KEGG   ORTHOLOGY: K11188
Entry
K11188                      KO                                     

Name
PRDX6
Definition
peroxiredoxin 6 [EC:1.11.1.7 1.11.1.27 3.1.1.-]
Pathway
ko00480  Glutathione metabolism
ko00940  Phenylpropanoid biosynthesis
ko01100  Metabolic pathways
ko01110  Biosynthesis of secondary metabolites
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K11188  PRDX6; peroxiredoxin 6
  09110 Biosynthesis of other secondary metabolites
   00940 Phenylpropanoid biosynthesis
    K11188  PRDX6; peroxiredoxin 6
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.7  peroxidase
     K11188  PRDX6; peroxiredoxin 6
    1.11.1.27  glutathione-dependent peroxiredoxin
     K11188  PRDX6; peroxiredoxin 6
 3. Hydrolases
  3.1  Acting on ester bonds
   3.1.1  Carboxylic-ester hydrolases
    3.1.1.-  
     K11188  PRDX6; peroxiredoxin 6
Other DBs
RN: R00602 R02596 R03919 R04007 R07443 R12578
GO: 0004601 0051920
Genes
HSA: 9588(PRDX6)
PTR: 469589(PRDX6) 738041
PPS: 100971181(PRDX6) 100989391
GGO: 101139252(PRDX6)
PON: 100173342(PRDX6) 100447051
NLE: 100600005(PRDX6)
MCC: 706486(PRDX6)
CSAB: 103230573(PRDX6)
RRO: 104665513(PRDX6)
RBB: 108526264(PRDX6)
CJC: 100403759(PRDX6)
SBQ: 101044491 101053713(PRDX6)
MMU: 11758(Prdx6) 320769(Prdx6b)
MCAL: 110297143(Prdx6)
MPAH: 110321716(Prdx6)
RNO: 94167(Prdx6)
MUN: 110560514(Prdx6)
CGE: 100754867(Prdx6)
NGI: 103738936(Prdx6)
HGL: 101696758(Prdx6)
CCAN: 109698821(Prdx6)
OCU: 100344329(PRDX6)
TUP: 102500362(PRDX6)
CFA: 480069(PRDX6)
VVP: 112921870(PRDX6)
AML: 100468988(PRDX6)
UMR: 103668169(PRDX6)
UAH: 113262820(PRDX6)
ORO: 101376070(PRDX6)
FCA: 101092729(PRDX6)
PTG: 102958542(PRDX6)
PPAD: 109252554(PRDX6)
AJU: 106979850(PRDX6)
BTA: 282438(PRDX6)
BOM: 102286451(PRDX6)
BIU: 109570377(PRDX6)
BBUB: 102410427(PRDX6)
CHX: 102175786(PRDX6)
OAS: 101112748(PRDX6)
SSC: 399538(PRDX6)
CFR: 102506321(PRDX6)
CDK: 105092775(PRDX6)
BACU: 103000672(PRDX6)
LVE: 103072246(PRDX6)
OOR: 101273194(PRDX6)
DLE: 111170257(PRDX6)
PCAD: 102995831(PRDX6)
ECB: 100052382(PRDX6)
EPZ: 103544252(PRDX6)
EAI: 106824039 106838672(PRDX6)
MYD: 102761217(PRDX6)
MNA: 107543744(PRDX6)
HAI: 109385647(PRDX6)
DRO: 112298395(PRDX6)
PALE: 102882455(PRDX6)
RAY: 107512060(PRDX6)
MJV: 108388370(PRDX6)
LAV: 100659423(PRDX6)
TMU: 101353130
MDO: 100015705(PRDX6)
SHR: 100925534(PRDX6)
PCW: 110196977(PRDX6)
OAA: 100081676(PRDX6)
GGA: 429062(PRDX6)
MGP: 100539560(PRDX6)
CJO: 107317113(PRDX6)
NMEL: 110402548(PRDX6)
APLA: 101804478(PRDX6)
ACYG: 106041549(PRDX6)
TGU: 100190549(PRDX6)
LSR: 110479002(PRDX6)
SCAN: 103824684(PRDX6)
GFR: 102045087(PRDX6)
FAB: 101809261(PRDX6)
PHI: 102110723(PRDX6)
CCAE: 111932494(PRDX6)
CCW: 104695443(PRDX6)
ETL: 114063954(PRDX6)
FPG: 101911996(PRDX6)
FCH: 102047328(PRDX6)
CLV: 102097376(PRDX6)
EGZ: 104132114(PRDX6)
NNI: 104015969(PRDX6)
ACUN: 113482893(PRDX6)
PADL: 103914096(PRDX6)
AAM: 106499702(PRDX6)
ASN: 102385375(PRDX6)
AMJ: 102560047(PRDX6)
PSS: 102461415(PRDX6)
CMY: 102931014(PRDX6)
CPIC: 101951311(PRDX6)
ACS: 100551732(prdx6)
PVT: 110081638(PRDX6)
PBI: 103060278(PRDX6)
PMUR: 107302853(PRDX6)
TSR: 106537917(PRDX6)
PMUA: 114598534(PRDX6)
GJA: 107109865(PRDX6)
XLA: 398641(prdx6.S) 399434(prdx6.L)
XTR: 394706(prdx6)
NPR: 108786582(PRDX6)
DRE: 393778(prdx6)
CCAR: 109049750(prdx6)
IPU: 100304983(prdx6) 108267850
PHYP: 113545239(prdx6) 113547286
EEE: 113568698 113587378(prdx6)
NCC: 104954109 104967901(prdx6)
ONL: 100703953 100706151(prdx6)
XMA: 102229529 102234407(prdx6)
XCO: 114145923 114150865(prdx6)
PRET: 103463762(prdx6) 103478987
CVG: 107083629 107099975(prdx6)
AOCE: 111577521(prdx6) 111587176
CSEM: 103376720(prdx6)
HCQ: 109532291(prdx6)
SASA: 106569414(prdx6) 106584278(PRDX6)
OTW: 112248692(prdx6)
ELS: 105011733(prdx6) 105022123
PKI: 111834955(prdx6) 111847497
LCM: 102356486(PRDX6)
RTP: 109914066(prdx6)
SPU: 579284
APLC: 110976308
SKO: 100368122
DME: Dmel_CG3083(Prx6005)
DER: 6541547
DSE: 6613171
DSI: Dsimw501_GD22792(Dsim_GD22792)
DAN: 6497725
DSR: 110185584
DPE: 6596421
DMN: 108162863
DWI: 6643763
DAZ: 108610982
DNV: 115562622
DHE: 111602231
DVI: 6634192
MDE: 101887675
LCQ: 111675272
AGA: AgaP_AGAP007020(TPX5)
AAG: 5571409
AME: 411852
BIM: 100746673
BTER: 100644975
CCAL: 108628985
SOC: 105194614
MPHA: 105831695
AEC: 105148780
ACEP: 105619917
PBAR: 105425013
VEM: 105566444
HST: 105188579
DQU: 106751044
