KEGG   ORTHOLOGY: K08530Help
Entry
K08530                      KO                                     

Name
NR1C3, PPARG
Definition
peroxisome proliferator-activated receptor gamma
Pathway
ko03320  PPAR signaling pathway
ko04152  AMPK signaling pathway
ko04211  Longevity regulating pathway
ko04380  Osteoclast differentiation
ko04714  Thermogenesis
ko05016  Huntington disease
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
Disease
H00032  Thyroid cancer
H00409  Type 2 diabetes mellitus
H00420  Familial partial lipodystrophy
H02106  Genetic obesity
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04152 AMPK signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
 09150 Organismal Systems
  09152 Endocrine system
   03320 PPAR signaling pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09149 Aging
   04211 Longevity regulating pathway
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09159 Environmental adaptation
   04714 Thermogenesis
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
   05202 Transcriptional misregulation in cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09162 Cancer: specific types
   05216 Thyroid cancer
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09164 Neurodegenerative disease
   05016 Huntington disease
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone-like
    K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1C. Peroxisome proliferator-activated receptor (PPAR)
   K08530  NR1C3, PPARG; peroxisome proliferator-activated receptor gamma
BRITE hierarchy
Genes
HSA: 5468(PPARG)
PTR: 460178(PPARG)
PPS: 100974825(PPARG)
GGO: 101134077(PPARG)
PON: 100171496(PPARG)
NLE: 100581046(PPARG)
MCC: 574190(PPARG)
MCF: 102120453(PPARG)
CSAB: 103228027(PPARG)
RRO: 104673295(PPARG)
RBB: 108517991(PPARG)
CJC: 100414099(PPARG)
SBQ: 101028278(PPARG)
MMU: 19016(Pparg)
MCAL: 110295901(Pparg)
MPAH: 110317409(Pparg)
RNO: 25664(Pparg)
MUN: 110550822(Pparg)
CGE: 100689245(Pparg)
NGI: 103751484(Pparg)
HGL: 101711078(Pparg)
CCAN: 109694945(Pparg)
OCU: 100008892(PPARG)
TUP: 102495121(PPARG)
CFA: 403606(PPARG)
VVP: 112933683(PPARG)
AML: 100482938(PPARG)
UMR: 103669544(PPARG)
UAH: 113257185(PPARG)
ORO: 101370284(PPARG)
ELK: 111144031
FCA: 101095161(PPARG)
PTG: 102957164(PPARG)
PPAD: 109254341(PPARG)
AJU: 106977134(PPARG)
BTA: 281993(PPARG)
BOM: 102265537(PPARG)
BIU: 109576385(PPARG)
BBUB: 102399331(PPARG)
CHX: 100861309(PPARG)
OAS: 443513(PPARG)
SSC: 397671(PPARG)
CFR: 102516350(PPARG)
CDK: 105093103(PPARG)
BACU: 103013413(PPARG)
LVE: 103085722(PPARG)
OOR: 101271228(PPARG)
DLE: 111168952
PCAD: 102986529(PPARG)
ECB: 100051258(PPARG)
EPZ: 103554547(PPARG)
EAI: 106829341(PPARG)
MYB: 102254594(PPARG)
MYD: 102771129(PPARG)
MNA: 107534765(PPARG)
HAI: 109384577(PPARG)
DRO: 112301119(PPARG)
