KEGG   ORTHOLOGY: K10811
Entry
K10811                      KO                                     

Name
E2.5.1.2
Definition
thiamine pyridinylase [EC:2.5.1.2]
Pathway
ko00730  Thiamine metabolism
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09108 Metabolism of cofactors and vitamins
   00730 Thiamine metabolism
    K10811  E2.5.1.2; thiamine pyridinylase
Enzymes [BR:ko01000]
 2. Transferases
  2.5  Transferring alkyl or aryl groups, other than methyl groups
   2.5.1  Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
    2.5.1.2  thiamine pyridinylase
     K10811  E2.5.1.2; thiamine pyridinylase
Other DBs
RN: R02863
GO: 0050332
Genes
SRR: SerAS9_2400
SRS: SerAS12_2400
SRA: SerAS13_2401
BPS: BPSS1103
BPM: BURPS1710b_A0059
BPL: BURPS1106A_A1472
BPD: BURPS668_A1560
BPSE: BDL_4389
BPSM: BBQ_5068
BPSU: BBN_4528
BPSD: BBX_6232
BPK: BBK_6008
BPSH: DR55_4224
BPSA: BBU_4959
BPSO: X996_4304
BUT: X994_6054
BTQ: BTQ_4590
BTJ: BTJ_5573
BTZ: BTL_4040
BTD: BTI_3614
BTV: BTHA_3841
BTHE: BTN_3627
BTHM: BTRA_4326
BTHA: DR62_3661
BTHL: BG87_4047
BOK: DM82_5265
BOC: BG90_5344
BGU: KS03_4180
BUL: BW21_5615
DDE: Dde_0637
MXA: MXAN_4523
SCL: sce5380
HOH: Hoch_1390
RPOD: E0E05_16885(bcmE)
LABP: FJ695_26280(bcmE)
CBO: CBO0770
CBA: CLB_0812
CBH: CLC_0826
CBY: CLM_0920
CBL: CLK_0178
CBB: CLD_3794
CBI: CLJ_B0819
CBF: CLI_0856
CBM: CBF_0826
MED: MELS_1668
 » show all
LinkDB

KEGG   ENZYME: 2.5.1.2
Entry
EC 2.5.1.2                  Enzyme                                 

Name
thiamine pyridinylase;
pyrimidine transferase;
thiaminase I;
thiamin hydrolase;
thiamin pyridinolase;
thiaminase (ambiguous);
thiamine pyridinolase;
thiamin pyridinylase;
thiamin:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Class
Transferases;
Transferring alkyl or aryl groups, other than methyl groups;
Transferring alkyl or aryl groups, other than methyl groups (only sub-subclass identified to date)
Sysname
thiamine:base 2-methyl-4-aminopyrimidine-5-methenyltransferase
Reaction(IUBMB)
thiamine + pyridine = 1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium + 4-methyl-5-(2-hydroxyethyl)thiazole [RN:R02863]
Reaction(KEGG)
R02863
Substrate
thiamine [CPD:C00378];
pyridine [CPD:C00747]
Product
1-[(4-amino-2-methylpyrimidin-5-yl)methyl]pyridinium [CPD:C02691];
4-methyl-5-(2-hydroxyethyl)thiazole [CPD:C04294]
Comment
Various bases and thiol compounds can act instead of pyridine.
History
EC 2.5.1.2 created 1961, modified 1976, modified 2001
Pathway
ec00730  Thiamine metabolism
Orthology
K10811  thiamine pyridinylase
Genes
SRR: SerAS9_2400
SRS: SerAS12_2400
SRA: SerAS13_2401
BPS: BPSS1103
BPM: BURPS1710b_A0059
BPL: BURPS1106A_A1472
BPD: BURPS668_A1560
BPSE: BDL_4389
BPSM: BBQ_5068
BPSU: BBN_4528
BPSD: BBX_6232
BPK: BBK_6008
BPSH: DR55_4224
BPSA: BBU_4959
BPSO: X996_4304
BUT: X994_6054
BTQ: BTQ_4590
BTJ: BTJ_5573
BTZ: BTL_4040
BTD: BTI_3614
BTV: BTHA_3841
BTHE: BTN_3627
BTHM: BTRA_4326
BTHA: DR62_3661
BTHL: BG87_4047
BOK: DM82_5265
BOC: BG90_5344
BGU: KS03_4180
BUL: BW21_5615
DDE: Dde_0637
MXA: MXAN_4523
SCL: sce5380
HOH: Hoch_1390
RPOD: E0E05_16885(bcmE)
LABP: FJ695_26280(bcmE)
CBO: CBO0770
CBA: CLB_0812
CBH: CLC_0826
CBY: CLM_0920
CBL: CLK_0178
CBB: CLD_3794
CBI: CLJ_B0819
CBF: CLI_0856
CBM: CBF_0826
MED: MELS_1668
 » show all
Reference
1  [PMID:13158184]
  Authors
FUJITA A.
  Title
Thiaminase.
  Journal
Adv Enzymol Relat Subj Biochem 15:389-421 (1954)
DOI:10.1002/9780470122600.ch9
Reference
2  [PMID:13471505]
  Authors
KENTEN RH.
  Title
[Pteridium aquilinum (L.) Kuhn.]
  Journal
Biochem J 67:25-33 (1957)
DOI:10.1042/bj0670025
Reference
3  [PMID:4966932]
  Authors
Wittliff JL, Airth RL.
  Title
The extracellular thiaminase I of Bacillus thiaminolyticus. I. Purification and physicochemical properties.
  Journal
Biochemistry 7:736-44 (1968)
DOI:10.1021/bi00842a032
Other DBs
ExplorEnz - The Enzyme Database: 2.5.1.2
IUBMB Enzyme Nomenclature: 2.5.1.2
ExPASy - ENZYME nomenclature database: 2.5.1.2
BRENDA, the Enzyme Database: 2.5.1.2
CAS: 9030-35-7
LinkDB

KEGG   REACTION: R02863
Entry
R02863                      Reaction                               

Name
Thiamin:beta 2-methyl-4-aminopyrimidine-5-methenyltransferase
Definition
Thiamine + Pyridine <=> Heteropyrithiamine + 5-(2-Hydroxyethyl)-4-methylthiazole
Equation
Reaction class
RC00224  C00378_C04294
RC00795  C00747_C02691
Enzyme
Pathway
rn00730  Thiamine metabolism
Orthology
K10811  thiamine pyridinylase [EC:2.5.1.2]
Other DBs
RHEA: 17700
LinkDB

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