KEGG   ORTHOLOGY: K10140
Entry
K10140                      KO                                     

Name
DDB2
Definition
DNA damage-binding protein 2
Pathway
map03420  Nucleotide excision repair
map04115  p53 signaling pathway
map04120  Ubiquitin mediated proteolysis
map05161  Hepatitis B
map05169  Epstein-Barr virus infection
map05200  Pathways in cancer
map05202  Transcriptional misregulation in cancer
map05210  Colorectal cancer
map05212  Pancreatic cancer
map05213  Endometrial cancer
map05214  Glioma
map05216  Thyroid cancer
map05217  Basal cell carcinoma
map05218  Melanoma
map05220  Chronic myeloid leukemia
map05222  Small cell lung cancer
map05223  Non-small cell lung cancer
map05224  Breast cancer
map05225  Hepatocellular carcinoma
map05226  Gastric cancer
Disease
H00403  Disorders of nucleotide excision repair
H01428  Xeroderma pigmentosum
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10140  DDB2; DNA damage-binding protein 2
  09124 Replication and repair
   03420 Nucleotide excision repair
    K10140  DDB2; DNA damage-binding protein 2
 09140 Cellular Processes
  09143 Cell growth and death
   04115 p53 signaling pathway
    K10140  DDB2; DNA damage-binding protein 2
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K10140  DDB2; DNA damage-binding protein 2
   05202 Transcriptional misregulation in cancer
    K10140  DDB2; DNA damage-binding protein 2
  09162 Cancer: specific types
   05210 Colorectal cancer
    K10140  DDB2; DNA damage-binding protein 2
   05212 Pancreatic cancer
    K10140  DDB2; DNA damage-binding protein 2
   05225 Hepatocellular carcinoma
    K10140  DDB2; DNA damage-binding protein 2
   05226 Gastric cancer
    K10140  DDB2; DNA damage-binding protein 2
   05214 Glioma
    K10140  DDB2; DNA damage-binding protein 2
   05216 Thyroid cancer
    K10140  DDB2; DNA damage-binding protein 2
   05220 Chronic myeloid leukemia
    K10140  DDB2; DNA damage-binding protein 2
   05217 Basal cell carcinoma
    K10140  DDB2; DNA damage-binding protein 2
   05218 Melanoma
    K10140  DDB2; DNA damage-binding protein 2
   05213 Endometrial cancer
    K10140  DDB2; DNA damage-binding protein 2
   05224 Breast cancer
    K10140  DDB2; DNA damage-binding protein 2
   05222 Small cell lung cancer
    K10140  DDB2; DNA damage-binding protein 2
   05223 Non-small cell lung cancer
    K10140  DDB2; DNA damage-binding protein 2
  09172 Infectious disease: viral
   05161 Hepatitis B
    K10140  DDB2; DNA damage-binding protein 2
   05169 Epstein-Barr virus infection
    K10140  DDB2; DNA damage-binding protein 2
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10140  DDB2; DNA damage-binding protein 2
   03400 DNA repair and recombination proteins
    K10140  DDB2; DNA damage-binding protein 2
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Multi subunit Ring-finger type E3
   Cul4 complex
    Target recognizing subunit (DCAF)
     K10140  DDB2; DNA damage-binding protein 2
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  SSBR (single strand breaks repair)
   NER (nucleotide excision repair)
    GGR (global genome repair) factors
     Cul4-DDB2 complex
      K10140  DDB2; DNA damage-binding protein 2
Genes
HSA: 1643(DDB2)
PTR: 451165(DDB2)
PPS: 100972583(DDB2)
GGO: 101128036(DDB2)
