KEGG   ORTHOLOGY: K10757
Entry
K10757                      KO                                     

Name
E2.4.1.91
Definition
flavonol 3-O-glucosyltransferase [EC:2.4.1.91]
Pathway
ko00944  Flavone and flavonol biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09110 Biosynthesis of other secondary metabolites
   00944 Flavone and flavonol biosynthesis
    K10757  E2.4.1.91; flavonol 3-O-glucosyltransferase
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01003 Glycosyltransferases
    K10757  E2.4.1.91; flavonol 3-O-glucosyltransferase
Enzymes [BR:ko01000]
 2. Transferases
  2.4  Glycosyltransferases
   2.4.1  Hexosyltransferases
    2.4.1.91  flavonol 3-O-glucosyltransferase
     K10757  E2.4.1.91; flavonol 3-O-glucosyltransferase
Glycosyltransferases [BR:ko01003]
 Others
  Hydrophobic molecule
   K10757  E2.4.1.91; flavonol 3-O-glucosyltransferase
Other DBs
RN: R02158 R06611
CAZy: GT1
Genes
ATH: AT5G17050(UGT78D2)
CRB: 17881145
CSAT: 104705997 104769991
EUS: EUTSA_v10013472mg
BRP: 103851079
BNA: 106354432 106354433
BOE: 106327034
RSZ: 108842609 108842627
GHI: 107899989
Reference
  Authors
Tohge T, Nishiyama Y, Hirai MY, Yano M, Nakajima J, Awazuhara M, Inoue E, Takahashi H, Goodenowe DB, Kitayama M, Noji M, Yamazaki M, Saito K
  Title
Functional genomics by integrated analysis of metabolome and transcriptome of Arabidopsis plants over-expressing an MYB transcription factor.
  Journal
Plant J 42:218-35 (2005)
DOI:10.1111/j.1365-313X.2005.02371.x
  Sequence
[ath:AT5G17050]
Reference
  Authors
Kubo H, Nawa N, Lupsea SA
  Title
Anthocyaninless1 gene of Arabidopsis thaliana encodes a UDP-glucose:flavonoid-3-O-glucosyltransferase.
  Journal
J Plant Res 120:445-9 (2007)
DOI:10.1007/s10265-006-0067-7
  Sequence
[ath:AT5G17050]
LinkDB

KEGG   ENZYME: 2.4.1.91
Entry
EC 2.4.1.91                 Enzyme                                 

Name
flavonol 3-O-glucosyltransferase;
GTI;
uridine diphosphoglucose-flavonol 3-O-glucosyltransferase;
UDP-glucose:flavonol 3-O-glucosyltransferase;
UDPG:flavonoid-3-O-glucosyltransferase
Class
Transferases;
Glycosyltransferases;
Hexosyltransferases
Sysname
UDP-glucose:flavonol 3-O-D-glucosyltransferase
Reaction(IUBMB)
UDP-glucose + a flavonol = UDP + a flavonol 3-O-beta-D-glucoside [RN:R03267]
Reaction(KEGG)
R03267 > R02158 R06611
Substrate
UDP-glucose [CPD:C00029];
flavonol [CPD:C01495]
Product
UDP [CPD:C00015];
flavonol 3-O-beta-D-glucoside [CPD:C03946]
Comment
Acts on a variety of flavonols, including quercetin and quercetin 7-O-glucoside. Different from EC 2.4.1.81 (flavone 7-O-beta-glucosyltransferase).
History
EC 2.4.1.91 created 1976
Pathway
ec00944  Flavone and flavonol biosynthesis
ec01100  Metabolic pathways
ec01110  Biosynthesis of secondary metabolites
Orthology
K10757  flavonol 3-O-glucosyltransferase
Genes
ATH: AT5G17050(UGT78D2)
CRB: 17881145
CSAT: 104705997 104769991
EUS: EUTSA_v10013472mg
BRP: 103851079
BNA: 106354432 106354433
BOE: 106327034
RSZ: 108842609 108842627
GHI: 107899989
Reference
1
  Authors
Kleinehollenhorst, G., Behrens, H., Pegels, G., Srunk, N. and Wiermann, R.
  Title
Formation of flavonol 3-O-diglycosides and flavonol 3-O-triglycosides by enzyme extracts from anthers of Tulipa cv apeldoorn - characterization and activity of 3 different O-glycosyltransferases during anther development.
  Journal
Z Natursforsch C: Biosci 37:587-599 (1982)
Reference
2  [PMID:4731963]
  Authors
Sutter A, Grisebach H.
  Title
UDP-glucose: flavonol 3-0-glucosyltransferase from cell suspension cultures of parsley.
  Journal
Biochim Biophys Acta 309:289-95 (1973)
DOI:10.1016/0005-2744(73)90027-2
Other DBs
ExplorEnz - The Enzyme Database: 2.4.1.91
IUBMB Enzyme Nomenclature: 2.4.1.91
ExPASy - ENZYME nomenclature database: 2.4.1.91
BRENDA, the Enzyme Database: 2.4.1.91
CAS: 50812-18-5
LinkDB

KEGG   REACTION: R02158
Entry
R02158                      Reaction                               

Name
UDPglucose:flavonol 3-O-D-glucosyltransferase
Definition
UDP-glucose + Quercetin <=> UDP + Quercetin 3-O-glucoside
Equation
Comment
flavonol 3-O-glucosyltransferase
Reaction class
RC00005  C00015_C00029
RC00171  C00389_C05623
Enzyme
Pathway
rn00944  Flavone and flavonol biosynthesis
rn01100  Metabolic pathways
rn01110  Biosynthesis of secondary metabolites
Orthology
K10757  flavonol 3-O-glucosyltransferase [EC:2.4.1.91]
Other DBs
RHEA: 61183
LinkDB

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