KEGG   ORTHOLOGY: K08530
Entry
K08530                      KO                                     

Name
NR1C3, PPARG
Definition
peroxisome proliferator-activated receptor gamma
Pathway
ko03320  PPAR signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04380  Osteoclast differentiation
ko04714  Thermogenesis
ko04932  Non-alcoholic fatty liver disease
ko05016  Huntington disease
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
ko05417  Lipid and atherosclerosis
Disease
H00032  Thyroid cancer
H00409  Type 2 diabetes mellitus
H00420  Familial partial lipodystrophy
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09149 Aging
   04211 Longevity regulating pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09159 Environmental adaptation
   04714 Thermogenesis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
   05202 Transcriptional misregulation in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09162 Cancer: specific types
   05216 Thyroid cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09164 Neurodegenerative disease
   05016 Huntington disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09166 Cardiovascular disease
   05417 Lipid and atherosclerosis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1C. Peroxisome proliferator-activated receptor (PPAR)
   K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Genes
HSA: 5468(PPARG)
PTR: 460178(PPARG)
PPS: 100974825(PPARG)
GGO: 101134077(PPARG)
PON: 100171496(PPARG)
NLE: 100581046(PPARG)
MCC: 574190(PPARG)
MCF: 102120453(PPARG)
CSAB: 103228027(PPARG)
RRO: 104673295(PPARG)
RBB: 108517991(PPARG)
CJC: 100414099(PPARG)
SBQ: 101028278(PPARG)
MMU: 19016(Pparg)
MCAL: 110295901(Pparg)
MPAH: 110317409(Pparg)
RNO: 25664(Pparg)
MUN: 110550822(Pparg)
CGE: 100689245(Pparg)
NGI: 103751484(Pparg)
HGL: 101711078(Pparg)
CCAN: 109694945(Pparg)
OCU: 100008892(PPARG)
TUP: 102495121(PPARG)
CFA: 403606(PPARG)
VVP: 112933683(PPARG)
AML: 100482938(PPARG)
UMR: 103669544(PPARG)
UAH: 113257185(PPARG)
ORO: 101370284(PPARG)
ELK: 111144031
FCA: 101095161(PPARG)
PTG: 102957164(PPARG)
PPAD: 109254341(PPARG)
AJU: 106977134(PPARG)
BTA: 281993(PPARG)
BOM: 102265537(PPARG)
BIU: 109576385(PPARG)
BBUB: 102399331(PPARG)
CHX: 100861309(PPARG)
OAS: 443513(PPARG)
SSC: 397671(PPARG)
CFR: 102516350(PPARG)
CDK: 105093103(PPARG)
BACU: 103013413(PPARG)
LVE: 103085722(PPARG)
OOR: 101271228(PPARG)
DLE: 111168952
PCAD: 102986529(PPARG)
ECB: 100051258(PPARG)
EPZ: 103554547(PPARG)
EAI: 106829341(PPARG)
MYB: 102254594(PPARG)
MYD: 102771129(PPARG)
MNA: 107534765(PPARG)
HAI: 109384577(PPARG)
DRO: 112301119(PPARG)
PALE: 102892450(PPARG)
RAY: 107519731(PPARG)
MJV: 108394347(PPARG)
LAV: 100654408(PPARG)
TMU: 101356506
MDO: 100025091(PPARG)
SHR: 100934154(PPARG)
PCW: 110204887(PPARG)
OAA: 100080852(PPARG)
GGA: 373928(PPARG)
MGP: 100540960(PPARG)
CJO: 107319697(PPARG)
NMEL: 110404711(PPARG)
APLA: 101792429(PPARG)
ACYG: 106040065(PPARG)
TGU: 100231741(PPARG)
LSR: 110470665(PPARG)
SCAN: 103816936(PPARG)
GFR: 102035311(PPARG)
FAB: 101815733(PPARG)