PALE: 102892450(PPARG)
RAY: 107519731(PPARG)
MJV: 108394347(PPARG)
LAV: 100654408(PPARG)
TMU: 101356506
MDO: 100025091(PPARG)
SHR: 100934154(PPARG)
PCW: 110204887(PPARG)
OAA: 100080852(PPARG)
GGA: 373928(PPARG)
MGP: 100540960(PPARG)
CJO: 107319697(PPARG)
NMEL: 110404711(PPARG)
APLA: 101792429(PPARG)
ACYG: 106040065(PPARG)
TGU: 100231741(PPARG)
LSR: 110470665(PPARG)
SCAN: 103816936(PPARG)
GFR: 102035311(PPARG)
FAB: 101815733(PPARG)
PHI: 102104364(PPARG)
PMAJ: 107210458(PPARG)
CCAE: 111935235(PPARG)
CCW: 104695746(PPARG)
ETL: 114059219(PPARG)
FPG: 101911405(PPARG)
FCH: 102051838(PPARG)
CLV: 102097513(PPARG)
EGZ: 104124309(PPARG)
NNI: 104022931(PPARG)
ACUN: 113484975(PPARG)
PADL: 103915212(PPARG)
AAM: 106488868(PPARG)
ASN: 102375364(PPARG)
AMJ: 102575176(PPARG)
PSS: 102460093(PPARG)
CMY: 102947653(PPARG)
CPIC: 101930880(PPARG)
ACS: 100557020(pparg)
PVT: 110083807(PPARG)
PBI: 103056230(PPARG)
TSR: 106542303
PMUA: 114591638(PPARG)
GJA: 107118018(PPARG)
XLA: 108704054(nr1C3) 108704417 397769(pparg.L)
XTR: 100144687(pparg)
NPR: 108785475(PPARG)
DRE: 557037(pparg)
SRX: 107742034 107758005(pparg)
SANH: 107667870 107687310(pparg)
SGH: 107564291(pparg) 107571218
CCAR: 109081042(pparg) 109103539
IPU: 108254912(pparg) 108276331
PHYP: 113537934(pparg) 113545604
AMEX: 103026166 103030663(pparg)
EEE: 113589601(pparg)
TRU: 100049069(pparg)
LCO: 104919339(pparg)
NCC: 104947475(pparg)
MZE: 101485991(pparg)
ONL: 100711231(pparg)
OLA: 100304459(pparg)
XMA: 102229218(pparg)
XCO: 114136130(pparg)
PRET: 103464445(pparg)
CVG: 107087543(pparg)
NFU: 107385283(pparg)
KMR: 108231651(pparg)
ALIM: 106513826(pparg)
AOCE: 111564578(pparg)
CSEM: 103385631(pparg)
POV: 109635570(pparg)
LCF: 108890100(pparg)
SDU: 111224020(pparg)
HCQ: 109529222(pparg)
BPEC: 110168463(pparg)
MALB: 109965555(pparg)
SALP: 111966207 112069430(pparg)
SFM: 108929802(pparg)
PKI: 111837542(pparg)
LCM: 102360245(PPARG)
CMK: 103185017(pparg)
RTP: 109911575(pparg)
SPU: 579208
APLC: 110991238
SKO: 102802392
MYI: 110455413
 » show all
TaxonomyKoalaUniProt
Reference
PMID:9065481
  Authors
Mukherjee R, Jow L, Croston GE, Paterniti JR Jr
  Title
Identification, characterization, and tissue distribution of human peroxisome proliferator-activated receptor (PPAR) isoforms PPARgamma2 versus PPARgamma1 and  activation with retinoid X receptor agonists and antagonists.
  Journal
J Biol Chem 272:8071-6 (1997)
DOI:10.1074/jbc.272.12.8071
  Sequence
[hsa:5468]
Reference
  Authors
Eberhardt NL, Grebe SK, McIver B, Reddi HV
  Title
The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.
  Journal
Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013
Reference
  Authors
Park SH, Choi HJ, Yang H, Do KH, Kim J, Lee DW, Moon Y
  Title
Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma.
