KEGG   ORTHOLOGY: K08532
Entry
K08532                      KO                                     

Name
NR1F1, RORA
Definition
RAR-related orphan receptor alpha
Pathway
ko04659  Th17 cell differentiation
ko04710  Circadian rhythm
ko05017  Spinocerebellar ataxia
ko05321  Inflammatory bowel disease
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
  09159 Environmental adaptation
   04710 Circadian rhythm
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
 09160 Human Diseases
  09163 Immune disease
   05321 Inflammatory bowel disease
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
  09164 Neurodegenerative disease
   05017 Spinocerebellar ataxia
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08532  NR1F1, RORA; RAR-related orphan receptor alpha
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1F. RAR-related orphan receptor
   K08532  NR1F1, RORA; RAR-related orphan receptor alpha
Genes
HSA: 6095(RORA)
PTR: 747433(RORA)
PPS: 100989776(RORA)
GGO: 101125058(RORA)
PON: 100445142(RORA)
NLE: 100587959(RORA)
MCC: 704014(RORA)
MCF: 102142259(RORA)
CSAB: 103245526(RORA)
RRO: 104670920(RORA)
RBB: 108523788(RORA)
CJC: 100390648(RORA)
SBQ: 101049593(RORA)
MMU: 19883(Rora)
MPAH: 110327499(Rora)
RNO: 300807(Rora)
MUN: 110557983(Rora)
CGE: 100759952(Rora)
NGI: 103737163(Rora)
HGL: 101721524(Rora)
CCAN: 109689822(Rora)
OCU: 100357159(RORA)
TUP: 102490950(RORA)
CFA: 478328(RORA)
VVP: 112922319(RORA)  
AML: 100468759(RORA)
UMR: 103676810(RORA)
UAH: 113269696(RORA)
ORO: 101385407(RORA)
ELK: 111153212
FCA: 101099721(RORA)
PTG: 102957688(RORA)  
PPAD: 109262552(RORA)
AJU: 106973774(RORA)
BTA: 535597(RORA)
BOM: 102265071(RORA)
BIU: 109565074(RORA)
BBUB: 102395227(RORA)
CHX: 100861305(RORA)
OAS: 101102986(RORA)
SSC: 100156637(RORA)
CFR: 102504925(RORA)
CDK: 105095825(RORA)
BACU: 103012995(RORA)
LVE: 103089178(RORA)
OOR: 101280408(RORA)
DLE: 111177681(RORA)
PCAD: 102977156(RORA)
ECB: 100147460(RORA)
EPZ: 103546754(RORA)
EAI: 106837082(RORA)
MYB: 102254161(RORA)
MYD: 102774774(RORA)
MNA: 107533760(RORA)
HAI: 109387092(RORA)
DRO: 112311206(RORA)
PALE: 102895436(RORA)  
RAY: 107501081(RORA)
MJV: 108396761(RORA)
LAV: 100661375(RORA)
TMU: 101347664
MDO: 100022410(RORA)
SHR: 100928066(RORA)
PCW: 110195741(RORA)
OAA: 100079841(RORA)
GGA: 415377(RORA)
MGP: 100540183(RORA)
CJO: 107318548(RORA)
NMEL: 110403863(RORA)  
APLA: 101791752(RORA)
ACYG: 106033747(RORA)
TGU: 100230248(RORA)
LSR: 110483952(RORA)
SCAN: 103815958(RORA)
GFR: 102035874(RORA)
FAB: 101820155(RORA)
PHI: 102105980(RORA)
PMAJ: 107209120(RORA)
CCAE: 111934204(RORA)
CCW: 104683801(RORA)
ETL: 114068044(RORA)
FPG: 101922092(RORA)
FCH: 102054776(RORA)
CLV: 102098039(RORA)
EGZ: 104130752(RORA)
NNI: 104016754(RORA)
ACUN: 113484075(RORA)
