KEGG   ORTHOLOGY: K08860
Entry
K08860                      KO                                     

Name
EIF2AK3
Definition
eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
Pathway
ko04137  Mitophagy - animal
ko04140  Autophagy - animal
ko04141  Protein processing in endoplasmic reticulum
ko04210  Apoptosis
ko04214  Apoptosis - fly
ko04932  Non-alcoholic fatty liver disease
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05020  Prion disease
ko05022  Pathways of neurodegeneration - multiple diseases
ko05160  Hepatitis C
ko05162  Measles
ko05168  Herpes simplex virus 1 infection
Disease
H00512  Permanent neonatal diabetes mellitus
H00766  Wolcott-Rallison syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
 09140 Cellular Processes
  09141 Transport and catabolism
   04140 Autophagy - animal
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   04137 Mitophagy - animal
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
  09143 Cell growth and death
   04210 Apoptosis
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   04214 Apoptosis - fly
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05012 Parkinson disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05014 Amyotrophic lateral sclerosis
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05020 Prion disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05022 Pathways of neurodegeneration - multiple diseases
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
  09167 Endocrine and metabolic disease
   04932 Non-alcoholic fatty liver disease
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
  09172 Infectious disease: viral
   05160 Hepatitis C
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05162 Measles
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
   05168 Herpes simplex virus 1 infection
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01001 Protein kinases
    K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.11  Protein-serine/threonine kinases
    2.7.11.1  non-specific serine/threonine protein kinase
     K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
Protein kinases [BR:ko01001]
 Serine/threonine kinases: Other
  PEK family [OT]
   K08860  EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3
Other DBs
GO: 0004694
Genes
HSA: 9451(EIF2AK3)
PTR: 459388(EIF2AK3)
PPS: 100981333(EIF2AK3)
GGO: 101147776(EIF2AK3)
PON: 100447385(EIF2AK3)
NLE: 100589743(EIF2AK3)
MCC: 699575(EIF2AK3)
MCF: 102117377(EIF2AK3)
CSAB: 103241350(EIF2AK3)
RRO: 104674177(EIF2AK3)
RBB: 108518882(EIF2AK3)
CJC: 100394186(EIF2AK3)
SBQ: 101031964(EIF2AK3)
MMU: 13666(Eif2ak3)
MCAL: 110296130(Eif2ak3)
RNO: 29702(Eif2ak3)
MUN: 110561216(Eif2ak3)
CGE: 100765343(Eif2ak3)
NGI: 103740131(Eif2ak3)
HGL: 101713561(Eif2ak3)
OCU: 100354847(EIF2AK3)
TUP: 102468736(EIF2AK3)
CFA: 475756(EIF2AK3)
VVP: 112916653(EIF2AK3)
AML: 100479743(EIF2AK3)
UMR: 103671855(EIF2AK3)
UAH: 113242804(EIF2AK3)
ORO: 101365565(EIF2AK3)
ELK: 111148064
FCA: 101095973(EIF2AK3)
PTG: 102963843(EIF2AK3)
