KEGG   ORTHOLOGY: K10866
Entry
K10866                      KO                                     

Name
RAD50
Definition
DNA repair protein RAD50 [EC:3.6.-.-]
Pathway
ko03440  Homologous recombination
ko03450  Non-homologous end-joining
ko04218  Cellular senescence
Disease
H01344  Nijmegen syndrome
Brite
KEGG Orthology (KO) [BR:ko00001]
 09120 Genetic Information Processing
  09124 Replication and repair
   03440 Homologous recombination
    K10866  RAD50; DNA repair protein RAD50
   03450 Non-homologous end-joining
    K10866  RAD50; DNA repair protein RAD50
 09140 Cellular Processes
  09143 Cell growth and death
   04218 Cellular senescence
    K10866  RAD50; DNA repair protein RAD50
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K10866  RAD50; DNA repair protein RAD50
   03400 DNA repair and recombination proteins
    K10866  RAD50; DNA repair protein RAD50
Enzymes [BR:ko01000]
 3. Hydrolases
  3.6  Acting on acid anhydrides
   3.6.-  Acting on acid anhydrides
    3.6.-.-  
     K10866  RAD50; DNA repair protein RAD50
DNA replication proteins [BR:ko03032]
 Eukaryotic type
  DNA Replication Termination Factors
   Other telomere regulation proteins
    MRN complex
     K10866  RAD50; DNA repair protein RAD50
DNA repair and recombination proteins [BR:ko03400]
 Eukaryotic type
  DSBR (double strand breaks repair)
   HR (homologous recombination)
    MRN(MRX) complex
     K10866  RAD50; DNA repair protein RAD50
    BRCA1-C complex
     K10866  RAD50; DNA repair protein RAD50
   NHEJ (non-homologous end-joining)
    MRX complex
     K10866  RAD50; DNA repair protein RAD50
Genes
HSA: 10111(RAD50)
PTR: 107974853(RAD50)
PPS: 100990350(RAD50)
GGO: 101137829(RAD50)
PON: 100449962(RAD50)
NLE: 100597285(RAD50)
MCC: 710718(RAD50)
MCF: 101866312(RAD50)
CSAB: 103244511(RAD50)
RRO: 104659836(RAD50)
RBB: 108529586(RAD50)
CJC: 100398346
SBQ: 101039094(RAD50)
MMU: 19360(Rad50)
MCAL: 110305746(Rad50)
MPAH: 110331373(Rad50)
RNO: 64012(Rad50)
MUN: 110548767(Rad50)
CGE: 100755349(Rad50)
NGI: 103747027(Rad50)
HGL: 101719180(Rad50)
CCAN: 109694179(Rad50)
OCU: 100328725(RAD50)
TUP: 102495591(RAD50)
CFA: 474674(RAD50)
VVP: 112917079(RAD50)
AML: 100474262(RAD50)
UMR: 103663834(RAD50)
UAH: 113261715(RAD50)
ORO: 101383980(RAD50)
ELK: 111140866
FCA: 101095875(RAD50)
PTG: 102964063(RAD50)
PPAD: 109250889(RAD50)
AJU: 106970711(RAD50)
BTA: 788127(RAD50)
BOM: 102272621(RAD50)
BBUB: 102397992(RAD50)
CHX: 102187760(RAD50)
OAS: 101123035(RAD50)
SSC: 100522666(RAD50)
CFR: 102522123(RAD50)
CDK: 105090110(RAD50)
BACU: 103008292(RAD50)
