KEGG   ORTHOLOGY: K08775Help
Entry
K08775                      KO                                     

Name
BRCA2, FANCD1
Definition
breast cancer 2 susceptibility protein
Pathway
ko03440  Homologous recombination
ko03460  Fanconi anemia pathway
ko05200  Pathways in cancer
ko05212  Pancreatic cancer
ko05224  Breast cancer
Disease
H00019  Pancreatic cancer
H00027  Ovarian cancer
H00031  Breast cancer
H00238  Fanconi anemia
H01554  Fallopian tube cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03460 Fanconi anemia pathway
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
  09162 Cancer: specific types
   05212 Pancreatic cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   05224 Breast cancer
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03036 Chromosome and associated proteins
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   03400 DNA repair and recombination proteins
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   BRCC complex
    K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Other centrosome duplication proteins
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA complex
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
   FA (Fanconi anemia) pathway
    Downstream FA components
     K08775  BRCA2, FANCD1; breast cancer 2 susceptibility protein
BRITE hierarchy
Genes
HSA: 675(BRCA2)
PTR: 452526(BRCA2)
PPS: 100976403(BRCA2)
GGO: 101126719(BRCA2)
PON: 100435800(BRCA2)
NLE: 100601625(BRCA2)
MCC: 721981(BRCA2)
MCF: 102140332(BRCA2)
CSAB: 103214248(BRCA2)
RRO: 104665294(BRCA2)
RBB: 108517532 108524798(BRCA2)
CJC: 100397509(BRCA2)
SBQ: 101048321
MMU: 12190(Brca2)
MCAL: 110294557(Brca2)
MPAH: 110312957(Brca2)
RNO: 360254(Brca2)
CGE: 100689197(Brca2)
NGI: 103727209(Brca2)
HGL: 101698015(Brca2)
OCU: 100355331(BRCA2)
TUP: 102491921(BRCA2)
CFA: 474180(BRCA2)
VVP: 112918664(BRCA2)
AML: 100472854(BRCA2)
UMR: 103664352(BRCA2)
UAH: 113251242(BRCA2)
ORO: 101364023(BRCA2)
FCA: 493878(BRCA2)
PTG: 102965865(BRCA2)
PPAD: 109266065(BRCA2)
AJU: 106973859(BRCA2)
BTA: 507069(BRCA2)
BOM: 102276437(BRCA2)
BIU: 109566792(BRCA2)
BBUB: 102398645(BRCA2)
CHX: 102182417(BRCA2)
OAS: 101109980(BRCA2)
SSC: 100624979(BRCA2)
CFR: 102515425(BRCA2)
CDK: 105101018(BRCA2)
BACU: 103017905(BRCA2)
LVE: 103076579(BRCA2)
OOR: 101286498(BRCA2)
DLE: 111175212(BRCA2)
PCAD: 102995983(BRCA2)
ECB: 100064578(BRCA2)
EPZ: 103543936(BRCA2)
EAI: 106835608(BRCA2)
MYB: 102245665(BRCA2)
MYD: 102773822(BRCA2)
MNA: 107529959(BRCA2)
HAI: 109388018(BRCA2)
DRO: 112323192(BRCA2)
PALE: 102896802(BRCA2)
RAY: 107504798(BRCA2)
MJV: 108389342 108406123(BRCA2)
LAV: 100669658(BRCA2)
MDO: 100049015(BRCA2)
SHR: 100915673(BRCA2)
PCW: 110215556(BRCA2)
OAA: 100079887(BRCA2)
GGA: 374139(BRCA2)
MGP: 100542730(BRCA2)
CJO: 107308262(BRCA2)
NMEL: 110388671(BRCA2)
APLA: 101799101(BRCA2)
ACYG: 106041121(BRCA2)
TGU: 100218603(BRCA2)
LSR: 110476707(BRCA2)
SCAN: 103827353(BRCA2)
GFR: 102044477(BRCA2)
FAB: 101819655(BRCA2)
PHI: 102113036(BRCA2)
PMAJ: 107202642(BRCA2)
CCAE: 111922973(BRCA2)
CCW: 104689910(BRCA2)
ETL: 114064874(BRCA2)
FPG: 101912402(BRCA2)
FCH: 102052685(BRCA2)
CLV: 102091608(BRCA2)
EGZ: 104131391(BRCA2)
NNI: 104023078(BRCA2)
ACUN: 113481451(BRCA2)
PADL: 103920079(BRCA2)
AAM: 106500375(BRCA2)
ASN: 102383360(BRCA2)
AMJ: 102560146(BRCA2)
PSS: 102455975(BRCA2)
CMY: 102945068(BRCA2)
CPIC: 101936312(BRCA2)
ACS: 100554942(brca2)
PVT: 110076433(BRCA2)
PBI: 103068142(BRCA2)
PMUR: 107286819(BRCA2)
TSR: 106550252(BRCA2)
PMUA: 114589974 114595785(BRCA2)
GJA: 107121297(BRCA2)
XLA: 108708691(brca2.L)
XTR: 100038818(brca2)
NPR: 108785046(BRCA2)
DRE: 566758(brca2)
SANH: 107682889 107704788(brca2)
SGH: 107559013 107587266(brca2)
IPU: 108278342(brca2)
PHYP: 113539295(brca2)
AMEX: 103047230(brca2)
EEE: 113582267