AJU: 106978143(EIF2AK3)
BTA: 535820(EIF2AK3)
BIU: 109566145(EIF2AK3)
BBUB: 102406027(EIF2AK3)
CHX: 102185575(EIF2AK3)
OAS: 101110042(EIF2AK3)
SSC: 100513348(EIF2AK3)
CFR: 102523410(EIF2AK3)
CDK: 105104181(EIF2AK3)
BACU: 103020488(EIF2AK3)
LVE: 103068759(EIF2AK3)
OOR: 101282451(EIF2AK3)
DLE: 111187362(EIF2AK3)
PCAD: 102981822(EIF2AK3)
ECB: 100066488(EIF2AK3)
EPZ: 103549985(EIF2AK3)
EAI: 106838571(EIF2AK3)
MYB: 102256242(EIF2AK3)
MNA: 107528720(EIF2AK3)
HAI: 109394047(EIF2AK3)
DRO: 112297566(EIF2AK3)
PALE: 102894246(EIF2AK3)
RAY: 107512376(EIF2AK3)
MJV: 108410297(EIF2AK3)
LAV: 100671700(EIF2AK3)
TMU: 101342812
MDO: 100029557(EIF2AK3)
SHR: 100915385(EIF2AK3)
PCW: 110202783(EIF2AK3)
OAA: 100081193(EIF2AK3)
GGA: 422930(EIF2AK3)
CJO: 107313985(EIF2AK3)
NMEL: 110397823(EIF2AK3)
TGU: 100223479(EIF2AK3)
SCAN: 103823471(EIF2AK3)
GFR: 102039323(EIF2AK3)
PMAJ: 107203374(EIF2AK3)
EGZ: 104126987(EIF2AK3)
NNI: 104018561(EIF2AK3)
PADL: 103923526(EIF2AK3)
ACS: 100551680(eif2ak3)
PVT: 110086330(EIF2AK3)
PBI: 103053678(EIF2AK3)
PMUR: 107302385(EIF2AK3)
TSR: 106550345(EIF2AK3)
PMUA: 114581734(EIF2AK3)
XLA: 108697591 403386(eif2ak3.S)
XTR: 100190763(eif2ak3)
DRE: 559564(eif2ak3)
SANH: 107671339(eif2ak3)
CCAR: 109045292
TRU: 101068654(eif2ak3)
LCO: 104931193(eif2ak3)
NCC: 104951808(eif2ak3)
MZE: 101480980(eif2ak3)
ONL: 100691545(eif2ak3)
OLA: 101171373(eif2ak3)
XMA: 102220027(eif2ak3)
XCO: 114134784(eif2ak3)
PRET: 103458264(eif2ak3)
CVG: 107102124(eif2ak3)
NFU: 107373885(eif2ak3)
KMR: 108247269(eif2ak3)
ALIM: 106523590(eif2ak3)
AOCE: 111569316(eif2ak3)
CSEM: 103383108(eif2ak3)
POV: 109641514(eif2ak3)
LCF: 108889157(eif2ak3)
SDU: 111226127(eif2ak3)
SLAL: 111646809(eif2ak3)
HCQ: 109511559(eif2ak3)
BPEC: 110157424(eif2ak3)
MALB: 109962460(eif2ak3)
BFO: 118409008
DME: Dmel_CG2087(PEK)
DER: 6552401
DSE: 6613946
DSI: Dsimw501_GD19618(Dsim_GD19618)
DAN: 6500493
DSR: 110177163
DPE: 6591403
DMN: 108156119
DWI: 6649722
DAZ: 108620956
DNV: 108660208
DHE: 111598506
DVI: 6633051
AAG: 5563776
TCA: 658258
API: 100166491
CEL: CELE_F46C3.1(pek-1)
TSP: Tsp_11315
HMG: 101239642
ANI: AN7321.2
ANG: ANI_1_2152184(An04g08580)
ABE: ARB_03252
TVE: TRV_02482
PTE: PTT_19265
 » show all
Reference
  Authors
Schroder M, Kaufman RJ
  Title
Divergent roles of IRE1alpha and PERK in the unfolded protein response.
  Journal
Curr Mol Med 6:5-36 (2006)
DOI:10.2174/156652406775574569
Reference
  Authors
Baltzis D, Pluquet O, Papadakis AI, Kazemi S, Qu LK, Koromilas AE
  Title
The eIF2alpha kinases PERK and PKR activate glycogen synthase kinase 3 to promote the proteasomal degradation of p53.
  Journal
J Biol Chem 282:31675-87 (2007)
DOI:10.1074/jbc.M704491200
Reference
  Authors
Shi Y, An J, Liang J, Hayes SE, Sandusky GE, Stramm LE, Yang NN
  Title
Characterization of a mutant pancreatic eIF-2alpha kinase, PEK, and co-localization with somatostatin in islet delta cells.
  Journal
J Biol Chem 274:5723-30 (1999)
DOI:10.1074/jbc.274.9.5723
  Sequence
[hsa:9451]
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