KEGG   ORTHOLOGY: K08692
Entry
K08692                      KO                                     

Name
mtkB
Definition
malate-CoA ligase subunit alpha [EC:6.2.1.9]
Pathway
ko00630  Glyoxylate and dicarboxylate metabolism
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00346  Formaldehyde assimilation, serine pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K08692  mtkB; malate-CoA ligase subunit alpha
  09102 Energy metabolism
   00680 Methane metabolism
    K08692  mtkB; malate-CoA ligase subunit alpha
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.9  malate---CoA ligase
     K08692  mtkB; malate-CoA ligase subunit alpha
Other DBs
RN: R01256
GO: 0050074
Genes
MCA: MCA1741(sucD-2)
MMT: Metme_2693
MDN: JT25_000145
MDH: AYM39_08400
MKO: MKLM6_1754
METL: U737_10270(sucD)
MAH: MEALZ_3215(mtkB)
MBUR: EQU24_04640(sucD)
MPSY: CEK71_18045
TSN: W908_06420
BPH: Bphy_5926
MPT: Mpe_A3256
NEU: NE1811
NET: Neut_0605
METR: BSY238_255(sucD)
FMY: HO273_03890(sucD)
MLO: mlr1326
MHUA: MCHK_2944(sucD)
MJR: EB229_19615(sucD)
MERD: EB233_16960(sucD)
AMIH: CO731_05427(sucD_2)
SFH: SFHH103_02476(sucd1)
SFD: USDA257_c22010(mtkB)
SAME: SAMCFNEI73_pC0658(mtkB)
LNE: FZC33_08685(sucD)
MEA: Mex_1p1731(mtkB)
MDI: METDI2483(mtkB)
MEX: Mext_1800
MCH: Mchl_2136
MPO: Mpop_1752
MET: M446_6557
MNO: Mnod_7117
MOR: MOC_4188
META: Y590_08605
MAQU: Maq22A_c19260(mtkB)
MSL: Msil_1717
BBAR: RHAL1_03824(sucD_2)
HDN: Hden_3151
HMC: HYPMC_4393(mtkB)
FIL: BN1229_v1_1242(sucD)
FIY: BN1229_v1_1240(sucD)
MSC: BN69_1173
MROS: EHO51_12195(sucD)
MHEY: H2LOC_011815(sucD)
MPAR: F7D14_09165(sucD)
PLEO: OHA_1_00679(sucD_1)
MCG: GL4_3373
HDI: HDIA_2219(sucD_2)
NOH: G5V57_12990(sucD)
METG: HT051_02835(sucD)
SIL: SPO1569
RUT: FIU92_19880(sucD2)
RDE: RD1_4246(mtkB)
RLI: RLO149_c036810(mtkB)
PAMN: pAMV1p0131(mtkA)
DSH: Dshi_2492(sucD2)
LEJ: ETW24_17890(sucD)
LAQU: R2C4_19810(sucD)
CID: P73_3960
RMM: ROSMUCSMR3_03453(sucD)
RID: RIdsm_02781(sucD_1)
ROM: EI983_08260(sucD)
ROH: FIU89_11595(sucD3)
TAW: EI545_00090(sucD)
PAED: G5B38_01655(sucD)
 » show all
Reference
PMID:7961516
  Authors
Chistoserdova LV, Lidstrom ME
  Title
Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB.
  Journal
J Bacteriol 176:7398-404 (1994)
DOI:10.1128/JB.176.23.7398-7404.1994
  Sequence
LinkDB