PON: 100454099(DDB2)
NLE: 100605065(DDB2)
MCC: 114672263 713813(DDB2)
MCF: 102124623(DDB2)
CSAB: 103236219(DDB2)
CATY: 105592813(DDB2)
PANU: 100998564(DDB2)
RRO: 104668405(DDB2)
RBB: 108521962(DDB2)
TFN: 117080146(DDB2)
PTEH: 111544893(DDB2)
CJC: 100390419(DDB2)
SBQ: 101027903(DDB2)
MMUR: 105884857(DDB2)
MMU: 107986(Ddb2)
MCAL: 110290093(Ddb2)
MPAH: 110319597(Ddb2)
RNO: 100362121(Ddb2)
MCOC: 116090466(Ddb2)
MUN: 110550733(Ddb2)
CGE: 100756705(Ddb2)
PLEU: 114699687(Ddb2)
NGI: 103742505(Ddb2)
HGL: 101715591(Ddb2)
CCAN: 109696190(Ddb2)
OCU: 100352386(DDB2)
TUP: 102472614(DDB2)
CFA: 483626(DDB2)
VVP: 112924073(DDB2)
VLG: 121472218(DDB2)
AML: 100479738(DDB2)
UMR: 103672315(DDB2)
UAH: 113264969(DDB2)
ORO: 101378738(DDB2)
ELK: 111150113
MPUF: 101691261(DDB2)
EJU: 114215282(DDB2)
MLX: 118015830(DDB2)
FCA: 101092211(DDB2)
PTG: 102961097(DDB2)
PPAD: 109245111(DDB2)
AJU: 106978021(DDB2)
HHV: 120228475(DDB2)
BTA: 519357(DDB2)
BOM: 102272760(DDB2)
BIU: 109569541(DDB2)
BBUB: 102390671(DDB2)
CHX: 102171356(DDB2)
OAS: 101116344(DDB2)
ODA: 120876950(DDB2)
SSC: 100513197(DDB2)
CFR: 102523860(DDB2)
CDK: 105106872(DDB2)
BACU: 103017537(DDB2)
LVE: 103079116(DDB2)
OOR: 101270094(DDB2)
DLE: 111183968(DDB2)
PCAD: 102974256(DDB2)
ECB: 100051180(DDB2)
EPZ: 103566732(DDB2)
EAI: 106844006(DDB2)
MYB: 102256502(DDB2)
MYD: 102756511(DDB2)
MMYO: 118665064(DDB2)
MNA: 107530310(DDB2)
HAI: 109390202(DDB2)
DRO: 112303349(DDB2)
SHON: 118974481(DDB2)
AJM: 119064434(DDB2)
MMF: 118627554(DDB2)
PALE: 102879479(DDB2)
RAY: 107511851(DDB2)
MJV: 108388647(DDB2)
TOD: 119255301(DDB2)
LAV: 100665802(DDB2)
TMU: 101349998
MDO: 100016157(DDB2) 100021792
SHR: 100916232(DDB2)
PCW: 110223919(DDB2)
OAA: 100088212(DDB2)
GGA: 423185(DDB2)
PCOC: 116229153(DDB2)
MGP: 100548596(DDB2)
CJO: 107314743(DDB2)
NMEL: 110400968(DDB2)
APLA: 101791096(DDB2)
ACYG: 106043656(DDB2)
TGU: 100221888(DDB2)
LSR: 110472060(DDB2)
SCAN: 103826693(DDB2)
PMOA: 120500408(DDB2)
GFR: 102035276(DDB2)
FAB: 101813959(DDB2)
PHI: 102113625(DDB2)
PMAJ: 107205447(DDB2)
CCAE: 111930172(DDB2)
CCW: 104697960(DDB2)
ETL: 114058833(DDB2)
FPG: 101911160(DDB2)
FCH: 102048021(DDB2)
CLV: 102087151(DDB2)
EGZ: 104134072(DDB2)
NNI: 104020384(DDB2)
ACUN: 113480499(DDB2)
PADL: 103921706(DDB2)
AAM: 106498364(DDB2)
ASN: 102374438(DDB2)
AMJ: 102570152(DDB2)
CPOO: 109320949(DDB2)
GGN: 109298895(DDB2)
PSS: 102461762(DDB2)
CMY: 102941615(DDB2)
CPIC: 101941863(DDB2)
TST: 117876923(DDB2)
CABI: 116825871(DDB2)
ACS: 100554400(ddb2)
PVT: 110081991(DDB2)
PBI: 103059573(DDB2)
PMUR: 107289836(DDB2)
TSR: 106552427(DDB2)
PGUT: 117665529(DDB2)
PMUA: 114595784(DDB2)
ZVI: 118084855(DDB2)
GJA: 107123208(DDB2)
XLA: 108713786(ddb2.L) 108715228(ddb2.S)
XTR: 493565(ddb2)
NPR: 108791609(DDB2)
DRE: 100004133(ddb2)
SANH: 107686311(ddb2)
CAUA: 113118377(ddb2)
AMEX: 103036503(ddb2)
EEE: 113585066(ddb2)
TRU: 101074409(ddb2)
LCO: 104922334(ddb2)
NCC: 104945738(ddb2)
ELY: 117262827(ddb2)
PLEP: 121950322(ddb2)
SLUC: 116038653(ddb2)
ECRA: 117948999(ddb2)
PFLV: 114560042(ddb2)
GAT: 120809393(ddb2)
MSAM: 119893989(ddb2)
CUD: 121515051(ddb2)
MZE: 101480006(ddb2)
ONL: 100709229(ddb2)
OAU: 116326282(ddb2)
OLA: 101159499(ddb2)
OML: 112151711(ddb2)
XMA: 102226772(ddb2)
XCO: 114134296(ddb2)
XHE: 116737520(ddb2)
PRET: 103466527(ddb2)
CVG: 107097841(ddb2)
