KEGG   ORTHOLOGY: K09101
Entry
K09101                      KO                                     

Name
NCOA1, SRC1, KAT13A
Definition
nuclear receptor coactivator 1 [EC:2.3.1.48]
Pathway
ko04915  Estrogen signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05200  Pathways in cancer
ko05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
   04919 Thyroid hormone signaling pathway
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
  09162 Cancer: specific types
   05224 Breast cancer
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.48  histone acetyltransferase
     K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    K09101  NCOA1, SRC1, KAT13A; nuclear receptor coactivator 1
Other DBs
GO: 0004402
Genes
HSA: 8648(NCOA1)
PTR: 459068(NCOA1)
PPS: 100995476(NCOA1)
GGO: 101143172(NCOA1)
PON: 100432710(NCOA1)
NLE: 100586410(NCOA1)
MCC: 718524(NCOA1)
MCF: 101925525(NCOA1)
CSAB: 103220667(NCOA1)
RRO: 104658456(NCOA1)
RBB: 108543020(NCOA1)
CJC: 100385756(NCOA1)
SBQ: 101039086(NCOA1)
MMU: 17977(Ncoa1)
MCAL: 110306510(Ncoa1)
MPAH: 110323985(Ncoa1)
RNO: 313929(Ncoa1)
MUN: 110555190(Ncoa1)
CGE: 100755152(Ncoa1)
NGI: 103746491(Ncoa1)
HGL: 101726578(Ncoa1)
CCAN: 109685685
OCU: 100341249(NCOA1)
TUP: 102476171(NCOA1)
CFA: 475684(NCOA1)
VVP: 112908518(NCOA1)
AML: 100471908(NCOA1)
UMR: 103671686(NCOA1)
UAH: 113270535(NCOA1)
ORO: 101369582(NCOA1)
ELK: 111154077
FCA: 101094588(NCOA1)
PTG: 102950417(NCOA1)
PPAD: 109267562(NCOA1)
AJU: 106989110(NCOA1)
BTA: 525346(NCOA1)
BOM: 102281335(NCOA1)
BIU: 109566334(NCOA1)
BBUB: 102406567(NCOA1)
CHX: 102169302(NCOA1)
OAS: 101107264(NCOA1)
SSC: 574068(NCOA1)
CFR: 102511907(NCOA1)
CDK: 105100028(NCOA1)
BACU: 103020002(NCOA1)
LVE: 103074990(NCOA1)
OOR: 101282808(NCOA1)
DLE: 111175004(NCOA1)
PCAD: 102994447(NCOA1)
ECB: 100056042(NCOA1)
EPZ: 103547826(NCOA1)
EAI: 106841182(NCOA1)
MYB: 102243087(NCOA1)
MYD: 102756974(NCOA1)
MNA: 107534051(NCOA1)
HAI: 109385708(NCOA1)
DRO: 112297749(NCOA1)
PALE: 102885576(NCOA1)
RAY: 107498504(NCOA1)
MJV: 108397348(NCOA1)
LAV: 100673959(NCOA1)
TMU: 101348769
MDO: 100025270(NCOA1)
SHR: 100924872(NCOA1)
PCW: 110206526(NCOA1)
OAA: 100086436(NCOA1)
GGA: 422016(NCOA1)
MGP: 100538778(NCOA1)
CJO: 107312353(NCOA1)
NMEL: 110395346(NCOA1)
APLA: 101791473(NCOA1)
ACYG: 106038102(NCOA1)
LSR: 110477405(NCOA1)
SCAN: 103824777(NCOA1)
FAB: 101807313
PHI: 102111489(NCOA1)
ETL: 114072359
FPG: 101918284(NCOA1)
FCH: 102057591(NCOA1)
CLV: 102092063(NCOA1)
EGZ: 104127265
NNI: 104014708(NCOA1)
ACUN: 113478859(NCOA1)
PADL: 103913284(NCOA1)
AAM: 106488019(NCOA1)
ASN: 102375151(NCOA1)
AMJ: 102570822(NCOA1)
PSS: 102458351(NCOA1)
CMY: 102943217(NCOA1)
CPIC: 101941430(NCOA1)
ACS: 100556605(ncoa1)
PVT: 110089950(NCOA1)
PBI: 103054110(NCOA1)
PMUR: 107284860(NCOA1)
TSR: 106553109
PMUA: 114594932(NCOA1)
GJA: 107105849(NCOA1)
XLA: 108717249(ncoa1.L) 108718303(ncoa1.S)