KEGG   ORTHOLOGY: K14067
Entry
K14067                      KO                                     

Name
mtkA
Definition
malate-CoA ligase subunit beta [EC:6.2.1.9]
Pathway
ko00630  Glyoxylate and dicarboxylate metabolism
ko00680  Methane metabolism
ko01100  Metabolic pathways
ko01120  Microbial metabolism in diverse environments
ko01200  Carbon metabolism
Module
M00346  Formaldehyde assimilation, serine pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09101 Carbohydrate metabolism
   00630 Glyoxylate and dicarboxylate metabolism
    K14067  mtkA; malate-CoA ligase subunit beta
  09102 Energy metabolism
   00680 Methane metabolism
    K14067  mtkA; malate-CoA ligase subunit beta
Enzymes [BR:ko01000]
 6. Ligases
  6.2  Forming carbon-sulfur bonds
   6.2.1  Acid-thiol ligases
    6.2.1.9  malate---CoA ligase
     K14067  mtkA; malate-CoA ligase subunit beta
Other DBs
RN: R01256
GO: 0050074
Genes
MCA: MCA1740(sucC-2)
METU: GNH96_10425(sucC)
MMT: Metme_2694
MDN: JT25_000150(sucC)
MDH: AYM39_08395(sucC)
MKO: MKLM6_1753
METL: U737_10265
MAH: MEALZ_3216(mtkA)
MBUR: EQU24_04635
MPSY: CEK71_18040
MMAI: sS8_2224
MMOB: F6R98_20175(sucC)
TSN: W908_06425(sucC)
BPH: Bphy_5927
MPT: Mpe_A3257
NEU: NE1810
NET: Neut_0606
NCO: AAW31_08290(sucC)
NUR: ATY38_03750(sucC)
METR: BSY238_256(sucC)
NIM: W01_13790(sucC_1)
MLO: mlr1324
MAMO: A6B35_22115(sucC)
MHUA: MCHK_2943
AMIH: CO731_05426(sucC_2)
SFH: SFHH103_02475(succ1)
SFD: USDA257_c22020(mtkA)
SAME: SAMCFNEI73_pC0657(mtkA)
MEA: Mex_1p1730(mtkA)
MDI: METDI2482(mtkA)
MEX: Mext_1799
MCH: Mchl_2135
MPO: Mpop_1751
MET: M446_6556
MNO: Mnod_7116
MOR: MOC_4189
META: Y590_08600(sucC)
MAQU: Maq22A_c19265(mtkA)
MSL: Msil_1716
MTUN: MTUNDRAET4_3406(mtkA)
BBAR: RHAL1_03823(sucC_2)
HDN: Hden_3152
HMC: HYPMC_4394(mtkA)
HNI: W911_15810(sucC)
FIL: BN1229_v1_1241(sucC) BN1229_v1_2531(mtkA)
FIY: BN1229_v1_1239(sucC) BN1229_v1_3385(mtkA)
MSC: BN69_1174(sucC1)
PLEO: OHA_1_00680(sucC_1)
MCG: GL4_3374
HDI: HDIA_2218(sucC_1)
SIL: SPO1568
RUT: FIU92_19885(sucC2)
RDE: RD1_1162(mtkA)
RLI: RLO149_c036820(mtkA)
PAMN: pAMV1p0132(mtkB)
DSH: Dshi_2491(sucC2)
LMD: METH_18375(sucC)
LAQU: R2C4_19805
CID: P73_3959
RID: RIdsm_02780(sucC_1)
ROH: FIU89_03745(sucC1) FIU89_11590(sucC3)
MALU: KU6B_14470(sucC_1) KU6B_40010(sucC_2)
 » show all
Reference
PMID:7961516
  Authors
Chistoserdova LV, Lidstrom ME
  Title
Genetics of the serine cycle in Methylobacterium extorquens AM1: identification, sequence, and mutation of three new genes involved in C1 assimilation, orf4, mtkA, and mtkB.
  Journal
J Bacteriol 176:7398-404 (1994)
DOI:10.1128/JB.176.23.7398-7404.1994
  Sequence
LinkDB

