KEGG   ORTHOLOGY: K10605Help
Entry
K10605                      KO                                     

Name
BRCA1
Definition
breast cancer type 1 susceptibility protein [EC:2.3.2.27]
Pathway
ko01524  Platinum drug resistance
ko03440  Homologous recombination
ko03460  Fanconi anemia pathway
ko04120  Ubiquitin mediated proteolysis
ko04151  PI3K-Akt signaling pathway
ko05206  MicroRNAs in cancer
ko05224  Breast cancer
Disease
H00027  Ovarian cancer
H00031  Breast cancer
H01554  Fallopian tube cancer
H01665  Primary peritoneal carcinoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09123 Folding, sorting and degradation
   04120 Ubiquitin mediated proteolysis
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09124 Replication and repair
   03440 Homologous recombination
    K10605  BRCA1; breast cancer type 1 susceptibility protein
   03460 Fanconi anemia pathway
    K10605  BRCA1; breast cancer type 1 susceptibility protein
 09130 Environmental Information Processing
  09132 Signal transduction
   04151 PI3K-Akt signaling pathway
    K10605  BRCA1; breast cancer type 1 susceptibility protein
 09160 Human Diseases
  09161 Cancer: overview
   05206 MicroRNAs in cancer
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09162 Cancer: specific types
   05224 Breast cancer
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09176 Drug resistance: antineoplastic
   01524 Platinum drug resistance
    K10605  BRCA1; breast cancer type 1 susceptibility protein
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01009 Protein phosphatases and associated proteins
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10605  BRCA1; breast cancer type 1 susceptibility protein
   03036 Chromosome and associated proteins
    K10605  BRCA1; breast cancer type 1 susceptibility protein
   03400 DNA repair and recombination proteins
    K10605  BRCA1; breast cancer type 1 susceptibility protein
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10605  BRCA1; breast cancer type 1 susceptibility protein
Protein phosphatases and associated proteins [BR:ko01009]
 Protein serine/threonine phosphatases
  Phosphoprotein phosphatases (PPPs)
   Protein phosphatase-1
    PP1-interacting proteins (PIPs)
     K10605  BRCA1; breast cancer type 1 susceptibility protein
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   Other single Ring-finger type E3
    K10605  BRCA1; breast cancer type 1 susceptibility protein
  Multi subunit Ring-finger type E3
   BRCC complex
    K10605  BRCA1; breast cancer type 1 susceptibility protein
Chromosome and associated proteins [BR:ko03036]
 Eukaryotic type
  Centrosome formation and ciliogenesis proteins
   Centrosome duplication proteins
    Regulators of centriole replication
     K10605  BRCA1; breast cancer type 1 susceptibility protein
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    BRCA1-A complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA1-B complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA1-C complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
    BRCA complex
     K10605  BRCA1; breast cancer type 1 susceptibility protein
   FA (Fanconi anemia) pathway
    Downstream FA components
     K10605  BRCA1; breast cancer type 1 susceptibility protein
BRITE hierarchy
Genes
HSA: 672(BRCA1)
PTR: 449497(BRCA1)
PPS: 100986197(BRCA1)
GGO: 101138567(BRCA1)
PON: 100439533(BRCA1)
NLE: 100580360(BRCA1)
MCC: 712634(BRCA1)
MCF: 102121313(BRCA1)
CSAB: 103243855(BRCA1)
RRO: 104673233
RBB: 108526765(BRCA1)
CJC: 100388186(BRCA1)
SBQ: 101046814(BRCA1)
MMU: 12189(Brca1)
MCAL: 110304614(Brca1)
MPAH: 110331180(Brca1)
RNO: 497672(Brca1)
MUN: 110550902(Brca1)
CGE: 100770724(Brca1)
NGI: 103751919(Brca1)
HGL: 101705460(Brca1)
CCAN: 109687320(Brca1)
OCU: 100347269(BRCA1)
TUP: 102494934(BRCA1)
