KEGG   ORTHOLOGY: K08669Help
Entry
K08669                      KO                                     

Name
HTRA2, PRSS25
Definition
HtrA serine peptidase 2 [EC:3.4.21.108]
Pathway
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04215  Apoptosis - multiple species
ko05012  Parkinson disease
Disease
H00057  Parkinson disease
H00754  3-Methylglutaconic aciduria
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04210 Apoptosis
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
   04214 Apoptosis - fly
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
   04215 Apoptosis - multiple species
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
 09160 Human Diseases
  09164 Neurodegenerative disease
   05012 Parkinson disease
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
  09182 Protein families: genetic information processing
   03110 Chaperones and folding catalysts
    K08669  HTRA2, PRSS25; HtrA serine peptidase 2
Enzymes [BR:ko01000]
 3. Hydrolases
  3.4  Acting on peptide bonds (peptidases)
   3.4.21  Serine endopeptidases
    3.4.21.108  HtrA2 peptidase
     K08669  HTRA2, PRSS25; HtrA serine peptidase 2
Peptidases [BR:ko01002]
 Serine Peptidases
  Family S1: chymotrypsin family
   K08669  HTRA2, PRSS25; HtrA serine peptidase 2
Chaperones and folding catalysts [BR:ko03110]
 Other chaperones and cochaperones
  DegP / HtrA
   K08669  HTRA2, PRSS25; HtrA serine peptidase 2
BRITE hierarchy
Genes
HSA: 27429(HTRA2)
PTR: 459339(HTRA2)
PPS: 100985283(HTRA2)
GGO: 101153780(HTRA2)
PON: 100461940(HTRA2)
NLE: 100591213(HTRA2)
MCC: 709938(HTRA2)
MCF: 102126403(HTRA2)
CSAB: 103220019(HTRA2)
RRO: 104674825(HTRA2)
RBB: 108531686(HTRA2)
CJC: 100385512(HTRA2)
SBQ: 101046884(HTRA2)
MMU: 64704(Htra2)
MCAL: 110295867(Htra2)
MPAH: 110317283(Htra2)
RNO: 297376(Htra2)
CGE: 100760629(Htra2)
NGI: 103726986(Htra2)
HGL: 101725239(Htra2)
CCAN: 109692441(Htra2)
OCU: 100338967(HTRA2)
TUP: 102501824(HTRA2)
CFA: 475782(HTRA2)
VVP: 112916707(HTRA2)
AML: 100471770(HTRA2)
UMR: 103671421(HTRA2)
UAH: 113243611(HTRA2)
ORO: 101375505 101382419(HTRA2)
FCA: 768259(HTRA2)
PTG: 102968855(HTRA2)
AJU: 106988577(HTRA2)
BTA: 523039(HTRA2)
BOM: 102273081
BIU: 109565903(HTRA2)
BBUB: 102389817(HTRA2)
PHD: 102334875(HTRA2)
CHX: 102181963(HTRA2)
OAS: 101120228(HTRA2)
SSC: 100512831(HTRA2)
CFR: 102522927(HTRA2)
CDK: 105105950(HTRA2)
BACU: 103003966(HTRA2)
LVE: 103086746(HTRA2)
OOR: 101276862(HTRA2)
DLE: 111169079(HTRA2)
ECB: 100053688(HTRA2)
EPZ: 103557683(HTRA2)
EAI: 106823864(HTRA2)
MYB: 102242360(HTRA2)
MYD: 102772576(HTRA2)
MNA: 107529250(HTRA2)
HAI: 109371208(HTRA2)
RSS: 109457409(HTRA2)
DRO: 112303094(HTRA2)
PALE: 102890616(HTRA2)
LAV: 100659066(HTRA2)
TMU: 101344176
MDO: 100025882(HTRA2)
SHR: 100923981(HTRA2)
PCW: 110221089(HTRA2)
OAA: 114811155(HTRA2)
GGA: 395990(HTRA2)
MGP: 100538527(HTRA2)
CJO: 107306835(HTRA2)
APLA: 101802615
ACYG: 106043211(HTRA2)
TGU: 100220514(HTRA2)
LSR: 110468691(HTRA2)
SCAN: 103823115(HTRA2)
GFR: 102042326(HTRA2)
FAB: 101806812(HTRA2)
PHI: 102107154(HTRA2)
PMAJ: 107203523(HTRA2)
CCAE: 111929153(HTRA2)
CCW: 104690945(HTRA2)
ETL: 114068870(HTRA2)
FPG: 101914636(HTRA2)
FCH: 102050387(HTRA2)
