KEGG   ORTHOLOGY: K08601
Entry
K08601                      KO                                     

Name
CYLD, USLP2
Definition
ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]
Pathway
ko04013  MAPK signaling pathway - fly
ko04064  NF-kappa B signaling pathway
ko04217  Necroptosis
ko04380  Osteoclast differentiation
ko04622  RIG-I-like receptor signaling pathway
ko04625  C-type lectin receptor signaling pathway
Disease
H00827  Brooke-Spiegler syndrome
H00828  Familial cylindromatosis
H00829  Multiple familial trichoepithelioma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04013 MAPK signaling pathway - fly
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
   04064 NF-kappa B signaling pathway
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
   04625 C-type lectin receptor signaling pathway
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
  09158 Development and regeneration
   04380 Osteoclast differentiation
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases and inhibitors
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.19  Omega peptidases
    3.4.19.12  ubiquitinyl hydrolase 1
     K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
Peptidases and inhibitors [BR:ko01002]
 Cysteine peptidases
  Family C67
   K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
Ubiquitin system [BR:ko04121]
 Deubiquitinating enzyme (DUB)
  Ubiquitin-specific proteases (UBPs)
   UBP/USP
    K08601  CYLD, USLP2; ubiquitin carboxyl-terminal hydrolase CYLD
Other DBs
GO: 0004843
Genes
HSA: 1540(CYLD)
PTR: 465165(CYLD)
PPS: 100986446(CYLD)
GGO: 101130233(CYLD)
PON: 100171734(CYLD)
NLE: 100591191(CYLD)
MCC: 695652(CYLD)
MCF: 101867233(CYLD)
CSAB: 103232722(CYLD)
RRO: 104655357(CYLD)
RBB: 108536319(CYLD)
CJC: 100407645(CYLD)
SBQ: 101034889(CYLD)
MMU: 74256(Cyld)
MCAL: 110299742(Cyld)
MPAH: 110337507(Cyld)
RNO: 312937(Cyld)
MUN: 110548860
CGE: 100758070(Cyld)
NGI: 103730125(Cyld)
HGL: 101707343(Cyld)
CCAN: 109699460(Cyld)
OCU: 100354572(CYLD)
TUP: 102491060(CYLD)
CFA: 611649(CYLD)
VVP: 112929607(CYLD)
AML: 100467467(CYLD)
UMR: 103673798(CYLD)
UAH: 113252226(CYLD)
ORO: 101374331(CYLD)
ELK: 111157321
FCA: 101094641(CYLD)
PTG: 102954153(CYLD)
PPAD: 109270945(CYLD)
AJU: 106977674(CYLD)
BTA: 536421(CYLD)
BOM: 102265067(CYLD)
BIU: 109572313(CYLD)
BBUB: 102392021(CYLD)
CHX: 102179035(CYLD)
OAS: 101113429(CYLD)
SSC: 100624570(CYLD)
CFR: 102504764(CYLD)
CDK: 105097521(CYLD)
BACU: 103020547(CYLD)
LVE: 103076921(CYLD)
OOR: 101272232(CYLD)
DLE: 111164987(CYLD)
PCAD: 102991203(CYLD)
ECB: 100050308(CYLD)
EPZ: 103556635(CYLD)
EAI: 106822687(CYLD)
MYB: 102247016(CYLD)
MYD: 102765473(CYLD)
MNA: 107531025(CYLD)
HAI: 109383313(CYLD)
DRO: 112296684(CYLD)
PALE: 102882294(CYLD)
RAY: 107512242(CYLD)
MJV: 108408573(CYLD)
LAV: 100677482(CYLD)
TMU: 101340355
MDO: 100014031(CYLD)
SHR: 100931361(CYLD)
PCW: 110207479(CYLD)
OAA: 100090868(CYLD)
GGA: 415725(CYLD) 420294
MGP: 100541966 100547998(CYLD)