PADL: 103921984(RORA)
AAM: 106496491(RORA)
ASN: 102383436(RORA)
AMJ: 106736689(RORA)
PSS: 102446179(RORA)
CMY: 102930088(RORA)
CPIC: 101940150(RORA)
ACS: 100561717(rora)
PVT: 110074509(RORA) 110074510
PBI: 103063815(RORA)
PMUR: 107283147(RORA)
TSR: 106552717
PMUA: 114584340(RORA)
GJA: 107126278(RORA)
XLA: 108711313(rora.L) 108712978(rora.S)
XTR: 780120(rora)
NPR: 108785559
DRE: 100004847(rorc) 554722(rorab) 564951(roraa)
IPU: 108273951 108275032(rora)
PHYP: 113529607(rora) 113533997
TRU: 101061119(rora) 101064540
NCC: 104952213(rora) 104959176
OLA: 101167704(rora) 101172927
CVG: 107087383(rora) 107097347
KMR: 108230126(rora) 108241160
ALIM: 106514366(rora) 106533278
CSEM: 103380018(rora) 103388168(rorc)
HCQ: 109519425(rora) 109529033
OTW: 112252394
SFM: 108925890 108940883(rora)
LCM: 102355343(RORA)
RTP: 109922324
CIN: 779001(ror)
APLC: 110974595
CRG: 105331187
SHX: MS3_01203
 » show all
Reference
  Authors
Jetten AM
  Title
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
  Journal
Nucl Recept Signal 7:e003 (2009)
DOI:10.1621/nrs.07003
  Sequence
[hsa:6095] [mmu:19883]
Reference
PMID:7926749
  Authors
Giguere V, Tini M, Flock G, Ong E, Evans RM, Otulakowski G
  Title
Isoform-specific amino-terminal domains dictate DNA-binding properties of ROR alpha, a novel family of orphan hormone nuclear receptors.
  Journal
Genes Dev 8:538-53 (1994)
DOI:10.1101/gad.8.5.538
  Sequence
[hsa:6095]
LinkDB

KEGG   ORTHOLOGY: K08533
Entry
K08533                      KO                                     

Name
NR1F2, RORB
Definition
RAR-related orphan receptor beta
Pathway
ko04710  Circadian rhythm
Disease
H00808  Idiopathic generalized epilepsies
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09159 Environmental adaptation
   04710 Circadian rhythm
    K08533  NR1F2, RORB; RAR-related orphan receptor beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08533  NR1F2, RORB; RAR-related orphan receptor beta
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08533  NR1F2, RORB; RAR-related orphan receptor beta
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08533  NR1F2, RORB; RAR-related orphan receptor beta
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1F. RAR-related orphan receptor
   K08533  NR1F2, RORB; RAR-related orphan receptor beta
Genes
HSA: 6096(RORB)
PTR: 472956(RORB)
PPS: 100993965(RORB)
GGO: 101137996(RORB)
PON: 100447461(RORB)
NLE: 100586162(RORB)
MCC: 703310(RORB)
MCF: 102146956(RORB)
CSAB: 103219594(RORB)
RRO: 104682183(RORB)
RBB: 108517692(RORB)
CJC: 100405410(RORB)
SBQ: 101038582(RORB)
MMU: 225998(Rorb)
MCAL: 110285452(Rorb)  
MPAH: 110318357(Rorb)
RNO: 309288(Rorb)
MUN: 110553085(Rorb)
CGE: 100771338(Rorb)
NGI: 103737703(Rorb)
HGL: 101707549(Rorb)
CCAN: 109700787(Rorb)