CFO: 105255420
LHU: 105674955
PGC: 109853938
OBO: 105287654
PCF: 106785988
NVI: 100117827
CSOL: 105368698
MDL: 103571441
TCA: 659242
DPA: 109540610
ATD: 109599752
BMOR: 692792
BMAN: 114252526
PMAC: 106717122
PRAP: 110996318
HAW: 110373881
TNL: 113495619
PXY: 105386051
API: 100570136
DNX: 107169022
AGS: 114126282
RMD: 113554732
BTAB: 109035650
CLEC: 106668844
ZNE: 110833882
FCD: 110845679
TUT: 107371848
PTEP: 107451105
CEL: CELE_Y38C1AA.11(prdx-6)
BMY: Bm1_33935
PCAN: 112576081
CRG: 105343429
MYI: 110442486
OBI: 106882799
LAK: 106180792
NVE: 5519318
ADF: 107332921
AMIL: 114963462
DGT: 114530246
HMG: 100205201
AQU: 100631830
ATH: AT1G48130(PER1)
ALY: 9330158
CRB: 17900650
RSZ: 108860944
THJ: 104821806
CPAP: 110808356
CIT: 102622715
TCC: 18603742
GRA: 105778178
GAB: 108488386
EGR: 104453606
GMX: 100820616
VRA: 106768028
VAR: 108319109
VUN: 114177397
CCAJ: 109812815
LJA: Lj4g3v0200160.1(Lj4g3v0200160.1)
ADU: 107481617
AIP: 107631482
LANG: 109362119
FVE: 101291715
RCN: 112195921
PPER: 18790191
PMUM: 103323248
PAVI: 110751599
PXB: 103961241
ZJU: 107433375
CSV: 101203261
CMO: 103483915
MCHA: 111009213
CMAX: 111470853
CMOS: 111464561
CPEP: 111800223
RCU: 8262608
JCU: 105630346
HBR: 110637206
POP: 7498229
PEU: 105121934
JRE: 109001164
QSU: 111986967
SLY: 101260517
SPEN: 107013901
SOT: 102604099
CANN: 107848474
NSY: 104213523
NTO: 104105996
SIND: 105178844
OEU: 111367780
HAN: 110868247
LSV: 111880404
CCAV: 112521913
DCR: 108195583
BVG: 104884628
SOE: 110779424
DOSA: Os07t0638300-01(Os07g0638300) Os07t0638400-01(Os07g0638400)
BDI: 100821892
ATS: 109757966(LOC109757966)
SBI: 8073081
ZMA: 100037830(PER1)
SITA: 101757638
AOF: 109842952
ATR: 18430056
MNG: MNEG_3882
PCB: PCHAS_122870(PC000545.03.0)
SPAR: SPRG_05699
 » show all
Reference
  Authors
Chen JW, Dodia C, Feinstein SI, Jain MK, Fisher AB
  Title
1-Cys peroxiredoxin, a bifunctional enzyme with glutathione peroxidase and phospholipase A2 activities.
  Journal
J Biol Chem 275:28421-7 (2000)
DOI:10.1074/jbc.M005073200
  Sequence
[hsa:9588] [rno:94167]
Reference
PMID:9497358
  Authors
Kang SW, Baines IC, Rhee SG
  Title
Characterization of a mammalian peroxiredoxin that contains one conserved cysteine.
  Journal
J Biol Chem 273:6303-11 (1998)
DOI:10.1074/jbc.273.11.6303
  Sequence
[hsa:9588]
Reference
  Authors
Manevich Y, Feinstein SI, Fisher AB
  Title
Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.
  Journal
Proc Natl Acad Sci U S A 101:3780-5 (2004)
DOI:10.1073/pnas.0400181101
  Sequence
[rno:94167]
LinkDB

KEGG   ORTHOLOGY: K24137
Entry
K24137                      KO                                     

Name
PRX1
Definition
glutaredoxin/glutathione-dependent peroxiredoxin [EC:1.11.1.25 1.11.1.27]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K24137  PRX1; glutaredoxin/glutathione-dependent peroxiredoxin
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.25  glutaredoxin-dependent peroxiredoxin
     K24137  PRX1; glutaredoxin/glutathione-dependent peroxiredoxin
    1.11.1.27  glutathione-dependent peroxiredoxin
     K24137  PRX1; glutaredoxin/glutathione-dependent peroxiredoxin
Other DBs
RN: R12578
COG: COG0450
Genes
QSU: 111984201 111991456 112010120 112015429
SCE: YBL064C(PRX1)
AGO: AGOS_AGR368W
ERC: Ecym_4687
KLA: KLLA0_E20285g
KMX: KLMA_80358(PRX1b)
LTH: KLTH0C06798g
ZRO: ZYRO0B03256g
CGR: CAGL0A04433g
NCS: NCAS_0E02630(NCAS0E02630)
NDI: NDAI_0E04200(NDAI0E04200)
TDL: TDEL_0C01590(TDEL0C01590)
CAL: CAALFM_C702810WA(PRX1)
SLB: AWJ20_10(PRX1) AWJ20_285(PRX1)
NCR: NCU06031(rhd)
NTE: NEUTE1DRAFT118365(NEUTE1DRAFT_118365)
MGR: MGG_08256
SSCK: SPSK_10791
MAW: MAC_09051
MAJ: MAA_06893
BFU: BCIN_01g08520(Bcprx4) BCIN_16g00120(Bcprx3)
ANI: AN3973.2
ANG: ANI_1_644184(An04g03360) ANI_1_984094(An11g07650)
ABE: ARB_05934
TVE: TRV_04264
CNE: CNK00130
CNB: CNBK3300
TASA: A1Q1_03218
LBC: LACBIDRAFT_172363(LbPrx1-Cys)
MRR: Moror_998
MGL: MGL_0914
MRT: MRET_2558
 » show all
Reference
  Authors
Pedrajas JR, Padilla CA, McDonagh B, Barcena JA
  Title
Glutaredoxin participates in the reduction of peroxides by the mitochondrial 1-CYS peroxiredoxin in Saccharomyces cerevisiae.
  Journal
Antioxid Redox Signal 13:249-58 (2010)
DOI:10.1089/ars.2009.2950
  Sequence
[sce:YBL064C]
Reference
  Authors
Greetham D, Grant CM
  Title
Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo.