LVE: 103091664(RAD50)
OOR: 101289427(RAD50)
DLE: 111182414(RAD50)
PCAD: 102983917(RAD50)
ECB: 100063198(RAD50)
EPZ: 103563186(RAD50)
EAI: 106841016(RAD50)
MYB: 102243443(RAD50)
MYD: 102765582(RAD50)
MNA: 107525024(RAD50)
HAI: 109382573(RAD50)
DRO: 112318100(RAD50)
PALE: 102890531(RAD50)
RAY: 107497037(RAD50)
MJV: 108390064(RAD50)
LAV: 100663283(RAD50)
TMU: 101355635
MDO: 100015557(RAD50)
SHR: 100934305(RAD50)
PCW: 110211698(RAD50)
OAA: 100077732(RAD50)
GGA: 416329(RAD50)
MGP: 100549534(RAD50)
CJO: 107320089(RAD50)
NMEL: 110405324(RAD50)
APLA: 101800129(RAD50)
ACYG: 106032771(RAD50)
TGU: 100221910(RAD50)
LSR: 110481032(RAD50)
SCAN: 103817242(RAD50)
GFR: 102037092(RAD50)
FAB: 101817480(RAD50)
PHI: 102112616(RAD50)
PMAJ: 107210847(RAD50)
CCAE: 111935623(RAD50)
CCW: 104697981(RAD50)
ETL: 114070740(RAD50)
FPG: 101913627(RAD50)
FCH: 102048259(RAD50)
CLV: 102088399(RAD50)
EGZ: 104133508(RAD50)
NNI: 104012013(RAD50)
ACUN: 113485244(RAD50)
PADL: 103915802(RAD50)
AAM: 106487246(RAD50)
ASN: 102372882(RAD50)
AMJ: 102560605(RAD50)
PSS: 102447517(RAD50)
CMY: 102935242(RAD50)
CPIC: 101950622(RAD50)
ACS: 100566478(rad50)
PVT: 110090130(RAD50)
PBI: 103064733
PMUR: 107290655(RAD50)
TSR: 106547556
PMUA: 114591248(RAD50)
GJA: 107108756(RAD50)
XLA: 108713276(rad50.S) 495064(rad50.L)
XTR: 779556(rad50)
NPR: 108792440(RAD50)
DRE: 553029(rad50)
SGH: 107581981 107587251(rad50)
CCAR: 109056895 109087386(rad50)
IPU: 108279118(rad50)
PHYP: 113541563(rad50)
AMEX: 103041254(rad50)
EEE: 113585516(rad50)
TRU: 101070531(rad50)
LCO: 104924025(rad50)
MZE: 101477643(rad50)
ONL: 100692802(rad50)
OLA: 101172011(rad50)
XMA: 102219502(rad50)
XCO: 114153478(rad50)
PRET: 103475378(rad50)
CVG: 107094318(rad50)
NFU: 107386718(rad50)
KMR: 108239011(rad50)
ALIM: 106524942(rad50)
AOCE: 111574491(rad50)
CSEM: 103394855(rad50)
POV: 109635893(rad50)
LCF: 108893689(rad50)
SDU: 111217096(rad50)
SLAL: 111672118(rad50)
HCQ: 109512401(rad50)
BPEC: 110153968(rad50)
MALB: 109960027(rad50)
SASA: 106567455(rad50)
SALP: 111980702(rad50)
ELS: 105011230
SFM: 108934381(rad50)
PKI: 111857452(rad50)
LCM: 102346081(RAD50)
CMK: 103184121(rad50)
RTP: 109927708(rad50)
BFO: 118413658
CIN: 100182051
SPU: 581691
APLC: 110977216
SKO: 100369030
DME: Dmel_CG6339(rad50)
DER: 6548086
DSI: Dsimw501_GD11670(Dsim_GD11670)
DSR: 110176927
DPE: 6592385
DMN: 108159856
LCQ: 111685591
AAG: 5566192
AME: 726642
BTER: 100650605
OBB: 114876949
TCA: 658288(rad50)
BMAN: 114252612
PXY: 105392955
DNX: 107172760
BTAB: 109032268
CLEC: 106666363
ZNE: 110836742
PTEP: 107455150
CEL: CELE_T04H1.4(rad-50)
BMY: Bm1_51725