OCU: 100345295(RORB)
TUP: 102472010(RORB)
CFA: 484164(RORB)
VVP: 112922102(RORB)  
AML: 100480263(RORB)
UMR: 103663268(RORB)
UAH: 113269848(RORB)
ORO: 101366275(RORB)
ELK: 111153525
FCA: 101091819(RORB)
PTG: 102960697(RORB)  
PPAD: 109275387(RORB)
AJU: 106982972(RORB)
BTA: 528382(RORB)
BOM: 102280910(RORB)
BIU: 109562962(RORB)
BBUB: 102408417(RORB)
CHX: 100860875(RORB)
OAS: 100169935(RORB)
SSC: 100739111(RORB)
CFR: 102519287(RORB)
CDK: 105106288(RORB)
BACU: 103011646(RORB)
LVE: 103087612(RORB)
OOR: 101270960(RORB)
DLE: 111174591(RORB)
PCAD: 102980485(RORB)
ECB: 100049831(RORB)
EPZ: 103558422(RORB)
EAI: 106836108(RORB)
MYB: 102250117(RORB)
MYD: 102769371(RORB)
MNA: 107545040(RORB)
HAI: 109387019(RORB)
DRO: 112300269(RORB)
PALE: 102895604(RORB)  
RAY: 107511649(RORB)
MJV: 108403180(RORB)
LAV: 100660375(RORB)
TMU: 101350154
MDO: 100018507 100020137(RORB)
SHR: 100917048 100918183(RORB)
PCW: 110223226(RORB) 110223506
OAA: 100075132(RORB)
GGA: 395980(RORB) 431047(NR1D1)
CJO: 107306211(RORB) 107325652
APLA: 101791228
ACYG: 106044142(RORB) 106045650
TGU: 100221315 100226267(RORB)
LSR: 110469474 110476508(RORB)
SCAN: 103821004(RORB) 103821903
GFR: 102037229 102043473(RORB)
FAB: 101812007(RORB) 101822278
PHI: 102101365 102103883(RORB)
PMAJ: 107198346(RORB) 107215332
CCAE: 111940184 111941593(RORB)
CCW: 104685290(RORB) 104696946
ETL: 114058707(RORB) 114070719
FPG: 101916890(RORB) 101918051
FCH: 102051405 102058395(RORB)
CLV: 102083470(RORB) 102089183
EGZ: 104123830(RORB) 104131113
ACUN: 113489415 113490017(RORB)
PADL: 103920373(RORB)
ASN: 102373234 102383132(RORB)
AMJ: 102569438 102572689(RORB)
PSS: 102452458(RORB) 102458141
CMY: 102940776 102942762(RORB)
CPIC: 101931686(RORB) 101943709
ACS: 100562206(rorb)
PVT: 110072446 110075996(RORB)
PBI: 103056720 103059650(RORB)
PMUR: 107282300 107299384(RORB)
TSR: 106539711(RORB)
PMUA: 114606646(RORB)
GJA: 107115443 107120731(RORB)
XLA: 108704655 108704852(rorb.S) 108712240 108714514(rorb.L)
XTR: 100487062(rorb) 100491456(rorb.2)
NPR: 108795300(RORB)
DRE: 559245(rorca) 562258(rorcb) 567943(rorb)
LCM: 102346373 102367427(RORB)
BFO: 118412292
SPU: 592902
CRG: 105344042
MYI: 110445113
 » show all
Reference
  Authors
Jetten AM
  Title
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
  Journal
Nucl Recept Signal 7:e003 (2009)
DOI:10.1621/nrs.07003
Reference
  Authors
Takahashi JS, Hong HK, Ko CH, McDearmon EL
  Title
The genetics of mammalian circadian order and disorder: implications for physiology and disease.
  Journal
Nat Rev Genet 9:764-75 (2008)
DOI:10.1038/nrg2430
Reference
  Authors
Roforth MM, Liu G, Khosla S, Monroe DG
  Title
Examination of nuclear receptor expression in osteoblasts reveals Rorbeta as an important regulator of osteogenesis.