  Journal
Mol Cell Biol 29:3229-40 (2009)
DOI:10.1128/MCB.01918-08
  Sequence
[sce:YBL064C]
LinkDB

KEGG   ORTHOLOGY: K24136
Entry
K24136                      KO                                     

Name
pgdX
Definition
glutathione-dependent peroxiredoxin [EC:1.11.1.27]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K24136  pgdX; glutathione-dependent peroxiredoxin
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.27  glutathione-dependent peroxiredoxin
     K24136  pgdX; glutathione-dependent peroxiredoxin
Other DBs
RN: R12578
COG: COG0678 COG0695
Genes
FCY: FRACYDRAFT_269732
GQU: AWC35_12240
LPV: HYN51_11055
YPE: YPO3916
YPK: y0319
YPH: YPC_0299
YPA: YPA_0106
YPN: YPN_0051
YPM: YP_3132(aHP1)
YPP: YPDSF_3528
YPZ: YPZ3_3457
YPD: YPD4_3450
YPX: YPD8_3452
YPW: CH59_1863
YPJ: CH55_3089
YPV: BZ15_3789
YPL: CH46_1141
YPS: YPTB0119
YPO: BZ17_2477
YPY: YPK_4080
YPB: YPTS_0125
YPQ: DJ40_2304
YPU: BZ21_3461
YPR: BZ20_2003
YPC: BZ23_3737
YPF: BZ19_3580
YEN: YE0132
YEY: Y11_27961
YEW: CH47_3365
YET: CH48_1811
YAL: AT01_2347
YFR: AW19_3079
YIN: CH53_1927
YKR: CH54_2709
YRO: CH64_2717
YRU: BD65_1812
SMAR: SM39_4648
SPE: Spro_4776
SPLY: Q5A_024800
SMAF: D781_4440
SERF: L085_03800
RAA: Q7S_21830
SOD: Sant_3954
DDQ: DDI_4041
EAM: EAMY_0147(aHP1)
EAY: EAM_0141
ETA: ETA_01380
EPY: EpC_01600
EPR: EPYR_00169(aHP1)
EBI: EbC_01730
PVA: Pvag_3129(aHP1)
ETR: ETAE_3477
ETD: ETAF_3139
ETE: ETEE_1696
HIN: HI0572
HIT: NTHI0705(pdgX)
HIU: HIB_06970
HIE: R2846_0012(pgdX)
HIZ: R2866_0012(pgdX)
HIA: H733_0456
HDU: HD_0700
HSO: HS_0035
HSM: HSM_1928
PMU: PM1347
PMV: PMCN06_2015(ahp1)
PMP: Pmu_20130
PMUL: DR93_598
MSU: MS0155(ahp1)
MHT: D648_3780
MHAT: B824_22940
MHX: MHH_c09230(glrX)
MHAE: F382_09760
MHAM: J450_08685
MHAO: J451_09980
MHAL: N220_01850
MHAQ: WC39_12005
MHAY: VK67_12010
APL: APL_1482
APJ: APJL_1507
APA: APP7_1490
ASU: Asuc_0390
AAT: D11S_0298
AAN: D7S_01214
AACN: AANUM_0366
BTO: WQG_13340
BTRE: F542_8700
BTRH: F543_10010
BTRA: F544_13720
VCH: VC2637
VCS: MS6_2358
VCI: O3Y_12630
VPA: VP2753
VPB: VPBB_2611
VAG: N646_1847
VSP: VS_2880
VAN: VAA_02625
VTA: A2973
VFI: VF_2300
PPR: PBPRA0272(NMB0946)
MCT: MCR_0722
MCS: DR90_1217
CPS: CPS_4355
PHA: PSHAa0759
PAT: Patl_3338
PSM: PSM_A2303
PSEO: OM33_19400
PPHE: PP2015_885
PSPO: PSPO_b0640
PART: PARC_a1029
PAGA: PAGA_a1038
AMAL: I607_14495
AMAE: I876_14790
AMAO: I634_14735
AMAD: I636_14610
AMAI: I635_15165
AMAG: I533_14315
AAUS: EP12_15105
ASP: AOR13_411
GNI: GNIT_2711
GPS: C427_1465
PIN: Ping_3472
MYA: MORIYA_1748(PGdx)
TCX: Tcr_0139
HMAR: HVMH_0174
AEH: Mlg_1224
HHA: Hhal_1689
TKM: TK90_1856
TNI: TVNIR_0808(grxC_[C])
TVR: TVD_04035
HCH: HCH_00153
CSA: Csal_1255
ABO: ABO_2632
ADI: B5T_04266
APAC: S7S_17340
AXE: P40_20760
TOL: TOL_0673
OCE: GU3_14980
TBN: TBH_C0088
ENM: EBS_0324
NME: NMB0946
NMP: NMBB_1684
NMA: NMA1141
NMW: NMAA_0743
NMC: NMC0923
NMN: NMCC_0889
NMT: NMV_1449
NMI: NMO_0843
NGO: NGO0926
NGK: NGK_0873
NLA: NLA_13140
CVI: CV_2036
LHK: LHK_01491
PSE: NH8B_2293
REH: H16_B1097(h16_B1097)
RME: Rmet_4889(prx5)
CTI: RALTA_B0920(prx5)
CGD: CR3_4368
BPE: BP1728
BPC: BPTD_1706
BPER: BN118_2132
BPET: B1917_2107
BPEU: Q425_19050
BPAR: BN117_2746
BPA: BPP3048
BBR: BB3011
BPT: Bpet2539
BAV: BAV1973
BHO: D560_3693
BHM: D558_3668
AMIM: MIM_c03810
PNA: Pnap_1796
SCL: sce0905
BMX: BMS_1435
AFR: AFE_0367
ACU: Atc_2488
ATX: GCD22_00450(pgdx)
MAR: MAE_62780
MPK: VL20_2089
ANA: all1541
NSH: GXM_03596
AVA: Ava_4981
CTHE: Chro_2423
 » show all
Reference
  Authors
Pauwels F, Vergauwen B, Vanrobaeys F, Devreese B, Van Beeumen JJ
  Title
Purification and characterization of a chimeric enzyme from Haemophilus influenzae Rd that exhibits glutathione-dependent peroxidase activity.
  Journal
J Biol Chem 278:16658-66 (2003)
DOI:10.1074/jbc.M300157200
  Sequence
[hin:HI0572]
LinkDB

KEGG   ORTHOLOGY: K24138
Entry
K24138                      KO                                     

Name
prx3
Definition
glutaredoxin/glutathione-dependent peroxiredoxin [EC:1.11.1.25 1.11.1.27]
Pathway
ko00480  Glutathione metabolism
ko01100  Metabolic pathways
Brite
KEGG Orthology (KO) [BR:ko00001]
 09100 Metabolism
  09106 Metabolism of other amino acids
   00480 Glutathione metabolism
    K24138  prx3; glutaredoxin/glutathione-dependent peroxiredoxin
Enzymes [BR:ko01000]
 1. Oxidoreductases
  1.11  Acting on a peroxide as acceptor
   1.11.1  Peroxidases
    1.11.1.25  glutaredoxin-dependent peroxiredoxin
     K24138  prx3; glutaredoxin/glutathione-dependent peroxiredoxin
    1.11.1.27  glutathione-dependent peroxiredoxin
     K24138  prx3; glutaredoxin/glutathione-dependent peroxiredoxin
Other DBs
RN: R12578
COG: COG0678
Genes
XCC: XCC1046
XCB: XC_3200
XCA: xcc-b100_3298
XCP: XCR_1248
XCV: XCV1170
XAX: XACM_1116
XAC: XAC1150
XCI: XCAW_01251(aHP1)
XCT: J151_01284
XCJ: J158_01281
XOM: XOO0833(XOO0833)
XOO: XOO0908(AHP1)
XOP: PXO_02641
XOR: XOC_1204
XAL: XALC_0650
XPH: XppCFBP6546_05820(XppCFBP6546P_05820)
SML: Smlt3600
SMT: Smal_3020
SMZ: SMD_3172
PSUW: WQ53_14405
PSD: DSC_07920
LAB: LA76x_2482(prxIIE-2)
LEZ: GLE_2732
LEM: LEN_2294
DKO: I596_2052
VCH: VC1350
VCS: MS6_1128
VCI: O3Y_06285
VVU: VV2_0770
VVY: VVA1236
VPA: VPA1293