CTUL: 119780374(ddb2)
NFU: 107388695(ddb2)
KMR: 108230198(ddb2)
ALIM: 106534715(ddb2)
AOCE: 111582143(ddb2)
CSEM: 103380265(ddb2)
POV: 109624175(ddb2)
LCF: 108886614(ddb2)
SDU: 111228602(ddb2)
SLAL: 111666992(ddb2)
XGL: 120793553(ddb2)
HCQ: 109519449(ddb2)
BPEC: 110160813(ddb2)
MALB: 109971222(ddb2)
SASA: 106584815(ddb2)
OMY: 110515488(ddb2)
SALP: 112077473(ddb2)
ELS: 105029687(ddb2)
SFM: 108941276(ddb2)
PKI: 111858235(ddb2)
LOC: 102693465(ddb2)
PSPA: 121294299(ddb2)
ARUT: 117432036(ddb2)
BFO: 118430317
APLC: 110979161
BTAB: 109038745
CLEC: 106666549
CSEC: 111871881
FCD: 110853733
PVM: 113813693
EAF: 111709825
RSAN: 119389520
TUT: 107359138
SDM: 118197059
BGT: 106057429
CRG: 105347658
MYI: 110458911
LAK: 106171869
AQU: 105313700
ATH: AT5G58760(DDB2)
ALY: 9300664
CRB: 17877047
BRP: 103851625
BOE: 106322698
THJ: 104814912
CPAP: 110810054
CIT: 102616830
PVY: 116129594
TCC: 18590503
GRA: 105782070
GAB: 108484537
DZI: 111301325
EGR: 104432651
VRA: 106763140
VAR: 108343861
VUN: 114193119
CCAJ: 109795279
APRC: 113848401
CAM: 101499945
LJA: Lj2g3v2256250.1(Lj2g3v2256250.1) Lj2g3v2256250.2(Lj2g3v2256250.2)
ADU: 107458384
AIP: 107609534
LANG: 109355773
FVE: 101313874
RCN: 112201571
PPER: 18774206
PMUM: 103320795
PAVI: 110758733
PDUL: 117631472
MDM: 103447396
ZJU: 107410820
MNT: 21404847
CSV: 101212319
CMO: 103502024
BHJ: 120089338
MCHA: 111017106
CMAX: 111484454
CMOS: 111449106
CPEP: 111776752
RCU: 8286445
JCU: 105630445
HBR: 110666371
MESC: 110603390
POP: 7478534
PEU: 105111761
PALZ: 118032990
QSU: 112006141
QLO: 115989542
TWL: 119990492
VVI: 100250121
VRI: 117916075
SLY: 101265575
SPEN: 107029211
SOT: 102582170
CANN: 107842722
NSY: 104244550
NTO: 104111780
NAU: 109231397
INI: 109163509
ITR: 116017339
SIND: 105165177
OEU: 111390752
EGT: 105959820
HAN: 110868614
LSV: 111912535
CCAV: 112513496
DCR: 108209042
CSIN: 114323960
BVG: 104902748
SOE: 110803053
NNU: 104601256
MING: 122058264
NCOL: 116253846
OSA: 4325482
DOSA: Os01t0141700-01(Os01g0141700)
OBR: 102710627
BDI: 100842647
ATS: 109776954
SBI: 8060824
ZMA: 100381699
SITA: 101761501
PHAI: 112891853
PDA: 103704021
EGU: 105046232
MUS: 103972285
DCT: 110108807
PEQ: 110017980
ATR: 18437948
PPP: 112285391
APRO: F751_3019
 » show all
Reference
  Authors
Kulaksiz G, Reardon JT, Sancar A
  Title
Xeroderma pigmentosum complementation group E protein (XPE/DDB2): purification of various complexes of XPE and analyses of their damaged DNA binding and putative DNA repair properties.
  Journal
Mol Cell Biol 25:9784-92 (2005)
DOI:10.1128/MCB.25.22.9784-9792.2005
  Sequence
[hsa:1643]
Reference
  Authors
Kapetanaki MG, Guerrero-Santoro J, Bisi DC, Hsieh CL, Rapic-Otrin V, Levine AS
  Title
The DDB1-CUL4ADDB2 ubiquitin ligase is deficient in xeroderma pigmentosum group E and targets histone H2A at UV-damaged DNA sites.
  Journal
Proc Natl Acad Sci U S A 103:2588-93 (2006)
DOI:10.1073/pnas.0511160103
  Sequence
[hsa:1643]
Reference
PMID:8530102
  Authors
Dualan R, Brody T, Keeney S, Nichols AF, Admon A, Linn S
  Title
Chromosomal localization and cDNA cloning of the genes (DDB1 and DDB2) for the p127 and p48 subunits of a human damage-specific DNA binding protein.
  Journal
Genomics 29:62-9 (1995)
DOI:10.1006/geno.1995.1215
  Sequence
[hsa:1643]
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