 534280(RARA)
BOM: 102274769(RARA)
BIU: 109574115(RARA)
BBUB: 102412210(RARA)
CHX: 102188350(RARA)
OAS: 101107973(RARA)
SSC: 396709(RARA)
CFR: 102503688(RARA)
CDK: 105099020(RARA)
BACU: 103009412(RARA)
LVE: 103082251(RARA)
OOR: 101269345(RARA)
DLE: 111166235(RARA)
PCAD: 102981217(RARA)
ECB: 100054274(RARA)
EPZ: 103550195(RARA)
EAI: 106826262(RARA)
MYB: 102260476(RARA)
MYD: 102755605(RARA)
MNA: 107528992(RARA)
HAI: 109380809(RARA)
DRO: 112316405(RARA)
PALE: 102880130(RARA)
RAY: 107520689(RARA)
MJV: 108392195(RARA)
LAV: 100666758(RARA)
TMU: 101340976
MDO: 100015353(RARA)
SHR: 100923612(RARA)
PCW: 110215735(RARA)
OAA: 100092826(RARA)
GGA: 395213(RARA)
CJO: 107325261(RARA)
NMEL: 110388413
APLA: 101792081(RARA)
TGU: 778445(RARA)
LSR: 110471901(RARA)
SCAN: 103821620(RARA)
GFR: 102041075(RARA)
FAB: 101814830(RARA)
PHI: 102111110(RARA)
PMAJ: 107215144(RARA)
CCAE: 111940005(RARA)
CCW: 104697796(RARA)
ETL: 114069278(RARA)
FPG: 101912143(RARA)
FCH: 102055030(RARA)
CLV: 102092082(RARA)
AAM: 106486419(RARA)
ASN: 102387253(RARA)
AMJ: 102560946(RARA)
PSS: 102449811(RARA)
ACS: 100562365(rara)
PVT: 110085568(RARA)
PBI: 103066803(RARA)
PMUR: 107295660 107303084(RARA)
TSR: 106555178(RARA)
PMUA: 114582798(RARA)
GJA: 107108914(RARA)
XLA: 108702480 399081(rara.L)
XTR: 100038052(rara)
NPR: 108795221(RARA)
DRE: 30680(raraa) 555364(rarab)
EEE: 113582193
TRU: 101070619 445948(rara)
LCO: 104923246(rara) 104931638(rarb) 104935789
NCC: 104949876
ONL: 100690706(rara) 100692530
OLA: 100049282
XMA: 102222808(rara)
XCO: 114150468(rara)
PRET: 103481985(rara)
CVG: 107091050(rara)
NFU: 107388099(rara)
KMR: 108237228(rara) 108248182
ALIM: 106517345(rara)
CSEM: 103393600
LCF: 108875743(rara) 108898567
SDU: 111219812(rara) 111223734
SLAL: 111650283(rara) 111662467
BPEC: 110162387
SFM: 108928193(rara)
PKI: 111848637
LCM: 102356597(RARA)
CMK: 103173071 103189277(rara)
RTP: 109921635
BFO: 118405347
CBR: CBG06735 CBG08259(Cbr-nhr-26) CBG16291
MYI: 110442192
LAK: 106171053
 » show all
Reference
PMID:2825036
  Authors
Giguere V, Ong ES, Segui P, Evans RM
  Title
Identification of a receptor for the morphogen retinoic acid.
  Journal
Nature 330:624-9 (1987)
DOI:10.1038/330624a0
  Sequence
[hsa:5914]
Reference
  Authors
Parmar S, Tallman MS
  Title
Acute promyelocytic leukaemia:a review.
  Journal
Expert Opin Pharmacother 4:1379-92 (2003)
DOI:10.1517/14656566.4.8.1379
Reference
  Authors
Zelent A, Guidez F, Melnick A, Waxman S, Licht JD
  Title
Translocations of the RARalpha gene in acute promyelocytic leukemia.
  Journal
Oncogene 20:7186-203 (2001)
DOI:10.1038/sj.onc.1204766
LinkDB

