KEGG   ORTHOLOGY: K09054
Entry
K09054                      KO                                     

Name
ATF6A
Definition
cyclic AMP-dependent transcription factor ATF-6 alpha
Pathway
ko04141  Protein processing in endoplasmic reticulum
ko05010  Alzheimer disease
ko05012  Parkinson disease
ko05014  Amyotrophic lateral sclerosis
ko05022  Pathways of neurodegeneration - multiple diseases
Disease
H00971  Achromatopsia
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
 09160 Human Diseases
  09164 Neurodegenerative disease
   05010 Alzheimer disease
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
   05012 Parkinson disease
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
   05014 Amyotrophic lateral sclerosis
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
   05022 Pathways of neurodegeneration - multiple diseases
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09054  ATF6A; cyclic AMP-dependent transcription factor ATF-6 alpha
Genes
HSA: 22926(ATF6)
PTR: 457461(ATF6)
PPS: 100981924(ATF6)
GGO: 101144626(ATF6)
PON: 100451142(ATF6)
NLE: 100584219(ATF6)
MCC: 720056(ATF6)
MCF: 102135853(ATF6)
CSAB: 103223664(ATF6)
RRO: 104670391(ATF6)
RBB: 108542583(ATF6)
CJC: 100412913(ATF6)
SBQ: 101043094(ATF6)
MMU: 226641(Atf6)
MCAL: 110292204(Atf6)
MPAH: 110321899(Atf6)
RNO: 304962(Atf6)
MUN: 110550623(Atf6) 110554441
CGE: 100772173(Atf6)
NGI: 103746777(Atf6)
HGL: 101706597(Atf6)
CCAN: 109697613(Atf6)
OCU: 100358536(ATF6)
TUP: 102484816(ATF6)
CFA: 488660(ATF6)
VVP: 112914298(ATF6)
AML: 100481422(ATF6)
UMR: 103658290(ATF6)
UAH: 113268761(ATF6)
ORO: 101365204(ATF6)
ELK: 111151136
FCA: 101086780(ATF6)
PTG: 102967171(ATF6)
PPAD: 109276666(ATF6)
AJU: 106986766(ATF6)
BTA: 530610(ATF6)
BOM: 102274690(ATF6)
BIU: 109556667(ATF6)
BBUB: 102394003(ATF6)
CHX: 102184016(ATF6)
OAS: 541606(ATF6)
SSC: 100158076(ATF6)
CFR: 102515280(ATF6)
CDK: 105092786(ATF6)
BACU: 103016852(ATF6)
OOR: 101284204(ATF6)
DLE: 111170425(ATF6)
PCAD: 102983292(ATF6)
ECB: 111773414(ATF6)
EPZ: 103562010(ATF6)
EAI: 106831122(ATF6)
MYB: 102239267(ATF6)
MYD: 102755559(ATF6)
MNA: 107535122(ATF6)
HAI: 109392318(ATF6)
DRO: 112322369(ATF6)
PALE: 102878472(ATF6)
RAY: 107502472(ATF6)
MJV: 108402818(ATF6)
LAV: 100674349(ATF6)
TMU: 101353266
MDO: 100015495(ATF6)
SHR: 100925183(ATF6)
PCW: 110209901(ATF6)
OAA: 100091907(ATF6)
GGA: 424365(ATF6)
MGP: 100545177(ATF6)
CJO: 107317148(ATF6)
NMEL: 110402649(ATF6)
APLA: 101798949(ATF6)
ACYG: 106041594(ATF6)
TGU: 100228575(ATF6)
LSR: 110478967(ATF6)
SCAN: 103824317(ATF6)
GFR: 102038347(ATF6)
FAB: 101811583(ATF6)
PHI: 102107126(ATF6)
PMAJ: 107198626(ATF6)
CCAE: 111932685(ATF6)
CCW: 104695431(ATF6)
ETL: 114067479(ATF6)
FPG: 101919069(ATF6)
FCH: 102053563(ATF6)
CLV: 102093780(ATF6)
EGZ: 104132078(ATF6)
NNI: 104010410(ATF6)
ACUN: 113483062(ATF6)
PADL: 103913996(ATF6)