VAG: N646_3839
VNI: VIBNI_B0533(PrxII)
PPU: PP_2700
PPF: Pput_3052
PPT: PPS_2650
PPI: YSA_09706
PPX: T1E_2704
PPUH: B479_12835
PPUT: L483_11020
PPUN: PP4_31260
PPUD: DW66_2910
PMON: X969_12585
PMOT: X970_12230
SON: SO_4640
SDN: Sden_3541
SFR: Sfri_0215
SAZ: Sama_3513
SLO: Shew_3641
SWD: Swoo_0147
SWP: swp_4869
SVO: SVI_0158
SPSW: Sps_00228
ILO: IL2478
CPS: CPS_0141
PHA: PSHAa2650(ahpC)
PAT: Patl_0356
PSM: PSM_A2687(ahpC)
PSEO: OM33_00530
PPHE: PP2015_169
PSPO: PSPO_a2629
PART: PARC_a3482
PAGA: PAGA_a3392
MAD: HP15_3621
AMAL: I607_00695
AMAE: I876_00710
AMAO: I634_00700
AMAD: I636_00735
AMAI: I635_00735
AMAG: I533_00720
AMAC: MASE_00545
AAUS: EP12_00675
GNI: GNIT_0221
PIN: Ping_2855
FBL: Fbal_2362
MCA: MCA0042
MMAI: sS8_4176
MEJ: Q7A_2651
MEC: Q7C_1096
GAI: IMCC3135_32690(garA_3)
CSA: Csal_1130
HEL: HELO_3212
HBE: BEI_2655
ABO: ABO_0044
ADI: B5T_04321
AXE: P40_21050
KKO: Kkor_1581
KGE: TQ33_0866
AHA: AHA_1268
ASA: ASA_1254
AVR: B565_2944
AMED: B224_3935
ACAV: VI35_15110
OCE: GU3_08335
SVA: SVA_3395
RSO: RSc2838
RSN: RSPO_c00670(ahp1)
RSE: F504_2766
RPI: Rpic_3083
REH: H16_A3267(h16_A3267)
RME: Rmet_3122
CGD: CR3_2402
BMA: BMA2544
BMAL: DM55_738
BMAE: DM78_718
BMAQ: DM76_719
BMAI: DM57_1315
BMAF: DM51_2180
BMAZ: BM44_131
BMAB: BM45_2707
BPS: BPSL3019
BPSE: BDL_2402
BPSM: BBQ_282
BPSU: BBN_410
BPSD: BBX_799
BPK: BBK_1899
BPSH: DR55_1494
BPSA: BBU_2536
BPSO: X996_1115
BUT: X994_3130
BTE: BTH_I1124
BTQ: BTQ_2804
BTJ: BTJ_2891
BTZ: BTL_796
BTD: BTI_587
BTV: BTHA_912
BTHE: BTN_568
BTHM: BTRA_1028
BTHA: DR62_740
BTHL: BG87_1018
BOK: DM82_2686
BOC: BG90_2021
BVE: AK36_264
BCN: Bcen_0083
BCJ: BCAL3456
BCEN: DM39_379
BCEW: DM40_1272
BCEO: I35_0419
BAM: Bamb_0469
BMU: Bmul_2830
BMK: DM80_1102
BMUL: NP80_603
BCT: GEM_2953
BCED: DM42_1274
BDL: AK34_2577
BCON: NL30_21255
BUB: BW23_1180
BLAT: WK25_02715
BTEI: WS51_13190
BSEM: WJ12_02465
BPSL: WS57_20280
BMEC: WJ16_02445
BSTG: WT74_02770
BGU: KS03_1399
BGO: BM43_1896
BUK: MYA_0477
BUL: BW21_655
BXE: Bxe_A0492
BXB: DR64_2668
BFN: OI25_1952
PNU: Pnuc_0173
PNE: Pnec_0187
CABA: SBC2_31060
BPE: BP2715
BPC: BPTD_2673
BPER: BN118_2514
BPET: B1917_1136
BPEU: Q425_26610
BPAR: BN117_3534
BPA: BPP1118
BBR: BB1334
BPT: Bpet3666
BAV: BAV0828
BHO: D560_2892
BHM: D558_2869
PUT: PT7_2089
AMIM: MIM_c28440
AFQ: AFA_03120
ODI: ODI_R3390
RFR: Rfer_3785
POL: Bpro_0266
PNA: Pnap_0213
AAV: Aave_0348
AJS: Ajs_0288
AAA: Acav_0416
ACRA: BSY15_1769
VEI: Veis_1274
DAC: Daci_0401
CTES: O987_01610
RTA: Rta_03360
HYB: Q5W_24820
HPSE: HPF_02090
CBAA: SRAA_2104
CBAB: SMCB_2128
MPT: Mpe_A3433
HAR: HEAR2804(prdX1)
MMS: mma_3009(ahp1)
JAG: GJA_4469(PRXIID)
CFU: CFU_3935
CARE: LT85_4486
LCH: Lcho_3989
RGE: RGE_03390
BBAG: E1O_14740
BPRC: D521_0176
HOH: Hoch_5126
PACA: ID47_02715
MLO: mll7508
MHUA: MCHK_0990
MES: Meso_0751
PLA: Plav_0683
SME: SMc00072
SMER: DU99_04720
SMD: Smed_0530
EAD: OV14_1856
ATU: Atu0779
ARA: Arad_1253
AVI: Avi_1067
RLE: RL1037
RLG: Rleg_0661
RHT: NT26_0525
SHZ: shn_04290
BME: BMEI1456
BMEL: DK63_2031
BMEE: DK62_923
BMF: BAB1_0504
BABO: DK55_510
BABR: DO74_1377
BABT: DK49_273
BABB: DK48_1616
BABU: DK53_500
BABS: DK51_961
BABC: DO78_417
BMS: BR0478
BSZ: DK67_1406
BOV: BOV_0483
BCAR: DK60_562
BCAS: DA85_02285
BMR: BMI_I480
BPP: BPI_I507
BPV: DK65_882
OAN: Oant_0592
OAH: DR92_2348
BJA: bll1317
BRA: BRADO6585
BBT: BBta_0951
BRS: S23_64840
AOL: S58_10220
BRAD: BF49_3346
RPA: RPA4268
RPB: RPB_1343
RPC: RPC_4075
RPD: RPD_4027
RPE: RPE_1706
RPT: Rpal_4747
NWI: Nwi_2686
NHA: Nham_3732
OCA: OCAR_7328
XAU: Xaut_2596
AZC: AZC_0486
SNO: Snov_3080
MDI: METDI3328
MEX: Mext_2595
MCH: Mchl_2818
MPO: Mpop_2623
MET: M446_6266
MNO: Mnod_6935
MOR: MOC_4470
META: Y590_12400
MAQU: Maq22A_c19365(ahp1)
MSL: Msil_1257
HDN: Hden_2894
RVA: Rvan_3258
PHL: KKY_508
BVR: BVIR_79
BLAG: BLTE_33010
MSC: BN69_2285
PLEO: OHA_1_01825(garA)
MMED: Mame_03378
MCG: GL4_1001
HDI: HDIA_1130
RBM: TEF_09435
CCR: CC_3394
CAK: Caul_4490
CSE: Cseg_0296
PZU: PHZ_c0554
TSV: DSM104635_01353(garA)
SIL: SPO3736
RSP: RSP_0899
JAN: Jann_0439
RDE: RD1_0946
PDE: Pden_2325
DSH: Dshi_0113(ahpC)
KVL: KVU_0055
KVU: EIO_0494
KRO: BVG79_00318(ahpC)
PSF: PSE_1560
PGD: Gal_00502
OTM: OSB_01420
LAQU: R2C4_15215
CID: P73_0555
MALG: MALG_03091
RSU: NHU_03900
RHC: RGUI_2694
AHT: ANTHELSMS3_00150(tpx)
MALU: KU6B_07910
HNE: HNE_1052
HBA: Hbal_1035
GAK: X907_0998
NAR: Saro_2004
SAL: Sala_0166
SPHP: LH20_16475
SMAZ: LH19_18740
SPHU: SPPYR_0136
SWI: Swit_2670
SPHD: HY78_12160
SPHM: G432_16495
STAX: MC45_04730
SPHI: TS85_06360
SSAN: NX02_13515
SPKC: KC8_05480
SJP: SJA_C1-16860(ahpC)
SSY: SLG_23620
SPMI: K663_07670
SPHB: EP837_00189(prdX)
SPHR: BSY17_2971
SINB: SIDU_06200
SPHT: K426_13165
BLAS: BSY18_1301
SMIC: SmB9_12670
ELI: ELI_05035
ERF: FIU90_08970(garA)
AAY: WYH_00711
ALB: AEB_P2002
ACR: Acry_1905
SHUM: STHU_51600
RRU: Rru_A3057
RRF: F11_15660
RCE: RC1_3646
AZL: AZL_015390(ahpC)
TMO: TMO_2797
THAL: A1OE_267
EFK: P856_171(ahpC)
TXI: TH3_17525
MAGQ: MGMAQ_2812
PUB: SAR11_0127(pmpA)
PDX: Psed_0278
PSEA: WY02_05130
PSEE: FRP1_08225
PSEH: XF36_12395
PAUT: Pdca_26620
 » show all
Reference
  Authors
Lim JG, Bang YJ, Choi SH
  Title
Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.