XTR: 100127189(ncoa1)
NPR: 108795541(NCOA1)
DRE: 563288(ncoa1)
SANH: 107675037 107689458(ncoa1)
SGH: 107553471(ncoa1) 107558925
CCAR: 109080239
IPU: 108257093(ncoa1)
PHYP: 113529205(ncoa1)
AMEX: 103042471(ncoa1)
EEE: 113583167(ncoa1)
LCO: 104930087(ncoa1)
MZE: 101474484(ncoa1)
ONL: 100700776(ncoa1)
OLA: 101163052(ncoa1)
XMA: 102232836(ncoa1)
XCO: 114159063(fam184a)
PRET: 103457314(ncoa1)
CVG: 107083511(ncoa1)
NFU: 107377739(ncoa1)
KMR: 108244879(ncoa1)
ALIM: 106534579(ncoa1)
AOCE: 111565463(ncoa1)
CSEM: 103381159
POV: 109644845(ncoa1)
LCF: 108885261(ncoa1)
SDU: 111236426(ncoa1)
SLAL: 111672490(ncoa1)
HCQ: 109523538(ncoa1)
BPEC: 110154328
MALB: 109968845(ncoa1)
ELS: 105017790(ncoa1)
SFM: 108925185(ncoa1)
PKI: 111854025(ncoa1)
LCM: 102354127(NCOA1)
RTP: 109923709
 » show all
Reference
PMID:9427757
  Authors
Kalkhoven E, Valentine JE, Heery DM, Parker MG
  Title
Isoforms of steroid receptor co-activator 1 differ in their ability to potentiate transcription by the oestrogen receptor.
  Journal
EMBO J 17:232-43 (1998)
DOI:10.1093/emboj/17.1.232
  Sequence
[hsa:8648]
Reference
  Authors
Liu Z, Wong J, Tsai SY, Tsai MJ, O'Malley BW
  Title
Steroid receptor coactivator-1 (SRC-1) enhances ligand-dependent and receptor-dependent cell-free transcription of chromatin.
  Journal
Proc Natl Acad Sci U S A 96:9485-90 (1999)
DOI:10.1073/pnas.96.17.9485
Reference
  Authors
Litterst CM, Kliem S, Marilley D, Pfitzner E
  Title
NCoA-1/SRC-1 is an essential coactivator of STAT5 that binds to the FDL motif in the alpha-helical region of the STAT5 transactivation domain.
  Journal
J Biol Chem 278:45340-51 (2003)
DOI:10.1074/jbc.M303644200
LinkDB

KEGG   ORTHOLOGY: K11255
Entry
K11255                      KO                                     

Name
NCOA2, TIF2, KAT13C
Definition
nuclear receptor coactivator 2
Pathway
ko04915  Estrogen signaling pathway
ko04919  Thyroid hormone signaling pathway
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
   04919 Thyroid hormone signaling pathway
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    K11255  NCOA2, TIF2, KAT13C; nuclear receptor coactivator 2
Genes
HSA: 10499(NCOA2)
PTR: 464226(NCOA2)
PPS: 100976890(NCOA2)
GGO: 101143868(NCOA2)
PON: 100458310(NCOA2)
NLE: 100594525(NCOA2)
MCC: 693455(NCOA2)
MCF: 102130545(NCOA2)
CSAB: 103236947(NCOA2)
RRO: 104678873(NCOA2)
RBB: 108530079(NCOA2)
CJC: 100409563(NCOA2)
SBQ: 101031553(NCOA2)
MMU: 17978(Ncoa2)
MCAL: 110300251(Ncoa2)
MPAH: 110338922(Ncoa2)
RNO: 83724(Ncoa2)
MUN: 110559511(Ncoa2)
CGE: 100762955(Ncoa2)
NGI: 103746603(Ncoa2)
HGL: 101700727(Ncoa2)
CCAN: 109689156 109689158(Ncoa2)
OCU: 100348055(NCOA2)
TUP: 102479299(NCOA2)
CFA: 486989(NCOA2)
VVP: 112930085(NCOA2)
AML: 100468579(NCOA2)
UMR: 103681277(NCOA2)
UAH: 113253067(NCOA2)
ORO: 101368651(NCOA2)
ELK: 111156771
FCA: 101094648(NCOA2)