AAM: 106499712(ATF6)
ASN: 102381020(ATF6)
AMJ: 102562917(ATF6)
PSS: 102461928(ATF6)
CMY: 102942511(ATF6)
CPIC: 101939884(ATF6)
ACS: 100565571(atf6)
PVT: 110081632(ATF6)
PBI: 103051994(ATF6)
PMUR: 107302856(ATF6)
GJA: 107121031(ATF6)
XLA: 108714495(atf6.L) 496056(atf6.S)
XTR: 100498199(atf6)
NPR: 108801252(ATF6)
DRE: 558071(atf6)
CCAR: 109112752
IPU: 108257823(atf6)
PHYP: 113546871(atf6)
AMEX: 103039489
EEE: 113590476(atf6)
TRU: 101078942(atf6)
LCO: 104918457(atf6)
MZE: 101470925(atf6)
ONL: 100693055(atf6)
OLA: 101156317(atf6)
XMA: 102237149(atf6)
XCO: 114150294(atf6)
PRET: 103463576(atf6)
CVG: 107098581(atf6)
NFU: 107393224(atf6)
KMR: 108230853(atf6)
ALIM: 106513903(atf6)
AOCE: 111573401
CSEM: 103397986(atf6)
POV: 109625604(atf6)
LCF: 108877400(atf6)
SDU: 111232103(atf6)
SLAL: 111656333(atf6)
HCQ: 109532062(atf6)
BPEC: 110167827(atf6)
MALB: 109964064(atf6)
PKI: 111840080 111841038(atf6)
LCM: 102350356(ATF6)
CMK: 103184781(atf6)
RTP: 109933310
DME: Dmel_CG3136(Atf6)
DER: 6541903
DSE: 6620142
DSI: Dsimw501_GD17476(Dsim_GD17476)
DSR: 110177722
DPE: 6603252
DMN: 117188009
DWI: 6640571
DAZ: 108615491
DNV: 108652938
DHE: 111600126
MDE: 101891499
LCQ: 111678583
AAG: 5578356
AME: 412432
BIM: 100748569
BTER: 100650393
CCAL: 108625317
OBB: 114879270
SOC: 105195927
MPHA: 105835927
AEC: 105150042
ACEP: 105620651
PBAR: 105426938
HST: 105182542
DQU: 106745500
CFO: 105253163
LHU: 105670326
PGC: 109862198
OBO: 105287924
PCF: 106785238
NVI: 100122162
CSOL: 105364422
MDL: 103576854
TCA: 663194
NVL: 108566862
BMOR: 101739272
BMAN: 114245507
PMAC: 106719554
PRAP: 111004404
HAW: 110374455
TNL: 113494489
PXY: 105391620
API: 100571138
DNX: 107164925
AGS: 114126656
RMD: 113548179
BTAB: 109036364
CLEC: 106669590
ZNE: 110832194
FCD: 110863030
PVM: 113822238
DPTE: 113792705
CSCU: 111623424
PTEP: 107447806
CEL: CELE_F45E6.2(atf-6)
CBR: CBG00118(Cbr-atf-6)
OBI: 106883681
EGL: EGR_04051
EPA: 110250074
ADF: 107331321
PDAM: 113679374
SPIS: 111327056
DGT: 114530386
AQU: 105312032
 » show all
Reference
PMID:9271374
  Authors
Zhu C, Johansen FE, Prywes R
  Title
Interaction of ATF6 and serum response factor.
  Journal
Mol Cell Biol 17:4957-66 (1997)
DOI:10.1128/mcb.17.9.4957
  Sequence
[hsa:22926]
Reference
  Authors
Adachi Y, Yamamoto K, Okada T, Yoshida H, Harada A, Mori K
  Title
ATF6 is a transcription factor specializing in the regulation of quality control proteins in the endoplasmic reticulum.
  Journal
Cell Struct Funct 33:75-89 (2008)
DOI:10.1247/csf.07044
  Sequence
[mmu:226641]
Reference
  Authors
Yoshida H, Okada T, Haze K, Yanagi H, Yura T, Negishi M, Mori K
  Title
Endoplasmic reticulum stress-induced formation of transcription factor complex ERSF including NF-Y (CBF) and activating transcription factors 6alpha and 6beta that activates the mammalian unfolded protein response.
