KEGG ORTHOLOGY: K10742

ORTHOLOGY: K10742

Entry

K10742 KO

Name

DNA2

Definition

DNA replication ATP-dependent helicase Dna2 [EC:3.6.4.12]

Pathway

ko03030

DNA replication

Disease

H00992

Seckel syndrome

H01118

Progressive external ophthalmoplegia

Brite

KEGG Orthology (KO) [BR:ko00001]
09120 Genetic Information Processing
  09124 Replication and repair
   03030 DNA replication
    K10742  DNA2; DNA replication ATP-dependent helicase Dna2
09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K10742  DNA2; DNA replication ATP-dependent helicase Dna2
Enzymes [BR:ko01000]
3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.4  Acting on acid anhydrides to facilitate cellular and subcellular movement
    3.6.4.12  DNA helicase
     K10742  DNA2; DNA replication ATP-dependent helicase Dna2
DNA replication proteins [BR:ko03032]
Eukaryotic type
  DNA Replication Elongation Factors
   Other elongation factors
    K10742  DNA2; DNA replication ATP-dependent helicase Dna2
Prokaryotic type
  DNA Replication Elongation Factors
   Elongation factors (archaeal)
    Other elongation factors
     K10742  DNA2; DNA replication ATP-dependent helicase Dna2

Genes

HSA:	1763(DNA2)

PTR:	450496(DNA2)

PPS:	100981957(DNA2)

GGO:	101152809(DNA2)

PON:	100440358(DNA2)

NLE:	100587802(DNA2)

MCC:	694401(DNA2)

MCF:	102124685(DNA2)

CSAB:

103216094(DNA2)

RRO:	104671679(DNA2)

RBB:	108514888(DNA2)

CJC:	100391749(DNA2)

SBQ:	101045477(DNA2)

MMU:	327762(Dna2)

MCAL:

110302694(Dna2)

MPAH:

110327132(Dna2)

MUN:	110557210(Dna2)

CGE:	100761842(Dna2)

NGI:	103733774(Dna2)

HGL:	101702298(Dna2)

CCAN:

109695220(Dna2) 109701209

OCU:	100342227(DNA2)

TUP:	102499579(DNA2)

CFA:	489015(DNA2)

VVP:	112923762(DNA2)

AML:	100484071(DNA2)

UMR:	103667770(DNA2)

UAH:	113259112(DNA2)

ORO:	101385240(DNA2)

ELK:

111144952

FCA:	101097671(DNA2)

PTG:	102959831(DNA2)

PPAD:

109264332(DNA2)

AJU:	106967188(DNA2)

BTA:	540969(DNA2)

BOM:	102273558(DNA2)

BIU:	109553883(DNA2)

BBUB:

102394839(DNA2)

CHX:	102185810(DNA2)

OAS:	101105877(DNA2)

SSC:	100153906(DNA2)

CFR:	102512602(DNA2)

CDK:	105093881(DNA2)

BACU:

103005663(DNA2)

LVE:	103076908(DNA2)

OOR:	101276464(DNA2)

DLE:	111183441(DNA2)

PCAD:

102988942

ECB:	100072606(DNA2)

EPZ:	103540375(DNA2) 103544426

EAI:	106825796 106844996(DNA2)

MYB:	102259430(DNA2)

MYD:	102761584(DNA2)

MNA:	107526044(DNA2)

HAI:	109371783(DNA2)

DRO:	112305610(DNA2)

PALE:

102898443(DNA2)

RAY:	107501308(DNA2)

MJV:	108401740(DNA2)

TMU:

101340760

MDO:	100014931(DNA2)

SHR:	100920066(DNA2)

PCW:	110200076(DNA2)

OAA:	100091782(DNA2)

GGA:	423688(DNA2)

MGP:	100541252(DNA2)

CJO:

107315722

NMEL:

110399471(DNA2)

APLA:

101797686(DNA2)

ACYG:

106031012(DNA2)

TGU:	100227383(DNA2)