KEGG   ENZYME: 6.2.1.9
Entry
EC 6.2.1.9                  Enzyme                                 

Name
malate---CoA ligase;
malyl-CoA synthetase;
malyl coenzyme A synthetase;
malate thiokinase
Class
Ligases;
Forming carbon-sulfur bonds;
Acid-thiol ligases
Sysname
malate:CoA ligase (ADP-forming)
Reaction(IUBMB)
ATP + malate + CoA = ADP + phosphate + malyl-CoA [RN:R01256]
Reaction(KEGG)
R01256
Substrate
ATP [CPD:C00002];
malate [CPD:C00149];
CoA [CPD:C00010]
Product
ADP [CPD:C00008];
phosphate [CPD:C00009];
malyl-CoA [CPD:C04348]
History
EC 6.2.1.9 created 1972
Pathway
ec00630  Glyoxylate and dicarboxylate metabolism
ec00680  Methane metabolism
ec01100  Metabolic pathways
ec01120  Microbial metabolism in diverse environments
Orthology
K08692  malate-CoA ligase subunit alpha
K14067  malate-CoA ligase subunit beta
Genes
MCA: MCA1740(sucC-2) MCA1741(sucD-2)
METU: GNH96_10425(sucC)
MMT: Metme_2693 Metme_2694
MDN: JT25_000145 JT25_000150(sucC)
MDH: AYM39_08395(sucC) AYM39_08400
MKO: MKLM6_1753 MKLM6_1754
METL: U737_10265 U737_10270(sucD)
MAH: MEALZ_3215(mtkB) MEALZ_3216(mtkA)
MBUR: EQU24_04635 EQU24_04640(sucD)
MPSY: CEK71_18040 CEK71_18045
MMAI: sS8_2224
MMOB: F6R98_20175(sucC)
METR: BSY238_255(sucD) BSY238_256(sucC)
NIM: W01_13790(sucC_1)
MHUA: MCHK_2943 MCHK_2944(sucD)
AMIH: CO731_05426(sucC_2) CO731_05427(sucD_2)
SFH: SFHH103_02475(succ1) SFHH103_02476(sucd1)
SFD: USDA257_c22010(mtkB) USDA257_c22020(mtkA)
MEA: Mex_1p1730(mtkA) Mex_1p1731(mtkB)
MDI: METDI2482(mtkA) METDI2483(mtkB)
META: Y590_08600(sucC) Y590_08605
MAQU: Maq22A_c19260(mtkB) Maq22A_c19265(mtkA)
BBAR: RHAL1_03823(sucC_2) RHAL1_03824(sucD_2)
HMC: HYPMC_4393(mtkB) HYPMC_4394(mtkA)
MSC: BN69_1173 BN69_1174(sucC1)
PLEO: OHA_1_00679(sucD_1) OHA_1_00680(sucC_1)
HDI: HDIA_2218(sucC_1) HDIA_2219(sucD_2)
RUT: FIU92_19880(sucD2) FIU92_19885(sucC2)
RDE: RD1_1162(mtkA) RD1_4246(mtkB)
RLI: RLO149_c036810(mtkB) RLO149_c036820(mtkA)
PAMN: pAMV1p0131(mtkA) pAMV1p0132(mtkB)
DSH: Dshi_2491(sucC2) Dshi_2492(sucD2)
LAQU: R2C4_19805 R2C4_19810(sucD)
RID: RIdsm_02780(sucC_1) RIdsm_02781(sucD_1)
ROH: FIU89_03745(sucC1) FIU89_11590(sucC3) FIU89_11595(sucD3)
 » show all
Reference
1  [PMID:14244056]
  Authors
MUE S, TUBOI S, KIKUCHI G.
  Title
ON MALYL-COENZYME A SYNTHETASE.
  Journal
J Biochem 56:545-51 (1964)
DOI:10.1093/oxfordjournals.jbchem.a128032
Other DBs
ExplorEnz - The Enzyme Database: 6.2.1.9
IUBMB Enzyme Nomenclature: 6.2.1.9
ExPASy - ENZYME nomenclature database: 6.2.1.9
BRENDA, the Enzyme Database: 6.2.1.9
CAS: 37318-58-4
LinkDB

KEGG   REACTION: R01256
Entry
R01256                      Reaction                               

Name
(S)-malate:CoA ligase (ADP-forming)
Definition
ATP + (S)-Malate + CoA <=> ADP + Orthophosphate + L-Malyl-CoA
Equation
Comment
reversible
Reaction class
RC00002  C00002_C00008
RC00004  C00010_C04348
RC00014  C00149_C04348
Enzyme
Pathway
rn00630  Glyoxylate and dicarboxylate metabolism
rn00680  Methane metabolism
rn01100  Metabolic pathways
rn01120  Microbial metabolism in diverse environments
rn01200  Carbon metabolism
Module
M00346  Formaldehyde assimilation, serine pathway
Orthology
K08692  malate-CoA ligase subunit alpha [EC:6.2.1.9]
K14067  malate-CoA ligase subunit beta [EC:6.2.1.9]
Other DBs
RHEA: 26196
LinkDB

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