| Entry |
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| Name |
2-hydroxymuconate-6-semialdehyde hydrolase;
2-hydroxy-6-oxohepta-2,4-dienoate hydrolase;
2-hydroxymuconic semialdehyde hydrolase;
HMSH;
HOD hydrolase;
xylF (gene name);
2-hydroxymuconate-semialdehyde formylhydrolase;
2-hydroxymuconate-semialdehyde hydrolase
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| Class |
Hydrolases;
Acting on carbon-carbon bonds;
In ketonic substances
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| Sysname |
2-hydroxymuconate-6-semialdehyde formylhydrolase
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| Reaction(IUBMB) |
2-hydroxymuconate-6-semialdehyde + H2O = formate + 2-oxopent-4-enoate [RN: R02604]
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| Reaction(KEGG) |
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| Substrate |
2-hydroxymuconate-6-semialdehyde [CPD: C00682];
H2O [CPD: C00001]
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| Product |
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| Comment |
The enzyme is involved in the degradation of catechols.
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| History |
EC 3.7.1.9 created 1990, modified 2013
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| Pathway |
| ec01120 | Microbial metabolism in diverse environments |
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| Orthology |
| K10216 | 2-hydroxymuconate-semialdehyde hydrolase |
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| Genes |
» show all
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| Reference |
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| Authors |
Sala-Trepat JM, Evans WC. |
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| Title |
The meta cleavage of catechol by Azotobacter species. 4-Oxalocrotonate pathway. |
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| Journal |
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| Reference |
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| Authors |
Harayama S, Rekik M, Wasserfallen A, Bairoch A. |
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| Title |
Evolutionary relationships between catabolic pathways for aromatics: conservation of gene order and nucleotide sequences of catechol oxidation genes of pWW0 and NAH7 plasmids. |
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| Journal |
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| Reference |
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| Authors |
Diaz E, Timmis KN |
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| Title |
Identification of functional residues in a 2-hydroxymuconic semialdehyde hydrolase. A new member of the alpha/beta hydrolase-fold family of enzymes which cleaves carbon-carbon bonds. |
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| Journal |
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| Other DBs |
| ExplorEnz - The Enzyme Database: | 3.7.1.9 |
| ExPASy - ENZYME nomenclature database: | 3.7.1.9 |
| UM-BBD (Biocatalysis/Biodegradation Database): | 3.7.1.9 |
| BRENDA, the Enzyme Database: | 3.7.1.9 |
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| LinkDB |
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