KEGG   ORTHOLOGY: K08736
Entry
K08736                      KO                                     

Name
MSH3
Definition
DNA mismatch repair protein MSH3
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08736  MSH3; DNA mismatch repair protein MSH3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08736  MSH3; DNA mismatch repair protein MSH3
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08736  MSH3; DNA mismatch repair protein MSH3
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08736  MSH3; DNA mismatch repair protein MSH3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08736  MSH3; DNA mismatch repair protein MSH3
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08736  MSH3; DNA mismatch repair protein MSH3
Genes
HSA: 4437(MSH3)
PTR: 735384(MSH3)
PPS: 100972976(MSH3)
GGO: 101124461(MSH3)
PON: 100171924(MSH3)
NLE: 100595600(MSH3)
MCC: 711187(MSH3)
MCF: 102136760(MSH3)
CSAB: 103223859(MSH3)
RRO: 104680186(MSH3)
RBB: 108528914(MSH3)
CJC: 100406902(MSH3)
SBQ: 101044317(MSH3)
MMU: 17686(Msh3)
MCAL: 110308223(Msh3)
MPAH: 110328815(Msh3)
RNO: 499505(Msh3)
MUN: 110546895(Msh3)
CGE: 100762943(Msh3)
NGI: 103750270(Msh3)
HGL: 101700364(Msh3)
CCAN: 109688113(Msh3)
OCU: 100337807(MSH3)
TUP: 102501896(MSH3)
CFA: 479164(MSH3)
VVP: 112919583(MSH3)
AML: 100475866(MSH3)
UMR: 103681472(MSH3)
UAH: 113255156(MSH3)
ORO: 101381286(MSH3)
ELK: 111148257
FCA: 101090919(MSH3)
PTG: 102950877(MSH3)
PPAD: 109274919(MSH3)
AJU: 106972137(MSH3)
BTA: 616744(MSH3)
BOM: 102274795(MSH3)
BIU: 109562288(MSH3)
BBUB: 102415934(MSH3)
CHX: 102171330(MSH3)
OAS: 101121679(MSH3)
SSC: 100512158(MSH3)
CFR: 102505126(MSH3)
CDK: 105084838(MSH3)
BACU: 103019393(MSH3)
LVE: 103071096 103086628(MSH3)
OOR: 101286492(MSH3)
DLE: 111184789(MSH3)
PCAD: 102978499(MSH3)
ECB: 100073255(MSH3)
EPZ: 103549605(MSH3)
EAI: 106841188(MSH3)
MYB: 102254819(MSH3)
MYD: 102760014(MSH3)
MNA: 107543706
HAI: 109388130(MSH3)
DRO: 112307501(MSH3)
PALE: 102878992(MSH3)
RAY: 107499335(MSH3)
LAV: 100674995(MSH3)
TMU: 101358048
MDO: 100015958(MSH3)
SHR: 100916871(MSH3)
PCW: 110222556(MSH3)
OAA: 100081413(MSH3)
GGA: 427318(MSH3)
MGP: 104915285(MSH3)
CJO: 107306538(MSH3)
NMEL: 110389592(MSH3)
APLA: 101797839(MSH3)
ACYG: 106042720(MSH3)
TGU: 100220355(MSH3)
LSR: 110482513(MSH3)
SCAN: 103823071(MSH3)
GFR: 102037792(MSH3)
FAB: 101811685(MSH3)
PHI: 102113143(MSH3)
PMAJ: 107215881(MSH3)
CCAE: 111941610(MSH3)
CCW: 104695831(MSH3)
ETL: 114056083(MSH3)
FPG: 101913150(MSH3)
FCH: 102047877(MSH3)
CLV: 102092981(MSH3)
EGZ: 104128349(MSH3)
NNI: 104022997(MSH3)
ACUN: 113490261(MSH3)
PADL: 103923435(MSH3)
ASN: 102387295(MSH3)
AMJ: 102563518(MSH3)
PSS: 102450560(MSH3)
CMY: 102941347(MSH3)
CPIC: 101935055(MSH3)
ACS: 100554606(msh3)
PVT: 110077322(MSH3)
PBI: 103064642(MSH3)
PMUR: 107299642(MSH3)
TSR: 106538764(MSH3)
PMUA: 114606377(MSH3)
GJA: 107124616(MSH3)
XLA: 108717641(msh3.L)
XTR: 100486354(msh3)
NPR: 108794203(MSH3)
DRE: 565400(msh3)
SRX: 107720281
SANH: 107699681(msh3)
SGH: 107587513(msh3)
IPU: 108255996(msh3)
PHYP: 113537202(msh3)
AMEX: 103037699(msh3)
EEE: 113574961(msh3)
TRU: 101078721(msh3)
LCO: 104930140(msh3)
MZE: 101481912(msh3)
ONL: 100695943
OLA: 101156254(msh3)