KEGG   ORTHOLOGY: K10055
Entry
K10055                      KO                                     

Name
ZBTB16, PLZF
Definition
zinc finger and BTB domain-containing protein 16
Pathway
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05221  Acute myeloid leukemia
Disease
H00003  Acute myeloid leukemia
H00969  Skeletal defects, genital hypoplasia, and mental retardation
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
   05202 Transcriptional misregulation in cancer
    K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
  09162 Cancer: specific types
   05221 Acute myeloid leukemia
    K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
   04121 Ubiquitin system
    K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys2His2 BTB-ZF factors
    K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul3 complex
    Adoptor and target recognizing subunit (BTB)
     K10055  ZBTB16, PLZF; zinc finger and BTB domain-containing protein 16
Genes
HSA: 7704(ZBTB16)
PTR: 100614588(ZBTB16)
PPS: 100985460(ZBTB16)
GGO: 101124528(ZBTB16)
PON: 100451883(ZBTB16)
NLE: 100592350(ZBTB16)
MCC: 695064(ZBTB16)
MCF: 102128204(ZBTB16)
CSAB: 103248510(ZBTB16)
RRO: 104669404(ZBTB16)
RBB: 108536425(ZBTB16)
CJC: 100402990(ZBTB16)
SBQ: 101046694(ZBTB16)
MMU: 235320(Zbtb16)
MCAL: 110301499(Zbtb16)
MPAH: 110327725(Zbtb16)
RNO: 353227(Zbtb16)
MUN: 110546467(Zbtb16)
CGE: 100769421(Zbtb16)
NGI: 103733862(Zbtb16)
HGL: 101714671(Zbtb16)
CCAN: 109696849(Zbtb16)
OCU: 100340808(ZBTB16)
TUP: 102501823(ZBTB16)
CFA: 489398(ZBTB16)
VVP: 112926000(ZBTB16)
AML: 100476757(ZBTB16)
UMR: 103662371(ZBTB16)
UAH: 113260036(ZBTB16)
ORO: 101365084(ZBTB16)
ELK: 111153896
FCA: 101098251(ZBTB16)
PTG: 102952489(ZBTB16)
PPAD: 109278625(ZBTB16)
AJU: 106980593(ZBTB16)
BTA: 534401(ZBTB16)
BOM: 102277947(ZBTB16)
BIU: 109569240(ZBTB16)
BBUB: 102399156(ZBTB16)
CHX: 102178465(ZBTB16)
OAS: 101110790(ZBTB16)
SSC: 100625290(ZBTB16)
CFR: 102509663(ZBTB16)
CDK: 105091728(ZBTB16)
BACU: 103010548(ZBTB16)
LVE: 103090028(ZBTB16)
OOR: 101288827(ZBTB16)
DLE: 111166850(ZBTB16)
PCAD: 102991828(ZBTB16)
ECB: 100062269(ZBTB16)
EPZ: 103558247(ZBTB16)
EAI: 106840234(ZBTB16)
MYB: 102252823(ZBTB16)
MYD: 102769015(ZBTB16)
MNA: 107534004(ZBTB16)
HAI: 109376325(ZBTB16)
DRO: 112314295(ZBTB16)
PALE: 102881382(ZBTB16)
RAY: 107512947(ZBTB16)
MJV: 108402128(ZBTB16)
LAV: 100662039(ZBTB16)
TMU: 101350829
MDO: 100032135(ZBTB16)
SHR: 100933393(ZBTB16)
PCW: 110210661(ZBTB16)
OAA: 100075814(ZBTB16)
GGA: 419759(ZBTB16)
MGP: 100541579(ZBTB16)
CJO: 107324253(ZBTB16)
NMEL: 110387619
APLA: 101802143(ZBTB16)
ACYG: 106039780(ZBTB16)
TGU: 100232059(ZBTB16)
LSR: 110470422(ZBTB16)
SCAN: 103822789(ZBTB16)
GFR: 102043540(ZBTB16)
FAB: 101813128(ZBTB16)
PHI: 102109988(ZBTB16)
PMAJ: 107214362(ZBTB16)
CCAE: 111939218(ZBTB16)
ETL: 114056303(ZBTB16)
FPG: 101923073(ZBTB16)
FCH: 102059061(ZBTB16)
NNI: 104014503(ZBTB16)
PADL: 103916556
AAM: 106485169(ZBTB16)
ASN: 102372235(ZBTB16)
AMJ: 102567776(ZBTB16)
PSS: 102460537(ZBTB16)
CMY: 102945049(ZBTB16)
CPIC: 101938550(ZBTB16) 101949992(ZBTB32)
PVT: 110078859(ZBTB16)
PBI: 103052630(ZBTB16)
PMUR: 107284810(ZBTB16)
TSR: 106556365(ZBTB16)
PMUA: 114585540(ZBTB16)
GJA: 107119746
XTR: 100491672(zbtb16)
NPR: 108799952(ZBTB16)
DRE: 323269(zbtb16a) 569773(zbtb16b)
IPU: 108278134(zbtb32) 108278332 108279032(zbtb16)
TRU: 101072859(zbtb16) 101073528
LCO: 104921104(zbtb16) 104923551 109142303(zbtb32)
MZE: 101469068(zbtb16) 101470529 101480736(zbtb32)
ONL: 100698618 100711409(zbtb16) 102081037(zbtb32)
OLA: 101167059 101172923(zbtb16) 101175679(zbtb32)
XMA: 102232145 102233172(zbtb16) 111608037(zbtb32)
XCO: 114133674 114142155(zbtb32) 114152773(zbtb16)
PRET: 103474176 103476321(zbtb16) 103478523(zbtb32)
CVG: 107081864(zbtb16) 107090403
NFU: 107378654(zbtb32) 107380105 107396448(zbtb16)
KMR: 108238079(zbtb16) 108241921(zbtb32) 108243092
ALIM: 106514606(zbtb16) 106517682(zbtb32) 106520381
AOCE: 111569735 111577042(zbtb32) 111582764(zbtb16)
CSEM: 103378326 103395382(zbtb16)
POV: 109630208 109633032(zbtb32) 109635698(zbtb16)
LCF: 108877971 108890714(zbtb32) 108891921(zbtb16)
SDU: 111232317 111233091(zbtb16) 111234045(zbtb32)
SLAL: 111651921 111656077(zbtb16) 111664996(zbtb32)
HCQ: 109515667(zbtb16) 109518498
BPEC: 110153907(zbtb16) 110163737 110171810(zbtb32)
MALB: 109959215(zbtb16) 109968536 109971700(zbtb32)
ELS: 105019117(zbtb32) 105023202 105023959(zbtb16)
SFM: 108928729 108930325(zbtb32) 108936141(zbtb16)
PKI: 111833706(zbtb32) 111844800(zbtb16) 111851301
LCM: 102346444 102358637(ZBTB16)
CMK: 103190824
 » show all
Reference
  Authors
Furukawa M, He YJ, Borchers C, Xiong Y.
  Title
Targeting of protein ubiquitination by BTB-Cullin 3-Roc1 ubiquitin ligases.
  Journal
Nat Cell Biol 5:1001-7 (2003)
DOI:10.1038/ncb1056
  Sequence
[hsa:7704]
LinkDB

DBGET integrated database retrieval system