  Journal
Mol Cell Biol 21:1239-48 (2001)
DOI:10.1128/MCB.21.4.1239-1248.2001
  Sequence
[hsa:22926]
LinkDB

KEGG   ORTHOLOGY: K09049
Entry
K09049                      KO                                     

Name
ATF6B, CREBL1
Definition
cyclic AMP-dependent transcription factor ATF-6 beta
Pathway
ko04022  cGMP-PKG signaling pathway
ko04141  Protein processing in endoplasmic reticulum
ko04151  PI3K-Akt signaling pathway
ko04211  Longevity regulating pathway
ko04261  Adrenergic signaling in cardiomyocytes
ko04668  TNF signaling pathway
ko04728  Dopaminergic synapse
ko04911  Insulin secretion
ko04915  Estrogen signaling pathway
ko04918  Thyroid hormone synthesis
ko04925  Aldosterone synthesis and secretion
ko04926  Relaxin signaling pathway
ko04927  Cortisol synthesis and secretion
ko04928  Parathyroid hormone synthesis, secretion and action
ko04934  Cushing syndrome
ko04935  Growth hormone synthesis, secretion and action
ko05020  Prion disease
ko05030  Cocaine addiction
ko05031  Amphetamine addiction
ko05034  Alcoholism
ko05161  Hepatitis B
ko05163  Human cytomegalovirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05203  Viral carcinogenesis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04141 Protein processing in endoplasmic reticulum
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09130 Environmental Information Processing
  09132 Signal transduction
   04668 TNF signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04022 cGMP-PKG signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04151 PI3K-Akt signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09150 Organismal Systems
  09152 Endocrine system
   04911 Insulin secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04915 Estrogen signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04926 Relaxin signaling pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04935 Growth hormone synthesis, secretion and action
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04918 Thyroid hormone synthesis
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04928 Parathyroid hormone synthesis, secretion and action
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04925 Aldosterone synthesis and secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   04927 Cortisol synthesis and secretion
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09153 Circulatory system
   04261 Adrenergic signaling in cardiomyocytes
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09156 Nervous system
   04728 Dopaminergic synapse
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09149 Aging
   04211 Longevity regulating pathway
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09160 Human Diseases
  09161 Cancer: overview
   05203 Viral carcinogenesis
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09164 Neurodegenerative disease
   05020 Prion disease
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09165 Substance dependence
   05030 Cocaine addiction
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05031 Amphetamine addiction
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05034 Alcoholism
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09167 Endocrine and metabolic disease
   04934 Cushing syndrome
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05161 Hepatitis B
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
   05163 Human cytomegalovirus infection
