KEGG   ORTHOLOGY: K10652
Entry
K10652                      KO                                     

Name
TRIM25, EFP
Definition
tripartite motif-containing protein 25 [EC:2.3.2.27]
Pathway
ko04064  NF-kappa B signaling pathway
ko04622  RIG-I-like receptor signaling pathway
ko05164  Influenza A
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04064 NF-kappa B signaling pathway
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
 09150 Organismal Systems
  09151 Immune system
   04622 RIG-I-like receptor signaling pathway
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
 09160 Human Diseases
  09172 Infectious disease: viral
   05164 Influenza A
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   04121 Ubiquitin system
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
Enzymes [BR:ko01000]
 2. Transferases
  2.3  Acyltransferases
   2.3.2  Aminoacyltransferases
    2.3.2.27  RING-type E3 ubiquitin transferase
     K10652  TRIM25, EFP; tripartite motif-containing protein 25
Ubiquitin system [BR:ko04121]
 Ubiquitin ligases (E3)
  Single Ring-finger type E3
   TRIM/RBCC proteins
    K10652  TRIM25, EFP; tripartite motif-containing protein 25
Genes
HSA: 7706(TRIM25)
PTR: 455146(TRIM25)
PPS: 100971009(TRIM25)
GGO: 101151068(TRIM25)
PON: 100440167(TRIM25)
NLE: 100599729(TRIM25)
MCC: 712588(TRIM25)
MCF: 102117091(TRIM25)
CSAB: 103242879(TRIM25)
RRO: 104675987(TRIM25)
RBB: 108530313(TRIM25)
CJC: 100392057(TRIM25)
SBQ: 101050878(TRIM25)
MMU: 217069(Trim25)
MCAL: 110305541(Trim25)
MPAH: 110332510(Trim25)
RNO: 494338(Trim25)
MUN: 110555547(Trim25)
CGE: 100765402(Trim25)
HGL: 101710143(Trim25)
CCAN: 109696712(Trim25)
OCU: 100343500(TRIM25)
TUP: 102491192(TRIM25)
CFA: 491103(TRIM25)
VVP: 112917903(TRIM25)
AML: 100480984(TRIM25)
UMR: 103667472(TRIM25)
UAH: 113268845(TRIM25)
ORO: 101364706(TRIM25)
ELK: 111151515
FCA: 101084663(TRIM25)
PTG: 102949419(TRIM25)
PPAD: 109247230(TRIM25)
AJU: 106989931(TRIM25)
BTA: 510923(TRIM25)
BOM: 102277633(TRIM25)
BIU: 109573862(TRIM25)
BBUB: 102403751(TRIM25)
CHX: 102181625(TRIM25)
OAS: 101122873(TRIM25)
SSC: 100622285(TRIM25)
CFR: 102516528(TRIM25)
CDK: 105097789(TRIM25)
BACU: 103015462(TRIM25)
LVE: 103090776(TRIM25)
OOR: 101287056(TRIM25)
DLE: 111163657(TRIM25)
PCAD: 102991542(TRIM25)
ECB: 100146440 100147035(TRIM25)
EPZ: 103544306 103546322(TRIM25)
EAI: 106837979
MYD: 102773217(TRIM25)
MNA: 107532719(TRIM25)
HAI: 109379737(TRIM25)
DRO: 112316562(TRIM25)
PALE: 102879209(TRIM25)
RAY: 107515788(TRIM25)
MJV: 108404932
LAV: 100665415(TRIM25)
TMU: 101344128
MDO: 100013883(TRIM25)
SHR: 100928651(TRIM25)
PCW: 110212085(TRIM25) 110212109
OAA: 103168929(TRIM25)
GGA: 417401(TRIM25)
MGP: 100544253 100548159(TRIM25)
APLA: 101791574(TRIM25)
ACYG: 106034683(TRIM25)
TGU: 100221651(TRIM25)
LSR: 110479709 110484633(TRIM25)
SCAN: 103817379 103819976(TRIM25)
GFR: 102040965(TRIM25)
FAB: 101815485(TRIM25)
PHI: 102100676(TRIM25) 106628212
PMAJ: 107212286(TRIM25)
CCAE: 111937562(TRIM25)
CCW: 104694263(TRIM25)
ETL: 114056855(TRIM25)
FPG: 101923333(TRIM25) 106112107
FCH: 102049672 102057184(TRIM25)
CLV: 102084896(TRIM25) 102086931
EGZ: 104123746(TRIM25) 104133621
NNI: 104014381(TRIM25) 104019028
AAM: 106493109(TRIM25) 106493566
ASN: 102370282(TRIM25) 102371292
AMJ: 102558244(TRIM25) 102563553
PSS: 102460037(TRIM25)
CMY: 102947648(TRIM25)
CPIC: 101946714(TRIM25) 101951434
ACS: 100567794(trim25)
PVT: 110074006(TRIM25)
PBI: 103056401(TRIM25)
PMUR: 107287038(TRIM25)
TSR: 106539650(TRIM25)
PMUA: 114587320
GJA: 107124591(TRIM25)
DRE: 393144(trim25)
CCAR: 109075219 109092324(trim25)
 » show all
Reference
PMID:8248217
  Authors
Inoue S, Orimo A, Hosoi T, Kondo S, Toyoshima H, Kondo T, Ikegami A, Ouchi Y, Orimo H, Muramatsu M
  Title
Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein.
  Journal
Proc Natl Acad Sci U S A 90:11117-21 (1993)
DOI:10.1073/pnas.90.23.11117
  Sequence
[hsa:7706]
Reference
  Authors
Uchil PD, Quinlan BD, Chan WT, Luna JM, Mothes W
  Title
TRIM E3 ligases interfere with early and late stages of the retroviral life cycle.
  Journal
PLoS Pathog 4:e16 (2008)
DOI:10.1371/journal.ppat.0040016
  Sequence
[hsa:7706]
Reference
  Authors
Gack MU, Shin YC, Joo CH, Urano T, Liang C, Sun L, Takeuchi O, Akira S, Chen Z, Inoue S, Jung JU
  Title
TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity.
  Journal
Nature 446:916-920 (2007)
DOI:10.1038/nature05732
  Sequence
[hsa:7706]
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