  Journal
J Bone Miner Res 27:891-901 (2012)
DOI:10.1002/jbmr.1502
  Sequence
[mmu:225998]
LinkDB

KEGG   ORTHOLOGY: K08534
Entry
K08534                      KO                                     

Name
NR1F3, RORC
Definition
RAR-related orphan receptor gamma
Pathway
ko04659  Th17 cell differentiation
ko04710  Circadian rhythm
ko05321  Inflammatory bowel disease
Disease
H00089  IFN-gamma/IL-12 axis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09151 Immune system
   04659 Th17 cell differentiation
    K08534  NR1F3, RORC; RAR-related orphan receptor gamma
  09159 Environmental adaptation
   04710 Circadian rhythm
    K08534  NR1F3, RORC; RAR-related orphan receptor gamma
 09160 Human Diseases
  09163 Immune disease
   05321 Inflammatory bowel disease
    K08534  NR1F3, RORC; RAR-related orphan receptor gamma
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K08534  NR1F3, RORC; RAR-related orphan receptor gamma
  09183 Protein families: signaling and cellular processes
   03310 Nuclear receptors
    K08534  NR1F3, RORC; RAR-related orphan receptor gamma
Transcription factors [BR:ko03000]
 Eukaryotic type
  Zinc finger
   Cys4 thyroid hormone receptor-like
    K08534  NR1F3, RORC; RAR-related orphan receptor gamma
Nuclear receptors [BR:ko03310]
 1. Thyroid hormone like
  1F. RAR-related orphan receptor
   K08534  NR1F3, RORC; RAR-related orphan receptor gamma
Genes
HSA: 6097(RORC)
PTR: 457303(RORC)
PPS: 100982206(RORC)
GGO: 101137045(RORC)
PON: 100172603(RORC)
NLE: 100599319(RORC)
MCC: 717052(RORC)
MCF: 102145834(RORC)
CSAB: 103224018(RORC)
RRO: 104681029(RORC)
RBB: 108533216(RORC)
CJC: 100393008(RORC)
SBQ: 101032279(RORC)
MMU: 19885(Rorc)
MCAL: 110290822(Rorc)  
MPAH: 110320015(Rorc)
RNO: 368158(Rorc)
MUN: 110565683(Rorc)
CGE: 100769044(Rorc)
NGI: 103730051(Rorc)
HGL: 101700193(Rorc)
CCAN: 109696695(Rorc)
OCU: 100353540(RORC)
TUP: 102483789(RORC)
CFA: 483205(RORC)
VVP: 112907718(RORC)  
AML: 100472181(RORC)
UMR: 103667501(RORC)
UAH: 113246193(RORC)
ORO: 101386501(RORC)
ELK: 111161964
FCA: 101082078(RORC)
PTG: 102960935(RORC)  
PPAD: 109257052(RORC)
AJU: 106979433(RORC)
BTA: 527470(RORC)
BOM: 102278518(RORC)
BIU: 109554834(RORC)
BBUB: 102391720(RORC)
CHX: 100860876(RORC)
OAS: 101119104(RORC)
SSC: 100622477(RORC)
CFR: 102508089(RORC)
CDK: 105103230(RORC)
BACU: 103012395(RORC)
LVE: 103091221(RORC)
OOR: 101284638(RORC)
DLE: 111169760(RORC)
PCAD: 102986484(RORC)
ECB: 100060134(RORC)
EPZ: 103547922(RORC)
EAI: 106848355(RORC)
MYB: 102245286(RORC)
MYD: 102762023(RORC)
MNA: 107540772(RORC)
HAI: 109374397(RORC)
DRO: 112318335(RORC)
PALE: 102893852(RORC)  
RAY: 107500655(RORC)
MJV: 108396775(RORC)
LAV: 100672424(RORC)
TMU: 101361317
MDO: 100019046(RORC)
SHR: 100932806(RORC)
PCW: 110221000(RORC)
OAA: 100089518(RORC)
GGA: 777355(RORC)
CJO: 107324548(RORC)
NMEL: 110387802(RORC)  
APLA: 113841472
SCAN: 103825350
PHI: 106628750(RORC)
ETL: 114071449(RORC)
FPG: 101922976(RORC)
CLV: 102097313(RORC)
AAM: 106484811(RORC)
ASN: 102384236(RORC)
AMJ: 109281036(RORC)
PSS: 102447248(RORC)
CMY: 102930597(RORC)
CPIC: 101936012(RORC)
ACS: 100567231(rorc)
PVT: 110081530(RORC)
PBI: 103051649(RORC)
PMUR: 107285233(RORC)
PMUA: 114587071(RORC)
GJA: 107114527(RORC)
XLA: 495242(rorc.L)
XTR: 100489391(rorc)
NPR: 108802933
OTW: 112235376
LCM: 102361945(RORC)
CRG: 105331184
 » show all
Reference
  Authors
Jetten AM
  Title
Retinoid-related orphan receptors (RORs): critical roles in development, immunity, circadian rhythm, and cellular metabolism.
  Journal
Nucl Recept Signal 7:e003 (2009)
DOI:10.1621/nrs.07003
  Sequence
[hsa:6097] [mmu:19885]
Reference
PMID:7811290
  Authors
Hirose T, Smith RJ, Jetten AM
  Title
ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle.
  Journal
Biochem Biophys Res Commun 205:1976-83 (1994)
DOI:10.1006/bbrc.1994.2902
  Sequence
[hsa:6097]
LinkDB

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