XMA: 102235782
XCO: 114154114(msh3)
PRET: 103470074(msh3)
CVG: 107094525(msh3)
NFU: 107394171(msh3)
KMR: 108233536(msh3)
ALIM: 106513654(msh3)
AOCE: 111564701(msh3)
CSEM: 103397624(msh3)
POV: 109636975(msh3)
LCF: 108881996(msh3)
SDU: 111237718(msh3)
SLAL: 111661018(msh3)
HCQ: 109527053(msh3)
BPEC: 110175640(msh3)
MALB: 109956610(msh3)
OTW: 112249542
SALP: 111974598(msh3)
ELS: 105007963(msh3)
SFM: 108939000(msh3)
PKI: 111850310(msh3)
LCM: 102354624(MSH3)
CMK: 103182681(msh3)
RTP: 109919699
BFO: 118410011
SPU: 756012
APLC: 110990127
SKO: 102809104
ZNE: 110836230
PVM: 113804271
PTEP: 107437796
PCAN: 112554031
CRG: 105319347
MYI: 110455028
OBI: 106881712
NVE: 5510386
EPA: 110251923
ADF: 107334329
AMIL: 114958672
PDAM: 113672640
SPIS: 111340763
HMG: 100201087(msh3)
ATH: AT4G25540(MSH3)
ALY: 9305740
CRB: 17878284
BRP: 103861568
BOE: 106302084
RSZ: 108851483
THJ: 104811986
CPAP: 110810275
CIT: 102630910
TCC: 18605549
GRA: 105765551
GAB: 108480022
DZI: 111289365
GMX: 100789883
GSJ: 114403787
VRA: 106769933
VAR: 108326678
VUN: 114192537
CCAJ: 109804654
CAM: 101502126
LJA: Lj5g3v2013910.1(Lj5g3v2013910.1)
ADU: 107467000
AIP: 107618836
LANG: 109346802
FVE: 101296148
RCN: 112176623
PPER: 18785304
PMUM: 103333228
PAVI: 110767783
MDM: 103439741
PXB: 103960554
ZJU: 107414469
CSV: 101214720
CMO: 103484070
MCHA: 111011425
CMAX: 111482846
CMOS: 111430887
CPEP: 111810348
RCU: 8258259
JCU: 105648481
HBR: 110641131
MESC: 110600078
POP: 7474039
PEU: 105142659
JRE: 108998607
VVI: 100266933
SLY: 101248748
SPEN: 107012166
SOT: 102598298
CANN: 107863304
NSY: 104246604
NTO: 104091927
NAU: 109208515
INI: 109146560
SIND: 105160490
OEU: 111393177
HAN: 110940551
LSV: 111887335
CCAV: 112524172
DCR: 108210556
BVG: 104906479
SOE: 110782495
CQI: 110729674
NNU: 104596123
PSOM: 113283946
OSA: 4337442
DOSA: Os04t0682900-01(Os04g0682900)
OBR: 102710121
BDI: 100824247
ATS: 109775246(LOC109775246)
SBI: 8085890
ZMA: 103642206
SITA: 101784541
PDA: 103719424
EGU: 105054823
MUS: 103973219
DCT: 110099820
PEQ: 110022799
AOF: 109819808
ATR: 18423066
PPP: 112275975
APRO: F751_0287
MIS: MICPUN_58155(MSH3)
MPP: MICPUCDRAFT_56979(MSH3)
SCE: YCR092C(MSH3)
ERC: Ecym_6039
KMX: KLMA_40023(MSH3)
NCS: NCAS_0D04700(NCAS0D04700)
NDI: NDAI_0I00260(NDAI0I00260)
TPF: TPHA_0H02400(TPHA0H02400)
TBL: TBLA_0F00230(TBLA0F00230)
TDL: TDEL_0A07870(TDEL0A07870)
KAF: KAFR_0J02610(KAFR0J02610)
CAL: CAALFM_C208680WA(MSH3)
SLB: AWJ20_5128(MSH3)
NCR: NCU08115(msh3)
NTE: NEUTE1DRAFT88806(NEUTE1DRAFT_88806)
SMP: SMAC_08039(putative msh3)
MGR: MGG_09306
SSCK: SPSK_00073
MAW: MAC_01069
MAJ: MAA_05665
CMT: CCM_05581
BFU: BCIN_06g05300(Bcmsh3)
MBE: MBM_04892
ANI: AN3749.2
ANG: ANI_1_150114(An13g01060)
ABE: ARB_02429
TVE: TRV_03218
PNO: SNOG_03496(SNOG_03495)
PTE: PTT_17141
SPO: SPAC8F11.03(msh3)
CNE: CNC01550
CNB: CNBC5700
TASA: A1Q1_02991
ABP: AGABI1DRAFT34226(AGABI1DRAFT_34226)
ABV: AGABI2DRAFT141320(AGABI2DRAFT_141320)
MGL: MGL_3423
MRT: MRET_1458
DDI: DDB_G0281683(msh3)
DFA: DFA_00628(msh3)
 » show all
Reference
PMID:7926796
  Authors
Liu K, Niu L, Linton JP, Crouse GF
  Title
Characterization of the mouse Rep-3 gene: sequence similarities to bacterial and yeast mismatch-repair proteins.