CLV: 102085893(HTRA2)
EGZ: 104130002(HTRA2)
NNI: 104013943(HTRA2)
ACUN: 113490506(HTRA2)
AAM: 106487415(HTRA2)
ASN: 102378167(HTRA2)
AMJ: 102573820(HTRA2)
PSS: 102456624(HTRA2)
CMY: 102937290(HTRA2)
CPIC: 101936375(HTRA2)
ACS: 100565079(htra2)
PVT: 110079828(HTRA2)
PBI: 103059726(HTRA2)
PMUR: 107292494(HTRA2)
GJA: 107110467(HTRA2)
XLA: 108706463(htra2.S)
XTR: 100492982(htra2)
NPR: 108804097
DRE: 100137109(zgc:174193) 110438965 560917 797799 799791(si:dkey-33c12.10)
CCAR: 109054998
IPU: 108263241
PHYP: 113539574(htra2)
AMEX: 103043568
EEE: 113585783(htra2)
TRU: 101079124
LCO: 104921575
NCC: 104960364
MZE: 101482753
OLA: 101174474
XMA: 102226566(htra2)
XCO: 114134420(htra2)
PRET: 103458895(htra2)
NFU: 107392303
KMR: 108235278(htra2)
CSEM: 103376892
LCF: 108892481
SDU: 111225343
HCQ: 109522905(htra2)
BPEC: 110155255(htra2)
MALB: 109955094
SASA: 106589831
OTW: 112224672
SALP: 111968136
ELS: 105015851
SFM: 108918851
PKI: 111845796
LCM: 102356234(HTRA2)
SPU: 756975
APLC: 110973949
SKO: 102807217
DME: Dmel_CG8464(HtrA2)
DER: 6552632
DPE: 6588623
DSI: Dsimw501_GD20417(Dsim_GD20417)
DWI: 6647029
DAZ: 108620802
DNV: 108660102
DHE: 111601551
MDE: 101893592
AAG: 5567933
AME: 551969
BIM: 100747622
BTER: 100651265
SOC: 105199767
MPHA: 105830742
AEC: 105152625
ACEP: 105624355
PBAR: 105432441
HST: 105188006
DQU: 106750279
CFO: 105256231
LHU: 105672452
PGC: 109861450
OBO: 105274742
PCF: 106791733
NVI: 100122950
MDL: 103578876
DPA: 109538837
BMOR: 100533207(htra2)
PMAC: 106713982
PRAP: 110994139
HAW: 110379176
PXY: 105386447
CLEC: 106670287
ZNE: 110835296
FCD: 110858213
DPTE: 113798514
PCAN: 112565039
CRG: 105347711
OBI: 106876978
LAK: 106151169
SHX: MS3_03139
EGL: EGR_02598
EPA: 110232501
ADF: 107348404
PDAM: 113671173
SPIS: 111326210
HMG: 101239153
CRB: 17883659
BRP: 103874520
BOE: 106306356
THJ: 104802800
CIT: 102608405
TCC: 18600462
GRA: 105792510
GHI: 107894209
GAB: 108468039
DZI: 111293631
LJA: Lj1g3v4921060.1(Lj1g3v4921060.1) Lj1g3v4921060.2(Lj1g3v4921060.2) Lj1g3v4921060.3(Lj1g3v4921060.3)
ADU: 107492133
AIP: 107645908
LANG: 109329681
PPER: 18772880
PMUM: 103344586
PAVI: 110759195
PXB: 103965318
CSV: 101212324
CMO: 103494739
CMAX: 111465556
CMOS: 111444435
RCU: 8287072
JCU: 105647513
HBR: 110659756
POP: 7473270
JRE: 109012743
VVI: 100264796
CANN: 107863029
NSY: 104247943
NTO: 104112327
NAU: 109242764
INI: 109181984
SIND: 105172372
OEU: 111386814
LSV: 111884540
CCAV: 112505655
BVG: 104890298
SOE: 110794681
CQI: 110736872
NNU: 104609043
OBR: 102706235
ATS: 109732288(LOC109732288) 109783003(LOC109783003)
SBI: 8057143
ZMA: 100277723(cl62390_1)
SITA: 101768487
PDA: 103715494
EGU: 105051535
DCT: 110101476
PEQ: 110033765
AOF: 109827286
PPP: 112283886
APRO: F751_2338
SPAR: SPRG_10340
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Balakrishnan MP, Cilenti L, Mashak Z, Popat P, Alnemri ES, Zervos AS
  Title
THAP5 is a human cardiac-specific inhibitor of cell cycle that is cleaved by the proapoptotic Omi/HtrA2 protease during cell death.
  Journal
Am J Physiol Heart Circ Physiol 297:H643-53 (2009)
DOI:10.1152/ajpheart.00234.2009
  Sequence
[hsa:27429]
LinkDB All DBs

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