PTG: 102954553(NCOA2)
PPAD: 109269324(NCOA2)
AJU: 106968350 113600767(NCOA2)
BTA: 508162(NCOA2)
BOM: 102267236(NCOA2)
BIU: 109568437(NCOA2)
BBUB: 102389410(NCOA2)
CHX: 102176142(NCOA2)
OAS: 101104249(NCOA2)
SSC: 100135658(NCOA2)
CFR: 102514348(NCOA2)
CDK: 105103892(NCOA2)
BACU: 103011177(NCOA2)
LVE: 103086311(NCOA2)
OOR: 101273803(NCOA2)
DLE: 111185570(NCOA2)
PCAD: 102976427(NCOA2)
ECB: 100051656(NCOA2)
EPZ: 103547393(NCOA2)
EAI: 106844927(NCOA2)
MYB: 102263306(NCOA2)
MYD: 102770108(NCOA2)
MNA: 107539520(NCOA2)
HAI: 109372624(NCOA2)
DRO: 112315347(NCOA2)
PALE: 102892305(NCOA2)
RAY: 107514828(NCOA2)
MJV: 108386902(NCOA2)
LAV: 100677439(NCOA2)
TMU: 101341463
MDO: 100028678(NCOA2)
SHR: 100933368(NCOA2)
PCW: 110219067(NCOA2)
OAA: 100089041(NCOA2)
GGA: 420176(NCOA2)
MGP: 100544860(NCOA2)
CJO: 107310240(NCOA2)
NMEL: 110393111(NCOA2)
APLA: 101792456(NCOA2)
ACYG: 106030606(NCOA2)
TGU: 100220180(NCOA2)
LSR: 110477537(NCOA2)
SCAN: 103812767(NCOA2)
GFR: 102035459(NCOA2)
FAB: 101816739(NCOA2)
PHI: 102111859(NCOA2)
PMAJ: 107200090(NCOA2)
CCAE: 111924660(NCOA2)
CCW: 104692824(NCOA2)
ETL: 114062523(NCOA2)
FPG: 101912290(NCOA2)
FCH: 102053022(NCOA2)
CLV: 102090460(NCOA2)
EGZ: 104122387(NCOA2)
NNI: 104009666(NCOA2)
ACUN: 113476238(NCOA2)
PADL: 103926197(NCOA2)
AAM: 106484633(NCOA2)
ASN: 102387638(NCOA2)
AMJ: 106737113(NCOA2)
PSS: 102456412(NCOA2)
CMY: 102937245(NCOA2)
CPIC: 101951032(NCOA2)
ACS: 100567715(ncoa2)
PVT: 110089449(NCOA2)
PBI: 103059976(NCOA2)
PMUR: 107290247(NCOA2)
TSR: 106543691(NCOA2)
PMUA: 114601316(NCOA2)
GJA: 107121057(NCOA2)
XLA: 100301960(ncoa2.L) 394405(ncoa2.S)
XTR: 100216190(ncoa2)
NPR: 108796964(NCOA2)
DRE: 81884(ncoa2)
IPU: 108256456(ncoa2)
PHYP: 113541135(ncoa2)
AMEX: 103038623(ncoa2)
EEE: 113586081
TRU: 101064944 101075599(ncoa2)
LCO: 104921439(ncoa2) 104932643
NCC: 104959314(ncoa2)
MZE: 101464197(ncoa2) 101483328
ONL: 100698057 100706110(ncoa2)
OLA: 101169987(ncoa2) 101175434
XMA: 102226120 102236393(ncoa2)
XCO: 114136787(ncoa2) 114146583
PRET: 103456662(ncoa2) 103479938
CVG: 107093225(ncoa2) 107093636
NFU: 107382908(ncoa2) 107383425
KMR: 108230418(ncoa2) 108243856
ALIM: 106530250(ncoa2) 106535094
AOCE: 111563871 111587689(ncoa2)
CSEM: 103377091(ncoa2)
LCF: 108880950 108881805(ncoa2)
SDU: 111220956(ncoa2) 111233890
SLAL: 111662894(ncoa2) 111669755
HCQ: 109513675(ncoa2) 109518905
BPEC: 110155739 110160934(ncoa2)
MALB: 109960120(ncoa2) 109967098
ELS: 105018361(ncoa2) 105019647
SFM: 108935411(ncoa2)
PKI: 111834873(ncoa2)
LCM: 102350063 102367030(NCOA2)
CMK: 103174523(ncoa2)
RTP: 109919934(ncoa2)
BFO: 118403997
SPU: 576243
APLC: 110985072
SKO: 100373546
AME: 410637
BIM: 100747735
BTER: 100648067
CCAL: 108628886
OBB: 114871438
SOC: 105197264
MPHA: 105841162
AEC: 105154207
ACEP: 105622807
PBAR: 105433511
VEM: 105562067
HST: 105186478
DQU: 106743841
CFO: 105254664
LHU: 105674502
PGC: 109851789