  Journal
Gene 147:169-77 (1994)
DOI:10.1016/0378-1119(94)90062-0
  Sequence
[mmu:17686]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YCR092C]
LinkDB

KEGG   ORTHOLOGY: K08737
Entry
K08737                      KO                                     

Name
MSH6
Definition
DNA mismatch repair protein MSH6
Pathway
ko01524  Platinum drug resistance
ko03430  Mismatch repair
ko05200  Pathways in cancer
ko05210  Colorectal cancer
Disease
H00020  Colorectal cancer
H00876  Mismatch repair deficiency
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03430 Mismatch repair
    K08737  MSH6; DNA mismatch repair protein MSH6
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09162 Cancer: specific types
   05210 Colorectal cancer
    K08737  MSH6; DNA mismatch repair protein MSH6
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K08737  MSH6; DNA mismatch repair protein MSH6
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03400 DNA repair and recombination proteins
    K08737  MSH6; DNA mismatch repair protein MSH6
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   MMR (mismatch excision repair)
    Mismatch and loop recognition factors
     K08737  MSH6; DNA mismatch repair protein MSH6
Genes
HSA: 2956(MSH6)
PTR: 459218(MSH6)
PPS: 100986695(MSH6)
GGO: 101148740(MSH6)
PON: 100458732(MSH6)
NLE: 100593553(MSH6)
MCC: 715701(MSH6)
MCF: 102143419(MSH6)
CSAB: 103220318(MSH6)
RRO: 104663162(MSH6)
RBB: 108527513(MSH6)
CJC: 100386465(MSH6)
SBQ: 101039649(MSH6)
MMU: 17688(Msh6)
MCAL: 110284330(Msh6)
MPAH: 110335576(Msh6)
RNO: 100360342(Msh6)
MUN: 110561037(Msh6)
CGE: 100771087(Msh6)
NGI: 103725738(Msh6)
HGL: 101708261(Msh6)
CCAN: 109691597(Msh6)
OCU: 100351645(MSH6)
TUP: 102476727(MSH6)
CFA: 474585(MSH6)
VVP: 112915230(MSH6)
AML: 100471984(MSH6)
UMR: 103671242(MSH6)
UAH: 113245929(MSH6)
ORO: 101368929(MSH6)
ELK: 111148106
FCA: 101082303(MSH6)
PTG: 102953993(MSH6)
PPAD: 109247090(MSH6)
AJU: 106977218(MSH6)
BTA: 540526(MSH6)
BOM: 102269162(MSH6)
BIU: 109566061(MSH6)
BBUB: 102409894(MSH6)
CHX: 102173474(MSH6)
OAS: 101107426(MSH6)
SSC: 100624450(MSH6)
CFR: 102513599(MSH6)
CDK: 105092358(MSH6)
BACU: 102999040(MSH6)
LVE: 103089181(MSH6)
OOR: 101271574(MSH6)
DLE: 111174785(MSH6)
PCAD: 102994456(MSH6)
ECB: 100068065(MSH6)
EPZ: 103558461(MSH6)
EAI: 106825979(MSH6)
MYB: 102245110(MSH6)
MYD: 102755448(MSH6)
MNA: 107544300(MSH6)
HAI: 109389905(MSH6)
DRO: 112297935(MSH6)
PALE: 102892999(MSH6)
RAY: 107509550(MSH6)
MJV: 108394002(MSH6)
LAV: 100677382(MSH6)
TMU: 101345932
MDO: 100033356(MSH6)