LSR:	110469901(DNA2)

SCAN:

103821157(DNA2)

GFR:	102032635(DNA2)

FAB:	101813036(DNA2)

PHI:	102113019(DNA2)

PMAJ:

107206935(DNA2)

CCAE:

111931504(DNA2)

CCW:	104690153(DNA2)

ETL:	114066281(DNA2)

FPG:	101919877(DNA2)

FCH:	102056246(DNA2)

CLV:	102093637(DNA2)

EGZ:	104124612(DNA2)

NNI:	104013482(DNA2)

ACUN:

113481886(DNA2)

PADL:

103918612(DNA2)

AAM:	106486972(DNA2)

ASN:	102386229(DNA2)

AMJ:	102575273(DNA2)

PSS:	102447676(DNA2)

CMY:	102939043(DNA2)

CPIC:

101938843(DNA2)

ACS:	100564995(dna2)

PVT:	110086797(DNA2)

PBI:	103048518(DNA2)

PMUR:

107288094(DNA2)

TSR:	106542767(DNA2)

PMUA:

114597186(DNA2)

GJA:	107112680(DNA2)

XLA:	378492(dna2.S)

XTR:	100170166(dna2)

NPR:	108795777(DNA2)

DRE:	559535(dna2)

SRX:	107725437 107743557

SANH:

107666538 107676588

SGH:	107563052 107601824 107601826

CCAR:

109092528

IPU:	108261390 108263385(dna2)

PHYP:

113540250(dna2)

AMEX:

103040169(dna2)

EEE:	113579907(dna2)

TRU:	101072400(dna2)

TNG:	GSTEN00003012G001 GSTEN00025786G001

LCO:	104920174(dna2)

NCC:	104955497(dna2)

MZE:	101466662(dna2)

ONL:	100694443(dna2)

OLA:	101165382(dna2)

XMA:	102229759(dna2)

XCO:	114143446(dna2)

PRET:

103462825(dna2)

CVG:	107092167(dna2)

NFU:	107381872(dna2)

KMR:	108237303(dna2)

ALIM:

106513157(dna2)

AOCE:

111576202(dna2)

CSEM:

103379136(dna2)

POV:	109636867(dna2)

LCF:	108876918(dna2)

SDU:	111221110(dna2)

SLAL:

111645927(dna2)

HCQ:	109531536(dna2)

BPEC:

110175405(dna2)

MALB:

109954474(dna2)

SASA:

106612394(dna2)

OTW:	112257315(dna2)

SALP:

111978796(dna2)

ELS:	105021325(dna2)

SFM:	108932863(dna2)

PKI:	111849019(dna2)

LCM:	102365891(DNA2)

CMK:	103182183(dna2)

RTP:	109916497(dna2)

CIN:

100177218

SPU:

592140

APLC:

110991160

DME:	Dmel_CG2990(CG2990)

DER:

6551454

DSE:	Dsec_GM11399

DSI:	Dsimw501_GD16967(Dsim_GD16967)

DYA:	Dyak_GE17824

DAN:	Dana_GF24887

DSR:

110179045

DPO:	Dpse_GA15562

DPE:

6597908

DMN:

108164057

DWI:

6649072

DGR:	Dgri_GH10987

DMO:	Dmoj_GI17500

DAZ:

108612043

DNV:

108649368

DHE:

111592084

DVI:	Dvir_GJ15173

MDE:

101898323

LCQ:

111679957

AGA:	AgaP_AGAP004685

AAG:

5570012

CQU:	CpipJ_CPIJ000737

AME:

BIM:

BTER:

CCAL:

OBB:

SOC:

MPHA:

AEC:

ACEP:

PBAR:

VEM:

HST:

DQU:

CFO:

LHU:

PGC:

OBO:

PCF:

NVI:

CSOL:

MDL:

TCA:

DPA:

ATD:

NVL:

BMOR:

BMAN:

DPL:	KGM_206898

PMAC:

PRAP:

HAW:

TNL:

PXY:	105384046 105394812

API:

DNX:

AGS:

RMD:

BTAB:

CLEC:

PHU:	Phum_PHUM444960

ZNE:

110838443

FCD:

110851300

DPX:	DAPPUDRAFT_116978

PVM:	113813181 113813195

ISC:	IscW_ISCW014928

TUT:

DPTE:

CSCU:

PTEP:

CEL:	CELE_F43G6.1(dna-2)

CBR:	CBG03123(Cbr-dna-2)

BMY:

Bm1_11930

LOA:	LOAG_06948

TSP:

PCAN:

CRG:

MYI:

OBI:

LAK:	106150783 106170223

SMM:	Smp_197880

SHX:

MS3_07184

OVI:	T265_12528

NVE:	NEMVE_v1g94785

EPA:	110232720 110232732

ADF:	107334414 107335749

AMIL:

PDAM:

SPIS:

DGT:

HMG:

AQU:

ATH:	AT1G08840(emb2411)

CRB:

17899317

CSAT:

104739477 104755070 104767136

EUS:	EUTSA_v10006571mg

BRP:

103843376

BNA:	106377018 106412824 106420166

BOE:

RSZ:

THJ:

CIT:

CIC:	CICLE_v100185211m CICLE_v100185212m

TCC:

18585710

GRA:

105779816

GHI:	107896297 107948602

GAB:

108458113

DZI:

111297035

EGR:

104441316

GMX:	100799415 100808092

GSJ:

114417356

PVU:	PHAVU_005G016100g

VRA:

VAR:

VUN:

CCAJ:

MTR:	MTR_7g034575

CAM:

101502632

LJA:	Lj0g3v0281719.1(Lj0g3v0281719.1)

ADU:	107489017 107494791

AIP:

LANG:

FVE:

RCN:

PPER:

PMUM:

PAVI:

MDM:

PXB:	103929759 103965518

ZJU:

CSV:

CMO:

MCHA:

CMAX:

CMOS:

CPEP:

RCU:	8266680 8279948

JCU:

HBR:

MESC:

POP:

PEU:

JRE:

QSU:	111998300 112009171 112014289

VVI:

100247844

SLY:	101244042 101247601

SPEN:

107020558

SOT:

102578342

CANN:

107844063

NTA:	107759114 107766417 107821610

NSY:	104211239 104229656 104232956 104243592

NTO:	104096918 104101056

NAU:	109216142 109216146 109217744 109221791 109222672

INI:

SIND:

OEU:

HAN:

LSV:

CCAV:

DCR:

BVG:

SOE:

CQI:	110720447 110721596

NNU:

104610411

PSOM:

113297351 113302080

OSA:

4336807

DOSA:

Os04t0588200-00(Os04g0588200)

OBR:

102699683

BDI:

100823226

ATS:	109734099(LOC109734099) 109738329(LOC109738329)

SBI:

ZMA:

SITA:

PDA:

EGU:

MUS:

DCT:

PEQ:

AOF:

ATR:

SMO:	SELMODRAFT_451020 SELMODRAFT_451029

MNG:	MNEG_14027

CSL:	COCSUDRAFT_16037

OLU:	OSTLU_37931

OTA:	OT_ostta10g00340

BPG:	Bathy11g00410

MPP:	MICPUCDRAFT_43116

CME:	CYME_CMK133C

CCP:	CHC_T00007752001

SCE:	YHR164C(DNA2)

AGO:	AGOS_AEL218W

ERC:

Ecym_5575

KLA:	KLLA0_A05324g

KMX:	KLMA_10328(DNA2)

LTH:	KLTH0H00770g

VPO:	Kpol_1050p80

ZRO:	ZYRO0C11528g

CGR:	CAGL0I02222g

NCS:	NCAS_0D01420(NCAS0D01420)

NDI:	NDAI_0C03320(NDAI0C03320)

TPF:	TPHA_0A05270(TPHA0A05270)