  Journal
J Biol Chem 285:35330-9 (2010)
DOI:10.1074/jbc.M110.136259
  Sequence
[hsa:5468]
LinkDB All DBs

KEGG   ORTHOLOGY: K09293Help
Entry
K09293                      KO                                     

Name
PAX8
Definition
paired box protein 8
Pathway
ko04918  Thyroid hormone synthesis
ko05200  Pathways in cancer
ko05202  Transcriptional misregulation in cancer
ko05216  Thyroid cancer
Disease
H00032  Thyroid cancer
H00250  Congenital nongoitrous hypothyroidism (CHNG)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04918 Thyroid hormone synthesis
    K09293  PAX8; paired box protein 8
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09293  PAX8; paired box protein 8
   05202 Transcriptional misregulation in cancer
    K09293  PAX8; paired box protein 8
  09162 Cancer: specific types
   05216 Thyroid cancer
    K09293  PAX8; paired box protein 8
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09293  PAX8; paired box protein 8
Transcription factors [BR:ko03000]
 Eukaryotic type
  Helix-turn-helix
   Paired box domain only
    K09293  PAX8; paired box protein 8
BRITE hierarchy
Genes
HSA: 7849(PAX8)
PTR: 459503(PAX8)
PPS: 100988818(PAX8)
GGO: 101137174(PAX8)
PON: 100189903(PAX8)
NLE: 100591164(PAX8)
MCC: 701906(PAX8)
MCF: 102128714(PAX8)
CSAB: 103241300(PAX8)
RRO: 104664521(PAX8)
RBB: 108541813(PAX8)
CJC: 100386350(PAX8)
SBQ: 101036832(PAX8)
MMU: 18510(Pax8)
MCAL: 110288541(Pax8)
MPAH: 110319687(Pax8)
RNO: 81819(Pax8)
MUN: 110565132(Pax8)
CGE: 100758326(Pax8)
NGI: 103750879(Pax8)
HGL: 101708397(Pax8)
CCAN: 109674600(Pax8)
OCU: 100356013(PAX8)
TUP: 102490939(PAX8)
CFA: 403927(PAX8)
VVP: 112916651(PAX8)
AML: 100480115(PAX8)
UMR: 103671861(PAX8)
UAH: 113242539(PAX8)
ORO: 101366440(PAX8)
ELK: 111158488
FCA: 101096468(PAX8)
PTG: 102965881(PAX8)
PPAD: 109264411(PAX8)
AJU: 106978160(PAX8)
BTA: 534661(PAX8)
BOM: 102284473(PAX8)
BIU: 109566138(PAX8)
BBUB: 102391536(PAX8)
CHX: 102182513(PAX8)
OAS: 101105489(PAX8)
CFR: 102522995(PAX8)
CDK: 105104189(PAX8)
BACU: 103010950(PAX8)
LVE: 103091318(PAX8)
OOR: 101283473(PAX8)
DLE: 111187442(PAX8)
PCAD: 102977097(PAX8)
ECB: 100065303(PAX8)
EPZ: 103556362(PAX8)
EAI: 106838567(PAX8)
MYB: 102245803(PAX8)
MYD: 102763999(PAX8)
MNA: 107528648(PAX8)
HAI: 109392002(PAX8)
DRO: 112303046(PAX8)
PALE: 102894983(PAX8)
RAY: 107514881(PAX8)
MJV: 108399296(PAX8)
LAV: 100674361(PAX8)
TMU: 101341443
MDO: 100026381(PAX8)
SHR: 100924183(PAX8)
PCW: 110192497(PAX8)
OAA: 100092700(PAX8)
ASN: 102383886
AMJ: 102561272(PAX8)
CMY: 102932253(PAX8)
CPIC: 101948804(PAX8)
PVT: 110072062(PAX8)
PMUA: 114602725(PAX8)
GJA: 107118734(PAX8)
XLA: 108712742 398132(pax8.L)
XTR: 780226(pax8)
NPR: 108786488(PAX8)
DRE: 60637(pax8)
SGH: 107565649(pax8) 107566853
IPU: 108259728(pax8)
PHYP: 113531649(pax8)
AMEX: 103024056(pax8)
EEE: 113588085(pax8)
TRU: 101061486(pax8)
LCO: 104924975(pax8)
NCC: 104956502(pax8)
MZE: 101470942(pax8)
ONL: 100701954
OLA: 101175252(pax8)
XMA: 102232356(pax8)
XCO: 114149040(pax8)
PRET: 103473805(pax8)
CVG: 107095650(pax8)
NFU: 107374241
KMR: 108247529(pax8)
ALIM: 106514428(pax8)
AOCE: 111567309(pax8)
CSEM: 103390235(pax8)
POV: 109643688(pax8)
LCF: 108874435(pax8)
SDU: 111240033(pax8)
SLAL: 111664727(pax8)
HCQ: 109520439(pax8)
BPEC: 110160502(pax8)
MALB: 109960648(pax8)
SALP: 111961618(pax8) 111964523
ELS: 105015027(pax8)
SFM: 108920169 108927195(pax8)
PKI: 111847430(pax8) 111848554
LCM: 102349238(PAX8)
CMK: 103174080
BMY: Bm1_38865
CRG: 105342795
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Eberhardt NL, Grebe SK, McIver B, Reddi HV
  Title
The role of the PAX8/PPARgamma fusion oncogene in the pathogenesis of follicular thyroid cancer.
  Journal
Mol Cell Endocrinol 321:50-6 (2010)
DOI:10.1016/j.mce.2009.10.013
LinkDB All DBs

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