PHI: 102104364(PPARG)
PMAJ: 107210458(PPARG)
CCAE: 111935235(PPARG)
CCW: 104695746(PPARG)
ETL: 114059219(PPARG)
FPG: 101911405(PPARG)
FCH: 102051838(PPARG)
CLV: 102097513(PPARG)
EGZ: 104124309(PPARG)
NNI: 104022931(PPARG)
ACUN: 113484975(PPARG)
PADL: 103915212(PPARG)
AAM: 106488868(PPARG)
ASN: 102375364(PPARG)
AMJ: 102575176(PPARG)
PSS: 102460093(PPARG)
CMY: 102947653(PPARG)
CPIC: 101930880(PPARG)
ACS: 100557020(pparg)
PVT: 110083807(PPARG)
PBI: 103056230(PPARG)
TSR: 106542303
PMUA: 114591638(PPARG)
GJA: 107118018(PPARG)
XLA: 108704054(nr1C3) 108704417 397769(pparg.L)
XTR: 100144687(pparg)
NPR: 108785475(PPARG)
DRE: 557037(pparg)
SRX: 107742034 107758005(pparg)
SANH: 107667870 107687310(pparg)
SGH: 107564291(pparg) 107571218
CCAR: 109081042(pparg) 109103539
IPU: 108254912(pparg) 108276331
PHYP: 113537934(pparg) 113545604
AMEX: 103026166 103030663(pparg)
EEE: 113589601(pparg)
TRU: 100049069(pparg)
LCO: 104919339(pparg)
NCC: 104947475(pparg)
MZE: 101485991(pparg)
ONL: 100711231(pparg)
OLA: 100304459(pparg)
XMA: 102229218(pparg)
XCO: 114136130(pparg)
PRET: 103464445(pparg)
CVG: 107087543(pparg)
NFU: 107385283(pparg)
KMR: 108231651(pparg)
ALIM: 106513826(pparg)
AOCE: 111564578(pparg)
CSEM: 103385631(pparg)
POV: 109635570(pparg)
LCF: 108890100(pparg)
SDU: 111224020(pparg)
HCQ: 109529222(pparg)
BPEC: 110168463(pparg)
MALB: 109965555(pparg)
SALP: 111966207 112069430(pparg)
SFM: 108929802(pparg)
PKI: 111837542(pparg)
LCM: 102360245(PPARG)
CMK: 103185017(pparg)
RTP: 109911575(pparg)
BFO: 118405726
SPU: 579208
APLC: 110991238
SKO: 102802392
MYI: 110455413
 » show all
Reference
PMID:9065481
  Authors
Mukherjee R, Jow L, Croston GE, Paterniti JR Jr
  Title
Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and  activation with retinoid X receptor agonists and antagonists.
  Journal
J Biol Chem 272:8071-6 (1997)
DOI:10.1074/jbc.272.12.8071
  Sequence
[hsa:5468]
Reference
  Authors
Eberhardt NL, Grebe SK, McIver B, Reddi HV
  Title
The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.
  Journal
Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013
Reference
  Authors
Park SH, Choi HJ, Yang H, Do KH, Kim J, Lee DW, Moon Y
  Title
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.
  Journal
J Biol Chem 285:35330-9 (2010)
DOI:10.1074/jbc.M110.136259
  Sequence
[hsa:5468]
LinkDB

KEGG   ORTHOLOGY: K09293
Entry
K09293                      KO                                     

Name
PAX8
Definition
paired box protein 8
Pathway
ko04918  Thyroid hormone synthesis
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
Disease
H00032  Thyroid cancer
H00250  Congenital nongoitrous hypothyroidism (CHNG)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    K09293  PAX8; paired box protein 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09293  PAX8; paired box protein 8
   05202 Transcriptional misregulation in cancer
    K09293  PAX8; paired box protein 8
  09162 Cancer: specific types
   05216 Thyroid cancer
    K09293  PAX8; paired box protein 8