  Journal
J Biol Chem 289:36263-74 (2014)
DOI:10.1074/jbc.M114.611020
  Sequence
LinkDB

KEGG   ENZYME: 1.11.1.27
Entry
EC 1.11.1.27                Enzyme                                 

Name
glutathione-dependent peroxiredoxin;
PRDX6 (gene name);
prx3 (gene name)
Class
Oxidoreductases;
Acting on a peroxide as acceptor;
Peroxidases
Sysname
glutathione:hydroperoxide oxidoreductase
Reaction(IUBMB)
2 glutathione + ROOH = glutathione disulfide + H2O + ROH [RN:R12578]
Reaction(KEGG)
R12578
Substrate
glutathione [CPD:C00051];
ROOH [CPD:C15498]
Product
glutathione disulfide [CPD:C00127];
H2O [CPD:C00001];
ROH [CPD:C01335]
Comment
Peroxiredoxins (Prxs) are a ubiquitous family of antioxidant proteins. They can be divided into three classes: typical 2-Cys, atypical 2-Cys and 1-Cys peroxiredoxins [1]. The peroxidase reaction comprises two steps centred around a redox-active cysteine called the peroxidatic cysteine. All three peroxiredoxin classes have the first step in common, in which the peroxidatic cysteine attacks the peroxide substrate and is oxidized to S-hydroxycysteine (a sulfenic acid) (see {single/111115a::mechanism}). The second step of the peroxidase reaction, the regeneration of cysteine from S-hydroxycysteine, distinguishes the three peroxiredoxin classes. For typical 2-Cys Prxs, in the second step, the peroxidatic S-hydroxycysteine from one subunit is attacked by the 'resolving' cysteine located in the C-terminus of the second subunit, to form an intersubunit disulfide bond, which is then reduced by one of several cell-specific thiol-containing reductants completing the catalytic cycle. In the atypical 2-Cys Prxs, both the peroxidatic cysteine and its resolving cysteine are in the same polypeptide, so their reaction forms an intrachain disulfide bond. The 1-Cys Prxs conserve only the peroxidatic cysteine, so its regeneration involves direct interaction with a reductant molecule. Glutathione-dependent peroxiredoxins have been reported from bacteria and animals, and appear to be 1-Cys enzymes. The mechanism for the mammalian PRDX6 enzyme involves heterodimerization of the enzyme with pi-glutathione S-transferase, followed by glutathionylation of the oxidized cysteine residue. Subsequent dissociation of the heterodimer yields glutathionylated peroxiredoxin, which is restored to the active form via spontaneous reduction by a second glutathione molecule.
History
EC 1.11.1.27 created 1983 as EC 1.11.1.15, part transferred 2020 to EC 1.11.1.27
Pathway
ec00480  Glutathione metabolism
ec01100  Metabolic pathways
Orthology
K11188  peroxiredoxin 6
K24136  glutathione-dependent peroxiredoxin
K24137  glutaredoxin/glutathione-dependent peroxiredoxin
K24138  glutaredoxin/glutathione-dependent peroxiredoxin
Genes
HSA: 9588(PRDX6)
PTR: 469589(PRDX6) 738041
PPS: 100971181(PRDX6) 100989391
GGO: 101139252(PRDX6)
PON: 100173342(PRDX6) 100447051
NLE: 100600005(PRDX6)
MCC: 706486(PRDX6)
CSAB: 103230573(PRDX6)
RRO: 104665513(PRDX6)
RBB: 108526264(PRDX6)
CJC: 100403759(PRDX6)
SBQ: 101044491 101053713(PRDX6)
MMU: 11758(Prdx6) 320769(Prdx6b)
MCAL: 110297143(Prdx6)
MPAH: 110321716(Prdx6)
RNO: 94167(Prdx6)
MUN: 110560514(Prdx6)
CGE: 100754867(Prdx6)
NGI: 103738936(Prdx6)
HGL: 101696758(Prdx6)
CCAN: 109698821(Prdx6)
OCU: 100344329(PRDX6)
TUP: 102500362(PRDX6)
CFA: 480069(PRDX6)
VVP: 112921870(PRDX6)
AML: 100468988(PRDX6)
UMR: 103668169(PRDX6)
UAH: 113262820(PRDX6)
ORO: 101376070(PRDX6)
FCA: 101092729(PRDX6)
PTG: 102958542(PRDX6)
PPAD: 109252554(PRDX6)
AJU: 106979850(PRDX6)
BTA: 282438(PRDX6)
BOM: 102286451(PRDX6)
BIU: 109570377(PRDX6)
BBUB: 102410427(PRDX6)
CHX: 102175786(PRDX6)
OAS: 101112748(PRDX6)
SSC: 399538(PRDX6)
CFR: 102506321(PRDX6)
CDK: 105092775(PRDX6)
BACU: 103000672(PRDX6)
LVE: 103072246(PRDX6)
OOR: 101273194(PRDX6)
DLE: 111170257(PRDX6)
PCAD: 102995831(PRDX6)
ECB: 100052382(PRDX6)
EPZ: 103544252(PRDX6)
EAI: 106824039 106838672(PRDX6)
MYD: 102761217(PRDX6)
MNA: 107543744(PRDX6)
HAI: 109385647(PRDX6)
DRO: 112298395(PRDX6)
PALE: 102882455(PRDX6)
RAY: 107512060(PRDX6)
MJV: 108388370(PRDX6)
LAV: 100659423(PRDX6)
TMU: 101353130
MDO: 100015705(PRDX6)
SHR: 100925534(PRDX6)
PCW: 110196977(PRDX6)
OAA: 100081676(PRDX6)
GGA: 429062(PRDX6)
MGP: 100539560(PRDX6)
CJO: 107317113(PRDX6)
NMEL: 110402548(PRDX6)
APLA: 101804478(PRDX6)
ACYG: 106041549(PRDX6)
TGU: 100190549(PRDX6)
LSR: 110479002(PRDX6)
SCAN: 103824684(PRDX6)
GFR: 102045087(PRDX6)
FAB: 101809261(PRDX6)
