KEGG   ORTHOLOGY: K11126Help
Entry
K11126                      KO                                     

Name
TERT, EST2
Definition
telomerase reverse transcriptase [EC:2.7.7.49]
Pathway
ko05165  Human papillomavirus infection
ko05166  Human T-cell leukemia virus 1 infection
ko05200  Pathways in cancer
ko05225  Hepatocellular carcinoma
ko05226  Gastric cancer
Disease
H00018  Gastric cancer
H00048  Hepatocellular carcinoma
H00507  Dyskeratosis congenita
H00764  Chromosme 5p deletion syndrome
H01132  Aplastic anemia
H01299  Idiopathic pulmonary fibrosis
H01667  Medulloblastoma
Brite
KEGG Orthology (KO) [BR:ko00001]
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11126  TERT, EST2; telomerase reverse transcriptase
  09162 Cancer: specific types
   05225 Hepatocellular carcinoma
    K11126  TERT, EST2; telomerase reverse transcriptase
   05226 Gastric cancer
    K11126  TERT, EST2; telomerase reverse transcriptase
  09172 Infectious disease: viral
   05166 Human T-cell leukemia virus 1 infection
    K11126  TERT, EST2; telomerase reverse transcriptase
   05165 Human papillomavirus infection
    K11126  TERT, EST2; telomerase reverse transcriptase
 09180 Brite Hierarchies
  09182 Protein families: genetic information processing
   03032 DNA replication proteins
    K11126  TERT, EST2; telomerase reverse transcriptase
Enzymes [BR:ko01000]
 2. Transferases
  2.7  Transferring phosphorus-containing groups
   2.7.7  Nucleotidyltransferases
    2.7.7.49  RNA-directed DNA polymerase
     K11126  TERT, EST2; telomerase reverse transcriptase
DNA replication proteins [BR:ko03032]
 Eukaryotic Type
  DNA Replication Termination Factors
   Telomerase complex (animals)
    K11126  TERT, EST2; telomerase reverse transcriptase
   Telomerase complex (fungi)
    K11126  TERT, EST2; telomerase reverse transcriptase
BRITE hierarchy
Other DBs
GO: 0003721
Genes
HSA: 7015(TERT)
PTR: 101058547(TERT)
PPS: 100993498(TERT)
GGO: 101129159(TERT)
PON: 100936787
NLE: 101175959(TERT)
MCC: 709865(TERT)
MCF: 102141055(TERT)
CSAB: 103214928(TERT)
RRO: 104668701(TERT)
RBB: 108513704(TERT)
SBQ: 101033079(TERT)
MMU: 21752(Tert)
MCAL: 110307847(Tert)
MPAH: 110329002(Tert)
RNO: 301965(Tert)
MUN: 110545360(Tert)
CGE: 100774541(Tert)
NGI: 103749674(Tert)
HGL: 101706965(Tert)
CCAN: 109698261(Tert)
OCU: 103345693
TUP: 102469468(TERT)
CFA: 403412(TERT)
VVP: 112935454(TERT)
AML: 105237456(TERT)
UMR: 103679263(TERT)
UAH: 113260787(TERT)
ORO: 101386324(TERT)
FCA: 100144612(TERT)
PTG: 102971944(TERT)
AJU: 106985112(TERT)
BTA: 518884(TERT)
BIU: 109575079(TERT)
BBUB: 102388955(TERT)
PHD: 102335244(TERT)
CHX: 102187716(TERT)
OAS: 100126866(TERT)
SSC: 492280(TERT)