TRU: 101079601(brca2)
LCO: 109139185
NCC: 104967210(brca2)
MZE: 101485201(brca2)
ONL: 100534447(brca2)
OLA: 101156345(brca2)
XMA: 102225954(brca2)
XCO: 114161835(brca2)
PRET: 103474967(brca2)
CVG: 107092105(brca2)
NFU: 107380244(brca2)
KMR: 108235962(brca2)
ALIM: 106521498(brca2)
AOCE: 111563668(brca2)
CSEM: 103378186(brca2)
POV: 109630257(brca2)
LCF: 108876019(brca2)
SDU: 111224419
SLAL: 111653091
HCQ: 109507836(brca2)
BPEC: 110162211(brca2)
MALB: 109967492(brca2)
SASA: 106612363(brca2)
OTW: 112216675(brca2)
SALP: 111960628(brca2)
ELS: 105007503(brca2)
SFM: 108941845(brca2)
PKI: 111851369(brca2)
LCM: 102351607(BRCA2)
CMK: 103177244(brca2)
RTP: 109928012(brca2)
SPU: 584780(brca2)
APLC: 110988636
SKO: 102803273
AALB: 109430923
AME: 725687
BIM: 100747199
BTER: 100645246
OBB: 114873926
SOC: 105204033
MPHA: 105841082
AEC: 105149590
ACEP: 105622356
PBAR: 105425887
VEM: 105568564
HST: 105184371
DQU: 106749340
CFO: 105248036
LHU: 105669691
PGC: 109855937
OBO: 105284068
PCF: 106790114
CSOL: 105360414
MDL: 103579169
TCA: 103312217
DPA: 109546455
ATD: 109594117
NVL: 108569399
PMAC: 106715806
PRAP: 110996495
HAW: 110382284
TNL: 113498750
API: 100166339
DNX: 107163136
RMD: 113554382
BTAB: 109039621
CLEC: 106660835
ZNE: 110836322
PVM: 113807455
CSCU: 111619758
TSP: Tsp_00590
PCAN: 112575292
CRG: 105327701
MYI: 110455004
OBI: 106876073
SHX: MS3_01472
EPA: 110240621
ADF: 107348661
PDAM: 113675091
SPIS: 111331323
DGT: 114531084
HMG: 101237032
ATH: AT4G00020(BRCA2(IV)) AT5G01630(BRCA2B)
CRB: 17882096
CPAP: 110822814
CIT: 102628548
TCC: 18597460
GRA: 105780797
GAB: 108458420
DZI: 111311147
EGR: 104426355
GMX: 100797849
GSJ: 114380889
VRA: 106779926
VAR: 108343332
VUN: 114187401
CCAJ: 109811696
CAM: 101498291
LJA: Lj0g3v0089779.1(Lj0g3v0089779.1)
ADU: 107482461
AIP: 107635814
LANG: 109344405
FVE: 101314804
RCN: 112191507
PPER: 18780662
PMUM: 103327228
PAVI: 110762693
MDM: 103427770
ZJU: 107431037
CSV: 101215906
CMO: 103486259
MCHA: 111025723
CMAX: 111481499
CMOS: 111441510
CPEP: 111789840
RCU: 8263118
JCU: 105648094
HBR: 110641626
MESC: 110622456
POP: 7463421
JRE: 108982294
QSU: 111988228
VVI: 100241398
SLY: 101244820
SPEN: 107008750
SOT: 102591010
CANN: 107857600
NTO: 104091081
NAU: 109223180
INI: 109180700
SIND: 105174738
OEU: 111406546
HAN: 110912213
LSV: 111890809
CCAV: 112512803
DCR: 108202960
BVG: 104892556
SOE: 110804778
NNU: 104597269
OSA: 4324417
OBR: 102701484
BDI: 100832537
ATS: 109768542(LOC109768542)
ZMA: 103641455
SITA: 101775022
PDA: 103696436
EGU: 105057159
MUS: 103986476
DCT: 110092985
PEQ: 110039460
AOF: 109846737
ATR: 18423456
MIS: MICPUN_62958(BRCA2)
APRO: F751_6831
CNE: CNG03110
CNB: CNBG1640
ABP: AGABI1DRAFT104048(AGABI1DRAFT_104048)
ABV: AGABI2DRAFT113908(AGABI2DRAFT_113908)
MRT: MRET_3539
DFA: DFA_00009
FCY: FRACYDRAFT_183976(BRCA2a)
TPS: THAPS_263089(BRAC2)
NGD: NGA_0400600(BRCA2)
SPAR: SPRG_07704
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Holloman WK
  Title
Unraveling the mechanism of BRCA2 in homologous recombination.
  Journal
Nat Struct Mol Biol 18:748-54 (2011)
DOI:10.1038/nsmb.2096
  Sequence
[hsa:675]
Reference
  Authors
Hussain S, Wilson JB, Medhurst AL, Hejna J, Witt E, Ananth S, Davies A, Masson JY, Moses R, West SC, de Winter JP, Ashworth A, Jones NJ, Mathew CG
  Title
Direct interaction of FANCD2 with BRCA2 in DNA damage response pathways.
  Journal
Hum Mol Genet 13:1241-8 (2004)
DOI:10.1093/hmg/ddh135
  Sequence
[hsa:675]
Reference
PMID:8524414
  Authors
Wooster R, Bignell G, Lancaster J, Swift S, Seal S, Mangion J, Collins N, Gregory S, Gumbs C, Micklem G
  Title
Identification of the breast cancer susceptibility gene BRCA2.
  Journal
Nature 378:789-92 (1995)
DOI:10.1038/378789a0
  Sequence
[hsa:675]
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