OBO: 105285307
PCF: 106787623
NVI: 100680400
CSOL: 105359905
MDL: 103576844
TCA: 656017(TcSRC)
DPA: 109543867
ATD: 109598477
NVL: 108564162
BMOR: 101741527(SRC)
BMAN: 114247799
PMAC: 106710701
PRAP: 110997282
HAW: 110371968
API: 100161757
DNX: 107165204
AGS: 114122699
RMD: 113555645
BTAB: 109038851
CLEC: 106666969
ZNE: 110834389
CSCU: 111620008
TSP: Tsp_03769
PCAN: 112561375
CRG: 105320588
MYI: 110455764
OBI: 106869828
LAK: 106163668
 » show all
Reference
PMID:9430642
  Authors
Voegel JJ, Heine MJ, Tini M, Vivat V, Chambon P, Gronemeyer H
  Title
The coactivator TIF2 contains three nuclear receptor-binding motifs and mediates transactivation through CBP binding-dependent and -independent pathways.
  Journal
EMBO J 17:507-19 (1998)
DOI:10.1093/emboj/17.2.507
  Sequence
[hsa:10499]
Reference
  Authors
Zhuravleva J, Solary E, Chluba J, Bastie JN, Delva L
  Title
A role for the transcription intermediary factor 2 in zebrafish myelopoiesis.
  Journal
Exp Hematol 36:559-67 (2008)
DOI:10.1016/j.exphem.2007.12.014
  Sequence
[dre:81884]
LinkDB

KEGG   ORTHOLOGY: K11256
Entry
K11256                      KO                                     

Name
NCOA3, ACTR, KAT13B
Definition
nuclear receptor coactivator 3 [EC:2.3.1.48]
Pathway
ko01522  Endocrine resistance
ko04915  Estrogen signaling pathway
ko04919  Thyroid hormone signaling pathway
ko05200  Pathways in cancer
ko05224  Breast cancer
Brite
KEGG Orthology (KO) [BR:ko00001]
 09150 Organismal Systems
  09152 Endocrine system
   04915 Estrogen signaling pathway
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
   04919 Thyroid hormone signaling pathway
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
  09162 Cancer: specific types
   05224 Breast cancer
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
  09176 Drug resistance: antineoplastic
   01522 Endocrine resistance
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03036 Chromosome and associated proteins
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.1  Transferring groups other than aminoacyl groups
    2.3.1.48  histone acetyltransferase
     K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Histone modification proteins
   HATs (histone acetyltransferases)
    K11256  NCOA3, ACTR, KAT13B; nuclear receptor coactivator 3
Other DBs
GO: 0004402
Genes
HSA: 8202(NCOA3)
PTR: 458308(NCOA3)
PPS: 100982357(NCOA3)
GGO: 101136145(NCOA3)
PON: 100432859(NCOA3)
NLE: 100587426(NCOA3)
MCC: 705431(NCOA3)
MCF: 102145890(NCOA3)
CSAB: 103244688(NCOA3)
RRO: 104678795(NCOA3)
RBB: 108533304(NCOA3)
CJC: 100392051(NCOA3)
SBQ: 101032962(NCOA3)
MMU: 17979(Ncoa3)
MCAL: 110311955(Ncoa3)
MPAH: 110318560(Ncoa3)
RNO: 84584(Ncoa3)
MUN: 110549109(Ncoa3)
CGE: 100774568(Ncoa3)
NGI: 103729385(Ncoa3)
HGL: 101708253(Ncoa3)
CCAN: 109697081(Ncoa3)
OCU: 100356750(NCOA3)
TUP: 102496469(NCOA3)