CFR: 102510014(TERT)
CDK: 105102193(TERT)
BACU: 103011022(TERT)
LVE: 103088173(TERT)
OOR: 101289653(TERT)
DLE: 111178537(TERT)
ECB: 100630695(TERT)
EPZ: 103553592(TERT)
EAI: 106835880(TERT)
MYB: 102238613(TERT)
MYD: 102760152(TERT)
MNA: 107536477(TERT)
HAI: 109371675(TERT)
RSS: 109454191(TERT)
DRO: 112321116(TERT)
PALE: 102895256(TERT)
LAV: 100676312(TERT)
TMU: 101341753
MDO: 103104146(TERT)
SHR: 100914433(TERT)
PCW: 110201216(TERT)
OAA: 102060413(TERT)
GGA: 420972(TERT)
MGP: 104910192(TERT)
CJO: 107309452(TERT)
APLA: 101791475(TERT)
ACYG: 106045034(TERT)
TGU: 101233273(TERT)
LSR: 110469715(TERT)
SCAN: 103815548(TERT)
GFR: 102036521(TERT)
FAB: 101821512(TERT)
PHI: 102107935(TERT)
PMAJ: 107200300(TERT)
CCAE: 111925326(TERT)
CCW: 104685843(TERT)
ETL: 114060990(TERT)
FPG: 101915763(TERT)
FCH: 102047198(TERT)
CLV: 102094253(TERT)
EGZ: 104128514(TERT)
NNI: 104013406(TERT)
ACUN: 113477200(TERT)
AAM: 106492846(TERT)
ASN: 102382597(TERT)
AMJ: 102562972(TERT)
CMY: 102930177(TERT)
CPIC: 101947379(TERT)
ACS: 103278585(tert)
PVT: 110080890(TERT)
PBI: 103054955(TERT)
PMUR: 107292114(TERT)
GJA: 107120143
XLA: 373635(tert.L)
XTR: 101731917(tert)
NPR: 108797611(TERT)
DRE: 796551(tert)
SRX: 107714753(tert)
SANH: 107659343(tert)
SGH: 107575103
CCAR: 109111099
IPU: 108274792(tert)
PHYP: 113525259(tert)
AMEX: 103046547(tert)
EEE: 113590696(tert)
TRU: 101064919(tert)
LCO: 104920435(tert)
NCC: 104952726(tert)
MZE: 101471256(tert)
OLA: 100049443(tert)
XMA: 102237215(tert)
XCO: 114155381 114156360(tert)
PRET: 103472108(tert)
NFU: 107383216(tert)
KMR: 108238757(tert)
CSEM: 103394651(tert)
LCF: 108900386(tert)
SDU: 111223022(tert)
HCQ: 109519612(tert)
BPEC: 110167527(tert)
MALB: 109951683(tert)
SASA: 106570713(tert)
ELS: 105027725(tert)
SFM: 108933422(tert)
PKI: 111846892(tert)
LCM: 102365365(TERT)
CMK: 103176217(tert)
CIN: 100187276
SPU: 100169700(TERT-S) 105447117 575612(TERT-L)
APLC: 110980811
SKO: 102801535
AME: 692346(Tert)
BIM: 100747169
BTER: 100649323
SOC: 105205248
MPHA: 105830406
AEC: 105153801
PBAR: 105433991
HST: 105184349
DQU: 106750122
CFO: 105259510
LHU: 105668839
PGC: 109859771
OBO: 105284938
MDL: 103577737
TCA: 658162(Tert)
PMAC: 106720475
PRAP: 110998712
HAW: 110380293
TNL: 113495296
PXY: 105392665
API: 100750257(TERT)
DNX: 107162933
AGS: 114125867
CLEC: 106662824
ZNE: 110829667
DPX: DAPPUDRAFT_346816(TERT)
TUT: 107359267
DPTE: 113792620
PCAN: 112563972
CRG: 109618372
MYI: 110466567
LAK: 106151756
EPA: 110238390
ADF: 107343849
PDAM: 113684973
SPIS: 111343476
AQU: 105312267
ATH: AT5G16850(TERT)
CRB: 17884564
BRP: 103846289
BOE: 106317925
THJ: 104827206
CPAP: 110826330
CIT: 102625932
TCC: 18587027
GRA: 105780812