PHI: 102110723(PRDX6)
CCAE: 111932494(PRDX6)
CCW: 104695443(PRDX6)
ETL: 114063954(PRDX6)
FPG: 101911996(PRDX6)
FCH: 102047328(PRDX6)
CLV: 102097376(PRDX6)
EGZ: 104132114(PRDX6)
NNI: 104015969(PRDX6)
ACUN: 113482893(PRDX6)
PADL: 103914096(PRDX6)
AAM: 106499702(PRDX6)
ASN: 102385375(PRDX6)
AMJ: 102560047(PRDX6)
PSS: 102461415(PRDX6)
CMY: 102931014(PRDX6)
CPIC: 101951311(PRDX6)
ACS: 100551732(prdx6)
PVT: 110081638(PRDX6)
PBI: 103060278(PRDX6)
PMUR: 107302853(PRDX6)
TSR: 106537917(PRDX6)
PMUA: 114598534(PRDX6)
GJA: 107109865(PRDX6)
XLA: 398641(prdx6.S) 399434(prdx6.L)
XTR: 394706(prdx6)
NPR: 108786582(PRDX6)
DRE: 393778(prdx6)
CCAR: 109049750(prdx6)
IPU: 100304983(prdx6) 108267850
PHYP: 113545239(prdx6) 113547286
EEE: 113568698 113587378(prdx6)
NCC: 104954109 104967901(prdx6)
ONL: 100703953 100706151(prdx6)
XMA: 102229529 102234407(prdx6)
XCO: 114145923 114150865(prdx6)
PRET: 103463762(prdx6) 103478987
CVG: 107083629 107099975(prdx6)
AOCE: 111577521(prdx6) 111587176
CSEM: 103376720(prdx6)
HCQ: 109532291(prdx6)
SASA: 106569414(prdx6) 106584278(PRDX6)
OTW: 112248692(prdx6)
ELS: 105011733(prdx6) 105022123
PKI: 111834955(prdx6) 111847497
LCM: 102356486(PRDX6)
RTP: 109914066(prdx6)
SPU: 579284
APLC: 110976308
SKO: 100368122
DME: Dmel_CG3083(Prx6005)
DER: 6541547
DSE: 6613171
DSI: Dsimw501_GD22792(Dsim_GD22792)
DAN: 6497725
DSR: 110185584
DPE: 6596421
DMN: 108162863
DWI: 6643763
DAZ: 108610982
DNV: 115562622
DHE: 111602231
DVI: 6634192
MDE: 101887675
LCQ: 111675272
AGA: AgaP_AGAP007020(TPX5)
AAG: 5571409
AME: 411852
BIM: 100746673
BTER: 100644975
CCAL: 108628985
SOC: 105194614
MPHA: 105831695
AEC: 105148780
ACEP: 105619917
PBAR: 105425013
VEM: 105566444
HST: 105188579
DQU: 106751044
CFO: 105255420
LHU: 105674955
PGC: 109853938
OBO: 105287654
PCF: 106785988
NVI: 100117827
CSOL: 105368698
MDL: 103571441
TCA: 659242
DPA: 109540610
ATD: 109599752
BMOR: 692792
BMAN: 114252526
PMAC: 106717122
PRAP: 110996318
HAW: 110373881
TNL: 113495619
PXY: 105386051
API: 100570136
DNX: 107169022
AGS: 114126282
RMD: 113554732
BTAB: 109035650
CLEC: 106668844
ZNE: 110833882
FCD: 110845679
TUT: 107371848
PTEP: 107451105
CEL: CELE_Y38C1AA.11(prdx-6)
BMY: Bm1_33935
PCAN: 112576081
CRG: 105343429
MYI: 110442486
OBI: 106882799
LAK: 106180792
NVE: 5519318
ADF: 107332921
AMIL: 114963462
DGT: 114530246
HMG: 100205201
AQU: 100631830
ATH: AT1G48130(PER1)
ALY: 9330158
CRB: 17900650
RSZ: 108860944
THJ: 104821806
CPAP: 110808356
CIT: 102622715
TCC: 18603742
GRA: 105778178
GAB: 108488386
EGR: 104453606
GMX: 100820616
VRA: 106768028
VAR: 108319109
VUN: 114177397
CCAJ: 109812815
LJA: Lj4g3v0200160.1(Lj4g3v0200160.1)
ADU: 107481617
AIP: 107631482
LANG: 109362119
FVE: 101291715
RCN: 112195921
PPER: 18790191
PMUM: 103323248
PAVI: 110751599
PXB: 103961241
ZJU: 107433375
CSV: 101203261
CMO: 103483915
MCHA: 111009213
CMAX: 111470853
CMOS: 111464561
CPEP: 111800223
RCU: 8262608
JCU: 105630346
HBR: 110637206
POP: 7498229
PEU: 105121934
JRE: 109001164
SLY: 101260517
SPEN: 107013901
SOT: 102604099
CANN: 107848474
NSY: 104213523
NTO: 104105996
SIND: 105178844
OEU: 111367780
HAN: 110868247
LSV: 111880404
CCAV: 112521913
DCR: 108195583
BVG: 104884628
SOE: 110779424
DOSA: Os07t0638300-01(Os07g0638300) Os07t0638400-01(Os07g0638400)
BDI: 100821892
ATS: 109757966(LOC109757966)
SBI: 8073081
ZMA: 100037830(PER1)
SITA: 101757638
AOF: 109842952
ATR: 18430056
MNG: MNEG_3882
SCE: YBL064C(PRX1)
ERC: Ecym_4687
KMX: KLMA_80358(PRX1b)
NCS: NCAS_0E02630(NCAS0E02630)
NDI: NDAI_0E04200(NDAI0E04200)
TDL: TDEL_0C01590(TDEL0C01590)
CAL: CAALFM_C702810WA(PRX1)
SLB: AWJ20_10(PRX1) AWJ20_285(PRX1)
NCR: NCU06031(rhd)
NTE: NEUTE1DRAFT118365(NEUTE1DRAFT_118365)
MGR: MGG_08256
SSCK: SPSK_10791
MAW: MAC_09051
MAJ: MAA_06893
BFU: BCIN_01g08520(Bcprx4) BCIN_16g00120(Bcprx3)
ANI: AN3973.2
ANG: ANI_1_644184(An04g03360) ANI_1_984094(An11g07650)
ABE: ARB_05934
TVE: TRV_04264
CNE: CNK00130
CNB: CNBK3300
TASA: A1Q1_03218
LBC: LACBIDRAFT_172363(LbPrx1-Cys)
MRR: Moror_998
MGL: MGL_0914
MRT: MRET_2558
PCB: PCHAS_122870(PC000545.03.0)
SPAR: SPRG_05699
YPE: YPO3916
YPK: y0319
YPH: YPC_0299
YPA: YPA_0106
YPN: YPN_0051
YPM: YP_3132(aHP1)
YPZ: YPZ3_3457
YPD: YPD4_3450
YPX: YPD8_3452
YPW: CH59_1863
YPJ: CH55_3089
YPV: BZ15_3789
YPL: CH46_1141
YPS: YPTB0119
YPO: BZ17_2477
YPY: YPK_4080
YPB: YPTS_0125
YPQ: DJ40_2304
YPU: BZ21_3461
YPR: BZ20_2003
YPC: BZ23_3737
YPF: BZ19_3580
YEN: YE0132
YEY: Y11_27961
YEW: CH47_3365
YET: CH48_1811
YAL: AT01_2347