SHR: 100919645(MSH6)
PCW: 110218568(MSH6)
OAA: 103168521(MSH6)
GGA: 421291(MSH6)
MGP: 100541959(MSH6)
CJO: 107310861(MSH6)
NMEL: 110396244(MSH6)
APLA: 101799348(MSH6)
ACYG: 106043138(MSH6)
TGU: 100227810(MSH6)
LSR: 110475791(MSH6)
SCAN: 103819208(MSH6)
GFR: 102033560(MSH6)
FAB: 101815194(MSH6)
PHI: 102104034(MSH6)
PMAJ: 107201864(MSH6)
CCAE: 111926311(MSH6)
CCW: 104685591(MSH6)
ETL: 114060404(MSH6)
FPG: 101921710(MSH6)
FCH: 102051882(MSH6)
CLV: 102090300(MSH6)
EGZ: 104134625(MSH6)
NNI: 104018105(MSH6)
ACUN: 113478822(MSH6)
PADL: 103924992(MSH6)
AAM: 106490408(MSH6)
ASN: 102388051(MSH6)
AMJ: 102573895(MSH6)
PSS: 102456308(MSH6)
CMY: 102943356(MSH6)
CPIC: 101951836(MSH6)
ACS: 100562407(msh6)
PVT: 110079554(MSH6)
PBI: 103056083(MSH6)
PMUR: 107290122(MSH6)
TSR: 106541523(MSH6)
PMUA: 114594849(MSH6)
GJA: 107124261(MSH6)
XLA: 734294(msh6.L)
XTR: 100145639(msh6)
NPR: 108787598(MSH6)
DRE: 260437(msh6)
SRX: 107725009
SANH: 107679164(msh6)
SGH: 107588437
IPU: 108263456(msh6)
PHYP: 113542145(msh6)
AMEX: 103027666(msh6)
EEE: 113588072(msh6)
TRU: 101079280(msh6)
LCO: 104918635(msh6)
NCC: 104951340(msh6)
MZE: 101470032(msh6)
ONL: 100710916(msh6)
OLA: 101160935(msh6)
XMA: 102229772(msh6)
XCO: 114137762(msh6)
PRET: 103477050(msh6)
CVG: 107089290(msh6)
NFU: 107375752(msh6)
KMR: 108234081(msh6)
ALIM: 106532862(msh6)
AOCE: 111567184(msh6)
CSEM: 103387561(msh6)
POV: 109632657(msh6)
LCF: 108894383(msh6)
SDU: 111220543(msh6)
SLAL: 111659027(msh6)
HCQ: 109516232(msh6)
BPEC: 110157016(msh6)
MALB: 109961974(msh6)
SASA: 106589736(msh6)
OTW: 112224594(msh6)
SALP: 111968060(msh6)
ELS: 105028409(msh6)
SFM: 108918060(msh6)
PKI: 111848812(msh6)
LCM: 102366015(MSH6)
CMK: 103180839(msh6)
RTP: 109919222
BFO: 118404634
CIN: 100185806
SPU: 593059
APLC: 110987988
SKO: 102805174
DME: Dmel_CG7003(Msh6)
DER: 6544520
DSE: 6605754
DSI: Dsimw501_GD12570(Dsim_GD12570)
DAN: 6493604
DSR: 110176127
DPE: 6596937
DMN: 108151407
DWI: 6645793
DAZ: 108613429
DNV: 108651428
DHE: 111595124
DVI: 6623428
MDE: 101889577
LCQ: 111685162
AAG: 5575374
AALB: 109414186
AME: 408815
BIM: 100745752
BTER: 100647842
CCAL: 108625901
OBB: 114872506
SOC: 105205867
MPHA: 105831306
AEC: 105147089
ACEP: 105623738
PBAR: 105431572
VEM: 105565711
HST: 105183383
DQU: 106742167
CFO: 105255559
LHU: 105677715
PGC: 109859322
OBO: 105281412
PCF: 106789002
NVI: 100115613
CSOL: 105362758
TCA: 660174
DPA: 109543134
ATD: 109596295
NVL: 108567736
BMOR: 101744671
BMAN: 114249524
PMAC: 106709764
PRAP: 110993015
HAW: 110379891
TNL: 113499169
API: 100166946
DNX: 107173209
AGS: 114122759