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09293  PAX8; paired box protein 8
Transcription factors [BR:ko03000]
 Eukaryotic type
  Helix-turn-helix
   Homeo domain Paired-related
    K09293  PAX8; paired box protein 8
Genes
HSA: 7849(PAX8)
PTR: 459503(PAX8)
PPS: 100988818(PAX8)
GGO: 101137174(PAX8)
PON: 100189903(PAX8)
NLE: 100591164(PAX8)
MCC: 701906(PAX8)
MCF: 102128714(PAX8)
CSAB: 103241300(PAX8)
RRO: 104664521(PAX8)
RBB: 108541813(PAX8)
CJC: 100386350(PAX8)
SBQ: 101036832(PAX8)
MMU: 18510(Pax8)
MCAL: 110288541(Pax8)
MPAH: 110319687(Pax8)
RNO: 81819(Pax8)
MUN: 110565132(Pax8)
CGE: 100758326(Pax8)
NGI: 103750879(Pax8)
HGL: 101708397(Pax8)
CCAN: 109674600(Pax8)
OCU: 100356013(PAX8)
TUP: 102490939(PAX8)
CFA: 403927(PAX8)
VVP: 112916651(PAX8)
AML: 100480115
UMR: 103671861(PAX8)
UAH: 113242539(PAX8)
ORO: 101366440(PAX8)
ELK: 111158488
FCA: 101096468(PAX8)
PTG: 102965881(PAX8)
PPAD: 109264411(PAX8)
AJU: 106978160(PAX8)
BTA: 534661(PAX8)
BOM: 102284473(PAX8)
BIU: 109566138(PAX8)
BBUB: 102391536(PAX8)
CHX: 102182513(PAX8)
OAS: 101105489(PAX8)
CFR: 102522995(PAX8)
CDK: 105104189(PAX8)
BACU: 103010950(PAX8)
LVE: 103091318(PAX8)
OOR: 101283473(PAX8)
DLE: 111187442(PAX8)
PCAD: 102977097(PAX8)
ECB: 100065303(PAX8)
EPZ: 103556362(PAX8)
EAI: 106838567(PAX8)
MYB: 102245803(PAX8)
MYD: 102763999(PAX8)
MNA: 107528648(PAX8)
HAI: 109392002(PAX8)
DRO: 112303046(PAX8)
PALE: 102894983(PAX8)
RAY: 107514881(PAX8)
MJV: 108399296(PAX8)
LAV: 100674361(PAX8)
TMU: 101341443
MDO: 100026381(PAX8)
SHR: 100924183(PAX8)
PCW: 110192497(PAX8)
OAA: 100092700(PAX8)
ASN: 102383886
AMJ: 102561272(PAX8)
CMY: 102932253(PAX8)
CPIC: 101948804(PAX8)
PVT: 110072062(PAX8)
PMUA: 114602725(PAX8)
GJA: 107118734(PAX8)
XLA: 108712742 398132(pax8.L)
XTR: 780226(pax8)
NPR: 108786488(PAX8)
DRE: 60637(pax8)
SGH: 107565649(pax8) 107566853
IPU: 108259728(pax8)
PHYP: 113531649(pax8)
AMEX: 103024056(pax8)
EEE: 113588085(pax8)
TRU: 101061486(pax8)
LCO: 104924975(pax8)
NCC: 104956502(pax8)
MZE: 101470942(pax8)
ONL: 100701954
OLA: 101175252(pax8)
XMA: 102232356(pax8)
XCO: 114149040(pax8)
PRET: 103473805(pax8)
CVG: 107095650(pax8)
NFU: 107374241
KMR: 108247529(pax8)
ALIM: 106514428(pax8)
AOCE: 111567309(pax8)
CSEM: 103390235(pax8)
POV: 109643688(pax8)
LCF: 108874435(pax8)
SDU: 111240033(pax8)
SLAL: 111664727(pax8)
HCQ: 109520439(pax8)
BPEC: 110160502(pax8)
MALB: 109960648(pax8)
SALP: 111961618(pax8) 111964523
ELS: 105015027(pax8)
SFM: 108920169 108927195(pax8)
PKI: 111847430(pax8) 111848554
LCM: 102349238(PAX8)
CMK: 103174080
BMY: Bm1_38865
CRG: 105342795
 » show all
Reference
  Authors
Carroll TJ, Vize PD
  Title
Synergism between Pax-8 and lim-1 in embryonic kidney development.
  Journal
Dev Biol 214:46-59 (1999)
DOI:10.1006/dbio.1999.9414
  Sequence
[xla:398132]
Reference
  Authors
Eberhardt NL, Grebe SK, McIver B, Reddi HV
  Title
The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.
  Journal
Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013
LinkDB

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