PCAN: 112559750
CRG: 105348735
MYI: 110441665
OBI: 106876178
LAK: 106168900
SHX: MS3_08938
NVE: 5516263
EPA: 110252838
ADF: 107337273
PDAM: 113683551
SPIS: 111327850
DGT: 114518935
AQU: 100639685
ATH: AT2G31970(RAD50)
ALY: 9315424
CRB: 17888755
BRP: 103857408
BOE: 106335770
THJ: 104826172
CPAP: 110807951
CIT: 102616752
TCC: 18602645
GRA: 105796483
GAB: 108476274
DZI: 111307833
EGR: 104456005
GMX: 100818545
GSJ: 114395596
VRA: 106778297
VAR: 108319056
VUN: 114186230
CCAJ: 109807917
CAM: 101491365
ADU: 107482802
AIP: 107638231
LANG: 109326448
PXB: 103962558
ZJU: 107422363
CSV: 101209902
CMO: 103483462
MCHA: 111016026
CMAX: 111479648
CMOS: 111432029
CPEP: 111790570
RCU: 8286892
JCU: 105633139
HBR: 110645035
MESC: 110611300
POP: 7495838
PEU: 105110325
JRE: 109008437
QSU: 112019138
VVI: 100243413
SLY: 101256382
SPEN: 107020535
SOT: 102580839
CANN: 107871287
NTA: 107800461
NAU: 109216638
INI: 109170498
SIND: 105166532
HAN: 110927276
BVG: 104889779
SOE: 110798991
NNU: 104609450
PSOM: 113296672
OSA: 4329409
OBR: 102714261
BDI: 100845007
ATS: 109733532(LOC109733532)
SBI: 8056059
ZMA: 103653563
SITA: 101763296
EGU: 105049145
MUS: 103997159
DCT: 110105633
PEQ: 110018809
AOF: 109830754
ATR: 18438248
PPP: 112287857
CRE: CHLREDRAFT_13480(RAD50)
SCE: YNL250W(RAD50)
ERC: Ecym_1108
KMX: KLMA_10132(RAD50)
NCS: NCAS_0A00770(NCAS0A00770)
NDI: NDAI_0F04000(NDAI0F04000)
TPF: TPHA_0B04210(TPHA0B04210)
TBL: TBLA_0A05720(TBLA0A05720)
TDL: TDEL_0C05910(TDEL0C05910)
KAF: KAFR_0D03760(KAFR0D03760)
PIC: PICST_53629(RAD50)
CAL: CAALFM_C302000WA(RAD50)
NCR: NCU00901(uvs-6)
SMP: SMAC_00184(putative rad50)
MGR: MGG_11387
SSCK: SPSK_00983
MAW: MAC_09543
MAJ: MAA_07439
CMT: CCM_00071
MBE: MBM_03862
ANI: AN3619.2
ANG: ANI_1_2790014(An01g08180)
CIM: CIMG_12856(CIMG00584)
PBL: PAAG_12326(PAAG_07058)
PTE: PTT_09208
SPO: SPAC1556.01c(rad50)
CNE: CNN01100
CNB: CNBN1090
TASA: A1Q1_01723
MGL: MGL_0431
DDI: DDB_G0292786(rad50)
DFA: DFA_00066(rad50)
EHI: EHI_079960(102.t00005)
TAN: TA11630
TPV: TP02_0154
CPV: cgd1_2410
PTI: PHATRDRAFT_51876(RAD50)
 » show all
Reference
  Authors
Lee JH, Paull TT
  Title
Direct activation of the ATM protein kinase by the Mre11/Rad50/Nbs1 complex.
  Journal
Science 304:93-6 (2004)
DOI:10.1126/science.1091496
  Sequence
[hsa:10111]
Reference
  Authors
Kim KK, Shin BA, Seo KH, Kim PN, Koh JT, Kim JH, Park BR
  Title
Molecular cloning and characterization of splice variants of human RAD50 gene.
  Journal
Gene 235:59-67 (1999)
DOI:10.1016/S0378-1119(99)00215-2
  Sequence
[hsa:10111]
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