VVP: 112931868(NCOA3)
AML: 100482382(NCOA3)
UMR: 103669689(NCOA3)
UAH: 113258689(NCOA3)
ORO: 101363340(NCOA3)
ELK: 111141850
FCA: 101083330(NCOA3)
PTG: 102961259(NCOA3)
PPAD: 109272315(NCOA3)
AJU: 106968987(NCOA3)
BTA: 523707(NCOA3)
BOM: 102279527(NCOA3)
BIU: 109567523(NCOA3)
BBUB: 102407392(NCOA3)
CHX: 102187330(NCOA3)
OAS: 101119237(NCOA3)
SSC: 100135659(NCOA3)
CFR: 102516884(NCOA3)
CDK: 105087857(NCOA3)
BACU: 103008665(NCOA3)
LVE: 103079443(NCOA3)
OOR: 101284169(NCOA3)
DLE: 111170158(NCOA3)
PCAD: 102985044(NCOA3)
ECB: 100071296(NCOA3)
EPZ: 103557987(NCOA3)
EAI: 106847617(NCOA3)
MYB: 102243034(NCOA3)
MYD: 102760868(NCOA3)
MNA: 107530884(NCOA3)
HAI: 109379939(NCOA3)
DRO: 112304222(NCOA3)
PALE: 102892705(NCOA3)
RAY: 107498277(NCOA3)
MJV: 108404060(NCOA3)
LAV: 100668174(NCOA3)
TMU: 101346625
MDO: 100029605(NCOA3)
SHR: 100923646(NCOA3)
PCW: 110206622(NCOA3)
OAA: 100074963(NCOA3)
GGA: 419208(NCOA3)
MGP: 100541071(NCOA3)
CJO: 107322953(NCOA3)
NMEL: 110408449(NCOA3)
APLA: 101802033(NCOA3)
ACYG: 106041263(NCOA3)
TGU: 100224552(NCOA3)
LSR: 110475243(NCOA3)
SCAN: 103818906(NCOA3)
GFR: 102032891(NCOA3)
FAB: 101821822(NCOA3)
PHI: 102112683(NCOA3)
PMAJ: 107213234(NCOA3)
CCAE: 111938404(NCOA3)
CCW: 104687576(NCOA3)
ETL: 114068575(NCOA3)
FPG: 101921737(NCOA3)
FCH: 102048487(NCOA3)
CLV: 102086104(NCOA3)
EGZ: 104131403(NCOA3)
NNI: 104019984(NCOA3)
ACUN: 113487399(NCOA3)
PADL: 103919257(NCOA3)
AAM: 106500136(NCOA3)
ASN: 102380608(NCOA3)
AMJ: 102575932(NCOA3)
PSS: 102463338(NCOA3)
CMY: 102947226(NCOA3)
CPIC: 101952354(NCOA3)
ACS: 100564123(ncoa3)
PVT: 110071787(NCOA3)
PBI: 103052159(NCOA3)
PMUR: 107290352(NCOA3)
TSR: 106541318(NCOA3)
PMUA: 114599608(NCOA3)
GJA: 107106974(NCOA3)
XLA: 108701773 398021(ncoa3.S)
XTR: 733554(ncoa3)
NPR: 108797447(NCOA3)
DRE: 564519(ncoa3)
EEE: 113567828 113586422(ncoa3)
MZE: 101476023 101481031(ncoa3)
OLA: 101156489 101161556(ncoa3)
ALIM: 106519035 106524080(ncoa3)
CSEM: 103385441(ncoa3) 103386331
POV: 109628986(ncoa3)
SDU: 111217273(ncoa3) 111221932
HCQ: 109521541 109528539(ncoa3)
BPEC: 110164909(ncoa3) 110170271
ELS: 105014003(ncoa3) 105017345
PKI: 111835931 111857345(ncoa3)
LCM: 102352470(NCOA3)
CMK: 103186268(ncoa3)
RTP: 109927930
 » show all
Reference
  Authors
Wu Z, Yang M, Liu H, Guo H, Wang Y, Cheng H, Chen L
  Title
Role of nuclear receptor coactivator 3 (ncoa3) in pluripotency maintenance.
  Journal
J Biol Chem 287:38295-304 (2012)
DOI:10.1074/jbc.M112.373092
Reference
PMID:9267036
  Authors
Chen H, Lin RJ, Schiltz RL, Chakravarti D, Nash A, Nagy L, Privalsky ML, Nakatani Y, Evans RM
  Title
Nuclear receptor coactivator ACTR is a novel histone acetyltransferase and forms a multimeric activation complex with P/CAF and CBP/p300.
  Journal
Cell 90:569-80 (1997)
DOI:10.1016/S0092-8674(00)80516-4
  Sequence
[hsa:8202]
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