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03000 Transcription factors
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
Transcription factors [BR:ko03000]
 Eukaryotic type
  Basic leucine zipper (bZIP)
   CREB
    K09049  ATF6B, CREBL1; cyclic AMP-dependent transcription factor ATF-6 beta
Genes
HSA: 1388(ATF6B)
PTR: 107975108(ATF6B)
PPS: 100993334(ATF6B)
GGO: 101146740(ATF6B)
PON: 100172895(ATF6B)
NLE: 100598020(ATF6B)
MCC: 717050(ATF6B)
MCF: 102129446(ATF6B)
CSAB: 103221718(ATF6B)
RRO: 104674035(ATF6B)
RBB: 108519898(ATF6B)
CJC: 100411862(ATF6B)
SBQ: 101047355(ATF6B)
MMU: 12915(Atf6b)
MCAL: 110312537(Atf6b)
MPAH: 110335526(Atf6b)
RNO: 406169(Atf6b)
MUN: 110565383(Atf6b)
CGE: 100767112(Atf6b)
NGI: 103724413(Atf6b)
HGL: 101715793(Atf6b)
CCAN: 109699672(Atf6b)
OCU: 100357489(ATF6B)
TUP: 102484080(ATF6B)
CFA: 474855(ATF6B)
VVP: 112913633(ATF6B)
AML: 100476017(ATF6B)
UMR: 103682282(ATF6B)
UAH: 113243741(ATF6B)
ORO: 101381436(ATF6B)
ELK: 111152366
FCA: 101094849(ATF6B)
PTG: 102965640(ATF6B)
PPAD: 109260558(ATF6B)
AJU: 106983500(ATF6B)
BTA: 513928(ATF6B)
BOM: 102288212(ATF6B)
BIU: 109576848(ATF6B)
BBUB: 102392963(ATF6B)
CHX: 102171671(ATF6B)
OAS: 101113631(ATF6B)
SSC: 100144516(ATF6B)
CFR: 102521467(ATF6B)
CDK: 105090854(ATF6B)
BACU: 103014625(ATF6B)
LVE: 103069101(ATF6B)
OOR: 101273605(ATF6B)
DLE: 111170946(ATF6B)
PCAD: 102978131(ATF6B)
ECB: 100059348(ATF6B)
EPZ: 103563297(ATF6B)
EAI: 106831009(ATF6B)
MYB: 102261840(ATF6B)
MYD: 102767346(ATF6B)
MNA: 107539006(ATF6B)
HAI: 109373089(ATF6B)
DRO: 112302085(ATF6B)
PALE: 102898128(ATF6B)
RAY: 107498439(ATF6B)
MJV: 108393793(ATF6B)
LAV: 100666885(ATF6B)
TMU: 101359783
MDO: 100025603(ATF6B)
SHR: 100932966(ATF6B)
PCW: 110199423(ATF6B)
OAA: 100080771(ATF6B)
PHI: 102113904(ATF6B)
ASN: 102383000(ATF6B)
AMJ: 102575911(ATF6B)
CPIC: 101948982(ATF6B)
ACS: 100557347(atf6b)
PVT: 110070069(ATF6B)
PBI: 103058912(ATF6B)
PMUR: 107298366
TSR: 106546721(ATF6B)
PMUA: 114592080(ATF6B)
GJA: 107118458(ATF6B)
XLA: 108698555(atf6b.L) 108700226(atf6b.S)
XTR: 100488855(atf6b)
NPR: 108786537(ATF6B)
DRE: 777612(atf6b)
CCAR: 109111390
IPU: 108274800(atf6b)
AMEX: 103031559
EEE: 113583832(atf6b)
TRU: 101073153
LCO: 104930576(atf6b)
MZE: 101468193(atf6b)
ONL: 100705378
XMA: 102225633(atf6b)
XCO: 114156358(atf6b)
PRET: 103472821(atf6b)
CVG: 107104477(atf6b)
NFU: 107394433(atf6b)
KMR: 108246380
ALIM: 106528703(atf6b)
AOCE: 111568555(atf6b)
CSEM: 103393796(atf6b)
POV: 109645876(atf6b)
LCF: 108891249(atf6b)
SDU: 111230666(atf6b)
SLAL: 111665658(atf6b)
HCQ: 109515145(atf6b)
BPEC: 110160837(atf6b)
MALB: 109952481(atf6b)
SASA: 106569944(ATF6) 106588375(ATF6)
ELS: 105028060
SFM: 108935684(atf6b)
PKI: 111842807(atf6b)
LCM: 102345323(ATF6B)
RTP: 109913847
BFO: 118420980
CIN: 778962
SPU: 589006
APLC: 110976451
PCAN: 112575671
MYI: 110464394
AMIL: 114954997
 » show all
Reference
PMID:8586413
  Authors
Min J, Shukla H, Kozono H, Bronson SK, Weissman SM, Chaplin DD
  Title
A novel Creb family gene telomeric of HLA-DRA in the HLA complex.
  Journal
Genomics 30:149-56 (1995)
DOI:10.1006/geno.1995.9891
  Sequence
[hsa:1388]
Reference
  Authors
Thuerauf DJ, Morrison L, Glembotski CC
  Title
Opposing roles for ATF6alpha and ATF6beta in endoplasmic reticulum stress response gene induction.
  Journal
J Biol Chem 279:21078-84 (2004)
DOI:10.1074/jbc.M400713200
  Sequence
[hsa:1388]
LinkDB

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