TBL:	TBLA_0B08000(TBLA0B08000)

TDL:	TDEL_0G00990(TDEL0G00990)

KAF:	KAFR_0E02220(KAFR0E02220)

PPA:	PAS_chr4_0279

DHA:	DEHA2G06820g

PGU:	PGUG_02862

SPAA:

SPAPADRAFT_63122

LEL:	LELG_04649

CAL:	CAALFM_C600320CA(DNA2)

CTP:	CTRG_03009

COT:	CORT_0F04450

CDU:	CD36_60270

YLI:	YALI0E33377g

CLU:	CLUG_00760

CLUS:

A9F13_10g00165

CAUR:

CJI97_002337

SLB:	AWJ20_432(DNA2)

PKZ:	C5L36_0D01180

NCR:

NCU04749

NTE:	NEUTE1DRAFT131702(NEUTE1DRAFT_131702)

SMP:	SMAC_03385

PAN:	PODANSg3003

TTT:	THITE_131345

MTM:	MYCTH_2119294

CTHR:

CTHT_0042860

MGR:

MGG_02491

TMN:	UCRPA7_757

SSCK:

SPSK_02975

FGR:	FGSG_09509

FPU:	FPSE_10739

FVR:	FVEG_15394

FOX:	FOXG_06205

NHE:	NECHADRAFT_76779

TRR:	M419DRAFT_73176

MAW:

MAC_02702

MAJ:

MAA_10711

CMT:

CCM_04686

PLJ:	VFPFJ_03994

VAL:	VDBG_08137

VDA:	VDAG_01633

CFJ:	CFIO01_05158

SAPO:

SAPIO_CDS0806

ELA:	UCREL1_9462

PFY:	PFICI_10353

SSL:	SS1G_06882

BFU:	BCIN_11g01000(Bcdna2)

MBE:

MBM_09674

GLZ:	GLAREA_00159

ANI:

AN3653.2

AFM:	AFUA_4G12210

AOR:	AO090009000423

ANG:	ANI_1_2728014(An01g07480)

AFV:	AFLA_050550

ACT:	ACLA_051220

NFI:	NFIA_104050

PCS:	Pc22g05360

PDP:	PDIP_85920

CIM:	CIMG_13558(CIMG10249)

CPW:	CPC735_013420

PBL:	PAAG_02795

PBN:	PADG_01822

URE:	UREG_03480

ABE:

ARB_00438

TVE:

TRV_02682

AJE:	HCAG_01473

PNO:	SNOG_07199(SNOG_07198)

PTE:

PTT_19173

BSC:	COCSADRAFT_122838 COCSADRAFT_95990

AALT:

CC77DRAFT_752394

PFJ:	MYCFIDRAFT_104185

NPA:	UCRNP2_6157

TML:	GSTUM_00002391001

SPO:	SPBC16D10.04c(dna2)

CNE:

CNE03980

CNB:

CNBE3970

CGI:	CGB_E5260C

PPL:	POSPLDRAFT_102755

TVS:	TRAVEDRAFT_129037

DSQ:	DICSQDRAFT_112321

PCO:	PHACADRAFT_147492

HIR:	HETIRDRAFT_322640

PSQ:	PUNSTDRAFT_75877

ADL:	AURDEDRAFT_82435

FME:	FOMMEDRAFT_78324

GTR:	GLOTRDRAFT_75510 GLOTRDRAFT_75513

MPR:	MPER_05657

MRR:	Moror_2529

CCI:	CC1G_11474

SCM:	SCHCODRAFT_259008

ABP:	AGABI1DRAFT104147(AGABI1DRAFT_104147)

CPUT:

CONPUDRAFT_57533

SLA:	SERLADRAFT_462742

WIC:	J056_000249

UMA:	UMAG_05028

PFP:	PFL1_01730

MGL:

MGL_1256

MRT:

MRET_2890

PGR:	PGTG_09547

MLR:	MELLADRAFT_113623

SRE:	PTSG_05196

DDI:	DDB_G0274777

DFA:

DFA_05709

ACAN:

ACA1_377340

TET:	TTHERM_000136019 TTHERM_00136030

PTM:	GSPATT00026356001 GSPATT00030674001

PTI:	PHATRDRAFT_27246

FCY:	FRACYDRAFT_188759

AAF:	AURANDRAFT_62312

PIF:	PITG_13336

SPAR:

SPRG_22285

EHX:	EMIHUDRAFT_463659

TVA:	TVAG_461790

VCT:	JV59_24670

HAHE:

ENC22_13380

DTI:	Desti_2577

BSED:

DN745_00655

BBAT:

Bdt_1344

BBW:

BDW_04720

DSL:	Dacsa_3377

KBS:	EPA93_25245

PIR:	VN12_24955(recD2_3)

PBT:	ING2E5B_1336

BVS:	BARVI_05155

ARAC:

E0W69_003120

FLI:	Fleli_3307

AALG:

AREALGSMS7_01638

MLS:	MSLAZ_1358

HAL:	VNG_1501G(hel)

HSL:	OE_3147F(dna2)

HDL:	HALDL1_12150

HHB:	Hhub_2625(dna2)

HJE:	HacjB3_09135

HALH:

HTSR_0689

HHSR:

HSR6_0715

HSU:	HLASF_1414

HSF:	HLASA_1401

SALR:

FQU85_12340

HMA:	rrnAC0954(hel)

HHI:

HAH_1583

HHN:	HISP_08080

HAB:	SG26_15900

HTA:	BVU17_07675

NPH:	NP_2944A(dna2)

NMO:	Nmlp_2872(dna2)

HUT:

HALA:

HMU:

HALZ:

HALL:

HALI:

HSN:	DV733_15250

HARC:

HARCEL1_07040

HWA:	HQ_2930A(dna2)

HWC:	Hqrw_3340(dna2)

HVO:	HVO_2767(dna2)

HME:

HFX_2778

HGI:	ABY42_13850

HBO:	Hbor_12390

HAQ:	DU484_11020

HAJ:	DU500_11285

HAER:

DU502_08640

HRA:	EI982_17285

HLM:	DV707_06270

HALM:

HLA:

HALP:

HALB:

HEZZ:

SRUB:

HAE:	halTADL_2753

HDF:	AArcSl_1439

HAH:	Halar_2200

HTU:

Htur_2916

HDA:	BB347_09050

HJT:	DVR14_13960

NMG:	Nmag_1059(dna2)

HXA:	Halxa_2461

NAT:

NJ7G_2001

NPE:	Natpe_0932

NVR:	FEJ81_04820

NPL:	FGF80_06025

NGE:	Natgr_2069

HRU:	Halru_2009

NOU:	Natoc_2742

SALI:

L593_03125

HLR:	HALLA_13505

HLC:	CHINAEXTREME09695

NAJ:	B1756_04515

NAG:	AArcMg_0521

NAN:	AArc1_0534

NBG:	DV706_10580

NAS:	GCU68_01460

PYR:

P186_2887

» show all

Reference

PMID:22570407

Authors

Gloor JW, Balakrishnan L, Campbell JL, Bambara RA

Title

Biochemical analyses indicate that binding and cleavage specificities define the ordered processing of human Okazaki fragments by Dna2 and FEN1.

Journal

Nucleic Acids Res 40:6774-86 (2012)
DOI:10.1093/nar/gks388

Sequence

[hsa:1763]

Reference

PMID:21841787

Authors

Chen X, Niu H, Chung WH, Zhu Z, Papusha A, Shim EY, Lee SE, Sung P, Ira G

Title

Cell cycle regulation of DNA double-strand break end resection by Cdk1-dependent Dna2 phosphorylation.

Journal

Nat Struct Mol Biol 18:1015-9 (2011)
DOI:10.1038/nsmb.2105

Sequence

[sce:YHR164C]

LinkDB

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