Entry |
|
Name |
O-phosphoserine sulfhydrylase;
O-phosphoserine(thiol)-lyase
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Class |
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
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Sysname |
O-phospho-L-serine:hydrogen-sulfide 2-amino-2-carboxyethyltransferase
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Reaction(IUBMB) |
O-phospho-L-serine + hydrogen sulfide = L-cysteine + phosphate [RN: R07274]
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Reaction(KEGG) |
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Substrate |
O-phospho-L-serine [CPD: C01005];
hydrogen sulfide [CPD: C00283]
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Product |
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Comment |
A pyridoxal-phosphate protein. The enzyme from Aeropyrum pernix acts on both O-phospho-L-serine and O3-acetyl-L-serine, in contrast with EC 2.5.1.47, cysteine synthase, which acts only on O3-acetyl-L-serine.
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History |
EC 2.5.1.65 created 2004
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Pathway |
ec00270 | Cysteine and methionine metabolism |
ec01110 | Biosynthesis of secondary metabolites |
ec01120 | Microbial metabolism in diverse environments |
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Orthology |
K10150 | cysteine synthase / O-phosphoserine sulfhydrylase / cystathionine beta-synthase |
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Genes |
» show all
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Reference |
|
Authors |
Mino K, Ishikawa K. |
Title |
A novel O-phospho-L-serine sulfhydrylation reaction catalyzed by O-acetylserine sulfhydrylase from Aeropyrum pernix K1. |
Journal |
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Reference |
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Authors |
Mino K, Ishikawa K |
Title |
Characterization of a novel thermostable O-acetylserine sulfhydrylase from Aeropyrum pernix K1. |
Journal |
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Sequence |
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Reference |
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Authors |
Mino K, Oda Y, Ataka M, Ishikawa K. |
Title |
Crystallization and preliminary X-ray diffraction analysis of O-acetylserine sulfhydrylase from Aeropyrum pernix K1. |
Journal |
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Other DBs |
ExplorEnz - The Enzyme Database: | 2.5.1.65 |
ExPASy - ENZYME nomenclature database: | 2.5.1.65 |
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LinkDB |
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