KEGG   ORTHOLOGY: K10630
Entry
K10630                      KO                                     

Name
RBCK1, HOIL1
Definition
RanBP-type and C3HC4-type zinc finger-containing protein 1 [EC:2.3.2.31]
Pathway
ko04217  Necroptosis
ko04621  NOD-like receptor signaling pathway
ko05131  Shigellosis
Disease
H01744  Autoinflammatory syndrome with pyogenic bacterial infection and amylopectinosis
Brite
KEGG Orthology (KO) [BR:ko00001]
 09140 Cellular Processes
  09143 Cell growth and death
   04217 Necroptosis
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
 09150 Organismal Systems
  09151 Immune system
   04621 NOD-like receptor signaling pathway
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
 09160 Human Diseases
  09171 Infectious disease: bacterial
   05131 Shigellosis
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.31  RBR-type E3 ubiquitin transferase
     K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   RBR proteins
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
  Multi subunit Ring-finger type E3
   LUBAC complex
    K10630  RBCK1, HOIL1; RanBP-type and C3HC4-type zinc finger-containing protein 1
Genes
HSA: 10616(RBCK1)
PTR: 458025(RBCK1)
PPS: 100981890(RBCK1)
GGO: 101147960(RBCK1)
PON: 100438712(RBCK1)
NLE: 100603577(RBCK1)
MCC: 714692(RBCK1)
MCF: 102126740(RBCK1)
CSAB: 103247827(RBCK1)
RRO: 104660808(RBCK1)
RBB: 108544535(RBCK1)
CJC: 100411512(RBCK1)
SBQ: 101038299(RBCK1)
MMU: 24105(Rbck1)
MCAL: 110284393(Rbck1)
MPAH: 110317671(Rbck1)
RNO: 60383(Rbck1)
MUN: 110555817(Rbck1)
CGE: 100761016(Rbck1)
NGI: 103751631(Rbck1)
HGL: 101721667(Rbck1)
CCAN: 109687017(Rbck1)
OCU: 100347560(RBCK1)
TUP: 102473168(RBCK1)
CFA: 485818(RBCK1)
VVP: 112909903(RBCK1)
AML: 100471387(RBCK1)
UMR: 103674489(RBCK1)
UAH: 113258444(RBCK1)
ORO: 101374350(RBCK1)
ELK: 111141517
FCA: 101083505(RBCK1)
PTG: 102970756(RBCK1)
PPAD: 109272618(RBCK1)
AJU: 106985976(RBCK1)
BTA: 504400(RBCK1)
BOM: 102280624(RBCK1)
BIU: 109567335(RBCK1)
BBUB: 102406758(RBCK1)
CHX: 102181220(RBCK1)
OAS: 101122207(RBCK1)
SSC: 100519985(RBCK1)
CFR: 102513471(RBCK1)
CDK: 105100807(RBCK1)
BACU: 103000245(RBCK1)
LVE: 103084814(RBCK1)
OOR: 101285270(RBCK1)
DLE: 111184340(RBCK1)
PCAD: 102977045(RBCK1)
ECB: 100067987(RBCK1)
EPZ: 103556916(RBCK1)
EAI: 106833755(RBCK1)
MYB: 102252422(RBCK1)
MYD: 102759068(RBCK1)
MNA: 107527772(RBCK1)
HAI: 109384455(RBCK1)
DRO: 112304086(RBCK1)
PALE: 102884021(RBCK1)
RAY: 107512902(RBCK1)
MJV: 108400431(RBCK1)
LAV: 100654220(RBCK1)
TMU: 101349597
MDO: 100011102(RBCK1)
SHR: 100919033(RBCK1)
PCW: 110211403(RBCK1)
OAA: 114806007(RBCK1)
MGP: 104915434(RBCK1)
CJO: 107307646
NMEL: 110391473
TGU: 115492363
LSR: 110479468
PHI: 102106906(SHARPIN)
FPG: 101917453(SHARPIN)
FCH: 102047647
CLV: 106146052
NNI: 104018239
ACUN: 113490525
ASN: 102374341(SHARPIN) 102381829(RBCK1)
AMJ: 102558277 102565394(RBCK1)
CMY: 102933957(RBCK1)
CPIC: 101952313(SHARPIN) 101954121(RBCK1)
ACS: 100562899(rbck1) 100564158(sharpin)
PVT: 110084806 110090830(RBCK1)
PMUA: 114599814(RBCK1) 114600121(SHARPIN)
GJA: 107117859(SHARPIN) 107119331(RBCK1)
XTR: 100491300(rbck1)
NPR: 108802101(RBCK1)
DRE: 431715(rbck1) 569903(shrprbck1r)
IPU: 108255080(rbck1) 108268220
AMEX: 103029459 103044240(rbck1)
EEE: 113580584(rbck1) 113588870
TRU: 101064989 101070545(rbck1)
LCO: 104922306(rbck1) 104922367
NCC: 104946202(rbck1)
MZE: 101476206 101485343(rbck1)
ONL: 100708611 100709282(rbck1)
XMA: 102226939 102234963(rbck1)
XCO: 114135617(rbck1) 114136946
PRET: 103482437 108166280(rbck1)
CVG: 107090634(rbck1) 107092260
AOCE: 111576256(rbck1) 111587713
SDU: 111237288 111239703(rbck1)
SLAL: 111662905 111669673(rbck1)
HCQ: 109511977 109521524(rbck1)
SASA: 100194956(ub7i3) 106590417
ELS: 105017073(rbck1) 105019569
LCM: 102349730(SHARPIN) 102349954(RBCK1)
CMK: 103179690(sharpin) 103188626(rbck1)
RTP: 109935122 109938984(rbck1)
BFO: 118417455
CIN: 100169995(zf(ring/rbz)-1)
APLC: 110974755
AME: 410462
BIM: 100744318
BTER: 100645959
CCAL: 108630025
SOC: 105194710
MPHA: 105830206
AEC: 105151339
ACEP: 105618461
PBAR: 105422878
VEM: 105564393
HST: 105182285
DQU: 106747325
CFO: 105255569
LHU: 105676353
PGC: 109853085
OBO: 105282091
PCF: 106788325
NVI: 100116938
CSOL: 105364932
TCA: 663202
DPA: 109542344
ATD: 109601778
NVL: 108561039
BMOR: 101741592
BMAN: 114248945
PMAC: 106713327
PRAP: 110998073
HAW: 110376927
TNL: 113493288
API: 100168362
DNX: 107163184
AGS: 114131976
RMD: 113556499
CLEC: 106670617
ZNE: 110833674
TUT: 107367038
PCAN: 112553397
CRG: 105321103
OBI: 106879872
NVE: 5510882
EPA: 110245865
ADF: 107358878
AMIL: 114952579
PDAM: 113674303
SPIS: 111322223
DGT: 114532797
HMG: 100206370
 » show all
Reference
  Authors
Zhang M, Tian Y, Wang RP, Gao D, Zhang Y, Diao FC, Chen DY, Zhai ZH, Shu HB
  Title
Negative feedback regulation of cellular antiviral signaling by RBCK1-mediated degradation of IRF3.
  Journal
Cell Res 18:1096-104 (2008)
DOI:10.1038/cr.2008.277
Reference
  Authors
Yamanaka K, Ishikawa H, Megumi Y, Tokunaga F, Kanie M, Rouault TA, Morishima I, Minato N, Ishimori K, Iwai K
  Title
Identification of the ubiquitin-protein ligase that recognizes oxidized IRP2.
  Journal
Nat Cell Biol 5:336-40 (2003)
DOI:10.1038/ncb952
  Sequence
[hsa:10616]
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