YFR: AW19_3079
YIN: CH53_1927
YKR: CH54_2709
YRO: CH64_2717
YRU: BD65_1812
SMAR: SM39_4648
SPE: Spro_4776
SPLY: Q5A_024800
SMAF: D781_4440
SERF: L085_03800
RAA: Q7S_21830
SOD: Sant_3954
DDQ: DDI_4041
EAM: EAMY_0147(aHP1)
EAY: EAM_0141
ETA: ETA_01380
EPY: EpC_01600
EPR: EPYR_00169(aHP1)
EBI: EbC_01730
PVA: Pvag_3129(aHP1)
ETR: ETAE_3477
ETD: ETAF_3139
ETE: ETEE_1696
HIN: HI0572
HIT: NTHI0705(pdgX)
HIU: HIB_06970
HIE: R2846_0012(pgdX)
HIZ: R2866_0012(pgdX)
HIA: H733_0456
HDU: HD_0700
HSO: HS_0035
HSM: HSM_1928
PMU: PM1347
PMV: PMCN06_2015(ahp1)
PMP: Pmu_20130
PMUL: DR93_598
MSU: MS0155(ahp1)
MHT: D648_3780
MHAT: B824_22940
MHX: MHH_c09230(glrX)
MHAE: F382_09760
MHAM: J450_08685
MHAO: J451_09980
MHAL: N220_01850
MHAQ: WC39_12005
MHAY: VK67_12010
APL: APL_1482
APJ: APJL_1507
APA: APP7_1490
ASU: Asuc_0390
AAT: D11S_0298
AAN: D7S_01214
AACN: AANUM_0366
BTO: WQG_13340
BTRE: F542_8700
BTRH: F543_10010
BTRA: F544_13720
XCC: XCC1046
XCB: XC_3200
XCP: XCR_1248
XCV: XCV1170
XAX: XACM_1116
XAC: XAC1150
XCI: XCAW_01251(aHP1)
XOM: XOO0833(XOO0833)
XOO: XOO0908(AHP1)
XOP: PXO_02641
XOR: XOC_1204
XAL: XALC_0650
XPH: XppCFBP6546_05820(XppCFBP6546P_05820)
SML: Smlt3600
SMT: Smal_3020
SMZ: SMD_3172
PSUW: WQ53_14405
PSD: DSC_07920
LAB: LA76x_2482(prxIIE-2)
LEZ: GLE_2732
LEM: LEN_2294
DKO: I596_2052
VVU: VV2_0770
VVY: VVA1236
VSP: VS_2880
VAN: VAA_02625
VTA: A2973
VFI: VF_2300
PPR: PBPRA0272(NMB0946)
PPU: PP_2700
PPF: Pput_3052
PPT: PPS_2650
PPI: YSA_09706
PPX: T1E_2704
PPUH: B479_12835
PPUT: L483_11020
PPUN: PP4_31260
PPUD: DW66_2910
PMON: X969_12585
PMOT: X970_12230
MCT: MCR_0722
MCS: DR90_1217
SON: SO_4640
SDN: Sden_3541
SFR: Sfri_0215
SAZ: Sama_3513
SLO: Shew_3641
SWD: Swoo_0147
SWP: swp_4869
SVO: SVI_0158
SPSW: Sps_00228
ILO: IL2478
PHA: PSHAa0759 PSHAa2650(ahpC)
PSM: PSM_A2303 PSM_A2687(ahpC)
MAD: HP15_3621
GPS: C427_1465
FBL: Fbal_2362
MYA: MORIYA_1748(PGdx)
MCA: MCA0042
MMAI: sS8_4176
TCX: Tcr_0139
HMAR: HVMH_0174
MEJ: Q7A_2651
MEC: Q7C_1096
AEH: Mlg_1224
HHA: Hhal_1689
TKM: TK90_1856
TNI: TVNIR_0808(grxC_[C])
TVR: TVD_04035
GAI: IMCC3135_32690(garA_3)
HCH: HCH_00153
HEL: HELO_3212
HBE: BEI_2655
APAC: S7S_17340
KKO: Kkor_1581
KGE: TQ33_0866
TOL: TOL_0673
AHA: AHA_1268
ASA: ASA_1254
AVR: B565_2944
AMED: B224_3935
ACAV: VI35_15110
SVA: SVA_3395
TBN: TBH_C0088
ENM: EBS_0324
NME: NMB0946
NMP: NMBB_1684
NMA: NMA1141
NMW: NMAA_0743
NMC: NMC0923
NMN: NMCC_0889
NMT: NMV_1449
NMI: NMO_0843
NGO: NGO0926
NGK: NGK_0873
NLA: NLA_13140
CVI: CV_2036
LHK: LHK_01491
PSE: NH8B_2293
RSO: RSc2838
RSN: RSPO_c00670(ahp1)
RSE: F504_2766
RPI: Rpic_3083
REH: H16_A3267(h16_A3267) H16_B1097(h16_B1097)
RME: Rmet_3122 Rmet_4889(prx5)
BMA: BMA2544
BMAL: DM55_738
BMAE: DM78_718
BMAQ: DM76_719
BMAI: DM57_1315
BMAF: DM51_2180
BMAZ: BM44_131
BMAB: BM45_2707
BPS: BPSL3019
BPSE: BDL_2402
BPSM: BBQ_282
BPSU: BBN_410
BPSD: BBX_799
BPK: BBK_1899
BPSH: DR55_1494
BPSA: BBU_2536
BPSO: X996_1115
BUT: X994_3130
BTE: BTH_I1124
BTQ: BTQ_2804
BTJ: BTJ_2891
BTZ: BTL_796
BTD: BTI_587
BTV: BTHA_912
BTHE: BTN_568
BTHM: BTRA_1028
BTHA: DR62_740
BTHL: BG87_1018
BOK: DM82_2686
BOC: BG90_2021
BVE: AK36_264
BCN: Bcen_0083
BCJ: BCAL3456
BCEN: DM39_379
BCEW: DM40_1272
BCEO: I35_0419
BAM: Bamb_0469
BMU: Bmul_2830
BMK: DM80_1102
BMUL: NP80_603
BCT: GEM_2953
BCED: DM42_1274
BDL: AK34_2577
BCON: NL30_21255
BUB: BW23_1180
BLAT: WK25_02715
BTEI: WS51_13190
BSEM: WJ12_02465
BPSL: WS57_20280
BMEC: WJ16_02445
BSTG: WT74_02770
BGU: KS03_1399
BGO: BM43_1896
BUK: MYA_0477
BUL: BW21_655
BXE: Bxe_A0492
BXB: DR64_2668
BFN: OI25_1952
PNU: Pnuc_0173
PNE: Pnec_0187
CABA: SBC2_31060
PUT: PT7_2089
AFQ: AFA_03120
ODI: ODI_R3390
RFR: Rfer_3785
POL: Bpro_0266
AAV: Aave_0348
AJS: Ajs_0288
AAA: Acav_0416
ACRA: BSY15_1769
VEI: Veis_1274
DAC: Daci_0401
CTES: O987_01610
RTA: Rta_03360
HYB: Q5W_24820
HPSE: HPF_02090
CBAA: SRAA_2104
CBAB: SMCB_2128
MPT: Mpe_A3433
HAR: HEAR2804(prdX1)
MMS: mma_3009(ahp1)
JAG: GJA_4469(PRXIID)
CFU: CFU_3935
CARE: LT85_4486
LCH: Lcho_3989
RGE: RGE_03390
BBAG: E1O_14740
BPRC: D521_0176
SCL: sce0905
HOH: Hoch_5126
PACA: ID47_02715
MLO: mll7508
MHUA: MCHK_0990
MES: Meso_0751
PLA: Plav_0683
SME: SMc00072
SMER: DU99_04720
SMD: Smed_0530
EAD: OV14_1856
ATU: Atu0779
ARA: Arad_1253
AVI: Avi_1067
RLE: RL1037
RLG: Rleg_0661
RHT: NT26_0525
SHZ: shn_04290
BME: BMEI1456
BMEL: DK63_2031
BMEE: DK62_923
BMF: BAB1_0504
BABO: DK55_510
BABR: DO74_1377
BABT: DK49_273
BABB: DK48_1616
BABU: DK53_500
BABS: DK51_961
BABC: DO78_417
