KEGG   ORTHOLOGY: K08849
Entry
K08849                      KO                                     

Name
MLKL
Definition
mixed lineage kinase domain-like [EC:2.7.11.1]
Pathway
ko04217  Necroptosis
ko04668  TNF signaling pathway
ko05132  Salmonella infection
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K08849  MLKL; mixed lineage kinase domain-like
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K08849  MLKL; mixed lineage kinase domain-like
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05132 Salmonella infection
    K08849  MLKL; mixed lineage kinase domain-like
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08849  MLKL; mixed lineage kinase domain-like
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08849  MLKL; mixed lineage kinase domain-like
Protein kinases [BR:ko01001]
 Serine/threonine kinases: TKL group
  Other
   K08849  MLKL; mixed lineage kinase domain-like
Genes
HSA: 197259(MLKL)
PTR: 736069(MLKL)
PPS: 100976874(MLKL)
GGO: 101131212(MLKL)
PON: 100431964(MLKL)
NLE: 100593775(MLKL)
MCC: 710316(MLKL)
MCF: 102140765(MLKL)
CSAB: 103233145(MLKL)
RRO: 104677830(MLKL)
RBB: 108527430(MLKL)
CJC: 100400130(MLKL)
SBQ: 101045007(MLKL)
MMU: 74568(Mlkl)
MCAL: 110300641(Mlkl)
MPAH: 110337670(Mlkl)
RNO: 690743(Mlkl)
MUN: 110546008(Mlkl)
CGE: 100772478(Mlkl)
NGI: 103725675(Mlkl)
CCAN: 109696571(Mlkl)
TUP: 102471426(MLKL)
BTA: 790225(MLKL)
BOM: 102269257(MLKL)
BIU: 109573003(MLKL)
BBUB: 102415271(MLKL)
CHX: 102172181(MLKL)
OAS: 101115147(MLKL)
SSC: 100736836(MLKL)
CFR: 102523997(MLKL)
CDK: 105094684(MLKL)
BACU: 103000454(MLKL)
LVE: 103071674(MLKL)
OOR: 101282908(MLKL)
DLE: 111179706(MLKL)
PCAD: 102989423(MLKL)
ECB: 100068748(MLKL)
EPZ: 103560158(MLKL)
EAI: 106836788(MLKL)
MYB: 102249398(MLKL)
MYD: 102754116(MLKL)
MNA: 107525577(MLKL)
HAI: 109384777(MLKL)
DRO: 112300647(MLKL)
PALE: 102898915(MLKL)
RAY: 107510414(MLKL)
MJV: 108409625(MLKL)
TMU: 101351635
OAA: 100081728(MLKL)
GGA: 415686(MLKL)
MGP: 100545440(MLKL)
CJO: 107319074(MLKL)
NMEL: 110404531(MLKL)
APLA: 101790564(MLKL)
ACYG: 106033317(MLKL)
TGU: 100223797(MLKL)
LSR: 110476371(MLKL)
SCAN: 103816664(MLKL)
GFR: 102041913(MLKL)
FAB: 101809477(MLKL)
PHI: 102104292(MLKL)
PMAJ: 107209967(MLKL)
CCAE: 111934765(MLKL)
CCW: 104687510(MLKL)
ETL: 114063430(MLKL)
FPG: 101919582(MLKL)
FCH: 102045724(MLKL)
CLV: 102091554(MLKL)
EGZ: 104130286(MLKL)
NNI: 104017499(MLKL)
ACUN: 113484312(MLKL)
PADL: 103918117(MLKL)
AAM: 106492728(MLKL)
ASN: 102387916(MLKL)
AMJ: 102566438(MLKL)
PSS: 102452795(MLKL)
CMY: 102931050(MLKL)
CPIC: 101953736(MLKL)
ACS: 100565272(mlkl)
PVT: 110081310(MLKL)
PBI: 103064224(MLKL)
PMUR: 107287365(MLKL)
PMUA: 114601806(MLKL)
GJA: 107126191(MLKL)
XLA: 108714143(mlkl.L)
XTR: 100379899(mlkl) 100497621
NPR: 108801508(MLKL)
SRX: 107707539(mlkl)
SANH: 107698231(mlkl)
SGH: 107562827(mlkl)
IPU: 108269146(mlkl)
PHYP: 113528812(mlkl)
AMEX: 103030498(mlkl)
EEE: 113585312(mlkl)
LCO: 104934603(mlkl)
NCC: 104942669(mlkl)
CVG: 107099717(mlkl)
NFU: 107372999(mlkl)
ALIM: 106534269(mlkl)
AOCE: 111564060(mlkl)
CSEM: 103379890(mlkl)
POV: 109624097(mlkl)
LCF: 108872681(mlkl) 108872682
SDU: 111235989(mlkl)
SLAL: 111665393(mlkl)
BPEC: 110166853(mlkl)
MALB: 109952780
ELS: 105031149(mlkl)
SFM: 108940805(mlkl)
PKI: 111861185(mlkl)
LCM: 102365452(MLKL)
CMK: 103185918(mlkl)
RTP: 109915552(mlkl)
CIN: 100185956
SPU: 100893872
APLC: 110977511
 » show all
Reference
  Authors
Sun L, Wang H, Wang Z, He S, Chen S, Liao D, Wang L, Yan J, Liu W, Lei X, Wang X
  Title
Mixed lineage kinase domain-like protein mediates necrosis signaling downstream of RIP3 kinase.
  Journal
Cell 148:213-27 (2012)
DOI:10.1016/j.cell.2011.11.031
  Sequence
[hsa:197259]
LinkDB

DBGET integrated database retrieval system