BTAB: 109039982
CLEC: 106668181
ZNE: 110831875
FCD: 110851254
PVM: 113803547
TUT: 107364943
DPTE: 113790436
CSCU: 111620331
PTEP: 107448365
CEL: CELE_Y47G6A.11(msh-6)
CBR: CBG14959(Cbr-msh-6)
BMY: Bm1_41770
TSP: Tsp_09358
PCAN: 112561418
CRG: 105344641
MYI: 110458103
OBI: 106880162
LAK: 106155648
SHX: MS3_02714
EGL: EGR_01292
NVE: 5518402
EPA: 110241459
AMIL: 114963837
PDAM: 113669812
SPIS: 111338428
DGT: 114528604
HMG: 100209507
AQU: 100631829
ATH: AT3G24495(MSH7) AT4G02070(MSH6)
LJA: Lj1g3v0246860.1(Lj1g3v0246860.1) Lj2g3v0777050.1(Lj2g3v0777050.1)
AIP: 107646082
VVI: 100255608 100260983(MSH7)
CANN: 107877977
DOSA: Os01t0180600-01(Os01g0180600) Os09t0407600-01(Os09g0407600)
ATS: 109772035(LOC109772035) 109786772(LOC109786772)
MNG: MNEG_2780
APRO: F751_5249
SCE: YDR097C(MSH6)
ERC: Ecym_3519
KMX: KLMA_30293(MSH6)
NCS: NCAS_0B03980(NCAS0B03980)
NDI: NDAI_0J01520(NDAI0J01520)
TPF: TPHA_0B03370(TPHA0B03370)
TBL: TBLA_0F03840(TBLA0F03840)
TDL: TDEL_0A01290(TDEL0A01290)
KAF: KAFR_0A02370(KAFR0A02370)
PIC: PICST_81012(MSH6)
CAL: CAALFM_C113170CA(MSH6)
SLB: AWJ20_1503(MSH6)
NCR: NCU08135(msh6)
NTE: NEUTE1DRAFT124150(NEUTE1DRAFT_124150)
SMP: SMAC_03612(putative msh56)
MGR: MGG_00704
SSCK: SPSK_02949
MAW: MAC_02355
MAJ: MAA_06876
CMT: CCM_06095
BFU: BCIN_01g04490(Bcmsh6)
MBE: MBM_04714
ANI: AN1708.2
ANG: ANI_1_590184(An04g03050)
ABE: ARB_00228
TVE: TRV_05220
PTE: PTT_11611
SPO: SPCC285.16c(msh6)
CNE: CNK02590
CNB: CNBK0960
TASA: A1Q1_04720
ABP: AGABI1DRAFT78171(AGABI1DRAFT_78171)
ABV: AGABI2DRAFT207943(AGABI2DRAFT_207943)
MGL: MGL_2919
MRT: MRET_3520
DDI: DDB_G0268614(msh6)
DFA: DFA_09956(msh6)
EHI: EHI_193340(139.t00016)
PCB: PCHAS_110480(PC000601.02.0)
TAN: TA19305
TPV: TP01_0185
BBO: BBOV_I004430(19.m02191)
CPV: cgd8_370
SMIN: v1.2.026874.t1(symbB.v1.2.026874.t1)
FCY: FRACYDRAFT_212924(MSH6)
TPS: THAPSDRAFT_261781(MutS)
SPAR: SPRG_05442
 » show all
Reference
  Authors
Yang Q, Zhang R, Wang XW, Linke SP, Sengupta S, Hickson ID, Pedrazzi G, Perrera C, Stagljar I, Littman SJ, Modrich P, Harris CC
  Title
The mismatch DNA repair heterodimer, hMSH2/6, regulates BLM helicase.
  Journal
Oncogene 23:3749-56 (2004)
DOI:10.1038/sj.onc.1207462
  Sequence
[hsa:2956]
Reference
  Authors
Lee SD, Surtees JA, Alani E
  Title
Saccharomyces cerevisiae MSH2-MSH3 and MSH2-MSH6 complexes display distinct requirements for DNA binding domain I in mismatch recognition.
  Journal
J Mol Biol 366:53-66 (2007)
DOI:10.1016/j.jmb.2006.10.099
  Sequence
[sce:YDR097C]
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