BMS: BR0478
BSZ: DK67_1406
BOV: BOV_0483
BCAR: DK60_562
BCAS: DA85_02285
BMR: BMI_I480
BPP: BPI_I507
BPV: DK65_882
OAN: Oant_0592
OAH: DR92_2348
BJA: bll1317
BRA: BRADO6585
BBT: BBta_0951
BRS: S23_64840
AOL: S58_10220
BRAD: BF49_3346
RPA: RPA4268
RPB: RPB_1343
RPC: RPC_4075
RPD: RPD_4027
RPE: RPE_1706
RPT: Rpal_4747
NWI: Nwi_2686
NHA: Nham_3732
OCA: OCAR_7328
XAU: Xaut_2596
AZC: AZC_0486
SNO: Snov_3080
MDI: METDI3328
MEX: Mext_2595
MCH: Mchl_2818
MPO: Mpop_2623
MET: M446_6266
MNO: Mnod_6935
MOR: MOC_4470
META: Y590_12400
MAQU: Maq22A_c19365(ahp1)
MSL: Msil_1257
HDN: Hden_2894
RVA: Rvan_3258
PHL: KKY_508
BVR: BVIR_79
BLAG: BLTE_33010
MSC: BN69_2285
PLEO: OHA_1_01825(garA)
MMED: Mame_03378
MCG: GL4_1001
HDI: HDIA_1130
RBM: TEF_09435
CCR: CC_3394
CAK: Caul_4490
CSE: Cseg_0296
PZU: PHZ_c0554
TSV: DSM104635_01353(garA)
SIL: SPO3736
RSP: RSP_0899
JAN: Jann_0439
RDE: RD1_0946
PDE: Pden_2325
DSH: Dshi_0113(ahpC)
KVL: KVU_0055
KVU: EIO_0494
KRO: BVG79_00318(ahpC)
PSF: PSE_1560
PGD: Gal_00502
OTM: OSB_01420
LAQU: R2C4_15215
CID: P73_0555
MALG: MALG_03091
RSU: NHU_03900
RHC: RGUI_2694
AHT: ANTHELSMS3_00150(tpx)
MALU: KU6B_07910
HNE: HNE_1052
HBA: Hbal_1035
GAK: X907_0998
NAR: Saro_2004
SAL: Sala_0166
SPHP: LH20_16475
SMAZ: LH19_18740
SPHU: SPPYR_0136
SWI: Swit_2670
SPHD: HY78_12160
SPHM: G432_16495
STAX: MC45_04730
SPHI: TS85_06360
SSAN: NX02_13515
SPKC: KC8_05480
SJP: SJA_C1-16860(ahpC)
SSY: SLG_23620
SPMI: K663_07670
SPHB: EP837_00189(prdX)
SPHR: BSY17_2971
SINB: SIDU_06200
SPHT: K426_13165
BLAS: BSY18_1301
SMIC: SmB9_12670
ELI: ELI_05035
ERF: FIU90_08970(garA)
AAY: WYH_00711
ALB: AEB_P2002
ACR: Acry_1905
SHUM: STHU_51600
RRU: Rru_A3057
RRF: F11_15660
RCE: RC1_3646
AZL: AZL_015390(ahpC)
TMO: TMO_2797
THAL: A1OE_267
EFK: P856_171(ahpC)
TXI: TH3_17525
MAGQ: MGMAQ_2812
PUB: SAR11_0127(pmpA)
BMX: BMS_1435
AFR: AFE_0367
ACU: Atc_2488
ATX: GCD22_00450(pgdx)
PDX: Psed_0278
PSEA: WY02_05130
PSEE: FRP1_08225
PSEH: XF36_12395
PAUT: Pdca_26620
MAR: MAE_62780
MPK: VL20_2089
ANA: all1541
NSH: GXM_03596
AVA: Ava_4981
CTHE: Chro_2423
 » show all
Reference
1  [PMID:12517450]
  Authors
Wood ZA, Schroder E, Robin Harris J, Poole LB.
  Title
Structure, mechanism and regulation of peroxiredoxins.
  Journal
Trends Biochem Sci 28:32-40 (2003)
DOI:10.1016/S0968-0004(02)00003-8
Reference
2  [PMID:12606554]
  Authors
Pauwels F, Vergauwen B, Vanrobaeys F, Devreese B, Van Beeumen JJ
  Title
Purification and characterization of a chimeric enzyme from Haemophilus influenzae Rd that exhibits glutathione-dependent peroxidase activity.
  Journal
J Biol Chem 278:16658-66 (2003)
DOI:10.1074/jbc.M300157200
  Sequence
[hin:HI0572]
Reference
3  [PMID:15004285]
  Authors
Manevich Y, Feinstein SI, Fisher AB
  Title
Activation of the antioxidant enzyme 1-CYS peroxiredoxin requires glutathionylation mediated by heterodimerization with pi GST.
  Journal
Proc Natl Acad Sci U S A 101:3780-5 (2004)
DOI:10.1073/pnas.0400181101
Reference
4  [PMID:19332553]
  Authors
Greetham D, Grant CM
  Title
Antioxidant activity of the yeast mitochondrial one-Cys peroxiredoxin is dependent on thioredoxin reductase and glutathione in vivo.
  Journal
Mol Cell Biol 29:3229-40 (2009)
DOI:10.1128/MCB.01918-08
Reference
5  [PMID:25398878]
  Authors
Lim JG, Bang YJ, Choi SH
  Title
Characterization of the Vibrio vulnificus 1-Cys peroxiredoxin Prx3 and regulation of its expression by the Fe-S cluster regulator IscR in response to oxidative stress and iron starvation.
  Journal
J Biol Chem 289:36263-74 (2014)
DOI:10.1074/jbc.M114.611020
  Sequence
Other DBs
ExplorEnz - The Enzyme Database: 1.11.1.27
IUBMB Enzyme Nomenclature: 1.11.1.27
ExPASy - ENZYME nomenclature database: 1.11.1.27
BRENDA, the Enzyme Database: 1.11.1.27
CAS: 207137-51-7
LinkDB

KEGG   REACTION: R12578
Entry
R12578                      Reaction                               

Name
glutathione:hydroperoxide oxidoreductase
Definition
2 Glutathione + ROOH <=> Glutathione disulfide + H2O + ROH
Equation
Reaction class
RC00011  C00051_C00127
Enzyme
Pathway
rn00480  Glutathione metabolism
rn01100  Metabolic pathways
Orthology
K11188  peroxiredoxin 6 [EC:1.11.1.7 1.11.1.27 3.1.1.-]
K24136  glutathione-dependent peroxiredoxin [EC:1.11.1.27]
K24137  glutaredoxin/glutathione-dependent peroxiredoxin [EC:1.11.1.25 1.11.1.27]
K24138  glutaredoxin/glutathione-dependent peroxiredoxin [EC:1.11.1.25 1.11.1.27]
LinkDB

DBGET integrated database retrieval system