GHI: 107927522
GAB: 108458479
EGR: 104420141
VRA: 106760534
VAR: 108334094
CCAJ: 109813804
CAM: 101515670
LJA: Lj3g3v0839410.1(Lj3g3v0839410.1) Lj3g3v0839410.2(Lj3g3v0839410.2)
ADU: 107462685
AIP: 107611329
LANG: 109363399
FVE: 101312102
PPER: 18785373
PMUM: 103330484
PAVI: 110744897
MDM: 103438500
PXB: 103945875
ZJU: 107430969
CSV: 101209644
CMO: 103500310
MCHA: 111020272
CMAX: 111481922
CMOS: 111442424
CPEP: 111790439
RCU: 8279167
JCU: 105636002
MESC: 110624386
POP: 7480795
JRE: 109001539
VVI: 104881309
SLY: 101244526
SPEN: 107011606
SOT: 102593334
CANN: 107839153
NTA: 107759516 107815112(TERT)
NSY: 104217220
NTO: 104105435
NAU: 109219212
INI: 109180066
SIND: 105169053
OEU: 111411173
HAN: 110895733
LSV: 111901173
CCAV: 112523592
BVG: 104905772
SOE: 110795589
CQI: 110710969
NNU: 104597430
OSA: 4352024
OBR: 102717485
BDI: 100830375
ATS: 109760004(LOC109760004)
SBI: 8082625
ZMA: 732781(TERT)
SITA: 101769857
PDA: 103724271
EGU: 105032643
MUS: 103972865
DCT: 110092187
PEQ: 110021683
AOF: 109844420
ATR: 18433477
PPP: 112282743
SCE: YLR318W(EST2)
ERC: Ecym_1438
KMX: KLMA_40031(EST2)
NCS: NCAS_0J01010(NCAS0J01010)
NDI: NDAI_0J01750(NDAI0J01750)
TPF: TPHA_0K01500(TPHA0K01500)
TBL: TBLA_0E01290(TBLA0E01290)
TDL: TDEL_0D03180(TDEL0D03180)
KAF: KAFR_0A06610(KAFR0A06610)
CAL: CAALFM_C108130CA(TERT)
SLB: AWJ20_200(EST2)
NCR: NCU02791
NTE: NEUTE1DRAFT19417(NEUTE1DRAFT_19417)
SSCK: SPSK_05840
MAW: MAC_05324
MAJ: MAA_03908
CMT: CCM_05923
BFU: BCIN_01g06720(Bcest2)
MBE: MBM_04787
ANI: AN3753.2
ABE: ARB_02417
TVE: TRV_04834
PTE: PTT_06880
SPO: SPBC29A3.14c(trt1)
CNE: CNE02180
CNB: CNBE2170
MGL: MGL_1546
TAN: TA05010
TPV: TP03_0519
BBO: BBOV_I004800(19.m02331)
 » show all
TaxonomyKoalaUniProt
Reference
  Authors
Wyatt HD, Lobb DA, Beattie TL
  Title
Characterization of physical and functional anchor site interactions in human telomerase.
  Journal
Mol Cell Biol 27:3226-40 (2007)
DOI:10.1128/MCB.02368-06
  Sequence
[hsa:7015]
Reference
PMID:9288757
  Authors
Meyerson M, Counter CM, Eaton EN, Ellisen LW, Steiner P, Caddle SD, Ziaugra L, Beijersbergen RL, Davidoff MJ, Liu Q, Bacchetti S, Haber DA, Weinberg RA
  Title
hEST2, the putative human telomerase catalytic subunit gene, is up-regulated in tumor cells and during immortalization.
  Journal
Cell 90:785-95 (1997)
DOI:10.1016/S0092-8674(00)80538-3
  Sequence
[hsa:7015]
Reference
  Authors
Wyatt HD, Tsang AR, Lobb DA, Beattie TL
  Title
Human telomerase reverse transcriptase (hTERT) Q169 is essential for telomerase function in vitro and in vivo.
  Journal
PLoS One 4:e7176 (2009)
DOI:10.1371/journal.pone.0007176
  Sequence
[hsa:7015]
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