CJO: 107310621 107319020(CYLD)
NMEL: 110393956 110404375(CYLD)
APLA: 101792318(CYLD) 110354256
ACYG: 106039578(CYLD) 106042201
TGU: 100226672(CYLD) 101232977
SCAN: 103816624(CYLD) 103826296
GFR: 102039156 102041520(CYLD)
FAB: 101814338 101815147(CYLD)
PHI: 102100766 102108525(CYLD)
PMAJ: 107200507 107209936(CYLD)
CCAE: 111925207 111934612(CYLD)
CCW: 104687458(CYLD) 104692595
ETL: 114055553(CYLD) 114070993
FPG: 101912553(CYLD) 101918460
FCH: 102046784 102051895(CYLD)
CLV: 102091076(CYLD) 102098890
EGZ: 104125180(CYLD) 104128858
NNI: 104011267(CYLD) 104020600
ACUN: 113477361 113484320(CYLD)
PADL: 103914175(CYLD) 103925969
AMJ: 102559694(CYLDL) 102564689 106736827(CYLD)
PSS: 102447826(CYLD) 102458553
CMY: 102946483 102947087(CYLD)
DRE: 556823(cylda) 561108(cyldl)
LCM: 102355135(CYLD) 102365523
CMK: 103176085(cyld) 103186291
BFO: 118417450
CIN: 100180643
APLC: 110974701
SKO: 102803626
DME: Dmel_CG5603(CYLD)
DER: 6541256
DSE: 6611953
DSI: Dsimw501_GD22283(Dsim_GD22283)
DAN: 6496947
DSR: 110183383
DPE: 6588711
DMN: 108161321
DWI: 111519113
DAZ: 108609699
DNV: 108649550
DHE: 111594741
MDE: 101889912
LCQ: 111675145
AAG: 5577549
AALB: 109430170
AME: 410344
BIM: 100747485
BTER: 100650168
CCAL: 108624311
OBB: 114881393
SOC: 105197243
MPHA: 105829031
AEC: 105149975
ACEP: 105621225
PBAR: 105433501
VEM: 105562079
HST: 105186488
DQU: 106743844
CFO: 105250083
LHU: 105679880
PGC: 109854338
OBO: 105276204
PCF: 106786195
NVI: 100115685
CSOL: 105363337
MDL: 103568633
TCA: 663788
DPA: 109533111
ATD: 109601800
NVL: 108561037
BMOR: 101741316
BMAN: 114250580
PMAC: 106713312
PRAP: 111001654
HAW: 110373128
TNL: 113493280
BTAB: 109041235
CLEC: 106670625
ZNE: 110833673
PVM: 113803819
TUT: 107364612
DPTE: 113789222
CSCU: 111624689
PTEP: 107440667
CEL: CELE_F40F12.5(cyld-1)
CBR: CBG09948
BMY: Bm1_26360
PCAN: 112577064
CRG: 105321100
MYI: 110466750
OBI: 106877142
LAK: 106152356
NVE: 5519468
EPA: 110245862
PDAM: 113670495
DGT: 114532796
HMG: 105845121
 » show all
Reference
  Authors
Bignell GR, Warren W, Seal S, Takahashi M, Rapley E, Barfoot R, Green H, Brown C, Biggs PJ, Lakhani SR, Jones C, Hansen J, Blair E, Hofmann B, Siebert R, Turner G, Evans DG, Schrander-Stumpel C, Beemer FA, van Den Ouweland A, Halley D, Delpech B, Cleveland MG, Leigh I, Leisti J, Rasmussen S
  Title
Identification of the familial cylindromatosis tumour-suppressor gene.
  Journal
Nat Genet 25:160-5 (2000)
DOI:10.1038/76006
  Sequence
[hsa:1540]
Reference
  Authors
Gao J, Sun L, Huo L, Liu M, Li D, Zhou J
  Title
CYLD regulates angiogenesis by mediating vascular endothelial cell migration.
  Journal
Blood 115:4130-7 (2010)
DOI:10.1182/blood-2009-10-248526
Reference
  Authors
Tauriello DV, Haegebarth A, Kuper I, Edelmann MJ, Henraat M, Canninga-van Dijk MR, Kessler BM, Clevers H, Maurice MM
  Title
Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl.
  Journal
Mol Cell 37:607-19 (2010)
DOI:10.1016/j.molcel.2010.01.035
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