KEGG   ORTHOLOGY: K08733
Entry
K08733                      KO                                     

Name
APPL1, DIP13A
Definition
DCC-interacting protein 13 alpha
Pathway
ko04211  Longevity regulating pathway
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00410  Maturity onset diabetes of the young (MODY)
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09149 Aging
   04211 Longevity regulating pathway
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04131 Membrane trafficking
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
Membrane trafficking [BR:ko04131]
 Endocytosis
  Rab GTPases and associated proteins
   Rab associated proteins
    K08733  APPL1, DIP13A; DCC-interacting protein 13 alpha
Genes
HSA: 26060(APPL1)
PTR: 460469(APPL1)
PPS: 100995535(APPL1)
GGO: 101126724(APPL1)
PON: 100442490(APPL1)
NLE: 100599415(APPL1)
MCC: 100425753(APPL1)
MCF: 102126071(APPL1)
CSAB: 103227788(APPL1)
RRO: 104660203(APPL1)
RBB: 108543582(APPL1)
CJC: 100389847(APPL1)
SBQ: 101034147(APPL1)
MMU: 72993(Appl1)
MCAL: 110309157(Appl1)  
MPAH: 110325445(Appl1)
RNO: 290537(Appl1)
MUN: 110566349(Appl1)
CGE: 100751324(Appl1)
NGI: 103747007(Appl1)
HGL: 101703342(Appl1)
OCU: 100353097(APPL1)
TUP: 102477144(APPL1)
CFA: 484716(APPL1)
VVP: 112908602(APPL1)  
AML: 100463883(APPL1)
UMR: 103675060(APPL1)
UAH: 113257000(APPL1)
ORO: 101375582(APPL1)
ELK: 111143849
FCA: 101096960(APPL1)
PTG: 102956094(APPL1)  
PPAD: 109279103(APPL1)
AJU: 106967026(APPL1)
BTA: 517850(APPL1)
BOM: 102266894(APPL1)
BIU: 109575959(APPL1)
BBUB: 102414857(APPL1)
CHX: 102169529(APPL1)
OAS: 101109218(APPL1)
SSC: 100188978(APPL1)
CFR: 102516958(APPL1)
CDK: 105089793(APPL1)
BACU: 103012463(APPL1)
LVE: 103085402(APPL1)
OOR: 101282807(APPL1)
DLE: 111174255(APPL1)
PCAD: 102987883(APPL1)
ECB: 100058653(APPL1)
EPZ: 103547870(APPL1)
EAI: 106848655(APPL1)
MYB: 102250837(APPL1)
MYD: 102773012(APPL1)
MNA: 107531462(APPL1)
HAI: 109377590(APPL1)
DRO: 112301169(APPL1)
PALE: 102887604(APPL1)  
RAY: 107503389(APPL1)
MJV: 108397387(APPL1)
LAV: 100657434(APPL1)
TMU: 101352321
MDO: 100010013(APPL1)
SHR: 100921499(APPL1)
PCW: 110195969(APPL1)
OAA: 100089140(APPL1)
GGA: 416002(APPL1)
MGP: 100547896(APPL1)
CJO: 107319769(APPL1)
NMEL: 110404658(APPL1)  
APLA: 101798507(APPL1)
ACYG: 106040513(APPL1)
TGU: 100226921(APPL1)
LSR: 110471716(APPL1)
SCAN: 103817003(APPL1)
GFR: 102036365(APPL1)
FAB: 101818861(APPL1)
PHI: 102101270(APPL1)
PMAJ: 107210342(APPL1)
CCAE: 111935108(APPL1)
CCW: 104683267(APPL1)
ETL: 114057939(APPL1)
FPG: 101918142(APPL1)
FCH: 102055056(APPL1)
CLV: 102087711(APPL1)
EGZ: 104126721(APPL1)
NNI: 104022664(APPL1)
ACUN: 113484944(APPL1)
PADL: 103915480(APPL1)
AAM: 106495171(APPL1)
ASN: 102384706(APPL1)
AMJ: 102573987(APPL1)
PSS: 102457050(APPL1)
CMY: 102937117(APPL1)
CPIC: 101950184(APPL1)
ACS: 100564640(appl1)
PVT: 110082404(APPL1)
PBI: 103061921(APPL1)
PMUR: 107297188(APPL1)
TSR: 106541673(APPL1)
PMUA: 114591700(APPL1)
GJA: 107107451(APPL1)
XLA: 398493(appl1.S) 398984(appl1.L)
XTR: 100038055(appl1)
NPR: 108786881(APPL1)
DRE: 571540(appl1)
SRX: 107712995 107747534(appl1)
SANH: 107657952 107680550(appl1)
SGH: 107557417(appl1)
CCAR: 109084093
IPU: 108254880(appl1)
PHYP: 113538084(appl1)
AMEX: 103038259(appl1)
EEE: 113572360(appl1)
LCO: 104940242(appl1)
NCC: 104951230(appl1)
MZE: 101469918(appl1)
ONL: 100691276(appl1)
OLA: 101169445(appl1)
XMA: 102221762(appl1)
XCO: 114135891(appl1)
PRET: 103464350(appl1)
CVG: 107101713(appl1)
NFU: 107385075(appl1)  
KMR: 108244943(appl1)
ALIM: 106525043(appl1)
CSEM: 103386656(appl1)
POV: 109635466(appl1)
LCF: 108874777(appl1)
SDU: 111219333(appl1)
SLAL: 111668209(appl1)
HCQ: 109521490(appl1)
BPEC: 110157714(appl1)  
MALB: 109966385(appl1)
SASA: 106566093(appl1) 106582698
OTW: 112221680(appl1) 112254175
ELS: 105017453(appl1)
SFM: 108936613(appl1)
PKI: 111837518(appl1)
LCM: 102354094(APPL1)
CMK: 103176777(appl1)  
RTP: 109916002(appl1)
BFO: 118416165
SPU: 579389
APLC: 110983942
SKO: 102802648
CSCU: 111619708
PTEP: 107450243
TSP: Tsp_07605
PCAN: 112571793
CRG: 105327258
MYI: 110461257
OBI: 106871906
AQU: 105314014
 » show all
Reference
  Authors
Miaczynska M, Christoforidis S, Giner A, Shevchenko A, Uttenweiler-Joseph S, Habermann B, Wilm M, Parton RG, Zerial M
  Title
APPL proteins link Rab5 to nuclear signal transduction via an endosomal compartment.
  Journal
Cell 116:445-56 (2004)
DOI:10.1016/S0092-8674(04)00117-5
  Sequence
[hsa:26060]
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