| Entry |
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| Name |
O-phosphoserine sulfhydrylase;
O-phosphoserine(thiol)-lyase
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| Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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| Sysname |
O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
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| Reaction(IUBMB) |
O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate [RN: R07274]
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| Reaction(KEGG) |
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| Substrate |
O-phospho-L-serine [CPD: C01005];
hydrogen sulfide [CPD: C00283]
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| Product |
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| Comment |
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.
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| History |
EC 2.5.1.65 created 2004
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| Pathway |
| ec00270 | Cysteine and methionine metabolism |
| ec01110 | Biosynthesis of secondary metabolites |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K10150 | cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase |
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| Genes |
» show all
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| Reference |
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| Authors |
Mino K, Ishikawa K. |
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| Title |
A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1. |
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| Journal |
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| Reference |
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| Authors |
Mino K, Ishikawa K |
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| Title |
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1. |
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| Journal |
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| Sequence |
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| Reference |
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| Authors |
Mino K, Oda Y, Ataka M, Ishikawa K. |
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| Title |
Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 2.5.1.65 |
| ExPASy - ENZYME nomenclature database: | 2.5.1.65 |
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| LinkDB |
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