KEGG   ORTHOLOGY: K11988Help
Entry
K11988                      KO                                     

Name
SHH
Definition
sonic hedgehog
Pathway
ko04340  Hedgehog signaling pathway
ko04360  Axon guidance
ko05200  Pathways in cancer
ko05205  Proteoglycans in cancer
ko05217  Basal cell carcinoma
ko05226  Gastric cancer
Disease
H00039  Basal cell carcinoma
H00267  Holoprosencephaly
H00652  Solitary median maxillary central incisor syndrome
H01027  Microphthalmia
H01160  Schizencephaly
Brite
KEGG Orthology (KO) [BR:ko00001]
 09130 Environmental Information Processing
  09132 Signal transduction
   04340 Hedgehog signaling pathway
    K11988  SHH; sonic hedgehog
 09150 Organismal Systems
  09158 Development and regeneration
   04360 Axon guidance
    K11988  SHH; sonic hedgehog
 09160 Human Diseases
  09161 Cancer: overview
   05200 Pathways in cancer
    K11988  SHH; sonic hedgehog
   05205 Proteoglycans in cancer
    K11988  SHH; sonic hedgehog
  09162 Cancer: specific types
   05226 Gastric cancer
    K11988  SHH; sonic hedgehog
   05217 Basal cell carcinoma
    K11988  SHH; sonic hedgehog
 09180 Brite Hierarchies
  09181 Protein families: metabolism
   01002 Peptidases
    K11988  SHH; sonic hedgehog
  09183 Protein families: signaling and cellular processes
   00536 Glycosaminoglycan binding proteins
    K11988  SHH; sonic hedgehog
Peptidases [BR:ko01002]
 Cysteine Peptidases
  Family C46: hedgehog family
   K11988  SHH; sonic hedgehog
Glycosaminoglycan binding proteins [BR:ko00536]
 Heparan sulfate/Haparin
  Morphogens
   K11988  SHH; sonic hedgehog
BRITE hierarchy
Other DBs
GO: 0005113
Genes
HSA: 6469(SHH)
PTR: 743371(SHH)
PPS: 100995872(SHH)
GGO: 101146888(SHH)
PON: 100461003(SHH)
NLE: 100582247(SHH)
MCC: 716553(SHH)
MCF: 102120970(SHH)
CSAB: 103227290(SHH)
RRO: 104666156(SHH)
RBB: 108520988(SHH)
CJC: 100395600(SHH)
SBQ: 101034605(SHH)
MMU: 20423(Shh)
MCAL: 110294612(Shh)
MPAH: 110316392(Shh)
RNO: 29499(Shh)
MUN: 110560215(Shh)
CGE: 100773402(Shh)
NGI: 103745341(Shh)
HGL: 101719896(Shh)
CCAN: 109702047(Shh)
OCU: 100352774(SHH)
TUP: 102483981(SHH)
CFA: 608860(SHH)
AML: 100481788(SHH)
UMR: 103660977(SHH)
UAH: 113241522(SHH)
ORO: 101374415(SHH)
FCA: 111557492(SHH)
AJU: 113596760(SHH)
BTA: 286821(SHH)
BOM: 102271735(SHH)
BIU: 109558045(SHH)
BBUB: 102412043(SHH)
PHD: 102336308(SHH)
CHX: 102170201(SHH)
OAS: 101117666(SHH)
SSC: 100512749(SHH)
CFR: 102522058(SHH)
CDK: 105098271(SHH)
BACU: 102998170(SHH)
LVE: 103077728(SHH)
OOR: 101270161(SHH)
DLE: 111176269(SHH)
ECB: 100147450(SHH)
EPZ: 103559504(SHH)
EAI: 106823318(SHH)
MYB: 102254867(SHH)
MYD: 102767220(SHH)
MNA: 107524916(SHH)
HAI: 109391492(SHH)
RSS: 109453035(SHH)
DRO: 112308317(SHH)
PALE: 102882514(SHH)
LAV: 100669796(SHH)
TMU: 101351744
MDO: 100016531(SHH)
SHR: 100925029(SHH)
PCW: 110223909(SHH)
OAA: 100081692(SHH)
GGA: 395615(SHH)
MGP: 100546709(SHH)
CJO: 107308849(SHH)
APLA: 101805147(SHH)
ACYG: 106038889(SHH)
TGU: 100222391(SHH)
LSR: 110468547(SHH)
SCAN: 103812722(SHH)
GFR: 102040849(SHH)
FAB: 101807935(SHH)
PHI: 102103261(SHH)
PMAJ: 107201071(SHH)
CCAE: 111944497
CCW: 104686517(SHH)
ETL: 114055534(SHH)
FPG: 101912554(SHH)
FCH: 102047067(SHH)
CLV: 102093186(SHH)
EGZ: 104125281
NNI: 104022293(SHH)
ACUN: 113477267(SHH)
AAM: 106492687(SHH)
ASN: 102383680(SHH)
AMJ: 102570851(SHH)
PSS: 102444691(SHH)
CMY: 102932065(SHH)
CPIC: 101935657(SHH)
ACS: 100557233(shh)
PVT: 110071907(SHH)
PBI: 103063349(SHH)
PMUR: 107303327(SHH)
GJA: 107116932(SHH)
XLA: 108719826 398047(shh.L)
XTR: 100487601(shh)
NPR: 108785020(SHH)
DRE: 30269(shha) 30444(shhb)
IPU: 108267066(shh) 108280234
AMEX: 103032897 103046459(shh)
TRU: 446055(shh)
LCO: 104926923(shh) 104930803
NCC: 104951474(shh)
MZE: 101468555(shh)
OLA: 100049186(shh)
XMA: 102222680(shh)
XCO: 114136393(shh)
PRET: 103456900(shh)
NFU: 107382481(shh)
KMR: 108230333(shh)
CSEM: 103377530(shh)
LCF: 108880474 108896315(shh)
SDU: 111233282 111237885(shh)
BPEC: 110170075(shh)
MALB: 109961432(shh)
SFM: 108937058 108937569(shh)
LCM: 102356687(SHH)
CMK: 103188357(shh)
 » show all
TaxonomyKoalaUniProt
Reference
PMID:7583126
  Authors
Lopez-Martinez A, Chang DT, Chiang C, Porter JA, Ros MA, Simandl BK, Beachy PA, Fallon JF
  Title
Limb-patterning activity and restricted posterior localization of the amino-terminal product of Sonic hedgehog cleavage.
  Journal
Curr Biol 5:791-6 (1995)
DOI:10.1016/S0960-9822(95)00156-4
Reference
  Authors
Pepinsky RB, Rayhorn P, Day ES, Dergay A, Williams KP, Galdes A, Taylor FR, Boriack-Sjodin PA, Garber EA
  Title
Mapping sonic hedgehog-receptor interactions by steric interference.
  Journal
J Biol Chem 275:10995-1001 (2000)
DOI:10.1074/jbc.275.15.10995
  Sequence
[hsa:6469]
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