CFA: 403437(BRCA1)
VVP: 112910801(BRCA1)
AML: 100480891(BRCA1)
UMR: 103672599(BRCA1)
UAH: 113265384(BRCA1)
ORO: 101362868(BRCA1)
FCA: 101081937(BRCA1)
PTG: 102966376(BRCA1)
PPAD: 109258507(BRCA1)
AJU: 106972629(BRCA1)
BTA: 353120(BRCA1)
BOM: 102266344(BRCA1)
BIU: 109573698(BRCA1)
BBUB: 102399547(BRCA1)
CHX: 102173121(BRCA1)
OAS: 101108584(BRCA1)
SSC: 100049662(BRCA1)
CFR: 102512160(BRCA1)
CDK: 105090493(BRCA1)
LVE: 103073470 103081109(BRCA1)
OOR: 101269506(BRCA1)
DLE: 111166258(BRCA1)
PCAD: 102986597(BRCA1)
ECB: 100051990(BRCA1)
EPZ: 103566867(BRCA1)
EAI: 106826352(BRCA1)
MYB: 102250563(BRCA1)
MYD: 102761726(BRCA1)
MNA: 107528909(BRCA1)
HAI: 109395752(BRCA1)
DRO: 112298867(BRCA1)
PALE: 102895982(BRCA1)
RAY: 107513858(BRCA1)
MJV: 108394617(BRCA1)
LAV: 100653763(BRCA1)
TMU: 101356605
MDO: 554178(BRCA1)
SHR: 100914310(BRCA1)
PCW: 110198384(BRCA1)
OAA: 103167900(BRCA1)
GGA: 373983(BRCA1)
MGP: 100548521
CJO: 107325322(BRCA1)
NMEL: 110388719(BRCA1)
APLA: 101789679(BRCA1)
ACYG: 106048796(BRCA1)
TGU: 100224649(BRCA1)
LSR: 110471836(BRCA1)
SCAN: 103821581(BRCA1)
GFR: 102034543(BRCA1)
FAB: 101814437(BRCA1)
PHI: 102105698(BRCA1)
PMAJ: 107215173(BRCA1)
CCAE: 111940108(BRCA1)
CCW: 104697774(BRCA1)
ETL: 114063608(BRCA1)
FPG: 106112589(BRCA1)
FCH: 102051878(BRCA1)
CLV: 102087906(BRCA1)
EGZ: 104134710(BRCA1)
NNI: 104009881(BRCA1)
ACUN: 113489164(BRCA1)
PADL: 103919153(BRCA1)
AAM: 106491786(BRCA1)
ASN: 102369036(BRCA1)
AMJ: 102573178(BRCA1)
PSS: 102444617(BRCA1)
CMY: 102936790(BRCA1)
CPIC: 101942702
ACS: 100553919(brca1)
PVT: 110080303(BRCA1)
PBI: 103057262(BRCA1)
PMUR: 107285925(BRCA1)
TSR: 106542500(BRCA1)
PMUA: 114581534(BRCA1)
XLA: 399391(brca1.L)
XTR: 733513(brca1)
NPR: 108786054(BRCA1)
IPU: 108273781(brca1)
PHYP: 113535268(brca1)
AMEX: 103023552(brca1)
TRU: 101064828(brca1)
LCO: 104930986(brca1)
NCC: 104967610(brca1)
MZE: 101470273(brca1)
ONL: 100708332(brca1)
OLA: 101160694(brca1)
XMA: 102225738(brca1)
XCO: 114151962(brca1)
PRET: 103481274(brca1)
CVG: 107094717(brca1)
NFU: 107387869(brca1)
KMR: 108246763(brca1)
ALIM: 106516970(brca1)
AOCE: 111567306(brca1)
CSEM: 103381460(brca1)
POV: 109626726(brca1)
LCF: 108898747(brca1)
SDU: 111219611(brca1)
SLAL: 111657129(brca1)
HCQ: 109523943(brca1)
BPEC: 110154390(brca1)
MALB: 109963046(brca1)
SASA: 106579155(brca1)
OTW: 112223766(brca1)
SALP: 111977731(brca1)
ELS: 105030602(brca1)
SFM: 108918991(brca1)
PKI: 111856111(brca1)
LCM: 102353765(BRCA1)
CMK: 103189703(brca1)
CIN: 100181169
SPU: 755086(brca1)
SKO: 102806679
AME: 100576640
BIM: 100740095
BTER: 100649216
CCAL: 108628902
OBB: 114874017
SOC: 105196247
MPHA: 105831361
AEC: 105150142
ACEP: 105618280
PBAR: 105426732
VEM: 105569674
HST: 105181096
DQU: 106743441
CFO: 105257458
LHU: 105679600
PGC: 109855601
OBO: 105280241
PCF: 106790481
NVI: 100114244
CSOL: 105367625
TCA: 103313062(P149)
DPA: 109535763
NVL: 108567117
PRAP: 110995488
HAW: 110376133
TNL: 113497643
PXY: 105385130
BTAB: 109043237
CLEC: 106665263
ZNE: 110828090
PVM: 113802497
PCAN: 112564770
MYI: 110448507
OBI: 106871917
SHX: MS3_05997
PDAM: 113672314
SPIS: 111323605
DGT: 114519990
HMG: 100213455
DFA: DFA_12254
 » show all
TaxonomyKoalaUniProt
Reference
PMID:8938427
  Authors
Smith TM, Lee MK, Szabo CI, Jerome N, McEuen M, Taylor M, Hood L, King MC
  Title
Complete genomic sequence and analysis of 117 kb of human DNA containing the gene BRCA1.
  Journal
Genome Res 6:1029-49 (1996)
DOI:10.1101/gr.6.11.1029
  Sequence
[hsa:672]
Reference
  Authors
Morris JR, Solomon E
  Title
BRCA1 : BARD1 induces the formation of conjugated ubiquitin structures, dependent on K6 of ubiquitin, in cells during DNA replication and repair.
  Journal
Hum Mol Genet 13:807-17 (2004)
DOI:10.1093/hmg/ddh095
  Sequence
[hsa:672]
LinkDB All DBs

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